LOCUS       NM_011019               4789 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus oncostatin M receptor (Osmr), transcript variant 1,
            mRNA.
ACCESSION   NM_011019
VERSION     NM_011019.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4789)
  AUTHORS   Wang,G., Munoz-Rojas,A.R., Spallanzani,R.G., Franklin,R.A.,
            Benoist,C. and Mathis,D.
  TITLE     Adipose-tissue Treg cells restrain differentiation of stromal
            adipocyte precursors to promote insulin sensitivity and metabolic
            homeostasis
  JOURNAL   Immunity 57 (6), 1345-1359 (2024)
   PUBMED   38692280
REFERENCE   2  (bases 1 to 4789)
  AUTHORS   Komori,T., Hisaoka,T., Kotaki,A., Iwamoto,M., Miyajima,A.,
            Esashi,E. and Morikawa,Y.
  TITLE     Blockade of OSMRbeta signaling ameliorates skin lesions in a mouse
            model of human atopic dermatitis
  JOURNAL   FASEB J 38 (1), e23359 (2024)
   PUBMED   38102969
  REMARK    Erratum:[FASEB J. 2024 Feb 29;38(4):e23509. doi:
            10.1096/fj.202400312.. PMID: 38393635]
REFERENCE   3  (bases 1 to 4789)
  AUTHORS   Munz,S., Feger,M. and Foller,M.
  TITLE     Oncostatin M is a regulator of fibroblast growth factor 23 (FGF23)
            in UMR106 osteoblast-like cells
  JOURNAL   Sci Rep 13 (1), 8420 (2023)
   PUBMED   37225713
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4789)
  AUTHORS   Feng,Y., Yuan,Y., Xia,H., Wang,Z., Che,Y., Hu,Z., Deng,J., Li,F.,
            Wu,Q., Bian,Z., Zhou,H., Shen,D. and Tang,Q.
  TITLE     OSMR deficiency aggravates pressure overload-induced cardiac
            hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling
  JOURNAL   J Transl Med 21 (1), 290 (2023)
   PUBMED   37120549
  REMARK    GeneRIF: OSMR deficiency aggravates pressure overload-induced
            cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3
            signalling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4789)
  AUTHORS   Zhou,J., Yang,J., Dong,Y., Shi,Y., Zhu,E., Yuan,H., Li,X. and
            Wang,B.
  TITLE     Oncostatin M receptor regulates osteoblast differentiation via
            extracellular signal-regulated kinase/autophagy signaling
  JOURNAL   Stem Cell Res Ther 13 (1), 278 (2022)
   PUBMED   35765036
  REMARK    GeneRIF: Oncostatin M receptor regulates osteoblast differentiation
            via extracellular signal-regulated kinase/autophagy signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4789)
  AUTHORS   Tamura,S., Morikawa,Y., Miyajima,A. and Senba,E.
  TITLE     Expression of oncostatin M receptor beta in a specific subset of
            nociceptive sensory neurons
  JOURNAL   Eur J Neurosci 17 (11), 2287-2298 (2003)
   PUBMED   12814362
  REMARK    GeneRIF: Expression of oncostatin M receptor beta in a specific
            subset of nociceptive sensory neurons.
REFERENCE   7  (bases 1 to 4789)
  AUTHORS   Tamura,S., Morikawa,Y., Tanaka,M., Miyajima,A. and Senba,E.
  TITLE     Developmental expression pattern of oncostatin M receptor beta in
            mice
  JOURNAL   Mech Dev 115 (1-2), 127-131 (2002)
   PUBMED   12049776
REFERENCE   8  (bases 1 to 4789)
  AUTHORS   Kamiya,A., Kinoshita,T., Ito,Y., Matsui,T., Morikawa,Y., Senba,E.,
            Nakashima,K., Taga,T., Yoshida,K., Kishimoto,T. and Miyajima,A.
  TITLE     Fetal liver development requires a paracrine action of oncostatin M
            through the gp130 signal transducer
  JOURNAL   EMBO J 18 (8), 2127-2136 (1999)
   PUBMED   10205167
REFERENCE   9  (bases 1 to 4789)
  AUTHORS   Tanaka,M., Hara,T., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Miyajima,A.
  TITLE     Reconstitution of the functional mouse oncostatin M (OSM) receptor:
            molecular cloning of the mouse OSM receptor beta subunit
  JOURNAL   Blood 93 (3), 804-815 (1999)
   PUBMED   9920829
REFERENCE   10 (bases 1 to 4789)
  AUTHORS   Lindberg,R.A., Juan,T.S., Welcher,A.A., Sun,Y., Cupples,R.,
            Guthrie,B. and Fletcher,F.A.
