LOCUS       NM_025699               1635 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus oxidative stress responsive serine rich 1 (Oser1),
            transcript variant 1, mRNA.
ACCESSION   NM_025699
VERSION     NM_025699.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1635)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1635)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   3  (bases 1 to 1635)
  AUTHORS   Clerk,A., Kemp,T.J., Zoumpoulidou,G. and Sugden,P.H.
  TITLE     Cardiac myocyte gene expression profiling during H2O2-induced
            apoptosis
  JOURNAL   Physiol Genomics 29 (2), 118-127 (2007)
   PUBMED   17148688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589876.11.
            
            On Mar 21, 2023 this sequence version replaced NM_025699.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005579.1, AK153499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AL589876.11        206472-206603       c
            133-253             AL589876.11        202595-202715       c
            254-367             AL589876.11        198457-198570       c
            368-1635            AL589876.11        192882-194149       c
FEATURES             Location/Qualifiers
     source          1..1635
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.26 cM"
     gene            1..1635
                     /gene="Oser1"
                     /gene_synonym="3230401D17Rik; Perit1"
                     /note="oxidative stress responsive serine rich 1"
                     /db_xref="GeneID:66680"
                     /db_xref="MGI:MGI:1913930"
     exon            1..132
                     /gene="Oser1"
                     /gene_synonym="3230401D17Rik; Perit1"
                     /inference="alignment:Splign:2.1.0"
     exon            133..253
                     /gene="Oser1"
                     /gene_synonym="3230401D17Rik; Perit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1052
                     /gene="Oser1"
                     /gene_synonym="3230401D17Rik; Perit1"
                     /note="isoform a is encoded by transcript variant 1;
                     oxidative stress-responsive protein 1; peroxide-inducible
                     transcript 1 protein; oxidative stress-responsive
                     serine-rich protein 1"
                     /codon_start=1
                     /product="oxidative stress-responsive serine-rich protein
                     1 isoform a"
                     /protein_id="NP_079975.2"
                     /db_xref="CCDS:CCDS17009.1"
                     /db_xref="GeneID:66680"
                     /db_xref="MGI:MGI:1913930"
                     /translation="MKSEAKDGEEESLQTAFKKLRVDASGSIISLSVGEGPSVRASAR
                     TAADDTKPKTMCASKDSWHGSTRKSSRGAVRTQRRRRSKSPVLHPPKFIHCSTTAPPS
                     SSQLKHRSQTEPPDGISGRGISTPKEFNAGENSTSLDVNHTGAAIEPLRSSVLRLPSE
                     SKTEELSDATQVSQESLTANDLSDFQSVSKLSQGKPCVCVGKECQCKRWHDMEVYSFS
                     GLQNVPPLAPERRSLEDYSQSLHTRTLSGSPRSCSEQARVYVDDVTIEDLAGYMEYYL
                     YIPKKMSHMAEMMYT"
     exon            254..367
                     /gene="Oser1"
                     /gene_synonym="3230401D17Rik; Perit1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..1635
                     /gene="Oser1"
                     /gene_synonym="3230401D17Rik; Perit1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1605..1610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oser1"
                     /gene_synonym="3230401D17Rik; Perit1"
                     /note="hexamer: AATAAA"
     polyA_site      1635
                     /gene="Oser1"
                     /gene_synonym="3230401D17Rik; Perit1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtacaac tctagaggcg cgggccaccc tatcggtggg gtttggatcc gggtcagaca
       61 gacgcggcgg acgcggagag acgctcggag ccgacggggc cggattcccg ggagcgcccc
      121 agctgcgagg agtattaacg ggagggaaca tcaataggcg tacagaaacc ttcacaatga
      181 aatccgaagc caaggatgga gaggaggaaa gtctgcaaac tgccttcaag aaattaagag
      241 tggacgcatc agggtccatc atatctctgt ctgttggaga aggcccaagt gtcagagcat
      301 cagccagaac agcagccgat gataccaaac cgaaaaccat gtgtgcatct aaagacagtt
      361 ggcatgggtc tacaaggaag tcttcacgag gagcagtgag aacccagcgt cgtagacggt
      421 ctaagtctcc tgttcttcat cctcccaaat tcatacattg cagtacaaca gcacctcctt
      481 ccagcagcca gcttaagcac agaagccaga ctgagccacc cgatggcatc agtggacggg
      541 gaatttcaac acccaaagag ttcaacgcag gagaaaactc tacttctctt gatgttaatc
      601 acacaggagc agccatcgag cctctgagaa gctcggttct gaggctccca tcagagagta
      661 aaacagaaga gctctctgat gctacccaag tctcccaaga aagtcttacg gctaacgatc
      721 tctctgactt tcaatctgtt tccaagctaa gtcagggcaa gccatgtgtg tgtgtaggca
      781 aggagtgcca gtgtaagagg tggcatgaca tggaagtgta ttccttttca ggtctgcaga
      841 atgtccctcc tctggcccca gaacgaagat cacttgagga ctactctcag tcactgcaca
      901 ccagaactct gtctggctcg cctcgatcct gttccgagca agctcgtgtc tatgtggatg
      961 atgtgaccat tgaggaccta gcaggctaca tggagtatta cttgtatatc cctaagaaaa
     1021 tgtcccacat ggcagagatg atgtacacct gataacaaaa ggctagttca tgtgctttaa
     1081 accaatgaaa ggttatcaga ggtttagtta acggcagacc cggtggccac tctgtgagaa
     1141 gacatctctt tctgctcact gcttgcaata aaaactattc ttggcatctc agttaatctt
     1201 cattctgtca gtttactggg ttcttatgta cctgtcaaag gcaagcaggt caaagaaaat
     1261 ctcctaaaaa tgttctgagg gctgaagaaa ccataatgac ttggagactg gcggcggtgg
     1321 ggacatggag acatccttat aagacagcat atttcagacc tgcttacgat gtggcagcaa
     1381 gaaactcaaa tgtgcatttg taactgaatt gaacacttgt catgctgtag atgccagccc
     1441 atcaatagta gagcttatga gactcattta aactgtcttt ggtttaacac gggtttgtgt
     1501 cattaaaggt ttcttacgtt actgttgagt cagatatcta aggtttagat tcaggtggcc
     1561 tgtcctattt tgttttgagg gagtcattaa ccttactgtc actaaataaa cccctgctgg
     1621 tgctgtttat ccaga
//
