LOCUS       NM_001013365            1862 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus oncostatin M (Osm), mRNA.
ACCESSION   NM_001013365 XM_137493
VERSION     NM_001013365.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1862)
  AUTHORS   Wang,G., Munoz-Rojas,A.R., Spallanzani,R.G., Franklin,R.A.,
            Benoist,C. and Mathis,D.
  TITLE     Adipose-tissue Treg cells restrain differentiation of stromal
            adipocyte precursors to promote insulin sensitivity and metabolic
            homeostasis
  JOURNAL   Immunity 57 (6), 1345-1359 (2024)
   PUBMED   38692280
REFERENCE   2  (bases 1 to 1862)
  AUTHORS   Domaniku-Waraich,A., Agca,S., Toledo,B., Sucuoglu,M., Ozen,S.D.,
            Bilgic,S.N., Arabaci,D.H., Kashgari,A.E. and Kir,S.
  TITLE     Oncostatin M signaling drives cancer-associated skeletal muscle
            wasting
  JOURNAL   Cell Rep Med 5 (4), 101498 (2024)
   PUBMED   38569555
  REMARK    GeneRIF: Oncostatin M signaling drives cancer-associated skeletal
            muscle wasting.
REFERENCE   3  (bases 1 to 1862)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1862)
  AUTHORS   Sims,N.A. and Levesque,J.P.
  TITLE     Oncostatin M: Dual Regulator of the Skeletal and Hematopoietic
            Systems
  JOURNAL   Curr Osteoporos Rep 22 (1), 80-95 (2024)
   PUBMED   38198032
  REMARK    GeneRIF: Oncostatin M: Dual Regulator of the Skeletal and
            Hematopoietic Systems.
            Review article
REFERENCE   5  (bases 1 to 1862)
  AUTHORS   Rapp,J., Hospach,A., Liang,P., Schwammle,M., Renz,L., Agostini,H.,
            Schlunck,G. and Bucher,F.
  TITLE     Oncostatin M Reduces Pathological Neovascularization in the Retina
            Through Muller Cell Activation
  JOURNAL   Invest Ophthalmol Vis Sci 65 (1), 22 (2024)
   PUBMED   38190125
  REMARK    GeneRIF: Oncostatin M Reduces Pathological Neovascularization in
            the Retina Through Muller Cell Activation.
REFERENCE   6  (bases 1 to 1862)
  AUTHORS   Fantuzzi,G., Benigni,F., Sironi,M., Conni,M., Carelli,M.,
            Cantoni,L., Shapiro,L., Dinarello,C.A., Sipe,J.D. and Ghezzi,P.
  TITLE     Ciliary neurotrophic factor (CNTF) induces serum amyloid A,
            hypoglycaemia and anorexia, and potentiates IL-1 induced
            corticosterone and IL-6 production in mice
  JOURNAL   Cytokine 7 (2), 150-156 (1995)
   PUBMED   7780034
REFERENCE   7  (bases 1 to 1862)
  AUTHORS   Piquet-Pellorce,C., Grey,L., Mereau,A. and Heath,J.K.
  TITLE     Are LIF and related cytokines functionally equivalent?
  JOURNAL   Exp Cell Res 213 (2), 340-347 (1994)
   PUBMED   8050491
REFERENCE   8  (bases 1 to 1862)
  AUTHORS   Yin,T. and Yang,Y.C.
  TITLE     Mitogen-activated protein kinases and ribosomal S6 protein kinases
            are involved in signaling pathways shared by interleukin-11,
            interleukin-6, leukemia inhibitory factor, and oncostatin M in
            mouse 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (5), 3731-3738 (1994)
   PUBMED   7508917
REFERENCE   9  (bases 1 to 1862)
  AUTHORS   Rose,T.M., Weiford,D.M., Gunderson,N.L. and Bruce,A.G.
  TITLE     Oncostatin M (OSM) inhibits the differentiation of pluripotent
            embryonic stem cells in vitro
  JOURNAL   Cytokine 6 (1), 48-54 (1994)
   PUBMED   8003633
REFERENCE   10 (bases 1 to 1862)
  AUTHORS   Conover,J.C., Ip,N.Y., Poueymirou,W.T., Bates,B., Goldfarb,M.P.,
            DeChiara,T.M. and Yancopoulos,G.D.
  TITLE     Ciliary neurotrophic factor maintains the pluripotentiality of
            embryonic stem cells
  JOURNAL   Development 119 (3), 559-565 (1993)
   PUBMED   8187629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807825.5.
