LOCUS       NP_001171038            2325 aa            linear   ROD 29-APR-2025
DEFINITION  otogelin-like protein isoform 1 precursor [Mus musculus].
ACCESSION   NP_001171038 XP_001478640 XP_898757
VERSION     NP_001171038.1
DBSOURCE    REFSEQ: accession NM_001177567.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2325)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 2325)
  AUTHORS   Li,Z., Zhang,Y., Zhang,X., Cao,C., Luo,X., Gui,Y., Tang,Y. and
            Yuan,S.
  TITLE     OTOGL, a gelforming mucin protein, is nonessential for male germ
            cell development and spermatogenesis in mice
  JOURNAL   Reprod Biol Endocrinol 19 (1), 95 (2021)
   PUBMED   34174893
  REMARK    GeneRIF: OTOGL, a gelforming mucin protein, is nonessential for
            male germ cell development and spermatogenesis in mice.
            Erratum:[Reprod Biol Endocrinol. 2021 Sep 8;19(1):136. doi:
            10.1186/s12958-021-00803-3. PMID: 34496867]
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2325)
  AUTHORS   Avan,P., Le Gal,S., Michel,V., Dupont,T., Hardelin,J.P., Petit,C.
            and Verpy,E.
  TITLE     Otogelin, otogelin-like, and stereocilin form links connecting
            outer hair cell stereocilia to each other and the tectorial
            membrane
  JOURNAL   Proc Natl Acad Sci U S A 116 (51), 25948-25957 (2019)
   PUBMED   31776257
  REMARK    GeneRIF: Otogelin, otogelin-like, and stereocilin form links
            connecting outer hair cell stereocilia to each other and the
            tectorial membrane.
REFERENCE   4  (residues 1 to 2325)
  AUTHORS   Yariz,K.O., Duman,D., Zazo Seco,C., Dallman,J., Huang,M.,
            Peters,T.A., Sirmaci,A., Lu,N., Schraders,M., Skromne,I.,
            Oostrik,J., Diaz-Horta,O., Young,J.I., Tokgoz-Yilmaz,S.,
            Konukseven,O., Shahin,H., Hetterschijt,L., Kanaan,M., Oonk,A.M.,
            Edwards,Y.J., Li,H., Atalay,S., Blanton,S., Desmidt,A.A., Liu,X.Z.,
            Pennings,R.J., Lu,Z., Chen,Z.Y., Kremer,H. and Tekin,M.
  TITLE     Mutations in OTOGL, encoding the inner ear protein otogelin-like,
            cause moderate sensorineural hearing loss
  JOURNAL   Am J Hum Genet 91 (5), 872-882 (2012)
   PUBMED   23122586
REFERENCE   5  (residues 1 to 2325)
  AUTHORS   Shahin,H., Rahil,M., Abu Rayan,A., Avraham,K.B., King,M.C.,
            Kanaan,M. and Walsh,T.
  TITLE     Nonsense mutation of the stereociliar membrane protein gene PTPRQ
            in human hearing loss DFNB84
  JOURNAL   J Med Genet 47 (9), 643-645 (2010)
   PUBMED   20472657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113439.14 and AC123948.4.
