LOCUS       NM_139310               3663 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus otoancorin (Otoa), mRNA.
ACCESSION   NM_139310 XM_913938
VERSION     NM_139310.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3663)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3663)
  AUTHORS   Quadros,R.M., Miura,H., Harms,D.W., Akatsuka,H., Sato,T., Aida,T.,
            Redder,R., Richardson,G.P., Inagaki,Y., Sakai,D., Buckley,S.M.,
            Seshacharyulu,P., Batra,S.K., Behlke,M.A., Zeiner,S.A.,
            Jacobi,A.M., Izu,Y., Thoreson,W.B., Urness,L.D., Mansour,S.L.,
            Ohtsuka,M. and Gurumurthy,C.B.
  TITLE     Easi-CRISPR: a robust method for one-step generation of mice
            carrying conditional and insertion alleles using long ssDNA donors
            and CRISPR ribonucleoproteins
  JOURNAL   Genome Biol 18 (1), 92 (2017)
   PUBMED   28511701
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3663)
  AUTHORS   Kim,H.J., Ryu,J., Woo,H.M., Cho,S.S., Sung,M.K., Kim,S.C.,
            Park,M.H., Park,T. and Koo,S.K.
  TITLE     Patterns of gene expression associated with Pten deficiency in the
            developing inner ear
  JOURNAL   PLoS One 9 (6), e97544 (2014)
   PUBMED   24893171
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3663)
  AUTHORS   Romand,R., Krezel,W., Beraneck,M., Cammas,L., Fraulob,V.,
            Messaddeq,N., Kessler,P., Hashino,E. and Dolle,P.
  TITLE     Retinoic acid deficiency impairs the vestibular function
  JOURNAL   J Neurosci 33 (13), 5856-5866 (2013)
   PUBMED   23536097
REFERENCE   5  (bases 1 to 3663)
  AUTHORS   Lukashkin,A.N., Legan,P.K., Weddell,T.D., Lukashkina,V.A.,
            Goodyear,R.J., Welstead,L.J., Petit,C., Russell,I.J. and
            Richardson,G.P.
  TITLE     A mouse model for human deafness DFNB22 reveals that hearing
            impairment is due to a loss of inner hair cell stimulation
  JOURNAL   Proc Natl Acad Sci U S A 109 (47), 19351-19356 (2012)
   PUBMED   23129639
REFERENCE   6  (bases 1 to 3663)
  AUTHORS   Deans,M.R., Peterson,J.M. and Wong,G.W.
  TITLE     Mammalian Otolin: a multimeric glycoprotein specific to the inner
            ear that interacts with otoconial matrix protein Otoconin-90 and
            Cerebellin-1
  JOURNAL   PLoS One 5 (9), e12765 (2010)
   PUBMED   20856818
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3663)
  AUTHORS   Zwaenepoel,I., Mustapha,M., Leibovici,M., Verpy,E., Goodyear,R.,
            Liu,X.Z., Nouaille,S., Nance,W.E., Kanaan,M., Avraham,K.B.,
            Tekaia,F., Loiselet,J., Lathrop,M., Richardson,G. and Petit,C.
  TITLE     Otoancorin, an inner ear protein restricted to the interface
            between the apical surface of sensory epithelia and their overlying
            acellular gels, is defective in autosomal recessive deafness DFNB22
  JOURNAL   Proc Natl Acad Sci U S A 99 (9), 6240-6245 (2002)
   PUBMED   11972037
  REMARK    GeneRIF: Otoancorin is defective in autosomal recessive deafness
            DFNB22
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140782.4.
