LOCUS       NM_001368665            1806 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus odd-skipped related 2 (Osr2), transcript variant 1,
            mRNA.
ACCESSION   NM_001368665 XM_006520013
VERSION     NM_001368665.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1806)
  AUTHORS   Zhang,J., Li,J., Hou,Y., Lin,Y., Zhao,H., Shi,Y., Chen,K., Nian,C.,
            Tang,J., Pan,L., Xing,Y., Gao,H., Yang,B., Song,Z., Cheng,Y.,
            Liu,Y., Sun,M., Linghu,Y., Li,J., Huang,H., Lai,Z., Zhou,Z., Li,Z.,
            Sun,X., Chen,Q., Su,D., Li,W., Peng,Z., Liu,P., Chen,W., Huang,H.,
            Chen,Y., Xiao,B., Ye,L., Chen,L. and Zhou,D.
  TITLE     Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T
            cell exhaustion in tumor
  JOURNAL   Cell 187 (13), 3409-3426 (2024)
   PUBMED   38744281
  REMARK    GeneRIF: Osr2 functions as a biomechanical checkpoint to aggravate
            CD8[+] T cell exhaustion in tumor.
REFERENCE   2  (bases 1 to 1806)
  AUTHORS   Ulschmid,C.M., Sun,M.R., Jabbarpour,C.R., Steward,A.C.,
            Rivera-Gonzalez,K.S., Cao,J., Martin,A.A., Barnes,M., Wicklund,L.,
            Madrid,A., Papale,L.A., Joseph,D.B., Vezina,C.M., Alisch,R.S. and
            Lipinski,R.J.
  TITLE     Disruption of DNA methylation-mediated cranial neural crest
            proliferation and differentiation causes orofacial clefts in mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (3), e2317668121 (2024)
   PUBMED   38194455
REFERENCE   3  (bases 1 to 1806)
  AUTHORS   Wilbourne,J., Jia,S., Fogarty,A., Takaku,M. and Zhao,F.
  TITLE     Crucial Roles of the Mesenchymal Androgen Receptor in Wolffian Duct
            Development
  JOURNAL   Endocrinology 165 (2) (2023)
   PUBMED   38146640
REFERENCE   4  (bases 1 to 1806)
  AUTHORS   Chen,X., Li,N., Hu,P., Li,L., Li,D., Liu,H., Zhu,L., Xiao,J. and
            Liu,C.
  TITLE     Deficiency of Fam20b-Catalyzed Glycosaminoglycan Chain Synthesis in
            Neural Crest Leads to Cleft Palate
  JOURNAL   Int J Mol Sci 24 (11), 9634 (2023)
   PUBMED   37298583
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1806)
  AUTHORS   Ono,Y., Schlesinger,S., Fukunaga,K., Yambe,S., Sato,T., Sasaki,T.,
            Shukunami,C., Asahara,H. and Inui,M.
  TITLE     Scleraxis-lineage cells are required for correct muscle patterning
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37246520
REFERENCE   6  (bases 1 to 1806)
  AUTHORS   Kawai,S., Kato,T., Sato,M. and Amano,A.
  TITLE     Odd-skipped related 2 gene transcription is regulated by CCAAT
            enhancer-binding protein delta in mesenchymal C3H10T1/2 cells
  JOURNAL   Genes Cells 11 (2), 163-175 (2006)
   PUBMED   16436053
  REMARK    GeneRIF: Osr2 expression is regulated by C/EBP regulatory elements
REFERENCE   7  (bases 1 to 1806)
  AUTHORS   Kawai,S., Kato,T., Inaba,H., Okahashi,N. and Amano,A.
  TITLE     Odd-skipped related 2 splicing variants show opposite
            transcriptional activity
  JOURNAL   Biochem Biophys Res Commun 328 (1), 306-311 (2005)
   PUBMED   15670784
  REMARK    GeneRIF: Our results indicate that Osr2 bifurcates its function by
            alternative splicing.
REFERENCE   8  (bases 1 to 1806)
  AUTHORS   Liu,W., Sun,X., Braut,A., Mishina,Y., Behringer,R.R., Mina,M. and
            Martin,J.F.
  TITLE     Distinct functions for Bmp signaling in lip and palate fusion in
            mice
  JOURNAL   Development 132 (6), 1453-1461 (2005)
   PUBMED   15716346
REFERENCE   9  (bases 1 to 1806)
  AUTHORS   Lan,Y., Ovitt,C.E., Cho,E.S., Maltby,K.M., Wang,Q. and Jiang,R.
  TITLE     Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of
            secondary palate growth and morphogenesis
  JOURNAL   Development 131 (13), 3207-3216 (2004)
   PUBMED   15175245
  REMARK    GeneRIF: Osr2 is a key intrinsic regulator of palatal growth and
            patterning
REFERENCE   10 (bases 1 to 1806)
  AUTHORS   Lan,Y., Kingsley,P.D., Cho,E.S. and Jiang,R.
  TITLE     Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits
            dynamic expression patterns during craniofacial, limb, and kidney
            development
  JOURNAL   Mech Dev 107 (1-2), 175-179 (2001)
   PUBMED   11520675
  REMARK    GeneRIF: expressed during craniofacial, limb, and kidney
            development
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116596.3.
