LOCUS       NM_133676               1608 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus O-sialoglycoprotein endopeptidase (Osgep), mRNA.
ACCESSION   NM_133676
VERSION     NM_133676.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1608)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1608)
  AUTHORS   Braun,D.A., Rao,J., Mollet,G., Schapiro,D., Daugeron,M.C., Tan,W.,
            Gribouval,O., Boyer,O., Revy,P., Jobst-Schwan,T., Schmidt,J.M.,
            Lawson,J.A., Schanze,D., Ashraf,S., Ullmann,J.F.P.,
            Hoogstraten,C.A., Boddaert,N., Collinet,B., Martin,G., Liger,D.,
            Lovric,S., Furlano,M., Guerrera,I.C., Sanchez-Ferras,O., Hu,J.F.,
            Boschat,A.C., Sanquer,S., Menten,B., Vergult,S., De Rocker,N.,
            Airik,M., Hermle,T., Shril,S., Widmeier,E., Gee,H.Y., Choi,W.I.,
            Sadowski,C.E., Pabst,W.L., Warejko,J.K., Daga,A., Basta,T.,
            Matejas,V., Scharmann,K., Kienast,S.D., Behnam,B., Beeson,B.,
            Begtrup,A., Bruce,M., Ch'ng,G.S., Lin,S.P., Chang,J.H., Chen,C.H.,
            Cho,M.T., Gaffney,P.M., Gipson,P.E., Hsu,C.H., Kari,J.A., Ke,Y.Y.,
            Kiraly-Borri,C., Lai,W.M., Lemyre,E., Littlejohn,R.O., Masri,A.,
            Moghtaderi,M., Nakamura,K., Ozaltin,F., Praet,M., Prasad,C.,
            Prytula,A., Roeder,E.R., Rump,P., Schnur,R.E., Shiihara,T.,
            Sinha,M.D., Soliman,N.A., Soulami,K., Sweetser,D.A., Tsai,W.H.,
            Tsai,J.D., Topaloglu,R., Vester,U., Viskochil,D.H.,
            Vatanavicharn,N., Waxler,J.L., Wierenga,K.J., Wolf,M.T.F.,
            Wong,S.N., Leidel,S.A., Truglio,G., Dedon,P.C., Poduri,A., Mane,S.,
            Lifton,R.P., Bouchard,M., Kannu,P., Chitayat,D., Magen,D.,
            Callewaert,B., van Tilbeurgh,H., Zenker,M., Antignac,C. and
            Hildebrandt,F.
  TITLE     Mutations in KEOPS-complex genes cause nephrotic syndrome with
            primary microcephaly
  JOURNAL   Nat Genet 49 (10), 1529-1538 (2017)
   PUBMED   28805828
REFERENCE   3  (bases 1 to 1608)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   4  (bases 1 to 1608)
  AUTHORS   Ikeda,S., Ayabe,H., Mori,K., Seki,Y. and Seki,S.
  TITLE     Identification of the functional elements in the bidirectional
            promoter of the mouse O-sialoglycoprotein endopeptidase and APEX
            nuclease genes
  JOURNAL   Biochem Biophys Res Commun 296 (4), 785-791 (2002)
   PUBMED   12200116
  REMARK    GeneRIF: promoter regions and tissue distribution of Osgep
REFERENCE   5  (bases 1 to 1608)
  AUTHORS   Seki,Y., Ikeda,S., Kiyohara,H., Ayabe,H., Seki,T. and Matsui,H.
  TITLE     Sequencing analysis of a putative human O-sialoglycoprotein
            endopeptidase gene (OSGEP) and analysis of a bidirectional promoter
            between the OSGEP and APEX genes
  JOURNAL   Gene 285 (1-2), 101-108 (2002)
   PUBMED   12039036
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA481753.1 and AK142730.1.