            
            On Jun 9, 2018 this sequence version replaced NM_139310.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY055122.1, AK157904.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC140782.4         136053-136142       c
            91-182              AC140782.4         127932-128023       c
            183-211             AC140782.4         126988-127016       c
            212-242             AC140782.4         126865-126895       c
            243-270             AC140782.4         126720-126747       c
            271-358             AC140782.4         124901-124988       c
            359-490             AC140782.4         120299-120430       c
            491-726             AC140782.4         116832-117067       c
            727-830             AC140782.4         113591-113694       c
            831-931             AC140782.4         108494-108594       c
            932-1071            AC140782.4         104957-105096       c
            1072-1195           AC140782.4         100901-101024       c
            1196-1411           AC140782.4         97483-97698         c
            1412-1579           AC140782.4         93979-94146         c
            1580-1720           AC140782.4         91794-91934         c
            1721-1779           AC140782.4         89473-89531         c
            1780-1897           AC140782.4         88182-88299         c
            1898-1971           AC140782.4         87128-87201         c
            1972-2107           AC140782.4         86644-86779         c
            2108-2298           AC140782.4         85448-85638         c
            2299-2392           AC140782.4         79696-79789         c
            2393-2522           AC140782.4         75584-75713         c
            2523-2710           AC140782.4         73927-74114         c
            2711-2866           AC140782.4         71778-71933         c
            2867-3009           AC140782.4         64295-64437         c
            3010-3146           AC140782.4         63655-63791         c
            3147-3244           AC140782.4         63041-63138         c
            3245-3440           AC140782.4         59041-59236         c
            3441-3663           AC140782.4         56477-56699         c
FEATURES             Location/Qualifiers
     source          1..3663
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 65.07 cM"
     gene            1..3663
                     /gene="Otoa"
                     /note="otoancorin"
                     /db_xref="GeneID:246190"
                     /db_xref="MGI:MGI:2149209"
     exon            1..90
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            91..182
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..3505
                     /gene="Otoa"
                     /codon_start=1
                     /product="otoancorin precursor"
                     /protein_id="NP_647471.1"
                     /db_xref="CCDS:CCDS40114.1"
                     /db_xref="GeneID:246190"
                     /db_xref="MGI:MGI:2149209"
                     /translation="MSQGPRTCSLLLVLLLSHGGAYQREPSPRQDLHPLLQKMAEEII
                     EGSYLNALLDLTLFERSHVWTADLSHRVLAYLNSKNVAFTIPSLQAVMEAHLEQYLYQ
                     PQKLLEDLRATDNQQFHTAMKCLLEDKWGHLDLEDVVINLGDIRDEALQSPGVNRSLF
                     LITLERCFQVLNALECVEVLGRVLRGSSGSFLQPDITERLPQDLHEDAFKNLSAVFKD
                     LYDQTSAHTQRALYSWMTGILRTPFNVTDGSVSWVSAEKLWILGRYMVHLSFEEIMNI
                     SPIEIGLFISYDNATKQLDMVYDITPELAQAFLERIRCSSFDVRNISTIHRLGLLVCF
                     YDGLELLDATLAQVLLHQMLKCSRLRGFQAGVQKLKANLLDIATENQTLNETLGSLSD
