LOCUS       NM_013624              10043 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus otogelin (Otog), mRNA.
ACCESSION   NM_013624 XM_001476814 XM_001477482
VERSION     NM_013624.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10043)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 10043)
  AUTHORS   Tian,C. and Johnson,K.R.
  TITLE     TBX1 is required for normal stria vascularis and semicircular canal
            development
  JOURNAL   Dev Biol 457 (1), 91-103 (2020)
   PUBMED   31550482
REFERENCE   3  (bases 1 to 10043)
  AUTHORS   Avan,P., Le Gal,S., Michel,V., Dupont,T., Hardelin,J.P., Petit,C.
            and Verpy,E.
  TITLE     Otogelin, otogelin-like, and stereocilin form links connecting
            outer hair cell stereocilia to each other and the tectorial
            membrane
  JOURNAL   Proc Natl Acad Sci U S A 116 (51), 25948-25957 (2019)
   PUBMED   31776257
  REMARK    GeneRIF: Otogelin, otogelin-like, and stereocilin form links
            connecting outer hair cell stereocilia to each other and the
            tectorial membrane.
REFERENCE   4  (bases 1 to 10043)
  AUTHORS   Goodyear,R.J., Lu,X., Deans,M.R. and Richardson,G.P.
  TITLE     A tectorin-based matrix and planar cell polarity genes are required
            for normal collagen-fibril orientation in the developing tectorial
            membrane
  JOURNAL   Development 144 (21), 3978-3989 (2017)
   PUBMED   28935705
REFERENCE   5  (bases 1 to 10043)
  AUTHORS   El Hakam Kamareddin,C., Magnol,L. and Blanquet,V.
  TITLE     A new Otogelin ENU mouse model for autosomal-recessive nonsyndromic
            moderate hearing impairment
  JOURNAL   Springerplus 4, 730 (2015)
   PUBMED   26636018
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10043)
  AUTHORS   Simmler,M.C., Cohen-Salmon,M., El-Amraoui,A., Guillaud,L.,
            Benichou,J.C., Petit,C. and Panthier,J.J.
  TITLE     Targeted disruption of otog results in deafness and severe
            imbalance
  JOURNAL   Nat Genet 24 (2), 139-143 (2000)
   PUBMED   10655058
REFERENCE   7  (bases 1 to 10043)
  AUTHORS   Cohen-Salmon,M., Mattei,M.G. and Petit,C.
  TITLE     Mapping of the otogelin gene (OTGN) to mouse chromosome 7 and human
            chromosome 11p14.3: a candidate for human autosomal recessive
            nonsyndromic deafness DFNB18
  JOURNAL   Mamm Genome 10 (5), 520-522 (1999)
   PUBMED   10337628
REFERENCE   8  (bases 1 to 10043)
  AUTHORS   Cohen-Salmon,M., El-Amraoui,A., Leibovici,M. and Petit,C.
  TITLE     Otogelin: a glycoprotein specific to the acellular membranes of the
            inner ear
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14450-14455 (1997)
   PUBMED   9405633
REFERENCE   9  (bases 1 to 10043)
  AUTHORS   Li,X., Luna,J., Lombroso,P.J. and Francke,U.
  TITLE     Molecular cloning of the human homolog of a striatum-enriched
            phosphatase (STEP) gene and chromosomal mapping of the human and
            murine loci
  JOURNAL   Genomics 28 (3), 442-449 (1995)
   PUBMED   7490079
REFERENCE   10 (bases 1 to 10043)
  AUTHORS   Steel,K.P.
  TITLE     Inherited hearing defects in mice
  JOURNAL   Annu Rev Genet 29, 675-701 (1995)
   PUBMED   8825490
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120135.7 and AC020786.20.