            
            On Feb 15, 2019 this sequence version replaced XM_006520013.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY038074.1, CB208864.2 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               AC116596.3         118426-118795
            371-1137            AC116596.3         122517-123283
            1138-1237           AC116596.3         124240-124339
            1238-1806           AC116596.3         125065-125633
FEATURES             Location/Qualifiers
     source          1..1806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.46 cM"
     gene            1..1806
                     /gene="Osr2"
                     /gene_synonym="5430409I15Rik; Osr2A; Osr2B"
                     /note="odd-skipped related 2"
                     /db_xref="GeneID:107587"
                     /db_xref="MGI:MGI:1930813"
     exon            1..370
                     /gene="Osr2"
                     /gene_synonym="5430409I15Rik; Osr2A; Osr2B"
                     /inference="alignment:Splign:2.1.0"
     exon            371..1137
                     /gene="Osr2"
                     /gene_synonym="5430409I15Rik; Osr2A; Osr2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..1420
                     /gene="Osr2"
                     /gene_synonym="5430409I15Rik; Osr2A; Osr2B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein odd-skipped-related 2"
                     /codon_start=1
                     /product="protein odd-skipped-related 2 isoform 1"
                     /protein_id="NP_001355594.1"
                     /db_xref="CCDS:CCDS88748.1"
                     /db_xref="GeneID:107587"
                     /db_xref="MGI:MGI:1930813"
                     /translation="MGSKALPAPIPLHPSLQLTNYSFLQAVNTFPAAVDHLQGLYGLS
                     AVQTMHMNHWTLGYPSVHEITRSTITEMAAAQGLVDARFPFPSLPFATHLFHPKQGAI
                     AHVLPALHKDRPRFDFANLAVAATQEDPPKMGDLSKLSPGLGSPISGLSKLNPDRKPS
                     RGRLPSKTKKEFICKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDH
                     RYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHMQESPHKCPTCGRTFNQRSNLKTHLL
                     THTDIKPYSCEQCGKVFRRNCDLRRHSLTHTPRQNF"
     exon            1138..1237
                     /gene="Osr2"
                     /gene_synonym="5430409I15Rik; Osr2A; Osr2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1806
                     /gene="Osr2"
                     /gene_synonym="5430409I15Rik; Osr2A; Osr2B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1748
                     /gene="Osr2"
                     /gene_synonym="5430409I15Rik; Osr2A; Osr2B"
     regulatory      1786..1791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osr2"
                     /gene_synonym="5430409I15Rik; Osr2A; Osr2B"
                     /note="hexamer: AATAAA"
     polyA_site      1806
                     /gene="Osr2"
                     /gene_synonym="5430409I15Rik; Osr2A; Osr2B"
                     /note="major polyA site"
ORIGIN      
        1 agcctggggc gggacgcggg ctgggacgga gctcagcgcg ctcgcagccg gagggtgatg
       61 gccctgcagg gctgcgggct ccgactttac ccgcagtccg cggtcagaaa ctggcccagg
      121 caccgggatc tgggcgagct ctgagcactc atcccaacac gctcgctctt tacacatccc
      181 gcttccacgg actgccgaag accaattacc gctgtcgctt tcgctccccc agatcatgtt
      241 ctcggttccc gggacaacgc gccgaaaaag aagttctccc agtttggacc tcatgacctt
      301 tccaagctgt gcgtcctgct gtccggacct agtctgaacc gcgctgccca ggcagacatc
      361 ggttctggcg ggattcctct gcgtgctgtt gttttgcggg cttttccccc tcacaccctc
      421 cggcctctga gacctggaag aaaggggcgg ctctctgcac cccttcggag ccttcaggaa
      481 gatggggagc aaggccctgc cagctcccat cccactgcac ccgtcactgc agctcaccaa
      541 ttactccttc ctgcaggcag tgaacacctt cccggccgca gtggaccacc ttcagggcct
      601 ctacggtctc agtgcggtgc agaccatgca catgaaccac tggacgctgg ggtaccccag
      661 tgtgcacgag atcacccgct ccaccatcac ggagatggcg gctgcgcagg gcctcgtgga
      721 cgctcgcttc cccttcccct cgctgccctt tgccacccac ctgttccacc ccaagcaggg
      781 ggccattgcc cacgtccttc cagccctaca caaggaccgg ccccgttttg actttgccaa
      841 cttggcggtg gccgccacgc aagaagatcc tcctaaaatg ggagacctga gcaagctgag
      901 cccagggctg gggagcccca tctcgggcct cagtaaactg aacccggaca gaaagccctc
      961 ccgagggaga ttgccctcca aaacgaaaaa ggagtttatc tgcaagtttt gcggcagaca
     1021 ctttaccaaa tcatacaatt tgctcattca cgagaggacc cacacagacg agaggccata
     1081 cacctgtgac atctgccaca aggcatttcg gaggcaagat cacctacggg atcacaggta
     1141 tatccattcc aaagaaaagc ccttcaaatg tcaggagtgt gggaaaggat tctgtcagtc
     1201 taggacccta gcagttcaca aaactttaca tatgcaggaa tctccacaca aatgtcccac
     1261 atgtggaaga acctttaatc agagaagtaa cctgaaaact caccttctca cccatacaga
     1321 catcaagccc tacagctgcg agcagtgcgg caaagtgttc aggcgaaact gcgatctgcg
     1381 gcggcacagc ctgactcaca ccccgcggca gaacttctag cgaagcccag gatctgtcct
     1441 gtgcggcccc ggctcccttc cccccagaca cctctcctcg cctcccaccc caggggccca
     1501 tccctaccct cactgacccc ggctcttccc tgcctgcagc cgcacctgca gctccaggga
     1561 gttaactgtt cttctgagga ctgagaactc tctagaaagc cacacactac ccccttccaa
     1621 accagcatgt gctagatcct tgtagatatt cacggctcat tttagagctc tgtacataat
     1681 attgtgggtc ttcgtccggt cgttctgtct gtttttgtat cttgttggat gcacctagac
     1741 atggaaaacg aaacgcaaat ttatctttaa agactgtatt ttcaaaataa aacctttctt
     1801 gattca
//
