LOCUS       NM_172416               3009 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus osteopetrosis associated transmembrane protein 1
            (Ostm1), mRNA.
ACCESSION   NM_172416
VERSION     NM_172416.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3009)
  AUTHORS   Mutabaruka,M.S., Pata,M. and Vacher,J.
  TITLE     A Foxo1-Klf2-S1pr1-Gnai1-Rac1 signaling axis is a critical mediator
            of Ostm1 regulatory network in T lymphopoiesis
  JOURNAL   iScience 25 (4), 104160 (2022)
   PUBMED   35434560
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3009)
  AUTHORS   Narimatsu,Y., Iwakoshi-Ukena,E., Naito,M., Moriwaki,S.,
            Furumitsu,M. and Ukena,K.
  TITLE     Neurosecretory Protein GL Accelerates Liver Steatosis in Mice Fed
            Medium-Fat/Medium-Fructose Diet
  JOURNAL   Int J Mol Sci 23 (4), 2071 (2022)
   PUBMED   35216187
  REMARK    GeneRIF: Neurosecretory Protein GL Accelerates Liver Steatosis in
            Mice Fed Medium-Fat/Medium-Fructose Diet.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3009)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   4  (bases 1 to 3009)
  AUTHORS   Pata,M., Yousefi Behzadi,P. and Vacher,J.
  TITLE     Expression pattern of the V5-Ostm1 protein in bacterial artificial
            chromosome transgenic mice
  JOURNAL   Genesis 59 (3), e23409 (2021)
   PUBMED   33484096
REFERENCE   5  (bases 1 to 3009)
  AUTHORS   Vacher,J., Bruccoleri,M. and Pata,M.
  TITLE     Ostm1 from Mouse to Human: Insights into Osteoclast Maturation
  JOURNAL   Int J Mol Sci 21 (16), 5600 (2020)
   PUBMED   32764302
  REMARK    GeneRIF: Ostm1 from Mouse to Human: Insights into Osteoclast
            Maturation.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3009)
  AUTHORS   Swank,R.T., Reddington,M., Howlett,O. and Novak,E.K.
  TITLE     Platelet storage pool deficiency associated with inherited
            abnormalities of the inner ear in the mouse pigment mutants muted
            and mocha
  JOURNAL   Blood 78 (8), 2036-2044 (1991)
   PUBMED   1912584
REFERENCE   7  (bases 1 to 3009)
  AUTHORS   Walker,D.G.
  TITLE     Spleen cells transmit osteopetrosis in mice
  JOURNAL   Science 190 (4216), 785-787 (1975)
   PUBMED   1198094
REFERENCE   8  (bases 1 to 3009)
  AUTHORS   Walker,D.G.
  TITLE     Bone resorption restored in osteopetrotic mice by transplants of
            normal bone marrow and spleen cells
  JOURNAL   Science 190 (4216), 784-785 (1975)
   PUBMED   1105786
REFERENCE   9  (bases 1 to 3009)
  AUTHORS   Hollinshead,M.B., Schneider,L.C. and Smith,M.E.
  TITLE     Prenatal development of the grey lethal mouse. I. Teeth and jaws
  JOURNAL   Anat Rec 182 (3), 305-319 (1975)
   PUBMED   1155801
REFERENCE   10 (bases 1 to 3009)
  AUTHORS   Murphy,H.M.
  TITLE     Calcitonin-like activity in the circulation of osteopetrotic
            grey-lethal mice
  JOURNAL   J Endocrinol 53 (1), 139-150 (1972)
   PUBMED   4336559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044897.1, AF533890.1 and BB286500.1.