            
            On or before Apr 17, 2010 this sequence version replaced
            XP_001478640.1, XP_898757.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2325
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 56.11 cM"
     Protein         1..2325
                     /product="otogelin-like protein isoform 1 precursor"
                     /note="otogelin-like protein"
                     /calculated_mol_wt=258491
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2458
     mat_peptide     23..2325
                     /product="Otogelin-like protein. /id=PRO_0000421106"
                     /note="propagated from UniProtKB/Swiss-Prot (F7A4A7.1)"
                     /calculated_mol_wt=258491
     Region          114..260
                     /region_name="VWD"
                     /note="von Willebrand factor type D domain; pfam00094"
                     /db_xref="CDD:459671"
     Region          311..371
                     /region_name="C8"
                     /note="C8 domain; pfam08742"
                     /db_xref="CDD:462584"
     Region          386..434
                     /region_name="TIL"
                     /note="Trypsin Inhibitor like cysteine rich domain;
                     pfam01826"
                     /db_xref="CDD:460351"
     Site            425
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (F7A4A7.1)"
     Region          463..625
                     /region_name="VWD"
                     /note="von Willebrand factor (vWF) type D domain;
                     smart00216"
                     /db_xref="CDD:214566"
     Region          668..732
                     /region_name="C8"
                     /note="C8 domain; pfam08742"
                     /db_xref="CDD:462584"
     Region          736..791
                     /region_name="TIL"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     cd19941"
                     /db_xref="CDD:410995"
     Site            order(745,749,762,766)
                     /site_type="other"
                     /note="reactive site [polypeptide binding]"
                     /db_xref="CDD:410995"
     Site            817
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (F7A4A7.1)"
     Region          834..899
                     /region_name="TIL"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     cd19941"
                     /db_xref="CDD:410995"
     Site            order(843,857,870,876)
                     /site_type="other"
                     /note="reactive site [polypeptide binding]"
                     /db_xref="CDD:410995"
     Site            867
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (F7A4A7.1)"
     Region          930..1085
                     /region_name="VWD"
                     /note="von Willebrand factor (vWF) type D domain;
                     smart00216"
                     /db_xref="CDD:214566"
     Region          1120..1194
                     /region_name="C8"
                     /note="This domain contains 8 conserved cysteine residues;
                     smart00832"
                     /db_xref="CDD:214843"
     Region          1199..1352
                     /region_name="beta-trefoil_ABD_ABFB-like"
                     /note="Arabinose-binding domain (ABD), beta-trefoil fold,
                     found in the ABFB family; cl49624"
                     /db_xref="CDD:483964"
     Site            order(1215,1325..1329,1341,1345)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:467807"
     Site            order(1277..1278,1280..1281,1297)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:467807"
     Site            1280
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (F7A4A7.1)"
     Region          1367..1418
                     /region_name="TIL"
                     /note="Trypsin Inhibitor like cysteine rich domain;
                     pfam01826"
                     /db_xref="CDD:460351"
     Site            order(1370,1374,1386,1391)
                     /site_type="other"
                     /note="reactive site [polypeptide binding]"
                     /db_xref="CDD:410995"
     Region          1498..1671
                     /region_name="VWD"
                     /note="von Willebrand factor (vWF) type D domain;
