LOCUS       NM_001310469            4786 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus oncostatin M receptor (Osmr), transcript variant 2,
            mRNA.
ACCESSION   NM_001310469 XM_006519975
VERSION     NM_001310469.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4786)
  AUTHORS   Wang,G., Munoz-Rojas,A.R., Spallanzani,R.G., Franklin,R.A.,
            Benoist,C. and Mathis,D.
  TITLE     Adipose-tissue Treg cells restrain differentiation of stromal
            adipocyte precursors to promote insulin sensitivity and metabolic
            homeostasis
  JOURNAL   Immunity 57 (6), 1345-1359 (2024)
   PUBMED   38692280
REFERENCE   2  (bases 1 to 4786)
  AUTHORS   Komori,T., Hisaoka,T., Kotaki,A., Iwamoto,M., Miyajima,A.,
            Esashi,E. and Morikawa,Y.
  TITLE     Blockade of OSMRbeta signaling ameliorates skin lesions in a mouse
            model of human atopic dermatitis
  JOURNAL   FASEB J 38 (1), e23359 (2024)
   PUBMED   38102969
  REMARK    Erratum:[FASEB J. 2024 Feb 29;38(4):e23509. doi:
            10.1096/fj.202400312.. PMID: 38393635]
REFERENCE   3  (bases 1 to 4786)
  AUTHORS   Munz,S., Feger,M. and Foller,M.
  TITLE     Oncostatin M is a regulator of fibroblast growth factor 23 (FGF23)
            in UMR106 osteoblast-like cells
  JOURNAL   Sci Rep 13 (1), 8420 (2023)
   PUBMED   37225713
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4786)
  AUTHORS   Feng,Y., Yuan,Y., Xia,H., Wang,Z., Che,Y., Hu,Z., Deng,J., Li,F.,
            Wu,Q., Bian,Z., Zhou,H., Shen,D. and Tang,Q.
  TITLE     OSMR deficiency aggravates pressure overload-induced cardiac
            hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling
  JOURNAL   J Transl Med 21 (1), 290 (2023)
   PUBMED   37120549
  REMARK    GeneRIF: OSMR deficiency aggravates pressure overload-induced
            cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3
            signalling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4786)
  AUTHORS   Zhou,J., Yang,J., Dong,Y., Shi,Y., Zhu,E., Yuan,H., Li,X. and
            Wang,B.
  TITLE     Oncostatin M receptor regulates osteoblast differentiation via
            extracellular signal-regulated kinase/autophagy signaling
  JOURNAL   Stem Cell Res Ther 13 (1), 278 (2022)
   PUBMED   35765036
  REMARK    GeneRIF: Oncostatin M receptor regulates osteoblast differentiation
            via extracellular signal-regulated kinase/autophagy signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4786)
  AUTHORS   Tamura,S., Morikawa,Y., Miyajima,A. and Senba,E.
  TITLE     Expression of oncostatin M receptor beta in a specific subset of
            nociceptive sensory neurons
  JOURNAL   Eur J Neurosci 17 (11), 2287-2298 (2003)
   PUBMED   12814362
  REMARK    GeneRIF: Expression of oncostatin M receptor beta in a specific
            subset of nociceptive sensory neurons.
REFERENCE   7  (bases 1 to 4786)
  AUTHORS   Tamura,S., Morikawa,Y., Tanaka,M., Miyajima,A. and Senba,E.
  TITLE     Developmental expression pattern of oncostatin M receptor beta in
            mice
  JOURNAL   Mech Dev 115 (1-2), 127-131 (2002)
   PUBMED   12049776
REFERENCE   8  (bases 1 to 4786)
  AUTHORS   Kamiya,A., Kinoshita,T., Ito,Y., Matsui,T., Morikawa,Y., Senba,E.,
            Nakashima,K., Taga,T., Yoshida,K., Kishimoto,T. and Miyajima,A.
  TITLE     Fetal liver development requires a paracrine action of oncostatin M
            through the gp130 signal transducer
  JOURNAL   EMBO J 18 (8), 2127-2136 (1999)
   PUBMED   10205167
REFERENCE   9  (bases 1 to 4786)
  AUTHORS   Tanaka,M., Hara,T., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Miyajima,A.
  TITLE     Reconstitution of the functional mouse oncostatin M (OSM) receptor:
            molecular cloning of the mouse OSM receptor beta subunit
  JOURNAL   Blood 93 (3), 804-815 (1999)
   PUBMED   9920829
REFERENCE   10 (bases 1 to 4786)
  AUTHORS   Lindberg,R.A., Juan,T.S., Welcher,A.A., Sun,Y., Cupples,R.,
            Guthrie,B. and Fletcher,F.A.