                     AVVGLTSSQLESLSSDAVHSAISTLNQVTGWGRSQIVILSAKYLAQEKVLSFYNVCQM
                     GVLLAGVGTQAFYSMDHKDLWQVLRSPLSQDMSDLSPVQQQGVLGKLMEAEDATSGIA
                     EVPRALFKEVSLYDLWKESRFNATVLKAKELRRSQALFLYEFLGKTTERPEELLSAGQ
                     LVKGVPCSHIDAMSDHLFLALFQYFDNNFSLLSPDQVNCLAWKYWEVSRSSMPPFLLA
                     TLPSRFLSSIPPSRCVRFLISLGKRRLETLVLDSDKRSVVVRKVQQCLDGVIADEYTV
                     DIVGHLLCHLPASFIERGISPRAWAAALHGLRSCTALSSEQKAAVRVRLLEQWGPPEN
                     WTAETTKDLAPFLAFFSGDELHTVATKFPEILQQTASKMVGVLLPKEFLWAVFESVQN
                     SSNESPSFDPTFGCHGVVTPSSDDIFKLAEANACWDPEVLLCMEEDTFIRNVELLGAV
                     KGFSRAQLMALKEKAIQVWDLPSRWKEHHIVSLGRIALALSESELEQLDLSSIDTVAS
                     LGQQTEWTPGQAKSILQAFLEDSGYGIQDLKSFHLVGFGPTLCAMDPTEIQLIKTSEF
                     RAVVARIGTLFCSTPVLAGFKKKAEVVFGRPTEWTSSILQELGTIAAGITKAELRMLN
                     KELMTYFQPSAIRCLPGEVFKELSTEQIASLGPQNAASVTHSQRLQLSSAQLQSLQRA
                     LDGAKTHSWQTDPLSSSPTWPASTGSPTGEPASQALWLGCTLLLLTAKS"
     exon            183..211
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            212..242
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            243..270
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            271..358
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            359..490
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            491..726
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            727..830
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            831..931
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1071
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1195
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1411
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1579
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1720
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1779
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1897
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1971
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2107
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2298
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2392
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2522
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2710
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2866
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3009
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3146
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3244
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3440
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3663
                     /gene="Otoa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagagcct gcagctcagc aagtgaggac ctgccgggca ggcgctgggg accggagtga
       61 acagacagaa ggacggtagg ccaagtgcag gatgtctcag ggacctagga cgtgctccct
      121 tctcctggtc ctccttctga gccatggagg tgcctatcag agagagccaa gccccaggca
      181 ggatttacat ccattgttgc agaaaatggc ggaagaaata atagagggaa gctatctgaa
      241 tgcgttactg gatctcacac tatttgaaag gtcccatgtc tggactgcag acctgtccca
      301 cagagtcctt gcctatctga actcaaagaa tgtggccttc accattccca gcctgcaggc
      361 agtcatggaa gcacacctgg aacagtatct gtaccagcca cagaagctgc tggaggacct
      421 gagggctact gataaccagc agttccacac cgccatgaaa tgccttctgg aagacaaatg
      481 gggccacctg gatctggagg acgtcgtcat caacttggga gacattcggg acgaggccct
      541 tcagagccct ggtgtgaacc gcagcctctt tctcatcacg ttggaacgct gtttccaggt
      601 gctgaatgcc ttggagtgtg tggaggtcct gggcagggtg ctcagagggt cctccggcag
      661 cttcctgcag ccagacatta cagaaaggct accccaggac ctgcacgagg atgcctttaa
      721 gaacctgtcc gcagtgttca aagacctcta tgaccagact tcagctcaca cccagagagc