                     smart00216"
                     /db_xref="CDD:214566"
     Site            1576
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (F7A4A7.1)"
     Region          1705..1775
                     /region_name="C8"
                     /note="This domain contains 8 conserved cysteine residues;
                     smart00832"
                     /db_xref="CDD:214843"
     Region          1778..1836
                     /region_name="TIL"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     cl20226"
                     /db_xref="CDD:473303"
     Site            2170
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (F7A4A7.1)"
     Region          2252..2325
                     /region_name="GHB_like"
                     /note="Glycoprotein hormone beta chain homologues;
                     cl21545"
                     /db_xref="CDD:473907"
     Site            2296
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (F7A4A7.1)"
     CDS             1..2325
                     /gene="Otogl"
                     /gene_synonym="EG628870; Gm6924"
                     /coded_by="NM_001177567.2:252..7229"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS56747.1"
                     /db_xref="GeneID:628870"
                     /db_xref="MGI:MGI:3647600"
ORIGIN      
        1 mvpwralslp illvslrgyv cassvlsets esefyeneqr rallavqfea tspryffhea
       61 inwgeskikg scpheclnga fcsktgtcdc qifqalgtrc qivpnmgsgr dgicktwgqy
      121 hfetfdgiyy yfpgscsyif akdcgnlepq ytvwvhnspk clgsvyscyr sislffsnqe
      181 eiriygheir kngislslpq tlgqvhlekv adyilvkttf gfslawdgis giylklseeh
      241 rgkscglcan yngiqsddfv ilqedytedi amfanswlvl tpddtkcvpt psdfpnpcss
      301 gmpafeaiff kcqillqfpf lscheyidpy lyiascvndl cktdddetyc raateyarac
      361 shagfpiqdw rddfpactdk cddsfvhrdc isccppsctf ekqclgsnlh cldgcycadg
      421 limdngtcis lescpcsfhg laysvgskie qectecvcvg gvwnctehdc pvqcsvvgds
      481 hfttfdgrhy sfiglcqyil vkgtgkdrft itlqkahceq nlglvclqsi tlileddfnk
      541 qvtlsrggqi vtspnqgftl ngiveiqtls slfillrttf glkilfaidg eriyiqlssa
      601 wkrrtlglcg tfngnirddf lspsgmiegt pqlhahawrv sstcfapvhv pmvdpcninq
      661 qnigyaahcd vihqelfapc hvyvspglyy qlcrhdackc gspclcnala hyaylcgqrg
      721 vpidfrahis fcavvcqkgm lyhhcsslcl rsctslsspe qckddcaegc ncpegkfyee
      781 tlnfcvpiyh crchyrgsiy qpgeliptps glcqcsngtv kcdelatpst vhacpegkey
      841 fdcrfpdpal paggincett canlamnftc apsspcisgc vcaagmaehk gkcyvpescp
      901 ciwkdweyss gevistpcyt cvcrrgmfnc tyypcpavct vygdrhyhsf dgleydyisd
      961 cqvflikstd dsdisvisqn kkcfdndivc sksvlisigd teiylndapy kqkrsgffle
     1021 srpeyqlwka gfyiviyfpe editilwdek ttihikvgpq wknklaglcg nfdkctsndm
     1081 ttsnnievrn aqvfgdswal gqcedlmeal kpceahqnkf pyakrecsil ysdvfapcrn
     1141 vidvtsfakn chedtcncnl ggdceclcts vaayaykccq egvpvhwrsp tvcaldceyy
     1201 nqglgegpym lasygqsglv lganmtsrsv fslprsnnrg nlffifmitp glfkektssl
     1261 alvslesaer pnyflyvhdn dtlslklwra nsefhqratf fhhqglwipg ysafelyskk
     1321 gyfivfmgss vkaskyddse efkqsssfsi eeiqavvpyr rmcewryepc atpcfktcsd
     1381 pealactflp pvegclpycp knmildettl kcvhpedcip lfptepalpp ditpsdmtpt
     1441 pglecepqqf dpvyncsqyi clnmewtfyn wslncpkdle mpdcgfrgwp vqvntdiccp
     1501 ewecpcrcsm lselsiitfd gnsaalssma syilvrvpge ivvvhidkcs mnqnghalkk
     1561 pasfgrisgl cfkklnvtts ihkilinrvv rkvdvdsivv plpfsshelf iedsgtmyvi
     1621 ttpagliikw ahltgiidih fgpqfnlssy teglcgicnd npdddlrmqn gtiitnmedi
     1681 elfigsweie ksfevtmrrp vrncteydcs hciellnreg fipchdkvsp rdfcekmwin
     1741 ytyfwsyecd aisayvalcn kfdiciqwrt pdycplscpe gkeyqpcvrp ceartclnkw
     1801 fyghssclnl redcvckngt ilhrpdktlc ipeqecvctd reehprsage iwnggidect
     1861 lykcledgni ipiepvceee pspicertae vvigivdklt ccskkvcgcd mslcdrtipp
     1921 ctnsqklivg ysalsccpqy ececdtvrcp distpvcrdd qfvlqvrqge pccfypscvc
     1981 ktcteptpqc tdgefltvni ntthlccpqy ycvcepdlcp ppslecakdm nlvkenvsgq
     2041 ccpnwrcecn cetlvmptcd vgefaaidqn fqtdcgcvqy lcekddvcvf qevsvlnpgq
     2101 slikyleeef cyiiecldek dnytdfhtln vtmvncskdc dahqiyipss sdydccgtck
     2161 nisckfimen gtsviyeegs twhyncstye cvnteegati lnysmvcppf netecklneg
     2221 ivklynegcc kickreeric qkviiksiik kqdcvsqssi svascdgkcp satiyninve
     2281 shlrfckccr engvrnvtvp lhcsgngtev mytlqepidc tcqwn
//