            
            On or before Jun 15, 2008 this sequence version replaced
            XM_001477482.1, XM_001476814.1, NM_013624.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164138
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC120135.7         949-1081            c
            134-194             AC120135.7         498-558             c
            195-255             AC120135.7         296-356             c
            256-331             AC020786.20        164580-164655       c
            332-424             AC020786.20        163614-163706       c
            425-579             AC020786.20        163310-163464       c
            580-698             AC020786.20        160844-160962       c
            699-904             AC020786.20        159821-160026       c
            905-1035            AC020786.20        158870-159000       c
            1036-1142           AC020786.20        158575-158681       c
            1143-1252           AC020786.20        157871-157980       c
            1253-1381           AC020786.20        157372-157500       c
            1382-1490           AC020786.20        155740-155848       c
            1491-1537           AC020786.20        155441-155487       c
            1538-1683           AC020786.20        154866-155011       c
            1684-1816           AC020786.20        150606-150738       c
            1817-1994           AC020786.20        149900-150077       c
            1995-2119           AC020786.20        148156-148280       c
            2120-2332           AC020786.20        147107-147319       c
            2333-2525           AC020786.20        145732-145924       c
            2526-2600           AC020786.20        144189-144263       c
            2601-2644           AC020786.20        143976-144019       c
            2645-2798           AC020786.20        142563-142716       c
            2799-2906           AC020786.20        140594-140701       c
            2907-3045           AC020786.20        138582-138720       c
            3046-3180           AC020786.20        136119-136253       c
            3181-3327           AC020786.20        135730-135876       c
            3328-3447           AC020786.20        135336-135455       c
            3448-3564           AC020786.20        133224-133340       c
            3565-3721           AC020786.20        132452-132608       c
            3722-3748           AC020786.20        128829-128855       c
            3749-3916           AC020786.20        126049-126216       c
            3917-4195           AC020786.20        124787-125065       c
            4196-4313           AC020786.20        124096-124213       c
            4314-4393           AC020786.20        123133-123212       c
            4394-6159           AC020786.20        120974-122739       c
            6160-6328           AC020786.20        120126-120294       c
            6329-6474           AC020786.20        119729-119874       c
            6475-6564           AC020786.20        118931-119020       c
            6565-6748           AC020786.20        113933-114116       c
            6749-6969           AC020786.20        111608-111828       c
            6970-7108           AC020786.20        111317-111455       c
            7109-7303           AC020786.20        109759-109953       c
            7304-7516           AC020786.20        109370-109582       c
            7517-7621           AC020786.20        108730-108834       c
            7622-7729           AC020786.20        108467-108574       c
            7730-7831           AC020786.20        107037-107138       c
            7832-7930           AC020786.20        106722-106820       c