            
            On Mar 1, 2011 this sequence version replaced NM_172416.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044897.1, AF533890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AK044897.1         1-1
            2-3002              AF533890.1         1-3001
            3003-3009           BB286500.1         262-268
FEATURES             Location/Qualifiers
     source          1..3009
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.89 cM"
     gene            1..3009
                     /gene="Ostm1"
                     /gene_synonym="1200002H13Rik; gl; HSPC019"
                     /note="osteopetrosis associated transmembrane protein 1"
                     /db_xref="GeneID:14628"
                     /db_xref="MGI:MGI:2655574"
     exon            1..482
                     /gene="Ostm1"
                     /gene_synonym="1200002H13Rik; gl; HSPC019"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1085
                     /gene="Ostm1"
                     /gene_synonym="1200002H13Rik; gl; HSPC019"
                     /note="grey lethal osteopetrosis; chloride channel 7 beta
                     subunit"
                     /codon_start=1
                     /product="osteopetrosis-associated transmembrane protein 1
                     precursor"
                     /protein_id="NP_766004.1"
                     /db_xref="CCDS:CCDS23814.1"
                     /db_xref="GeneID:14628"
                     /db_xref="MGI:MGI:2655574"
                     /translation="MARDAELARSSGWPWRWLPALLLLQLLRWRCALCALPFTSSRHP
                     GFADLLSEQQLLEVQDLTLSLLQGGGLGPLSLLPPDLPDLEPECRELLMDFANSSAEL
                     TACMVRSARPVRLCQTCYPLFQQVAIKMDNISRNIGNTSEGPRCGGSLLTADRMQIVL
                     MVSEFFNSTWQEANCANCLTNNGEDLSNNTEDFLSLFNKTLACFEHNLQGHTYSLLPP
                     KNYSEVCRNCKEAYKNLSLLYSQMQKLNGLENKAEPETHLCIDVEDAMNITRKLWSRT
                     FNCSVTCSDTVSVVAVSVFILFLPVVFYLSSFLHSEQKKRKLILPKRLKSSTSFANIQ
                     ENAT"
     exon            483..597
                     /gene="Ostm1"
                     /gene_synonym="1200002H13Rik; gl; HSPC019"
                     /inference="alignment:Splign:2.1.0"
     exon            598..695
                     /gene="Ostm1"
                     /gene_synonym="1200002H13Rik; gl; HSPC019"
                     /inference="alignment:Splign:2.1.0"
     exon            696..863
                     /gene="Ostm1"
                     /gene_synonym="1200002H13Rik; gl; HSPC019"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1029
                     /gene="Ostm1"
                     /gene_synonym="1200002H13Rik; gl; HSPC019"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..3009
                     /gene="Ostm1"
                     /gene_synonym="1200002H13Rik; gl; HSPC019"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2984..2989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ostm1"
                     /gene_synonym="1200002H13Rik; gl; HSPC019"
                     /note="hexamer: AATAAA"
     polyA_site      3006
                     /gene="Ostm1"
                     /gene_synonym="1200002H13Rik; gl; HSPC019"
                     /note="major polyA site"
ORIGIN      
        1 cggccgaagc cggaagcggc tgctgtcgga agcaccgggc gagctatctg ttacagtccg
       61 gcccggggat ggctcgggac gcggagctgg cgcgcagtag cgggtggccg tggcggtggc
      121 tgccggcgct gctgctgctg cagctgctgc ggtggaggtg cgccctgtgc gcgctcccct
      181 tcaccagcag tcggcaccca ggctttgcgg acctgctgtc ggagcagcag ctgttggagg
