LOCUS       XM_017321186            7428 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  PREDICTED: Mus musculus otoferlin (Otof), transcript variant X4,
            mRNA.
ACCESSION   XM_017321186
VERSION     XM_017321186.2
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000071.7) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Sep 21, 2020 this sequence version replaced XM_017321186.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/01/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7428
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="5"
     gene            1..7428
                     /gene="Otof"
                     /note="otoferlin; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 52 ESTs, 18 long SRA
                     reads, 1 Protein, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 7 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:83762"
                     /db_xref="MGI:MGI:1891247"
     CDS             907..6876
                     /gene="Otof"
                     /codon_start=1
                     /product="otoferlin isoform X3"
                     /protein_id="XP_017176675.1"
                     /db_xref="GeneID:83762"
                     /db_xref="MGI:MGI:1891247"
                     /translation="MALIVHLKTVSELRGKGDRIAKVTFRGQSFYSRVLENCEGVADF
                     DETFRWPVASSIDRNEVLEIQIFNYSKVFSNKLIGTFCMVLQKVVEENRVEVTDTLMD
                     DSNAIIKTSLSMEVRYQATDGTVGPWDDGDFLGDESLQEEKDSQETDGLLPGSRPSTR
                     ISGEKSFRRAGRSVFSAMKLGKTRSHKEEPQRQDEPAVLEMEDLDHLAIQLGDGLDPD
                     SVSLASVTALTSNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCV
                     EVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVG
                     SFKMDVGTVYSQPEHQFHHKWAILSDPDDISAGLKGYVKCDVAVVGKGDNIKTPHKAN
                     ETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDL
                     VDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVA
                     IGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYTLLDEHQDLNEGLGEGVSFRA
                     RLMLGLAVEILDTSNPELTSSTEVQVEQATPVSESCTGRMEEFFLFGAFLEASMIDRK
                     NGDKPITFEVTIGNYGNEVDGMSRPLRPRPRKEPGDEEEVDLIQNSSDDEGDEAGDLA
                     SVSSTPPMRPQITDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEG
                     LNDVQEMIKTEKSYPERRLRGVLEELSCGCHRFLSLSDKDQGRSSRTRLDRERLKSCM
                     RELESMGQQAKSLRAQVKRHTVRDKLRSCQNFLQKLRFLADEPQHSIPDVFIWMMSNN
                     KRIAYARVPSKDLLFSIVEEELGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKLELYLW
                     LGLSKQRKDFLCGLPCGFEEVKAAQGLGLHSFPPISLVYTKKQAFQLRAHMYQARSLF
                     AADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPI
                     IVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGSATAGDLL
                     AAFELLQIGPSGKADLPPINGPVDMDRGPIMPVPVGIRPVLSKYRVEVLFWGLRDLKR
                     VNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIR
                     VVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPNWNTTVRLLRGCHRLRNGGPSSRP
                     TGEVVVSMEPEEPVKKLETMVKLDATSDAVVKVDVAEDEKERKKKKKKGPSEEPEEEE
                     PDESMLDWWSKYFASIDTMKEQLRQHETSGTDLEEKEEMESAEGLKGPMKSKEKSRAA
                     KEEKKKKNQSPGPGQGSEAPEKKKAKIDELKVYPKELESEFDSFEDWLHTFNLLRGKT
                     GDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDPTYGMFQGIPSNDPINVLV
                     RIYVVRATDLHPADINGKADPYIAIKLGKTDIRDKENYISKQLNPVFGKSFDIEASFP
                     MESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSIHGYNIWRDPM
                     KPSQILTRLCKEGKVDGPHFGPHGRVRVANRVFTGPSEIEDENGQRKPTDEHVALSAL
                     RHWEDIPRVGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISP
                     RKPKKYELRVIVWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLT
                     GEGNFNWRYLFPFDYLAAEEKIVMSKKESMFSWDETEYKIPARLTLQIWDADHFSADD
                     FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDE
                     FELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPKPIMGFNPSTLPSTPKLPLPS
                     EPKEAHLQRKLLLSQEAQPPSLTVVWVLPSF"
ORIGIN      
        1 ttccttattt atttatctga cttgtttatt taaagacggg tctctttagc aaacctggag
       61 cttctccatt cagatagctc cgctgccatt aaactccagg ggttctcctg tctccacctt
      121 tctgccaccg cagagctggg ttagaagccc ttgcccctgc accggtcttt accatagact
      181 ctggaatcta aactcagatc ttcatgctcc tgtggcagac actttaccta ctgaggcatc
      241 tcctttgccc tcggctgagg cacagcatga tttatccaga gcagtcaggt ctgtcccgtc
      301 catgatctcc aagccttctg agcatccaca accctggtga ttagctagac acatcaagag
      361 acatcgtgga tactgcccaa gagaccagtg ccccattcaa gctcagacag tgaagttcca
      421 gatccccatg agaagtggcc tgacccctca tctgcccatc tgcatgccct ctgcaatctg
      481 ttggctctga gtggcacagc ttgctctgcc ctgccaagtg gcaggagctt ccattccagg
      541 agctggcagg agacacctga agccggacag ggctttatct cggagctggt gctgctgaat
      601 aatggattca gcatgcgttc ctgggctcct gcacacactc actcacacac acacacacac
      661 acacacacac acacacacac acacgcgcgc tacacacatg ctgggctgac aacccagagg
      721 ggcggggctg ccggggctgc acagctctga tgagctgaag gagcagcttg ctttggttgc
      781 cttggtctct gtgggcagca gcaggaggag gcggcagcag ccagagaaga gggaggcgtg
      841 tgagccacac tccaccagcg agcttcttcc cgctgctctg gaactgccca ggctctcccc
      901 accagcatgg ccctgattgt tcacctcaag actgtctcag agctccgagg caaaggtgac
      961 cggattgcca aagtcacttt ccgagggcag tctttctact cccgggtcct ggagaactgc
     1021 gagggtgtgg ctgactttga tgagacgttc cggtggccag tggccagcag catcgaccgg
     1081 aatgaagtgt tggagattca gattttcaac tacagcaaag tcttcagcaa caagctgata
     1141 gggaccttct gcatggtgct gcagaaagtg gtggaggaga atcgggtaga ggtgaccgac
     1201 acgctgatgg atgacagcaa tgctatcatc aagaccagcc tgagcatgga ggtccggtat
     1261 caggccacag atggcactgt gggcccctgg gatgatggag acttcctggg agatgaatcc
     1321 ctccaggagg agaaggacag ccaggagaca gatgggctgc tacctggttc ccgacccagc
     1381 acccggatat ctggcgagaa gagctttcgc agagcgggaa ggagtgtgtt ctcggccatg
     1441 aaactcggca aaactcggtc ccacaaagag gagccccaaa gacaagatga gccagcagtg
     1501 ctggagatgg aggacctgga ccacctagcc attcagctgg gggatgggct ggatcctgac
     1561 tccgtgtctc tagcctcggt caccgctctc accagcaatg tctccaacaa acggtctaag
     1621 ccagatatta agatggagcc cagtgctgga aggcccatgg attaccaggt cagcatcaca
     1681 gtgattgagg ctcggcagct ggtgggcttg aacatggacc ctgtggtgtg tgtggaggtg
     1741 ggtgatgaca agaaatacac gtcaatgaag gagtccacaa actgccctta ctacaacgag
     1801 tactttgtct tcgacttcca tgtctctcct gatgtcatgt ttgacaagat catcaagatc
     1861 tcggttatcc attctaagaa cctgcttcgg agcggcaccc tggtgggttc cttcaaaatg
     1921 gatgtgggga ctgtgtattc ccagcctgaa caccagttcc atcacaaatg ggccatcctg
     1981 tcagaccccg atgacatctc tgctgggttg aagggttatg taaagtgtga tgtcgctgtg