            7931-7971           AC020786.20        105711-105751       c
            7972-8047           AC020786.20        104657-104732       c
            8048-8226           AC020786.20        104371-104549       c
            8227-8331           AC020786.20        104038-104142       c
            8332-8451           AC020786.20        103719-103838       c
            8452-8497           AC020786.20        102867-102912       c
            8498-8577           AC020786.20        100105-100184       c
            8578-10043          AC020786.20        98525-99990         c
FEATURES             Location/Qualifiers
     source          1..10043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.66 cM"
     gene            1..10043
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /note="otogelin"
                     /db_xref="GeneID:18419"
                     /db_xref="MGI:MGI:1202064"
     exon            1..133
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..8778
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /note="twister"
                     /codon_start=1
                     /product="otogelin precursor"
                     /protein_id="NP_038652.2"
                     /db_xref="CCDS:CCDS52251.1"
                     /db_xref="GeneID:18419"
                     /db_xref="MGI:MGI:1202064"
                     /translation="MGARMPRRCLLLLSCFCLLRVESTAEVQHQASALTWKISAELQQ
                     EPAPEPSHTYQEMSLAVEDVTTVMEGQEAEALAASAMSSWERRLHRAKCAPSYLFSCF
                     NGGECVHPALCDCRRFNATGPRCQLVYNVGPERDSICRTWGQHHVETFDGLYYYFSGK
                     GSYTLVGHHEPEGQSFSIQVHNDPQCGSAHYTCPRSVSLFLSGEREICLAKEVTHGGV
                     RVQLPQVVGGVQLQQLAGYVIARHPSAFTLAWDGISAIYIKMSPEFLGWTHGLCGNNN
                     ADPQDDLVTSYGKVTDDVGEFVHSWQEQVPNSPPGPVTTSLPRPPCLQQSPASMQGVY
                     ERCEVLLRPPFDTCHAYVSPLPFAASCTSDLCQSGGDEATWCRALMEYARACAQAGRP
                     LQGWRTQLSQCTVHCKEKAFIYNECIACCPASCQSRASCVDSEITCVDGCYCPNGLIF
                     EDGGCMSPAECPCEFHGTLHPPGSVVTEDCNACTCTAGKWVCSSSVCPAECSVTGDIH
                     FTTFDGRRYTFPATCQYILAKSRSSGTFTVTLQNAPCGLNQDGACVQSVSVILHQDPR
                     RQVTLTQAGDVLLFDQYKITPPYSDDAFEIRRLSSVFLRVRTNVGVRILYDREGLRLY
                     LQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSACVPLVPGSL
                     LDPCDVHLQAASYALQSCSVLTGELFAPCSAYLSPIPYFEQCRRDACRCGQPCLCATL
                     AHYARLCRRHGLPVDFRAHLPACALSCEATKEYSPCVTLCAPTCQDLASPDVCGANGG
                     GNFSREECVEGCTCPPDTFLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGHCHCK
                     DGVMSCDSRAPAAACPAGQVFVNCSELHPDPELSRERTCEQQLLNLSVPARGPCLSGC
                     ACPQGLLRHGDACFPPEECPCTWKGKEYFPGDQVVSSCHTCVCQRGSFQCTLHPCAST
                     CTAYGDRHYRTFDGLPYDFVGACKVHLVKSTSELSFSVMVEDVNCYGSGVICRKSISI
                     NVGSSLIIFDDDSGDPSPESFLDEKQAVHIWRAGFFTLVHFPREHITLLWDQRTTVHV
                     QAGPQWQGQLVGLCGNFDLKTINEMRTPENLELTNPQEFGSSWAAVECPDTPDPRDTC
                     VLNPLREPFARKECGILLSEVFETCHPVVDVTWFYSNCLTDTCGCSRGGDCECFCASV
                     AAYAHQCCQHGVVIDWRTPRICPYDCDFFNKALGKGPYQLSSVAAGGTLVATKAVDSD
                     IALVRAEDLAPGDISSFLLTAALYKAKAHDPDVVSLEAADRPNFFLHTTANGSIGLAK
                     WQRDEAFHQHASFSLHRGTWQAGLVALESLAKPGSFLHSSGLELALRAYEHTEVFRGG
                     ALFRLLDAKPLGAAYPTCEWRYDACASPCFQTCRDPRATSCQDVPRVEGCVPVCPTPK
                     VLDEVTQRCVYLEDCVEPAPRGPTETLGNETLVPGQVPPTTSAEQQLPQGLPGASAYS
                     PAPVPVAPPTSAPNPPMAATEGQAPSPGSTQPTLQTPLGLTTSNFPAGHTEATAREEG
                     AASLLTTSHPPGFSSSLPSSLQMPTSGIVSGATETTKVTITFTGSPNTTVASRSPPIP
                     RFPLMTKAVTVPSHDSFPVKTTPLQPSWLWSLSSRPMTSLGATSWPPTSPGSHLSTAV