  TITLE     Cloning and characterization of a specific receptor for mouse
            oncostatin M
  JOURNAL   Mol Cell Biol 18 (6), 3357-3367 (1998)
   PUBMED   9584176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109183.17 and AC102825.6.
            
            On Oct 5, 2022 this sequence version replaced NM_001310469.1.
            
            Transcript Variant: This variant (2) uses an alternate, in-frame
            acceptor splice site in the 3' coding region compared to variant 1.
            The resulting isoform (2) is 1 amino acid shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB015978.1, SRR17253014.2549399.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC109183.17        20089-20157         c
            70-154              AC102825.6         7672-7756
            155-324             AC102825.6         15461-15630
            325-496             AC102825.6         20851-21022
            497-775             AC102825.6         23550-23828
            776-911             AC102825.6         25132-25267
            912-1063            AC102825.6         25945-26096
            1064-1203           AC102825.6         30218-30357
            1204-1357           AC102825.6         30980-31133
            1358-1434           AC102825.6         39340-39416
            1435-1657           AC102825.6         40738-40960
            1658-1834           AC102825.6         43400-43576
            1835-1939           AC102825.6         44393-44497
            1940-2113           AC102825.6         45862-46035
            2114-2281           AC102825.6         46961-47128
            2282-2363           AC102825.6         51061-51142
            2364-2436           AC102825.6         51395-51467
            2437-4786           AC102825.6         52121-54470
FEATURES             Location/Qualifiers
     source          1..4786
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 3.3 cM"
     gene            1..4786
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /note="oncostatin M receptor"
                     /db_xref="GeneID:18414"
                     /db_xref="MGI:MGI:1330819"
     exon            1..69
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            70..154
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..2994
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; oncostatin-M-specific receptor subunit beta;
                     IL-31RB; IL-31R-beta; IL-31R subunit beta; IL-31 receptor
                     subunit beta; interleukin-31 receptor subunit beta;
                     oncostatin receptor"
                     /codon_start=1
                     /product="oncostatin-M-specific receptor subunit beta
                     isoform 2 precursor"
                     /protein_id="NP_001297398.1"
                     /db_xref="CCDS:CCDS79358.1"
                     /db_xref="GeneID:18414"
                     /db_xref="MGI:MGI:1330819"
                     /translation="MAFSVVLHPAFLLAVLSLRASRSEVLEEPLPLTPEIHKVSFQLK
                     LQEVNLEWTVPALTHEELNMIFQIEISRLNISNTIWVENYSTTVKREEAVRWNWTSDI
                     PLECVKHFIRIRALVDDTKSLPQSSWGNWSSWKEVNAKVSVEPDKSLIFPKDKVLEEG
                     SNVTICLMYGQNVYNVSCKLQDEPIHGEQLDSHVSLLKLNNVVFLSDTGTNINCQATK
                     GPKRIFGTVLFVSKVLEEPKNVSCETRDFKTLDCSWEPGVDTTLTWRKQRFQNYTLCE
                     SFSKRCEVSNYRNSYTWQITEGSQEMYNFTLTAENQLRKRSVNINFNLTHRVHPKAPQ
                     DVTLKIIGATKANMTWKVHSHGNNYTLLCQVKLQYGEVIHEHNVSVHMSANYLFSDLD
                     PDTKYKAFVRCASANHFWKWSDWTQKEFSTPETAPSQALDVWRQVWSENGRRIVTLFW
                     KPLLKSQANGKIISYNIVVENEAKPTESEHYCVWAPALSTNLSLDLQPYKIRITANNS
                     MGASPESLMVLSNDSGHEVKEKTIKGIKDAFNISWEPVSGDTMGYVVDWCAHSQDQRC
                     DLQWKNLGPNTTSTTITSDDFKPGVRYNFRIFERSVEHKARLVEKQRGYTQELAPLVN
                     PKVEIPYSTPNSFVLRWPDYDSDFQAGFIKGYLVYVKSKEMQCNQPWERTLLPDNSVL