     2041 gtgggcaagg gagacaacat caagacaccc cacaaggcca acgagacgga tgaggacgac
     2101 attgaaggga acttgctgct ccccgagggc gtgccccccg aacggcagtg ggcacggttc
     2161 tatgtgaaaa tttaccgagc agagggactg ccccggatga acacaagcct catggccaac
     2221 gtgaagaagg cgttcatcgg tgagaacaag gacctcgtcg acccctatgt gcaagtcttc
     2281 tttgctggac aaaagggcaa aacatcagtg cagaagagca gctatgagcc gctatggaat
     2341 gagcaggtcg tcttcacaga cttgttcccc ccactctgca aacgcatgaa ggtgcagatc
     2401 cgggactctg acaaggtcaa tgatgtggcc atcggcaccc acttcatcga cctgcgcaag
     2461 atttccaacg atggagacaa aggcttcctg cctaccctcg gtccagcctg ggtgaacatg
     2521 tacggctcca cgcgcaacta cacactgctg gacgagcacc aggacttgaa tgaaggcctg
     2581 ggggagggtg tgtccttccg ggcccgcctc atgttgggac tagctgtgga gatcctggac
     2641 acctccaacc cagagctcac cagctccacg gaggtgcagg tggagcaggc cacgcctgtc
     2701 tcggagagct gcacagggag aatggaagaa ttttttctat ttggagcctt cttggaagcc
     2761 tcaatgattg accggaaaaa tggggacaag ccaattacct ttgaggtgac cataggaaac
     2821 tacggcaatg aagtcgatgg tatgtcccgg cccctgaggc ctcggccccg gaaagagcct
     2881 ggggatgaag aagaggtaga cctgattcag aactccagtg acgatgaagg tgacgaagcc
     2941 ggggacctgg cctcggtgtc ctccacccca cctatgcggc cccagatcac ggacaggaac
     3001 tatttccacc tgccctacct ggagcgcaag ccctgcatct atatcaagag ctggtggcct
     3061 gaccagaggc ggcgcctcta caatgccaac atcatggatc acattgctga caagctggaa
     3121 gaaggcctga atgatgtaca ggagatgatc aaaacggaga agtcctaccc ggagcgccgc
     3181 ctgcggggtg tgctagagga actcagctgt ggctgccacc gcttcctctc cctctcggac
     3241 aaggaccagg gccgctcgtc ccgcaccagg ctggatcgag agcgtcttaa gtcctgtatg
     3301 agggagttgg agagcatggg acagcaggcc aagagcctga gggctcaggt gaagcggcac
     3361 actgttcggg acaagctgag gtcatgccag aactttctgc agaagctacg cttcctggcg
     3421 gatgagcccc agcacagcat tcctgatgtg ttcatttgga tgatgagcaa caacaaacgt
     3481 atcgcctatg cccgcgtgcc ttccaaagac ctgctcttct ccatcgtgga ggaggaactg
     3541 ggcaaggact gcgccaaagt caagaccctc ttcctgaagc tgccagggaa gaggggcttc
     3601 ggctcggcag gctggacagt acaggccaag ctggagctct acctgtggct gggcctcagc
     3661 aagcagcgaa aggacttcct gtgtggtctg ccctgtggct tcgaggaggt caaggcagcc
     3721 caaggcctgg gcctgcattc ctttccgccc atcagcctag tctacaccaa gaagcaagcc
     3781 ttccagctcc gagcacacat gtatcaggcc cgaagcctct ttgctgctga cagcagtggg
     3841 ctctctgatc cctttgcccg tgtcttcttc atcaaccaga gccaatgcac tgaggttcta
     3901 aacgagacac tgtgtcccac ctgggaccag atgctggtat ttgacaacct ggagctgtac
     3961 ggtgaagctc acgagttacg agatgatccc cccatcattg tcattgaaat ctacgaccag
     4021 gacagcatgg gcaaagccga cttcatgggc cggaccttcg ccaagcccct ggtgaagatg
     4081 gcagatgaag catactgccc acctcgcttc ccgccgcagc ttgagtacta ccagatctac
     4141 cgaggcagtg ccactgccgg agacctactg gctgccttcg agctgctgca gattgggcca
     4201 tcagggaagg ctgacctgcc acccatcaat ggcccagtgg acatggacag agggcccatc
     4261 atgcctgtgc ccgtgggaat ccggccagtg ctcagcaagt accgagtgga ggtgctgttc
     4321 tggggcctga gggacctaaa gagggtgaac ctggcccagg tggaccgacc acgggtggac
     4381 atcgagtgtg caggaaaggg ggtacaatcc tccctgattc acaattataa gaagaacccc
     4441 aacttcaaca cgctggtcaa gtggtttgaa gtggacctcc cggagaatga gctcctgcac
     4501 ccacccttga acatccgagt ggtagattgc cgggcctttg gacgatacac cctggtgggt
     4561 tcccacgcag tcagctcact gaggcgcttc atctaccgac ctccagaccg ctcagccccc
     4621 aactggaaca ccacagtcag gctgctccgg ggctgccaca ggctgcgcaa tgggggcccc
     4681 tcttctcgcc ccacagggga ggttgtagta agcatggagc ctgaggagcc agttaagaag