                     TKVANKTMTSLSVLAQSTSSSSQPLAAVTTAHRAPASPLVTKGLEVVSATEKGEAGHS
                     QLTELPVSPPPSPAPIDLPHPAQHTTTAPGPSALSPGILAAGSPSTGAHRPGATALAS
                     LEPTRPPHLLSGLPLDTSLPLAKVGTSAPVATPGSKGYIPTPPPQHQATTLATAMTVS
                     PLTQSLSLTVPLMSAVEEQAHSPSPKPPQGTGMAPDQMLGATLPSFGASSVIAGVPPT
                     VSAAPRKSTTQRAAILSKKVSPPTLISDSVQGGFTELTPIVSHTVTPLATEAEGPRAG
                     TVPLVPTTYSLSRVSARTASREGPLVLLPQLAEAYGTPAGLQPQEDLVRQATTEQSGR
                     SAPAKSIAEESMEAEVNTSATCVPIAEQDCVRHICLEGQLIRVNQTQHCPQGAVRPRC
                     GVLGLAVRVGGDRCCPQWECACRCSIFPDLSFVTFDGSHAALFKEAIYVLSQSPDETI
                     SVHVLDCKSANLGHLNWPPFCLVILNVTHLAHHVSIDRFNRKVTVDSQVVWPPMSRYG
                     FRIEDTGHMYIVRTPSHIQIQWLHSSGLMILEASKVSKTQGHGLCGICDGDAANDLTL
                     KDGSVLGEAEDPAPFLDSWQVPSSLTSEGQTRFRPDSCATADCSPCLRMVSNRTFSAC
                     HSFVSPESFCELWIRDTKYVQQPCVALTVYVAMCHKFHVCIEWRGSDYCPFLCSSDST
                     YQACVAACEPPDTCQDGILGPLDPEQCQVLGEGCVCTEGTILHRRHSALCIPEDKCAC
                     TDSTGVPRALGETWNSSLSGCCQQQCQAPDTIIPVDLDCPGPRPESCPRFGEVILLQP
                     TEDPCCLGSVCVCNQTLCEGLAPTCRPGHSLITHFQEDSCCPSYSCECDPGLCEAEQV
                     PTCREDQILIEGRLGDSCCTSYFCGCGECSDPMPECQEGEALTVHRNTTELCCPLYQC
                     VCENFRCPQVQCGMGTSLVEVWSPDRCCPYKSCECDCDTIPVPRCHLWEKSQLDEEFM
                     HSVENVCGCAKYECVKAPVCLSRELGVMQPGQTVVELSADGVCHTSRCTDVLDPLTNF
                     YQINITSVLCDMHCEANQEYDHPRDLAACCGSCRNVSCLFTFPNGTTSLFLPGASWIA
                     DCARHHCGSTPLGAVLVRSPISCPPFNETECAKVGGSVVPSLEGCCRACKEDGRSCKK
                     VTIRMTIRKNDCRSNTPVNLVSCDGRCPSASIYNHNINTYARFCKCCREVGLQRRSVQ
                     LFCATNATWVPYTVQEPTDCACQWS"
     exon            134..194
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            195..255
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            256..331
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            332..424
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            425..579
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            580..698
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            699..904
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1035
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1142
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1252
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1381
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1490
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1537
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1683
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1816
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1994
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2119
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2332
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2525
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2600
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2644
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2798
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2906
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3045
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3180
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3327
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3447
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3564
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            3565..3721
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3748
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..3916
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4195