                     CKYDINGSETKTLTVENLQPESLYEFFVTPYTSAGPGPNETFTKVTTPDARSHMLLQI
                     ILPMTLCVLLSIIVCYWKSQWVKEKCYPDIPNPYKSSILSLIKSKKNPHLIMNVKDCI
                     PDVLEVINKAEGSKTQCVGSGKLHIEDVPTKPPIVPTEKDSSGPVPCIFFENFTYDQS
                     AFDSGSHGLIPGPLKDTAHQLGLLAPPNKFQNVLKNDYMKPLVESPTEETSLIYVSQL
                     ASPMCGDKDTLATEPPVPVHGSEYKRQMVVPGSLASPSLKEDNSLTSTVLLGQGEQ"
     exon            155..324
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            325..496
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            497..775
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            776..911
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1063
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1203
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1357
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1434
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1657
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1834
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1939
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2113
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2281
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2363
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2436
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..4786
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4766..4771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /note="hexamer: AATAAA"
     polyA_site      4786
                     /gene="Osmr"
                     /gene_synonym="OSMRB"
                     /note="major polyA site"
ORIGIN      
        1 acagacgtcc gcgcccgttc ccctgtgagg ccgaggaccg gcaaggctcc ggagcaggtc
       61 gccaggcggg taatcagacc aatggctttc tctgtggtcc ttcatccagc cttcctcctg
      121 gcagtgctgt ccctgagggc atcccgaagc gaagtcttgg aggagccttt accattgact
      181 cctgagatac ataaagtttc ttttcaattg aaacttcaag aagtgaattt agaatggact
      241 gtcccagccc ttactcatga agaattaaac atgatatttc agatagagat cagtagactg
      301 aacatatcca acaccatctg ggtggagaat tatagcacca ctgtgaagcg tgaagaagct
      361 gtgcgttgga actggacgtc tgatatccct ttggagtgtg tcaaacattt cataagaatc
      421 agggctctgg tagatgacac caagtccctt ccacagagtt cctggggcaa ctggagttcc
      481 tggaaagaag ttaatgcaaa ggtttccgtt gaacctgata aatcattaat atttcctaaa
      541 gacaaagtgt tggaagaagg ctccaatgtc accatctgtc tgatgtatgg gcagaatgta
      601 tataatgtat cctgtaagtt gcaagatgag ccaatccatg gagaacaact tgattcccac
      661 gtgtcattat taaaattgaa caatgtagtt ttccttagtg acacagggac aaacatcaat
      721 tgtcaagcca cgaagggtcc taaaagaata tttggtactg ttctctttgt ctcgaaagtg
      781 ctcgaggaac ctaagaatgt ttcctgtgaa acccgagact ttaagacttt ggactgttca
      841 tgggaacctg gggtagatac gactttgact tggcgtaaac aaagattcca aaactacact
      901 ttatgtgaat cgttctctaa gagatgtgag gtttctaact acaggaactc ctatacctgg
      961 caaatcactg aaggctcaca ggaaatgtat aactttactc tcacagctga aaaccaacta
     1021 aggaaaagaa gtgtcaacat taattttaac ctgacccata gagttcatcc aaaggctccg
     1081 caggacgtca cccttaaaat tataggtgct acaaaagcca acatgacttg gaaggttcac
     1141 tcccatggaa acaactacac acttttgtgt caggttaaac tccaatatgg agaagtgatt
     1201 catgagcaca atgtttctgt ccacatgagc gcaaactacc tcttcagtga tctggatcca
     1261 gacacaaagt acaaggcttt tgtgcgctgt gcaagtgcca accacttctg gaaatggagc
     1321 gactggaccc aaaaagagtt cagcacaccc gagactgctc cctcacaggc tcttgatgta
     1381 tggagacaag tgtggtcgga gaatggaaga cgcattgtga ctttattctg gaagccacta
     1441 ttaaaatcac aggccaatgg caaaatcata tcctataata tagttgtaga aaatgaagcc
     1501 aaaccaactg agtcagaaca ctactgtgtc tgggcaccag ccctcagcac aaacctgagc
     1561 cttgacctgc aaccttacaa gattcgcatc acagccaaca acagcatggg ggcatctcct
     1621 gagtccttga tggtcctttc taatgattct ggacacgagg tcaaggaaaa gacaattaaa
     1681 ggtataaagg atgcattcaa tatttcttgg gagcccgtat ctggagacac gatgggctat