     4741 ctggagacca tggtgaaact ggatgcgact tctgatgctg tggtcaaggt ggatgtggct
     4801 gaagatgaga aggaaaggaa gaagaagaaa aagaaaggcc cgtcagagga gccagaggag
     4861 gaagagcccg atgagagcat gctggattgg tggtccaagt acttcgcctc catcgacaca
     4921 atgaaggagc aacttcgaca acatgagacc tctggaactg acttggaaga gaaggaagag
     4981 atggaaagcg ctgagggcct gaagggacca atgaagagca aggagaagtc cagagctgca
     5041 aaggaggaga aaaagaagaa aaaccagagc cctggccctg gccagggatc ggaggctcct
     5101 gagaagaaga aagccaagat cgatgagctt aaggtgtacc ccaaggagct ggaatcggag
     5161 tttgacagct ttgaggactg gctgcacacc ttcaacctgt tgaggggcaa gacgggagat
     5221 gatgaggatg gctccacaga ggaggagcgc atagtaggcc gattcaaggg ctccctctgt
     5281 gtgtacaaag tgccactccc agaagatgta tctcgagaag ctggctatga tcccacctat
     5341 ggaatgttcc agggcatccc aagcaatgac cccatcaatg tgctggtccg aatctatgtg
     5401 gtccgggcca cagacctgca cccggccgac atcaatggca aagctgaccc ctatattgcc
     5461 atcaagttag gcaagaccga catccgagac aaggagaact acatctccaa gcagctcaac
     5521 cctgtgtttg ggaagtcctt tgacattgag gcctccttcc ccatggagtc catgttgaca
     5581 gtggccgtgt acgactggga tctggtgggc actgatgacc tcatcggaga aaccaagatt
     5641 gacctggaaa accgcttcta cagcaagcat cgcgccacct gcggcatcgc acagacctat
     5701 tccatacatg gctacaatat ctggagggac cccatgaagc ccagccagat cctgacacgc
     5761 ctctgtaaag agggcaaagt ggacggcccc cactttggtc cccatgggag agtgagggtt
     5821 gccaaccgtg tcttcacggg gccttcagaa atagaggatg agaatggtca gaggaagccc
     5881 acagatgagc acgtggcact gtctgctctg agacactggg aggacatccc ccgggtgggc
     5941 tgccgccttg tgccggaaca cgtggagacc aggccgctgc tcaaccctga caagccaggc
     6001 attgagcagg gccgcctgga gctgtgggtg gacatgttcc ccatggacat gccagcccct
     6061 gggacacctc tggatatatc ccccaggaaa cccaagaagt acgagctgcg ggtcatcgtg
     6121 tggaacacag acgaggtggt cctggaagac gatgatttct tcacgggaga gaagtccagt
     6181 gacatttttg tgagggggtg gctgaagggc cagcaggagg acaaacagga cacagatgtc
     6241 cactatcact ccctcacggg ggagggcaac ttcaactgga gatacctctt ccccttcgac
     6301 tacctagcgg ccgaagagaa gatcgttatg tccaaaaagg agtctatgtt ctcctgggat
     6361 gagacggagt acaagatccc tgcgcggctc accctgcaga tctgggacgc tgaccacttc
     6421 tcggctgacg acttcctggg ggctatcgag ctggacctga accggttccc gaggggcgct
     6481 aagacagcca agcagtgcac catggagatg gccaccgggg aggtggacgt acccctggtt
     6541 tccatcttta aacagaaacg tgtcaaaggc tggtggcccc tcctggcccg caatgagaat
     6601 gatgagtttg agctcacagg caaagtggag gcggagctac acctactcac ggcagaggag
     6661 gcagagaaga accctgtggg cctggctcgc aatgaacctg atcccctaga aaaacccaaa
     6721 cccatcatgg gcttcaaccc ttcaaccctt ccttcaaccc cgaagctacc tcttccctct
     6781 gaaccaaaag aagctcatct tcaaagaaag ctgttgcttt cccaggaagc ccagccccca
     6841 agtctgacag tggtatgggt tcttcctagt ttttgacaaa ggcaatgcaa gcactccaaa
     6901 ggtggccaga cttggtgcca gaaactcctg cttggtggag gtctctcacc aaaccccttc
     6961 ccactctcct gctatttccc tgtgcttgtc tgctcttccc aatgctccag tcggccggac
     7021 acaagcttca tctggttctt gaaccctctc aagtctgccc gctacttcct gtggcatacc
     7081 taccgctggc tactcctcaa attcctgctg ctcttcctcc tgctgctgct cttcgccctg
     7141 tttctctact ctctgcctgg ctacctggcc aagaagatcc ttggggcctg agccctgcag
     7201 tcgcctaggc ctggtacttc ttccttctgc ctttggacaa gggcgggcca gcacatggga
     7261 cacactcaac agacacacat aaagttcata tgtgtacaca cagtgcacac gcatgcagaa
     7321 gtgcacacac gcacataagc atacacagaa tacaagcaca tatgtgcatc cacataaaca
     7381 tgtattgcaa actttcgaac tttaaatgta gtcatactct catcagaa
//
