LOCUS       NM_198112               1268 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus osteocrin (Ostn), mRNA.
ACCESSION   NM_198112
VERSION     NM_198112.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1268)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1268)
  AUTHORS   Kang,X., Qian,J., Shi,Y.X., Bian,X.T., Zhang,L.D., Li,G.M.,
            Wang,L.T., Zhao,J., Dong,Z.Y., Yang,M.M., Chen,Y.J., Tang,K.L. and
            Miao,H.M.
  TITLE     Exercise-induced Musclin determines the fate of fibro-adipogenic
            progenitors to control muscle homeostasis
  JOURNAL   Cell Stem Cell 31 (2), 212-226 (2024)
   PUBMED   38232727
  REMARK    GeneRIF: Exercise-induced Musclin determines the fate of
            fibro-adipogenic progenitors to control muscle homeostasis.
REFERENCE   3  (bases 1 to 1268)
  AUTHORS   Jin,L., Han,S., Lv,X., Li,X., Zhang,Z., Kuang,H., Chen,Z., Lv,C.A.,
            Peng,W., Yang,Z., Yang,M., Mi,L., Liu,T., Ma,S., Qiu,X., Wang,Q.,
            Pan,X., Shan,P., Feng,Y., Li,J., Wang,F., Xie,L., Zhao,X., Fu,J.F.,
            Lin,J.D. and Meng,Z.X.
  TITLE     The muscle-enriched myokine Musclin impairs beige fat thermogenesis
            and systemic energy homeostasis via Tfr1/PKA signaling in male mice
  JOURNAL   Nat Commun 14 (1), 4257 (2023)
   PUBMED   37468484
  REMARK    GeneRIF: The muscle-enriched myokine Musclin impairs beige fat
            thermogenesis and systemic energy homeostasis via Tfr1/PKA
            signaling in male mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1268)
  AUTHORS   Kim,C.J., Singh,C., Lee,C., DiMagno,K., O'Donnell,M., Kaczmarek,M.,
            Ahmed,A., Salvo-Schaich,J., Perez,A., Letsou,W., Sepulveda,M.C.,
            Ramos,R.L. and Hadjiargyrou,M.
  TITLE     Mustn1 ablation in skeletal muscle results in increased glucose
            tolerance concomitant with upregulated GLUT expression in male mice
  JOURNAL   Physiol Rep 11 (9), e15674 (2023)
   PUBMED   37170065
  REMARK    GeneRIF: Mustn1 ablation in skeletal muscle results in increased
            glucose tolerance concomitant with upregulated GLUT expression in
            male mice.
REFERENCE   5  (bases 1 to 1268)
  AUTHORS   Harris,M.P., Zeng,S., Zhu,Z., Lira,V.A., Yu,L.,
            Hodgson-Zingman,D.M. and Zingman,L.V.
  TITLE     Myokine Musclin Is Critical for Exercise-Induced Cardiac
            Conditioning
  JOURNAL   Int J Mol Sci 24 (7), 6525 (2023)
   PUBMED   37047496
  REMARK    GeneRIF: Myokine Musclin Is Critical for Exercise-Induced Cardiac
            Conditioning.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1268)
  AUTHORS   Singh,S., Robinson,M., Ismail,I., Saha,M., Auer,H., Kornacker,K.,
            Robinson,M.L., Bates,C.M. and McHugh,K.M.
  TITLE     Transcriptional profiling of the megabladder mouse: a unique model
            of bladder dysmorphogenesis
  JOURNAL   Dev Dyn 237 (1), 170-186 (2008)
   PUBMED   18069694
REFERENCE   7  (bases 1 to 1268)
  AUTHORS   Moffatt,P., Thomas,G., Sellin,K., Bessette,M.C., Lafreniere,F.,
            Akhouayri,O., St-Arnaud,R. and Lanctot,C.
  TITLE     Osteocrin is a specific ligand of the natriuretic Peptide clearance
            receptor that modulates bone growth
  JOURNAL   J Biol Chem 282 (50), 36454-36462 (2007)
   PUBMED   17951249
  REMARK    GeneRIF: Ostn is a naturally occurring ligand of the NPR-C
            clearance receptor and may act to locally modulate the actions of
            the natriuretic system in bone by blocking the clearance action of
            NPR-C, thus locally elevating levels of C-type natriuretic peptide.
REFERENCE   8  (bases 1 to 1268)
  AUTHORS   Yasui,A., Nishizawa,H., Okuno,Y., Morita,K., Kobayashi,H.,
            Kawai,K., Matsuda,M., Kishida,K., Kihara,S., Kamei,Y., Ogawa,Y.,
            Funahashi,T. and Shimomura,I.
  TITLE     Foxo1 represses expression of musclin, a skeletal muscle-derived
            secretory factor
  JOURNAL   Biochem Biophys Res Commun 364 (2), 358-365 (2007)
   PUBMED   17950246
  REMARK    GeneRIF: Foxo1 downregulates musclin mRNA expression both in vitro
            and in vivo, which should explain insulin-mediated upregulation of
            this gene in muscle cells.
REFERENCE   9  (bases 1 to 1268)
  AUTHORS   Nishizawa,H., Matsuda,M., Yamada,Y., Kawai,K., Suzuki,E.,
            Makishima,M., Kitamura,T. and Shimomura,I.