     1741 gttgtggact ggtgtgcaca ttcccaggac caacgctgtg atttgcagtg gaagaacctt
     1801 ggtcccaata ccacaagcac caccatcacc tcagatgatt ttaaaccagg cgtccgttac
     1861 aacttcagaa tttttgaaag gtctgtggaa cacaaagctc ggttagtaga gaaacaaaga
     1921 ggatacaccc aggaactggc tcctttggtg aatccaaaag tggagattcc ttactcgacc
     1981 cctaactcct tcgttctaag atggccagat tatgacagcg acttccaggc tggttttata
     2041 aaagggtacc tcgtgtatgt gaaatccaag gagatgcagt gcaaccaacc ctgggaaagg
     2101 accctccttc cagataattc agtcctctgt aaatacgaca tcaatggctc agagacaaag
     2161 acactcaccg tggaaaacct tcagccagag tccctctatg agtttttcgt cactccgtac
     2221 accagcgctg gcccaggacc caatgaaacg ttcacaaagg tcacaactcc agatgcacgc
     2281 tcccacatgc tgctgcagat catactaccc atgaccctct gcgtcttgct cagcatcatt
     2341 gtctgctact ggaaaagtca gtgggtgaag gagaagtgct accctgacat tcccaatccg
     2401 tacaagagca gcattctgtc actcataaaa tccaagaaga atcctcactt aataatgaat
     2461 gtcaaagact gcattccaga tgtccttgaa gtgataaaca aagcagaagg cagcaagaca
     2521 cagtgtgtag gctctgggaa acttcacatt gaagatgtac ccactaagcc gccaatcgtg
     2581 ccaacagaaa aggattcctc agggcctgtg ccctgcatct tctttgagaa ttttacttac
     2641 gatcagtcag cttttgactc tggttcccat ggcctcattc caggtcccct aaaagacaca
     2701 gcacaccaac ttggactatt ggctccacct aacaagttcc agaacgtatt aaaaaatgac
     2761 tacatgaagc ccctggtcga aagtccaact gaagaaacta gcttgattta tgtgtcacag
     2821 ctggcttcac ccatgtgcgg agacaaggac acgcttgcca cagaaccacc cgtgccagtg
     2881 catggttcag agtataaaag gcaaatggta gttcccggga gcctcgcatc accttctctg
     2941 aaggaggata acagcttgac ctcaacggtc ctcttaggcc aaggtgaaca gtaaacacca
     3001 cgcagcacaa ataaatgcac tccacacact ataggcactt tgggagatgt agctgttacc
     3061 atgccaacac cacgtgccct ggttggttcc aggggtgggg gttgagggga gactcattat
     3121 ctgcagtgct gatttatcaa cgatcactac agaccaacag acttaaggac catataatat
     3181 ggtgttcacc ctgaaggcgt tccctagaaa tggcagatcc gagagcatgc tgaccttgct
     3241 attatttggt ccaggctcac ccttattgca gtagcttgac atagggtgta caccagtcat
     3301 ttcgcagagc ctacctactc aaaactacac accgaggctg tggtcctagg attttgattt
     3361 gcagcgagaa agcatcttct tgtaaactta acctcacact taaaagttta agggtaaaac
     3421 aagtgggtca gaagttttga ttagcaccgc aagagattgc ttactttgat tgtgcagatt
     3481 tatcacattt aatggaaagg ctacaaacta ggttttggcc ataccttgaa atgagaactt
     3541 gtggtcactg ataaagcaga aagaactctc ttcgtgtcta caccttatgt aactaaccag
     3601 taagatgtgc aaatggacag gagactcttc atgcgtctcc tgcagtcaaa caggattgca
     3661 aggagctcca gacctgctgc ccaggcgact gcatcctgtc caacagactc cagtcttcct
     3721 ctttagtttt tgactacctc agaacaggaa aaaaaggaca tttcattgag tgatgccttt
     3781 tacatataat atacaccacc tcccgcccct gcccccaccc caagctgtat ctagatgacc
     3841 tatttcacga gctgatctct gctttttgca cgcttggttg tctggttcaa gaaaattctg
     3901 tctcacattc ctattgtgct aaaatactat agccccagaa ctgggtataa tttaaactgt
     3961 agaagtcagt tgtgaaggac ccaaagcatg tcttttgaca aaaatctact tggtcctatc
     4021 tgtgggtttc acatcaagat tcaaccaatt tcagaaagaa gatattctgg aaaaaaaaat
     4081 tgtctgtact aaattcatag atttttcttg ttattccgta aataaggtat taacaatttc
     4141 catagcactt acacgcacca ggtattaggc cacagcatgg aggagtactc actgtataca
     4201 atgctatttt taggttaagg cctaaacttc tgaagatctt ggtaacagca gagctcctgt
     4261 aatcaactcc tggaatgtgc catagaggaa tgactatatg taacagctga acacttacac
     4321 cggttccttc ctcttaatgc ttgtcacatt gcagaccaag gtggagaggt tctccttttg
     4381 ttgttagcta cgtgtggtag cagtgatgac tttgtgcgca tgtgcagctg ttaagtgcta
     4441 tagcatgtgc tacagggtgt ggccatagaa catagtaaca gcaaccacga atgttcaaca
     4501 caagctgtcc aatcttctct ttacgtaata ccaagccttt gctagaaagc atggctacaa
     4561 cctaagctag gatcagccag tatcttgagt agtttaggtg ggagaagact ttgctcacta
     4621 ttgcagatgc tctgtttaca ttttcttgtc aatggacttc tcactggaaa cttgcaccca
     4681 gaaatgttaa tgacattgat ttgtgatttt gtttttcatt tcaattttgg ttaaaaaata
     4741 atccataaaa catttctgct gtttcaataa agcccaaatt aaaaca
//