            
            On Jan 10, 2006 this sequence version replaced NM_133676.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142730.1, AK157554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               CA481753.1         38-187
            151-1608            AK142730.1         151-1608
FEATURES             Location/Qualifiers
     source          1..1608
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.3 cM"
     gene            1..1608
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /note="O-sialoglycoprotein endopeptidase"
                     /db_xref="GeneID:66246"
                     /db_xref="MGI:MGI:1913496"
     exon            1..230
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1123
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /EC_number="2.3.1.234"
                     /note="probable O-sialoglycoprotein endopeptidase;
                     probable tRNA threonylcarbamoyladenosine biosynthesis
                     protein Osgep; mOsgep; t(6)A37 threonylcarbamoyladenosine
                     biosynthesis protein Osgep; probable tRNA N6-adenosine
                     threonylcarbamoyltransferase; t(6)A synthase;
                     N6-L-threonylcarbamoyladenine synthase"
                     /codon_start=1
                     /product="tRNA N6-adenosine threonylcarbamoyltransferase"
                     /protein_id="NP_598437.2"
                     /db_xref="CCDS:CCDS27026.1"
                     /db_xref="GeneID:66246"
                     /db_xref="MGI:MGI:1913496"
                     /translation="MPAVLGFEGSANKIGVGVVRDGTVLANPRRTYVTAPGTGFLPGD
                     TARHHRAVILDLLQEALTEAGLTSKDIDCIAFTKGPGMGSPLASVAVVARTVAQLWNK
                     PLLGVNHCIGHIEMGRLITGAVNPTVLYVSGGNTQVISYSEHRYRIFGETIDIAVGNC
                     LDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPYTVKGMDVSFSGILSFIEDAAQRM
                     LATGECTPEDLCFSLQETVFAMLVEITERAMAHCGSKEALIVGGVGCNLRLQEMMGTM
                     CQERGAQLFATDERFCVDNGAMIAQAGWEMFQAGHRTPLKDSAITQRYRTDEVEVTWR
                     D"
     exon            231..350
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..526
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..622
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..672
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..751
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..817
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..908
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..984
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1083
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1608
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1272..1277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /note="hexamer: AATAAA"
     polyA_site      1300
                     /gene="Osgep"
                     /gene_synonym="1500019L24Rik; GCPL-1; PRSMG1"
                     /note="major polyA site"
ORIGIN      
        1 acctcgtgac ataacttctg gcgcccgaaa gtcccttcgc ttggttctgg gttgttcgtg
       61 gtagtgccgg ttacagctcg tcactcggcc tcacgaccgg gagccgtgag gcaccatgcc
      121 cgcggtgctg gggttcgaag gcagcgccaa caagatcggc gtgggcgtgg tccgcgacgg
      181 cacggtgctg gcgaacccgc ggcgcactta cgtcacggcc ccgggcaccg gattccttcc
      241 aggtgacacg gccaggcacc atcgagctgt tatcctagac ctactgcagg aggcgctaac
      301 agaggcagga ttgacctcca aggacattga ttgtattgct ttcaccaaag gtcctggcat
      361 gggatcccca ttggcttctg tagctgttgt tgcccgtaca gtggcccagt tgtggaataa
      421 gcctttgctt ggcgtgaacc actgcatagg ccacattgaa atgggccgtc tcatcactgg
      481 agccgttaac ccaactgtcc tgtatgtgag cggaggaaat acccaggtga tttcctactc
      541 agaacatcgt tatcgcatct ttggagaaac tattgatatc gccgtgggaa actgcctgga
      601 tcgttttgct cgggtgctga agatttccaa tgaccccagt ccaggctaca acattgagca
      661 gatggcaaag cgaggcaaga agctagtcga gctgccatac actgtaaagg ggatggatgt
      721 ctcgttttca gggattctgt ctttcattga ggatgcagcg cagcgaatgc tggccactgg
      781 agagtgtact cctgaagacc tgtgtttctc cttacaggaa accgtgtttg caatgctagt
      841 ggaaatcacg gagcgagcca tggcacactg tggctccaag gaagccctca tcgtcggagg
      901 agttggatgt aacctgaggc tgcaggagat gatggggaca atgtgccagg agcggggagc
      961 ccagctcttt gcaacagatg agagattctg cgttgacaat ggagccatga tagcccaagc
     1021 tggttgggag atgtttcagg ctgggcacag gactcctctc aaagattctg caattactca
     1081 gaggtatagg acagatgaag tggaagtgac atggagggac taacaccatc atcagaaaga
     1141 gaagagcttt ccaggaggaa tgctcaactg agagtcagtc ttggtaatgt tctagactgc
     1201 cctcttcgct gacaagggta tggaccctat ataaggctta gggtccctat ggaaacccaa
     1261 catgacgcca caataaaaat ttggttttgt atgttgataa ttaggttgtg tttttcagtt
     1321 agcactgggt aaagtcttac tgatctcagg gacaactggt gggggtcaga gtagcacctt
     1381 ggttggtggc gcagctactt ttgatggctg ctacttggag aaaaccctgg gtgccatact
     1441 aacatcccat tagcagaaat accctagcta atagtatttt agtgccatgc cctgtgctga
     1501 ccactgtgca gttaactgtg tttacattca ctgaagtgga catccaggac aacccttaaa
     1561 aaggcctgga aatgtataat ttgtaattta agtaaaactg ctgccttc
//
