LOCUS       NM_017375               1714 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus osteoclast stimulating factor 1 (Ostf1), mRNA.
ACCESSION   NM_017375
VERSION     NM_017375.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1714)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1714)
  AUTHORS   Nakamura,S., Masuyama,R., Sakai,K., Fukuda,K., Takeda,K. and
            Tanimura,S.
  TITLE     SH3P2 suppresses osteoclast differentiation through restricting
            membrane localization of myosin 1E
  JOURNAL   Genes Cells 25 (11), 707-717 (2020)
   PUBMED   32916757
  REMARK    GeneRIF: SH3P2 suppresses osteoclast differentiation through
            restricting membrane localization of myosin 1E.
REFERENCE   3  (bases 1 to 1714)
  AUTHORS   Vermeren,M., Lyraki,R., Wani,S., Airik,R., Albagha,O., Mort,R.,
            Hildebrandt,F. and Hurd,T.
  TITLE     Osteoclast stimulation factor 1 (Ostf1) KNOCKOUT increases
            trabecular bone mass in mice
  JOURNAL   Mamm Genome 28 (11-12), 498-514 (2017)
   PUBMED   28936620
REFERENCE   4  (bases 1 to 1714)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 1714)
  AUTHORS   Ha,T.J., Swanson,D.J., Kirova,R., Yeung,J., Choi,K., Tong,Y.,
            Chesler,E.J. and Goldowitz,D.
  TITLE     Genome-wide microarray comparison reveals downstream genes of Pax6
            in the developing mouse cerebellum
  JOURNAL   Eur J Neurosci 36 (7), 2888-2898 (2012)
   PUBMED   22817342
REFERENCE   6  (bases 1 to 1714)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   7  (bases 1 to 1714)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1714)
  AUTHORS   Lee,C.G., Morse,H.C. 3rd, Kay,B.K. and Kozak,C.A.
  TITLE     Genetic mapping of eight SH3 domain genes on seven mouse
            chromosomes
  JOURNAL   Mamm Genome 10 (4), 402-404 (1999)
   PUBMED   10087302
REFERENCE   9  (bases 1 to 1714)
  AUTHORS   Hoffman,N.G., Sparks,A.B., Carter,J.M. and Kay,B.K.
  TITLE     Binding properties of SH3 peptide ligands identified from
            phage-displayed random peptide libraries
  JOURNAL   Mol Divers 2 (1-2), 5-12 (1996)
   PUBMED   9238627
REFERENCE   10 (bases 1 to 1714)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY065904.1, AK002899.1 and AK145949.1.
            
            On Nov 25, 2008 this sequence version replaced NM_017375.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145949.1, AK149175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY065904.1         1-22
            23-1323             AK002899.1         2-1302
            1324-1714           AK145949.1         1275-1665
FEATURES             Location/Qualifiers
     source          1..1714
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 13.17 cM"
     gene            1..1714
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /note="osteoclast stimulating factor 1"
                     /db_xref="GeneID:20409"
                     /db_xref="MGI:MGI:700012"
     exon            1..194
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..808
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /note="SH3 domain protein 3"
                     /codon_start=1
                     /product="osteoclast-stimulating factor 1"
                     /protein_id="NP_059071.1"
                     /db_xref="CCDS:CCDS37930.1"
                     /db_xref="GeneID:20409"
                     /db_xref="MGI:MGI:700012"
                     /translation="MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDM
                     SDTSWWKGTCKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGL
                     DKAGSTALYWACHGGHKDIVEVLFTQPNVELNQQNKLGDTALHAAAWKGYADIVQLLL
                     AKGARTDLRNNEKKLALDMATNAACASLLKKKQQGTDGARTLSNAEDYLDDEDSD"
     exon            195..241
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            242..292
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            293..356
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            357..410
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            411..518
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..568
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..647
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..749
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..1714
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1048..1053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /note="hexamer: AATAAA"
     polyA_site      1086
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /note="major polyA site"
     regulatory      1244..1249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /note="hexamer: AATAAA"
     polyA_site      1266
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
     regulatory      1301..1306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
                     /note="hexamer: AATAAA"
     polyA_site      1325
                     /gene="Ostf1"
                     /gene_synonym="Sh3d3; SH3P2"
ORIGIN      
        1 tggtgggaag gccgggctgt ctgcggagct cgctggtccg agtgtcccgc atcgggttgc
       61 gcgcggatcc ggagcggccg cggccagcgc aggcttggcg cccagttctc gtgtgcgtgt
      121 ggggctcccg cggctgagcc tggtcgctcc gtgtagcgcc atgtccaagc cacctcccaa
      181 accggtcaaa ccagggcaag ttaaagtctt cagagctcta tatacatttg aacccagaac
      241 tccagatgaa ttatactttg aagaaggaga cattatctac atcactgaca tgagtgatac
      301 cagctggtgg aaagggacat gcaagggcag aacaggactg atcccgagca actatgtggc
      361 tgagcaggca gaatccattg acaatccatt gcatgaagct gcaaaaagag gcaacctgag
      421 ctggttgagg gagtgcttgg acaaccgggt gggtgtgaac ggcctggaca aagctggaag
      481 cacagccctg tactgggcct gccacggtgg ccataaagac atagtggagg ttctgtttac
      541 tcagccgaat gtggagctga accagcagaa taagctggga gacacagctc tgcacgcggc
      601 tgcctggaag ggttatgcag acattgtcca gttgctactg gcaaaaggtg cgaggacaga
      661 cttgagaaac aatgagaaga agctggcctt ggacatggcc accaacgctg cctgtgcatc
      721 gctcctgaag aagaagcagc agggaacaga tggggctcga acgttaagca acgccgagga
      781 ctacctcgat gacgaagact cagactgatt ccccccgggg ccgctttgat tgttgcctaa
      841 acttcttttg cttttgccat tccggagcct gggttgtttg ccagaagagt attgataact
      901 gttgctttta aagtctgtat gagcgcgaca ctgctgcact gtgatctgtg aggagtcgtt
      961 gtgagggtgg gtcattctca cccacgcctt gccaataagt gaagagatac tttgttgtat
     1021 aaaatacata tatgctcacc agggtaaaat aaacgaaaaa aaattatttc tatttatcaa
     1081 gctaaaggaa ttgtaatagt tttttttctt ttaaaaaaaa tcattttttt aagttcttta
     1141 cctcaaggaa tgagatgttt tgagtgggtt tttcaagggg gaaatggtta ttataacaat
     1201 agaccaaaac tctcaacaga aaattgtcag ctcttctgac aaaaataaac atttaaagag
     1261 attttattat ctgtttttgt gctatcactc attgctggta aataaagctt tctatactca
     1321 ggtaagaacc gattcgatgt tacttttaga tcacatttga tattgattag cacagaagaa
     1381 tcacaatgct gtgttcctct cacagcttcc tagttttgtt ttgttttttt tccgagacaa
     1441 tgtttctctg tgtagccctg gctgtcctgg aactcactct gtagaccagg ctggcctcga
     1501 actcagaaat ccacctgcct ctgcctccca agtgctgggt ttaaaggcgt gggccaccac
     1561 cgcctggctc acagttcaac acagaacaca attgcatatc taagaaaaga taacacttta
     1621 acaattacga tatactcaga attatattca gggtagtacc tagactgtag aacctcagtg
     1681 acctcatttc agtttgatta aagtgtggaa gctt
//