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            4196..4313
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            4314..4393
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..6159
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            6160..6328
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            6329..6474
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            6475..6564
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            6565..6748
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            6749..6969
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            6970..7108
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            7109..7303
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            7304..7516
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            7517..7621
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            7622..7729
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            7730..7831
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            7832..7930
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            7931..7971
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            7972..8047
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            8048..8226
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            8227..8331
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            8332..8451
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            8452..8497
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            8498..8577
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     exon            8578..10043
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10017..10022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /note="hexamer: AATAAA"
     polyA_site      10043
                     /gene="Otog"
                     /gene_synonym="4932420K09; Otgn; twt"
                     /note="major polyA site"
ORIGIN      
        1 agcagagccc tgggccaggc tctctgattg cctggcaccc tgatgggagc ccgcatgccc
       61 agacgatgct tgcttcttct ctcttgcttt tgtctactta gggttgagtc cactgcagag
      121 gtgcagcacc aggcctcagc actcacatgg aaaatcagtg cagagctgca acaggagcct
      181 gctcctgagc ccagccacac ataccaggag atgtcccttg cagtggagga tgtcacaaca
      241 gttatggaag gccaggaggc tgaagcctta gccgcatcgg ccatgtcttc gtgggaaaga
      301 cggctccatc gcgccaagtg tgcaccgtcg tacttgttct cctgcttcaa tgggggtgag
      361 tgtgtgcacc cagctctctg tgactgcagg cgcttcaatg ccactggacc ccgttgccag
      421 ttggtgtata atgtaggtcc tgagcgggac agcatctgcc ggacctgggg gcagcaccac
      481 gtggagacgt ttgacggcct gtactactac ttttctggaa agggcagcta cacgctggtg
      541 ggacaccacg aacccgaggg tcagagtttt tccatccagg tgcacaatga cccacagtgt
      601 ggctctgccc actacacctg cccgaggtct gtcagcctct tcctctcagg tgaacgtgag
      661 atctgcctgg ccaaggaagt cacccatgga ggtgtaaggg tccagctgcc gcaggtggtg
      721 gggggtgtgc agctgcagca gctggctggt tacgtcatcg cgaggcatcc gtcagccttc
      781 accctggcct gggatggtat ctcagccatt tacatcaaga tgagccctga gtttctgggc
      841 tggacccatg ggctgtgtgg gaacaacaat gctgaccctc aggatgacct ggtgaccagt
      901 tacgggaagg tgactgatga tgtaggggag tttgtacaca gctggcagga gcaggtcccc
      961 aacagccctc caggacctgt gactacttcc ctgcctcgcc caccatgcct gcagcagagc
     1021 ccagcatcca tgcagggtgt gtatgagcgg tgtgaagtac tgttgaggcc tcctttcgac
     1081 acctgccatg cttatgtcag ccctctgccc ttcgcagcca gctgtaccag tgacctctgc
     1141 caatcaggag gcgatgaagc cacttggtgc cgagcactga tggaatatgc ccgggcatgt
     1201 gcacaggcag ggcgccctct gcagggctgg aggacccaac tctcacaatg cactgtgcac
     1261 tgcaaagaga aggccttcat ctataacgag tgtattgctt gctgtccggc ttcctgccaa