            
            On Oct 3, 2022 this sequence version replaced NM_001013365.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13862062.204786.1,
                                           SRR7345562.2484876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AL807825.5         108602-108684
            84-220              AL807825.5         110177-110313
            221-1862            AL807825.5         111157-112798
FEATURES             Location/Qualifiers
     source          1..1862
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.94 cM"
     gene            1..1862
                     /gene="Osm"
                     /gene_synonym="OncoM"
                     /note="oncostatin M"
                     /db_xref="GeneID:18413"
                     /db_xref="MGI:MGI:104749"
     exon            1..83
                     /gene="Osm"
                     /gene_synonym="OncoM"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..844
                     /gene="Osm"
                     /gene_synonym="OncoM"
                     /codon_start=1
                     /product="oncostatin-M precursor"
                     /protein_id="NP_001013383.1"
                     /db_xref="CCDS:CCDS24382.1"
                     /db_xref="GeneID:18413"
                     /db_xref="MGI:MGI:104749"
                     /translation="MQTRLLRTLLSLTLSLLILSMALANRGCSNSSSQLLSQLQNQAN
                     LTGNTESLLEPYIRLQNLNTPDLRAACTQHSVAFPSEDTLRQLSKPHFLSTVYTTLDR
                     VLYQLDALRQKFLKTPAFPKLDSARHNILGIRNNVFCMARLLNHSLEIPEPTQTDSGA
                     SRSTTTPDVFNTKIGSCGFLWGYHRFMGSVGRVFREWDDGSTRSRRQSPLRARRKGTR
                     RIRVRHKGTRRIRVRRKGTRRIWVRRKGSRKIRPSRSTQSPTTRA"
     exon            84..220
                     /gene="Osm"
                     /gene_synonym="OncoM"
                     /inference="alignment:Splign:2.1.0"
     exon            221..1862
                     /gene="Osm"
                     /gene_synonym="OncoM"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1862
                     /gene="Osm"
                     /gene_synonym="OncoM"
                     /note="major polyA site"
ORIGIN      
        1 agccaagctg tgtcacccct gagaggcacg ggccagagta ccaggaccca gtatgcagac
       61 acggcttcta agaacactgc tcagtttgac cctcagtctc ctcatcctga gcatggcact
      121 ggccaatcgt ggctgctcca actcttcctc tcagctcctc agccagctgc agaatcaggc
      181 gaacctcacg gggaacacag aatcactctt ggagccctat atccgcctcc aaaacctgaa
      241 cacacctgac ctgagagctg cctgcaccca gcactctgtg gccttcccca gtgaggacac
      301 actccggcaa ctgagcaagc ctcacttcct gagcactgtg tacaccacac tggacagagt
      361 cttgtaccaa ctggatgctt taagacagaa atttctgaag actccggctt ttccaaagct
      421 ggacagtgcc cggcacaata tcctcggcat aaggaacaat gttttctgca tggcccggct
      481 gctcaaccac tccctggaga tacctgagcc cacacagaca gactctgggg cctcacggtc
      541 cactacaaca ccagatgtct ttaataccaa gataggcagc tgtggctttc tctggggata
      601 ccatcgcttc atgggctcag tggggagggt cttcagggaa tgggacgatg gctccacacg
      661 cagccggaga cagagcccgc tccgggcccg gcgcaaggga acccgcagaa tccgggtccg
      721 gcacaaggga acccgcagaa tccgggtccg gcgcaaggga acccgcagaa tctgggtccg
      781 gcgcaaggga tcccgcaaaa tcagaccttc caggagcacc cagagcccga cgaccagggc
      841 ctaggttccc tggtagcctg aggacacact gacagacagc atagtctggt gatacaggat
      901 gtcgctctca gaggctttca aagctgcttc tgtcaccagg ggtcacacag aagagcactt
      961 taaggggtga agttgagtgt cccctactac cactcaggac ttcaaggata gtgaggttat
     1021 tgtgtcccca ctccaagcct ccagtcctag tggggtggct gggtcggacc acgtggggcc
     1081 ggaggttttc cattgattca ggggtctgat gacacaagct gattcaccac agggctggct
     1141 gggctgaacc cctcgggctg ttggtccttt cctctcatga cttgaaactg tttcctccag
     1201 acttcctcct ttccctgtgg ctgggttcca aagagaggtc tgatccggtg ctctctctca
     1261 tgccttatcc cactcaggac agatacctgg acctctgggt gacctcacac ttggcagttg
     1321 cgacaggggc agggtgtcct accaaggaac actgatctgg gcgttcaggg aagagagctc
     1381 agagcctagc ttgttcccta attctctgtg tgactgtgag caagacactt tatttatccg
     1441 aatgtcagcg ttctctgtgg aaagctgtgt tgtgtgtgtg ggtccttagg taatagcccc
     1501 ctctgcctgt cagctgctgg actctgacat agggtggaca tcaaagtctc tgtaaatggg
     1561 aacctgtggt gcaaacggtt gtggggtgtg tttatgggag atctcccagt gcctaaaagc
     1621 cctgttttgg gtcctcgctg catgatgctc cctctggtga tgtgttgtga aatttttcac
     1681 aggctgaacc agtcctcttg aaaggtctca gaagctggtg agcaattact tggagggaca
     1741 tgactaattt attgttttat tttttatcag tttaatccgt tttatattta taaggcctat
     1801 ttataatgta tatttaatgt taatattttg ctaacatatt taaaacctgt cttgtttcta
     1861 aa
//