      241 tgcaggactt gaccctgtct ttgctgcagg gcggaggtct agggccgctg tcactgctac
      301 ctccggacct gccggatctg gagcctgagt gccgggagct gctgatggac ttcgccaata
      361 gcagcgccga gctgaccgcc tgtatggtgc gcagcgctcg gcccgtgcgc ctctgccaga
      421 cctgctaccc gctcttccaa caggtcgcaa tcaagatgga caacatcagc cgaaacatcg
      481 ggaatacctc cgagggcccg cgctgtggcg gaagtctcct gacggcagac agaatgcaga
      541 tagttctcat ggtctctgag tttttcaaca gcacgtggca ggaggcgaac tgcgcaaatt
      601 gcctaacaaa caatggtgag gatttgtcaa acaacacaga ggacttcctc agtctgttta
      661 acaagacttt ggcctgcttt gagcataacc tgcaggggca cacatacagt ctcctcccac
      721 caaaaaatta ctccgaagtg tgcagaaact gtaaagaggc atataaaaac ctgagcctcc
      781 tgtacagtca aatgcagaaa ctgaacgggc ttgagaacaa ggctgagcct gagacgcact
      841 tgtgcatcga tgtggaggat gcaatgaaca ttactcggaa gctttggagt cgaaccttca
      901 actgttcggt cacctgcagc gacacggtgt ccgtggttgc tgtgtctgtg ttcattctct
      961 tcctgcctgt cgtcttctac ctcagtagct tccttcactc agagcaaaag aaacgcaaac
     1021 tcattctacc caaacgtctc aagtcgagca ccagttttgc caacattcaa gaaaatgcca
     1081 cctgaagcct gcaaaacggg gactcgacct cacgttgtgc cagtaagtgt tagaccacag
     1141 cacagtcgag aagaagatga gccaaggtcg gacaagttgc attctcacga aatgttggga
     1201 ctgcagacct ataatttatt ctgaataagg gttctcaaat tcccttttcc tgagcacccc
     1261 tttttttttt tttgaagatt tctgtatttt tagttttcaa acatagcaat gttacatatt
     1321 ttaaggtata tctgttacaa taacaagtga gggctttttt ctcaggcata tgaatgacta
     1381 ctggacactt ctgatttatc ctcgttagca gaagtacaca aagcagaaaa ggctgaggtc
     1441 tgctatttac acattagtca ctgggagccc actctgaaaa agaaacatac ttgccaaatg
     1501 gtagcaggct cagtgattaa cttaagtgaa ttcccattgt agtattgttg tatgtatata
     1561 catacatgca cacacacaca catatatata tacacgtata catagatgta tatatgtaat
     1621 gtatacttaa tatatcatac attaaaataa tgttctctag ttccctgaag tcccttttga
     1681 aaccactagt tgattataaa cctccttaac agttttcaga gagtgattcc acattatgca
     1741 tttatccttg ttaaaggttt acagtaactg aggttctaat atgactttta taaatactat
     1801 tttacatctt atttttgtct ttatttagta agtaatttat aatcactgga ctgcttaatt
     1861 acctttgagg acaagatgga ttcatcttat gccagggatt tgcatcatga atttcattaa
     1921 gttatttggc aacctgtaac ttgttagtag ttcaagtcga atgtcaccca agtgtgtcat
     1981 actgtgttta aatttgtgat tttttttaat gaaaatttta tcttggaata tttggagatt
     2041 tggggagaaa caaggacaaa cacaagagct taaatttcag aaaatagaca gggacctgag
     2101 ggatgctcac ggtgagacag ctgcgtggtt tacactggag atgactcggt tgacaggctc
     2161 gcacaggaag cctcccagtt acgggaaaga tgaaagtcac atgactgaaa cgaaattacc
     2221 catctcactg tcaggaaact agttcttctt tggcatattt ctagcaacct ttaaaaccat
     2281 gcttgtttca gtgtcactca gttgtatttc tcaagatgta gaagttgatg gttttgttgg
     2341 ttaatccggt ggaaacgggc tttgttgtaa aggtaatgaa taggaaactc ctcagattca
     2401 atggttaaga aaatgtgact cccttcacaa cctgtaattg ccctacagga aggcaggagt
     2461 gtttgggtat tttttgtatg tttcccacat atgcagagtg tgagagcagg ctagtcttag
     2521 tcccagagtg tgtcacaccg ggtatgtgac aatcagacga cgctgtgatc cactagatgt
     2581 gccggggttc attgtgctgt cattgttcct gtcttgattt gaagcacatg gttgagggtc
     2641 attggaagcc atcttcatca gtacatgtaa agcttattta catgtgcaaa gtgagtgaag
     2701 tgacatattt aaactgtgag tagcgactcc tcgggtacct ttcagtactg tgtgtacaaa
     2761 ccactgcttt tggctaagaa gctggagagc actttaacaa gccagccatc tctgttcctg
     2821 atcagggtct ggctctctag aggttgcatt agaaatatat ttgaaaatgt gccaaagaat
     2881 ttcatcttgt ggtcatatta aaaaaatgta catagttctg aatcctgagg cacatagggt
     2941 tatgtgtgtg cacaagaaaa cctgtttttt ccttatgctt tacaataaag gaaataacaa
     3001 ggaaaattg
//