     1321 tcccgtgctt catgtgtaga cagtgagatc acctgtgtgg atggctgcta ctgccccaat
     1381 gggctgatct ttgaggatgg aggctgcatg tcaccagctg agtgtccctg tgaattccat
     1441 ggaaccctgc acccgcctgg ctctgtggtg acagaagact gcaatgcctg tacgtgcaca
     1501 gcagggaagt gggtgtgcag ctcttccgtc tgtccagctg agtgctcagt gactggtgac
     1561 attcacttca cgacctttga tggacgccgg tacacattcc ctgccacgtg tcagtacatc
     1621 ctcgccaaga gccgttcctc aggcacattt acagtgacgc tgcagaacgc cccgtgtggc
     1681 ctgaaccagg atggggcctg tgtccagtcc gtgtcagtga tcctgcacca ggaccctcgg
     1741 agacaggtga ccctgaccca ggcaggagat gtccttctat ttgaccagta caagatcacc
     1801 ccaccctact cagatgatgc ttttgagatc cggaggctgt cctccgtgtt cctgagggtg
     1861 aggaccaatg tgggcgtgcg gatcctctat gaccgggaag ggttgcggct ttacctgcaa
     1921 gtggaccagc gatgggtgga ggataccgtg ggcctctgtg gcaccttcaa cggcaacaca
     1981 caggacgact tcctgtctcc agtgggtgta cctgagagca caccacagtt gtttggcaat
     2041 tcgtggaaaa ccctgtctgc ctgtgtcccg ctggtccctg gctctttgct ggacccctgc
     2101 gatgtgcatc tgcaagctgc ctcctatgca ctgcagtcct gcagtgtgct cacgggagag
     2161 ctctttgcac cctgctctgc gtatctgagc ccaataccct acttcgagca atgccgcagg
     2221 gatgcctgcc gctgtgggca gccctgcctt tgtgccacgc tggcccacta cgcacgacta
     2281 tgccggcgcc atggactccc ggttgacttc cgtgcccatc tgccagcctg tgcactgtcc
     2341 tgtgaggcca ctaaagagta cagcccttgt gtgaccctgt gcgcaccaac atgccaggac
     2401 ctggccagcc ctgacgtctg tggggctaac ggaggtggca acttcagcag ggaggagtgc
     2461 gtagagggtt gcacctgccc accggacaca tttctggaca cacaggctga cctctgtgtc
     2521 cccaggaacc aatgctcttg ccatttccaa ggagtggact acccccctgg ggacagtgac
     2581 atcccttccc tgggccactg ccactgcaaa gatggggtca tgagctgtga cagccgagcc
     2641 ccagctgctg cctgtccagc aggccaggtg ttcgtgaact gcagtgagct gcacccagac
     2701 cctgagctca gcagggagag gacgtgtgag cagcagctgc tgaacctgag cgtgccagca
     2761 cgtggcccct gcctgtcggg ctgtgcctgt ccccagggcc tgctcagaca tggggacgca
     2821 tgcttcccac cagaggaatg tccatgtacc tggaagggga aggaatattt ccctggggac
     2881 caggtagtct cttcctgcca cacctgtgtg tgccagcggg gctcgttcca gtgcaccctg
     2941 cacccctgcg cctccacctg taccgcctat ggggaccgac actatcgcac atttgacggg
     3001 cttccgtatg actttgtagg ggcgtgcaaa gtgcacctgg tcaagagtac atccgagctc
     3061 agcttctctg tcatggtgga ggatgtgaac tgctatggct ccggcgtcat ctgcaggaag
     3121 tccatctcca tcaacgttgg cagctcactc atcatctttg atgacgactc cggggatccc
     3181 agtcccgaga gcttcctgga tgagaagcag gctgtccaca tctggagagc aggctttttc
     3241 acactggtgc atttcccacg ggaacacatc accctcttgt gggaccagag aaccactgtg
     3301 catgtccagg cgggccctca gtggcagggt cagttggtgg gcctctgtgg gaactttgac
     3361 ctgaaaacca tcaatgagat gcggacccca gagaacctgg agttaacaaa cccccaggag
     3421 tttggaagca gttgggctgc ggtggagtgc ccagataccc ctgatcccag ggacacttgt
     3481 gtcctgaatc ctctccgaga accatttgca aggaaggagt gtggtattct gctcagtgag
     3541 gtgttcgaga cctgccaccc agtggttgat gtcacttggt tttactcaaa ctgcctgacg
     3601 gacacatgtg gctgcagccg gggtggcgac tgtgagtgct tctgtgccag tgtagctgcc
     3661 tatgcccatc agtgttgtca gcacggggtg gtcattgact ggcggacacc ccgcatctgc
     3721 ccatatgact gtgacttctt caacaaagcg ctaggtaagg gtccctacca gctgtccagt
     3781 gtggcggctg gcggtactct tgtggccacg aaggcagtag acagtgacat agcccttgtg
     3841 agggcagagg atctggcgcc aggggacatt tcaagcttcc tgctgacagc tgctctgtac
     3901 aaggccaagg cccatgaccc tgacgtggtg tccctggagg cggctgacag acccaacttc
     3961 ttcctgcaca ccacagccaa tggctctata gggctggcta agtggcagcg cgatgaggcc
     4021 ttccatcagc acgcttcctt ctcgctgcac cgggggacat ggcaggctgg cctggtggct
     4081 ctggagtccc tggcaaagcc tggctccttc ctccactcat caggccttga gctggcactg
     4141 cgggcatacg aacacacgga ggtgtttcgt ggtggtgcgc tcttccgcct tctggatgcc