  TITLE     Cloning and characterization of a specific receptor for mouse
            oncostatin M
  JOURNAL   Mol Cell Biol 18 (6), 3357-3367 (1998)
   PUBMED   9584176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109183.17 and AC102825.6.
            
            On Oct 5, 2022 this sequence version replaced NM_011019.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF058805.1, BC137703.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC109183.17        20089-20157         c
            70-154              AC102825.6         7672-7756
            155-324             AC102825.6         15461-15630
            325-496             AC102825.6         20851-21022
            497-775             AC102825.6         23550-23828
            776-911             AC102825.6         25132-25267
            912-1063            AC102825.6         25945-26096
            1064-1203           AC102825.6         30218-30357
            1204-1357           AC102825.6         30980-31133
            1358-1434           AC102825.6         39340-39416
            1435-1657           AC102825.6         40738-40960
            1658-1837           AC102825.6         43397-43576
            1838-1942           AC102825.6         44393-44497
            1943-2116           AC102825.6         45862-46035
            2117-2284           AC102825.6         46961-47128
            2285-2366           AC102825.6         51061-51142
            2367-2439           AC102825.6         51395-51467
            2440-4789           AC102825.6         52121-54470
FEATURES             Location/Qualifiers
     source          1..4789
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 3.3 cM"
     gene            1..4789
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /note="oncostatin M receptor"
                     /db_xref="GeneID:18414"
                     /db_xref="MGI:MGI:1330819"
     exon            1..69
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            70..154
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..2997
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; oncostatin-M-specific receptor subunit beta;
                     IL-31RB; IL-31R-beta; IL-31R subunit beta; IL-31 receptor
                     subunit beta; interleukin-31 receptor subunit beta;
                     oncostatin receptor"
                     /codon_start=1
                     /product="oncostatin-M-specific receptor subunit beta
                     isoform 1 precursor"
                     /protein_id="NP_035149.2"
                     /db_xref="CCDS:CCDS27368.1"
                     /db_xref="GeneID:18414"
                     /db_xref="MGI:MGI:1330819"
                     /translation="MAFSVVLHPAFLLAVLSLRASRSEVLEEPLPLTPEIHKVSFQLK
                     LQEVNLEWTVPALTHEELNMIFQIEISRLNISNTIWVENYSTTVKREEAVRWNWTSDI
                     PLECVKHFIRIRALVDDTKSLPQSSWGNWSSWKEVNAKVSVEPDKSLIFPKDKVLEEG
                     SNVTICLMYGQNVYNVSCKLQDEPIHGEQLDSHVSLLKLNNVVFLSDTGTNINCQATK
                     GPKRIFGTVLFVSKVLEEPKNVSCETRDFKTLDCSWEPGVDTTLTWRKQRFQNYTLCE
                     SFSKRCEVSNYRNSYTWQITEGSQEMYNFTLTAENQLRKRSVNINFNLTHRVHPKAPQ
                     DVTLKIIGATKANMTWKVHSHGNNYTLLCQVKLQYGEVIHEHNVSVHMSANYLFSDLD
                     PDTKYKAFVRCASANHFWKWSDWTQKEFSTPETAPSQALDVWRQVWSENGRRIVTLFW
                     KPLLKSQANGKIISYNIVVENEAKPTESEHYCVWAPALSTNLSLDLQPYKIRITANNS
                     MGASPESLMVLSNDSGHEEVKEKTIKGIKDAFNISWEPVSGDTMGYVVDWCAHSQDQR
                     CDLQWKNLGPNTTSTTITSDDFKPGVRYNFRIFERSVEHKARLVEKQRGYTQELAPLV
                     NPKVEIPYSTPNSFVLRWPDYDSDFQAGFIKGYLVYVKSKEMQCNQPWERTLLPDNSV
                     LCKYDINGSETKTLTVENLQPESLYEFFVTPYTSAGPGPNETFTKVTTPDARSHMLLQ
                     IILPMTLCVLLSIIVCYWKSQWVKEKCYPDIPNPYKSSILSLIKSKKNPHLIMNVKDC