      781 tctctactca tggatgacag ggatcctgag gacacccttc aacgtcactg atggctcagt
      841 ttcatgggtc agtgcagaaa agttatggat tttgggcaga tacatggttc acctatcgtt
      901 tgaagaaatt atgaacatta gccctataga aattgggttg tttatcagct atgacaacgc
      961 caccaagcag ttggacatgg tgtatgacat cacccctgaa ctggcccagg catttctgga
     1021 gaggatccgc tgttccagct ttgacgtgag gaacatctct accatccaca ggttggggct
     1081 gttggtttgt ttctatgatg gtttggagct gctggatgcc accctggccc aagtccttct
     1141 ccaccagatg ctcaagtgca gccgcctccg gggcttccag gctggcgtcc agaagctcaa
     1201 ggccaacctc ttggacattg ctacagagaa ccagaccctc aacgagaccc taggctctct
     1261 gtcagatgca gttgtaggtc tgaccagcag tcagctggaa tccctctcct ccgatgcagt
     1321 gcacagcgcc atctctaccc tcaaccaggt tacaggctgg ggcagaagcc agattgtcat
     1381 cttgtctgcc aaatatttgg ctcaggaaaa ggtgctgtcc ttctacaacg tctgccagat
     1441 gggcgtgctg ctggcagggg tgggtacgca agccttctac agcatggacc acaaggatct
     1501 ctggcaggtg ctgagaagcc ctctttccca ggatatgtct gatttgtcac ctgtccagca
     1561 gcaaggtgtc ctcggcaagc tgatggaagc agaagatgct acttcaggca tcgcggaggt
     1621 accaagagct ctctttaagg aggtgtctct ctatgattta tggaaagaat ctcgattcaa
     1681 tgctacagtc ctgaaggcaa aggagcttcg taggagccag gccctgttcc tgtatgagtt
     1741 tctgggaaag accacagaaa ggccagagga gctcctgagt gccgggcagc tggtgaaggg
     1801 cgtgccgtgc tcgcacatcg atgccatgag tgaccacctc ttcctggccc tcttccagta
     1861 ttttgacaac aacttctccc tgctttctcc agatcaggtc aattgcttgg cgtggaaata
     1921 ctgggaagtt tcaaggtcct ccatgccacc attcctcttg gccaccctcc cctcacggtt
     1981 cctgtcttca attcccccct ctcgctgtgt gcggtttctg atcagcctgg gtaagaggcg
     2041 cttggagact ttggttttag attctgacaa aaggagtgtg gtcgtcagga aggtgcagca
     2101 gtgcttggat ggtgtcattg ctgatgaata cactgtggac attgtgggac acctcctgtg
     2161 ccacttgcca gcctccttca ttgagagagg gatctccccc agagcctggg ccgctgctct
     2221 gcatggtctt agaagctgta cagctctcag ctctgagcag aaggctgcgg tgagggtcag
     2281 gctcctggag cagtggggac ctcctgagaa ctggacagca gagacaacca aggacttggc
     2341 tcctttctta gcgtttttct caggagatga actgcacact gttgccacaa agtttcctga
     2401 aatccttcag caaacagctt ccaagatggt tggggtgttg cttcctaaag aatttctctg
     2461 ggctgtcttt gagtctgttc agaatagcag taacgagagc cccagctttg accccacctt
     2521 tggttgtcat ggagttgtga ctccctcttc agatgatatc ttcaagttgg ccgaagccaa
     2581 tgcctgctgg gaccccgagg ttcttctctg catggaggag gacactttca tcaggaacgt
     2641 ggagctgctg ggggctgtga agggtttcag ccgggctcag ctgatggccc tgaaggagaa
     2701 ggcaattcag gtttgggact tgccctcccg ctggaaagaa caccatattg tctccctggg
     2761 gcgcattgct ttggctctca gcgagagtga gttggagcag ctggacctta gctccataga
     2821 caccgtggca tccctgggcc agcagacaga atggacacca ggacaggcta aatccattct
     2881 gcaggcattt cttgaagatt caggctatgg gatacaggat ctgaagagct tccatttggt
     2941 tgggtttggt cctactctat gtgctatgga ccccactgaa atacaactta taaagacctc
     3001 agaattcagg gcagtggtag ccagaattgg gacactgttc tgcagtaccc ccgtcttagc
     3061 tggatttaag aagaaagcag aagttgtatt tgggagaccc actgagtgga ccagctccat
     3121 cttgcaggag cttgggacca ttgcagctgg gataacgaag gcagagctcc gaatgctcaa
     3181 caaagaactg atgacgtatt tccagccgtc agccataaga tgcctgcctg gtgaggtatt
     3241 caaagagctg tccacggagc agatcgcttc cctgggtcct cagaatgcag cctctgtaac
     3301 ccactcccag cgcctgcagc tcagctcggc acagctgcag agcctccaga gggcactaga
     3361 tggcgccaag actcactcct ggcagaccga tcctctgagt tccagcccta cctggccagc
     3421 ctccactggg tccccaacag gagagcctgc ctcccaggcg ctttggcttg gctgtaccct
     3481 gctgcttctg acggccaagt cctgatgccg agtggcctgt tgagtgttgc aagaagctgg
     3541 tgaaggtgtg cagagtcaga agctgctttc agacggggga gacctttacc tgaggagcct
     3601 tatcgagggc agggagatca cggggccttg gaaaaaataa ttattaaaaa ccatcttgca
     3661 ttc
//