     4201 aagcctttgg gggctgccta ccccacctgt gagtggcgct acgatgcctg tgctagcccc
     4261 tgtttccaaa cctgccggga cccacgggca accagctgcc aggatgtgcc cagggtagaa
     4321 ggctgtgtcc ctgtgtgtcc cactcctaag gtcctggatg aagtcacaca gagatgtgtc
     4381 tacctggaag actgtgtgga gccagccccg cggggtccca cggagaccct tggcaatgag
     4441 actctggtac ctggtcaagt gccacccacc accagtgccg agcagcagct tccacagggg
     4501 ctccctggag cctctgccta cagccccgcc cctgttccag tagccccacc cacctcagcc
     4561 ccaaacccac caatggctgc cacggagggg caagcgccat ctccaggatc cacccaaccc
     4621 acactgcaga cacccctggg ccttacaaca tctaactttc ctgctggcca cacagaggcc
     4681 acagccagag aggaaggggc tgccagcctt ctaaccactt ctcatccccc agggttctcg
     4741 tcctccctcc ctagttccct gcagatgccc acatctggca ttgtatcagg tgcaacagag
     4801 acaaccaaag tgaccataac ctttacaggg agtcccaaca ccactgtcgc ttcccggtca
     4861 ccccctatac ctcgcttccc actcatgacc aaagctgtga cagtcccaag tcatgactcc
     4921 tttcctgtta aaaccacacc tctgcagccc tcttggctat ggagcctctc ttccagacct
     4981 atgacttccc ttggagctac gtcctggccc cccacctccc cgggatccca cctgtcaact
     5041 gcagtaacta aggtggcaaa taagacaatg acatccctgt ctgtcctggc ccagagcact
     5101 tcaagttcca gccagcccct ggctgcagtg accacagcac acagggctcc tgccagtccc
     5161 cttgtcacca agggcttgga ggtggtgtca gccacagaga agggagaagc tgggcacagc
     5221 cagcttacag agttgccagt gtccccaccc ccaagcccag cccccatcga cctgcctcac
     5281 ccagcccaac ataccaccac agcccctggg ccttctgctc tgtccccggg gatcctggct
     5341 gctggcagtc catccacagg tgctcacaga ccgggggcca cagctttagc ttctctagag
     5401 ccaactcggc caccccacct tctctctggc ctacctctgg acaccagcct gcccttggct
     5461 aaggtgggaa cctctgcccc agtggccaca cctggctcca aaggctatat ccccacccct
     5521 ccacctcagc accaggctac aactttggct acggccatga ctgtgagccc acttactcag
     5581 tcactcagtc tgacagtgcc actcatgtct gctgtagagg aacaggcaca ctcacctagc
     5641 cccaagcctc cccaaggaac aggtatggct ccagaccaga tgctgggagc cacattgcca
     5701 agctttggag cctcctctgt gattgctggg gtgcccccca cagtgtctgc ggccccacgg
     5761 aagagcacca cccagagagc agccattcta tctaagaagg tgtctccacc caccctcatc
     5821 tctgactctg tccagggtgg gttcacagaa ctcacaccta tagtgagcca tactgttacc
     5881 cccttggcga ctgaggctga aggcccccgg gctggcacag tgccactggt gcccacaacc
     5941 tactccctaa gccgggtgtc agccaggacg gcctcccggg aaggcccgct agttctgttg
     6001 cctcagctgg cagaggccta tgggacccca gcaggactcc agccccaaga agatctagtg
     6061 cgccaggcca ctacggagca gtcagggcgc tcagctccag ccaagagtat agcagaggag
     6121 tcgatggagg ccgaagtgaa tacttctgcc acctgtgtgc ccatcgctga acaagactgt
     6181 gtccgtcaca tatgcctaga aggccagctg atacgtgtga accagaccca gcactgtcct
     6241 cagggtgccg tacgccctcg ctgtggggtc ctgggcctcg ctgtgcgggt gggcggggat
     6301 cgctgctgcc cacaatggga atgtgcctgc cgatgctcaa tcttcccaga cctgagcttt
     6361 gtaactttcg atggcagcca tgcggctctg ttcaaggagg ccatctatgt cctcagccag
     6421 agcccagatg aaaccatctc tgtgcatgtc ctggactgca agagtgccaa cctgggacat
     6481 ctgaactggc ccccattctg tctggtgata ctgaatgtga ctcatctggc ccaccatgtc
     6541 agcatcgacc gcttcaacag gaaggtgact gtggactctc aagttgtgtg gccacccatg
     6601 agccgatatg gcttccgaat tgaggataca ggacacatgt atatcgtccg gacaccctca
     6661 cacatccaga tccagtggct tcacagctca ggactcatga tcttggaagc cagcaaagtc
     6721 agcaagaccc agggccatgg cctgtgtggt atctgtgatg gagatgcagc caatgacctc
     6781 accttgaagg atggctctgt gctgggtgag gcagaggacc ctgctccctt tctggacagc
     6841 tggcaggtgc ccagctccct gacttcagag ggtcagaccc gcttccgccc agacagttgt
     6901 gccacagctg actgctcgcc ctgccttcgc atggtgtcca accgaacctt cagtgcctgc
     6961 cacagctttg tctccccaga gtcattctgt gagctgtgga tccgggacac caagtacgtg
     7021 cagcagccct gtgtggcact caccgtgtat gtggctatgt gtcacaaatt ccacgtgtgc
     7081 atcgagtggc ggggctccga ctattgcccc ttcctgtgct ccagtgactc tacctaccag