                     IPDVLEVINKAEGSKTQCVGSGKLHIEDVPTKPPIVPTEKDSSGPVPCIFFENFTYDQ
                     SAFDSGSHGLIPGPLKDTAHQLGLLAPPNKFQNVLKNDYMKPLVESPTEETSLIYVSQ
                     LASPMCGDKDTLATEPPVPVHGSEYKRQMVVPGSLASPSLKEDNSLTSTVLLGQGEQ"
     exon            155..324
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            325..496
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            497..775
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            776..911
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1063
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1203
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1357
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1434
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1657
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1837
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1942
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2116
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2284
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2366
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2439
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..4789
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4769..4774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /note="hexamer: AATAAA"
     polyA_site      4789
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /note="major polyA site"
ORIGIN      
        1 acagacgtcc gcgcccgttc ccctgtgagg ccgaggaccg gcaaggctcc ggagcaggtc
       61 gccaggcggg taatcagacc aatggctttc tctgtggtcc ttcatccagc cttcctcctg
      121 gcagtgctgt ccctgagggc atcccgaagc gaagtcttgg aggagccttt accattgact
      181 cctgagatac ataaagtttc ttttcaattg aaacttcaag aagtgaattt agaatggact
      241 gtcccagccc ttactcatga agaattaaac atgatatttc agatagagat cagtagactg
      301 aacatatcca acaccatctg ggtggagaat tatagcacca ctgtgaagcg tgaagaagct
      361 gtgcgttgga actggacgtc tgatatccct ttggagtgtg tcaaacattt cataagaatc
      421 agggctctgg tagatgacac caagtccctt ccacagagtt cctggggcaa ctggagttcc
      481 tggaaagaag ttaatgcaaa ggtttccgtt gaacctgata aatcattaat atttcctaaa
      541 gacaaagtgt tggaagaagg ctccaatgtc accatctgtc tgatgtatgg gcagaatgta
      601 tataatgtat cctgtaagtt gcaagatgag ccaatccatg gagaacaact tgattcccac
      661 gtgtcattat taaaattgaa caatgtagtt ttccttagtg acacagggac aaacatcaat
      721 tgtcaagcca cgaagggtcc taaaagaata tttggtactg ttctctttgt ctcgaaagtg
      781 ctcgaggaac ctaagaatgt ttcctgtgaa acccgagact ttaagacttt ggactgttca
      841 tgggaacctg gggtagatac gactttgact tggcgtaaac aaagattcca aaactacact
      901 ttatgtgaat cgttctctaa gagatgtgag gtttctaact acaggaactc ctatacctgg
      961 caaatcactg aaggctcaca ggaaatgtat aactttactc tcacagctga aaaccaacta
     1021 aggaaaagaa gtgtcaacat taattttaac ctgacccata gagttcatcc aaaggctccg
     1081 caggacgtca cccttaaaat tataggtgct acaaaagcca acatgacttg gaaggttcac
     1141 tcccatggaa acaactacac acttttgtgt caggttaaac tccaatatgg agaagtgatt
     1201 catgagcaca atgtttctgt ccacatgagc gcaaactacc tcttcagtga tctggatcca
     1261 gacacaaagt acaaggcttt tgtgcgctgt gcaagtgcca accacttctg gaaatggagc
     1321 gactggaccc aaaaagagtt cagcacaccc gagactgctc cctcacaggc tcttgatgta
     1381 tggagacaag tgtggtcgga gaatggaaga cgcattgtga ctttattctg gaagccacta
     1441 ttaaaatcac aggccaatgg caaaatcata tcctataata tagttgtaga aaatgaagcc
     1501 aaaccaactg agtcagaaca ctactgtgtc tgggcaccag ccctcagcac aaacctgagc
     1561 cttgacctgc aaccttacaa gattcgcatc acagccaaca acagcatggg ggcatctcct
     1621 gagtccttga tggtcctttc taatgattct ggacacgaag aggtcaagga aaagacaatt
     1681 aaaggtataa aggatgcatt caatatttct tgggagcccg tatctggaga cacgatgggc
     1741 tatgttgtgg actggtgtgc acattcccag gaccaacgct gtgatttgca gtggaagaac