  TITLE     Musclin, a novel skeletal muscle-derived secretory factor
  JOURNAL   J Biol Chem 279 (19), 19391-19395 (2004)
   PUBMED   15044443
  REMARK    GeneRIF: Musclin expression level is tightly regulated by
            nutritional changes and its physiological role could be linked to
            glucose metabolism
REFERENCE   10 (bases 1 to 1268)
  AUTHORS   Thomas,G., Moffatt,P., Salois,P., Gaumond,M.H., Gingras,R.,
            Godin,E., Miao,D., Goltzman,D. and Lanctot,C.
  TITLE     Osteocrin, a novel bone-specific secreted protein that modulates
            the osteoblast phenotype
  JOURNAL   J Biol Chem 278 (50), 50563-50571 (2003)
   PUBMED   14523025
  REMARK    GeneRIF: osteocrin represents a novel, unique vitamin D-regulated
            bone-specific protein that appears to act as a soluble osteoblast
            regulator
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC154512.2.
            
            On Mar 21, 2007 this sequence version replaced NM_198112.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY395730.1, AY573932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC154512.2         103590-103650
            62-160              AC154512.2         117288-117386
            161-369             AC154512.2         120472-120680
            370-466             AC154512.2         142820-142916
            467-1268            AC154512.2         146357-147158
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 18.88 cM"
     gene            1..1268
                     /gene="Ostn"
                     /gene_synonym="Ostc"
                     /note="osteocrin"
                     /db_xref="GeneID:239790"
                     /db_xref="MGI:MGI:2677164"
     exon            1..61
                     /gene="Ostn"
                     /gene_synonym="Ostc"
                     /inference="alignment:Splign:2.1.0"
     exon            62..160
                     /gene="Ostn"
                     /gene_synonym="Ostc"
                     /inference="alignment:Splign:2.1.0"
     exon            161..369
                     /gene="Ostn"
                     /gene_synonym="Ostc"
                     /inference="alignment:Splign:2.1.0"
     exon            370..466
                     /gene="Ostn"
                     /gene_synonym="Ostc"
                     /inference="alignment:Splign:2.1.0"
     exon            467..1268
                     /gene="Ostn"
                     /gene_synonym="Ostc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      957..962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ostn"
                     /gene_synonym="Ostc"
                     /note="hexamer: AATAAA"
     polyA_site      977
                     /gene="Ostn"
                     /gene_synonym="Ostc"
                     /note="major polyA site"
     polyA_site      1074
                     /gene="Ostn"
                     /gene_synonym="Ostc"
     regulatory      1248..1253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ostn"
                     /gene_synonym="Ostc"
                     /note="hexamer: ATTAAA"
     polyA_site      1268
                     /gene="Ostn"
                     /gene_synonym="Ostc"
ORIGIN      
        1 gctaagtttg ggataagctg caggcaggac tctaaagtta ggagctctga cttctcacaa
       61 gatgctggac tggagattgg caagtacaca cttcatcctg gctatgattg tgatgctgtg
      121 gggctcagga aaggcattct ctgtggactt agcatcacag gagtttggaa cagcaagctt
      181 gcagtctcca cccacagcca gagaagagaa gtcagccact gagctttcgg ctaagctcct
      241 gcgtcttgat gatctggtgt ccttagagaa tgacgtattt gagaccaaga aaaagagaag
      301 cttctctggc tttgggtctc cccttgacag actctcagct gggtctgtag agcatagagg
      361 gaaacaaagg aaagcagtag atcattcaaa aaagcggttt ggtattccca tggatcggat
      421 tggtagaaac cggctctcca gttccagagg ctgatggatt cttattgtgc gacttacttg
      481 tgtgagatgg cacagaacta tagaagacac ttcagtgaag ttcactaccc cttttgtcaa
      541 ggaattggcc tttcgcaaac cttcccaaag cttgatcctc cccagaccat cacgtcatag
      601 tgttgctgtg gttttagttg agttgtgcag atcatttcag tgcatggata tctctgaaag
      661 tatttttcaa tgattcccaa attgtaacgt ggcccctgaa cctacttttt ttaaacagca
      721 gaccaatata atgcattctc ttgccattaa tattttcaca tttcagttaa tcaatgtgct
      781 ttctagaaac ctagtgtttg aagatctgat gatctaaaga aatcagaaat gagcacatgg
      841 tgatttatat aggtttcttt agtttttctg aggtttgtcg aattgttgta aacttcaact
      901 tcaagcttag aaaaaagaca ttacatgagt gtttgcttca actgtgtcag aaggcaaata
      961 aattttgaga aacctgagca attgtgttct ttaggaacta ataaaggata gtataattgg
     1021 cccatatgta atattctgac aaactctgaa tgtaaaagac tcatttgaaa agaagttact
     1081 gcctggcttg tttacttcta ccagcctagg ggtgaattgt tcaaatgttt cctatgttag
     1141 cagcttttct tcttcttttt ttttctttct attttacttt ttttcttcat tcaatgttta
     1201 taagctaaaa atccaaccaa atagtgcttt gtgctttaaa agggggtatt aaaatcaaca
     1261 ttaatcta
//