     7141 gcctgtgtgg cagcttgtga accccctgac acatgccagg acgggatact gggccccctg
     7201 gacccagagc agtgccaggt gctgggtgag ggctgtgtgt gcacggaggg caccattctg
     7261 caccgacgcc actcggcact ctgcatccct gaggacaagt gtgcctgcac tgacagcacc
     7321 ggggttccac gtgctctggg ggagacctgg aacagctccc tcagtggctg ctgtcagcag
     7381 caatgccagg ctccagacac catcataccc gtggacctgg actgccctgg tccccgacct
     7441 gagagctgcc cccgctttgg tgaagtgatc ctgttacagc ccacggagga cccctgctgc
     7501 ctggggagtg tctgcgtgtg taaccagacc ctgtgcgagg gcctcgctcc cacctgccgc
     7561 ccaggccaca gcctcatcac ccacttccag gaggattcct gctgtcccag ctacagctgc
     7621 gagtgtgacc ctggtctgtg tgaggctgag caggtcccca cctgtcgtga ggaccagatc
     7681 ttgatcgagg gccgcctagg agactcctgc tgcacctcct acttctgtgg ctgtggtgag
     7741 tgttcagatc ccatgcctga gtgtcaggaa ggagaggcac tcactgtgca caggaacacc
     7801 acagagctct gctgccctct gtatcagtgt gtgtgtgaga acttccgctg cccacaggta
     7861 cagtgtggca tgggcacttc cctggtggag gtgtggagcc cagaccgatg ctgcccctac
     7921 aagtcctgcg agtgtgactg tgacactatt cctgtgccca gatgccatct gtgggaaaag
     7981 tcgcagctgg atgaggagtt tatgcacagc gtggagaatg tgtgcggctg cgccaagtac
     8041 gagtgcgtga aagcccctgt atgcctgagc cgtgagctgg gtgtgatgca gccaggccag
     8101 actgtggtag agctctcagc ggatggtgtg tgtcatacgt cccgatgcac agacgtgctg
     8161 gaccctctca ccaacttcta ccagatcaac atcacctctg tcctctgtga catgcactgc
     8221 gaggcgaacc aggagtatga ccacccacgg gacctggcgg cctgctgcgg ctcctgcaga
     8281 aacgtgtcct gcctcttcac cttccccaat ggcaccactt ccctgttctt gcctggtgca
     8341 tcctggatcg cggactgtgc ccgccatcac tgtggcagca cccccctggg tgctgtgctt
     8401 gtccgctcgc ccatcagctg ccctccattc aatgaaaccg agtgtgccaa ggttggtggc
     8461 tctgtggtac catccttgga aggatgctgc agagcatgta aggaggatgg acggtcttgc
     8521 aagaaggtga ccattcgcat gaccatccgc aagaatgact gcaggagcaa tacccctgtg
     8581 aacctggtgt cttgcgatgg gaggtgccct tctgccagca tctacaacca caacatcaac
     8641 acctatgccc gcttctgcaa gtgctgccgt gaggtgggac tgcagcgtcg ctctgtgcag
     8701 ctcttctgtg ccacgaatgc tacctgggtg ccctatacag tacaggagcc tacagactgt
     8761 gcctgccagt ggtcctgaag cctgggtgcc aggcctggct gggtcaccct tgtcactttc
     8821 atgttctcct tccagctagt ctaggtgaca aaggggagag gttaaaggtg ggggatcttg
     8881 tttgtatgtg cacgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta
     8941 atccacaagg gactagaata ggccccactt gcccatcctg gctctctctc tctgagtcct
     9001 tttacatgca cataggaaag tgccattgct cagggctttt gggatccaac tctacatggc
     9061 ttgaggtcag gagggaagct gtaggcccag gagctgaagg cctgatccat ctgtgtctct
     9121 ggccaggact tctaggggga ggggccaagg tttcctgata cactgcaacc aaagcagaac
     9181 ccaatgctgg cttagggtta agatttggtg gcctgcttct ttcttgtccc tcttaacaat
     9241 ggaaaaccca taatataagg aaaggggatt taactaacat ttctgactgt ctcaagaggt
     9301 ctagaactcc ttgaagtgaa gagggtgagc ttggggctca gggatgccca tgaagatctg
     9361 tgagaccatg ctgtgactga gcaggtggct ctagactcct caagcctcag agagttccct
     9421 gacattctgg tatctagaag agcaggtcca ggtctgtgcc tctgtgtgtc acatgctcac
     9481 cattgagcca ggtttgagat acatgaagga taggcttctc agtgagggcc tgggtgccaa
     9541 tcccagaggg tgctggacag cccaaccctc caagcagttc tggagtacac agctggcact
     9601 tccagcctaa agctctgtcc cttttctcca agcatgtgaa aagtgtatct gcactaggtc
     9661 ttactgtgtt aggtggtggc tcagcgctgc ctgggactgt gttggtggag aatgtctgta
     9721 ggtgaaaatg cagccctgtg agtttgcaac ccaggtggcc ccgagtgtcc gtcagagcct
     9781 tgtctccaaa ccaaagtgtc ttccctaaag ccaggatcag agctcctgtc cacaagccac
     9841 tctgcagatc ccctcctttc tgcactgctt tgtgctactg ggtctcaaag gtcatgacct
     9901 gctgctgttc aggtcccagc actgttctga cggccccatg gggtaaaggt cctgtgtcga
     9961 gatggtccct acatccgctt tgtctctgtg actcttctgt atcttcttca tgtatcaata
    10021 aactgcaaga agtcttccaa gca
//