     1801 cttggtccca ataccacaag caccaccatc acctcagatg attttaaacc aggcgtccgt
     1861 tacaacttca gaatttttga aaggtctgtg gaacacaaag ctcggttagt agagaaacaa
     1921 agaggataca cccaggaact ggctcctttg gtgaatccaa aagtggagat tccttactcg
     1981 acccctaact ccttcgttct aagatggcca gattatgaca gcgacttcca ggctggtttt
     2041 ataaaagggt acctcgtgta tgtgaaatcc aaggagatgc agtgcaacca accctgggaa
     2101 aggaccctcc ttccagataa ttcagtcctc tgtaaatacg acatcaatgg ctcagagaca
     2161 aagacactca ccgtggaaaa ccttcagcca gagtccctct atgagttttt cgtcactccg
     2221 tacaccagcg ctggcccagg acccaatgaa acgttcacaa aggtcacaac tccagatgca
     2281 cgctcccaca tgctgctgca gatcatacta cccatgaccc tctgcgtctt gctcagcatc
     2341 attgtctgct actggaaaag tcagtgggtg aaggagaagt gctaccctga cattcccaat
     2401 ccgtacaaga gcagcattct gtcactcata aaatccaaga agaatcctca cttaataatg
     2461 aatgtcaaag actgcattcc agatgtcctt gaagtgataa acaaagcaga aggcagcaag
     2521 acacagtgtg taggctctgg gaaacttcac attgaagatg tacccactaa gccgccaatc
     2581 gtgccaacag aaaaggattc ctcagggcct gtgccctgca tcttctttga gaattttact
     2641 tacgatcagt cagcttttga ctctggttcc catggcctca ttccaggtcc cctaaaagac
     2701 acagcacacc aacttggact attggctcca cctaacaagt tccagaacgt attaaaaaat
     2761 gactacatga agcccctggt cgaaagtcca actgaagaaa ctagcttgat ttatgtgtca
     2821 cagctggctt cacccatgtg cggagacaag gacacgcttg ccacagaacc acccgtgcca
     2881 gtgcatggtt cagagtataa aaggcaaatg gtagttcccg ggagcctcgc atcaccttct
     2941 ctgaaggagg ataacagctt gacctcaacg gtcctcttag gccaaggtga acagtaaaca
     3001 ccacgcagca caaataaatg cactccacac actataggca ctttgggaga tgtagctgtt
     3061 accatgccaa caccacgtgc cctggttggt tccaggggtg ggggttgagg ggagactcat
     3121 tatctgcagt gctgatttat caacgatcac tacagaccaa cagacttaag gaccatataa
     3181 tatggtgttc accctgaagg cgttccctag aaatggcaga tccgagagca tgctgacctt
     3241 gctattattt ggtccaggct cacccttatt gcagtagctt gacatagggt gtacaccagt
     3301 catttcgcag agcctaccta ctcaaaacta cacaccgagg ctgtggtcct aggattttga
     3361 tttgcagcga gaaagcatct tcttgtaaac ttaacctcac acttaaaagt ttaagggtaa
     3421 aacaagtggg tcagaagttt tgattagcac cgcaagagat tgcttacttt gattgtgcag
     3481 atttatcaca tttaatggaa aggctacaaa ctaggttttg gccatacctt gaaatgagaa
     3541 cttgtggtca ctgataaagc agaaagaact ctcttcgtgt ctacacctta tgtaactaac
     3601 cagtaagatg tgcaaatgga caggagactc ttcatgcgtc tcctgcagtc aaacaggatt
     3661 gcaaggagct ccagacctgc tgcccaggcg actgcatcct gtccaacaga ctccagtctt
     3721 cctctttagt ttttgactac ctcagaacag gaaaaaaagg acatttcatt gagtgatgcc
     3781 ttttacatat aatatacacc acctcccgcc cctgccccca ccccaagctg tatctagatg
     3841 acctatttca cgagctgatc tctgcttttt gcacgcttgg ttgtctggtt caagaaaatt
     3901 ctgtctcaca ttcctattgt gctaaaatac tatagcccca gaactgggta taatttaaac
     3961 tgtagaagtc agttgtgaag gacccaaagc atgtcttttg acaaaaatct acttggtcct
     4021 atctgtgggt ttcacatcaa gattcaacca atttcagaaa gaagatattc tggaaaaaaa
     4081 aattgtctgt actaaattca tagatttttc ttgttattcc gtaaataagg tattaacaat
     4141 ttccatagca cttacacgca ccaggtatta ggccacagca tggaggagta ctcactgtat
     4201 acaatgctat ttttaggtta aggcctaaac ttctgaagat cttggtaaca gcagagctcc
     4261 tgtaatcaac tcctggaatg tgccatagag gaatgactat atgtaacagc tgaacactta
     4321 caccggttcc ttcctcttaa tgcttgtcac attgcagacc aaggtggaga ggttctcctt
     4381 ttgttgttag ctacgtgtgg tagcagtgat gactttgtgc gcatgtgcag ctgttaagtg
     4441 ctatagcatg tgctacaggg tgtggccata gaacatagta acagcaacca cgaatgttca
     4501 acacaagctg tccaatcttc tctttacgta ataccaagcc tttgctagaa agcatggcta
     4561 caacctaagc taggatcagc cagtatcttg agtagtttag gtgggagaag actttgctca
     4621 ctattgcaga tgctctgttt acattttctt gtcaatggac ttctcactgg aaacttgcac
     4681 ccagaaatgt taatgacatt gatttgtgat tttgtttttc atttcaattt tggttaaaaa
     4741 ataatccata aaacatttct gctgtttcaa taaagcccaa attaaaaca
//
