LOCUS       NM_001290377            1830 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus osteoclast associated receptor (Oscar), transcript
            variant 2, mRNA.
ACCESSION   NM_001290377 XM_006539749
VERSION     NM_001290377.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1830)
  AUTHORS   Park,D.R., Kim,J., Kim,G.M., Lee,H., Kim,M., Hwang,D., Lee,H.,
            Kim,H.S., Kim,W., Park,M.C., Shim,H. and Lee,S.Y.
  TITLE     Osteoclast-associated receptor blockade prevents articular
            cartilage destruction via chondrocyte apoptosis regulation
  JOURNAL   Nat Commun 11 (1), 4343 (2020)
   PUBMED   32859940
  REMARK    GeneRIF: Osteoclast-associated receptor blockade prevents articular
            cartilage destruction via chondrocyte apoptosis regulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1830)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1830)
  AUTHORS   Sinningen,K., Rauner,M., Goettsch,C., Al-Fakhri,N., Schoppet,M. and
            Hofbauer,L.C.
  TITLE     Monocytic expression of osteoclast-associated receptor (OSCAR) is
            induced in atherosclerotic mice and regulated by oxidized
            low-density lipoprotein in vitro
  JOURNAL   Biochem Biophys Res Commun 437 (2), 314-318 (2013)
   PUBMED   23817038
  REMARK    GeneRIF: OSCAR expression in monocytic cells is regulated by
            proatherogenic stimuli further pointing towards a role in vascular
            inflammation or plaque vulnerability during atherosclerosis
REFERENCE   5  (bases 1 to 1830)
  AUTHORS   Barrow,A.D., Raynal,N., Andersen,T.L., Slatter,D.A., Bihan,D.,
            Pugh,N., Cella,M., Kim,T., Rho,J., Negishi-Koga,T., Delaisse,J.M.,
            Takayanagi,H., Lorenzo,J., Colonna,M., Farndale,R.W., Choi,Y. and
            Trowsdale,J.
  TITLE     OSCAR is a collagen receptor that costimulates osteoclastogenesis
            in DAP12-deficient humans and mice
  JOURNAL   J Clin Invest 121 (9), 3505-3516 (2011)
   PUBMED   21841309
  REMARK    GeneRIF: Data suggest that OSCAR is a collagen receptor that binds
            to specific collagen motifs and costimulates osteoclastogenesis in
            DAP12-deficient humans and mice.
REFERENCE   6  (bases 1 to 1830)
  AUTHORS   Kim,K., Kim,J.H., Lee,J., Jin,H.M., Lee,S.H., Fisher,D.E., Kook,H.,
            Kim,K.K., Choi,Y. and Kim,N.
  TITLE     Nuclear factor of activated T cells c1 induces
            osteoclast-associated receptor gene expression during tumor
            necrosis factor-related activation-induced cytokine-mediated
            osteoclastogenesis
  JOURNAL   J Biol Chem 280 (42), 35209-35216 (2005)
   PUBMED   16109714
  REMARK    GeneRIF: analysis of a positive feedback circuit of TRANCE-induced
            activation of NFATc1, involving NFATc1-mediated OSCAR expression
            and its subsequent activation of NFATc1, necessary for efficient
            differentiation of osteoclasts
REFERENCE   7  (bases 1 to 1830)
  AUTHORS   Kim,Y., Sato,K., Asagiri,M., Morita,I., Soma,K. and Takayanagi,H.
  TITLE     Contribution of nuclear factor of activated T cells c1 to the
            transcriptional control of immunoreceptor osteoclast-associated
            receptor but not triggering receptor expressed by myeloid cells-2
            during osteoclastogenesis
  JOURNAL   J Biol Chem 280 (38), 32905-32913 (2005)
   PUBMED   16046394
  REMARK    GeneRIF: OSCAR but not TREM-2 is involved in the positive feedback
            loop of the immunoreceptor-NFATc1 pathway during osteoclastogenesis
REFERENCE   8  (bases 1 to 1830)
  AUTHORS   Ishikawa,S., Arase,N., Suenaga,T., Saita,Y., Noda,M., Kuriyama,T.,
            Arase,H. and Saito,T.
  TITLE     Involvement of FcRgamma in signal transduction of
            osteoclast-associated receptor (OSCAR)
  JOURNAL   Int Immunol 16 (7), 1019-1025 (2004)
   PUBMED   15184345
  REMARK    GeneRIF: the FcRgamma-mediated signal transduction by OSCAR is
            involved in osteoclast differentiation
REFERENCE   9  (bases 1 to 1830)
  AUTHORS   So,H., Rho,J., Jeong,D., Park,R., Fisher,D.E., Ostrowski,M.C.,
            Choi,Y. and Kim,N.
  TITLE     Microphthalmia transcription factor and PU.1 synergistically induce
            the leukocyte receptor osteoclast-associated receptor gene
            expression
  JOURNAL   J Biol Chem 278 (26), 24209-24216 (2003)
   PUBMED   12695521
  REMARK    GeneRIF: PU.1 and MITF transcription factors synergistically
            activate OSCAR gene expression, which is further enhanced by the
            TRANCE-induced MKK6/p38 signaling cascade.
REFERENCE   10 (bases 1 to 1830)
  AUTHORS   Kim,N., Takami,M., Rho,J., Josien,R. and Choi,Y.
  TITLE     A novel member of the leukocyte receptor complex regulates
            osteoclast differentiation
  JOURNAL   J Exp Med 195 (2), 201-209 (2002)
   PUBMED   11805147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF391160.1 and AF391159.1.
            
            On Mar 12, 2014 this sequence version replaced XM_006539749.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 3' end of the first exon compared to variant
            1. The resulting isoform (2) has the same N- and C-termini but is
            shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF391159.1, AF391160.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AF391160.1         1-24
            25-1830             AF391159.1         1-1806
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.08 cM"
     gene            1..1830
                     /gene="Oscar"
                     /gene_synonym="mOSCAR; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3"
                     /note="osteoclast associated receptor"
                     /db_xref="GeneID:232790"
                     /db_xref="MGI:MGI:2179720"
     exon            1..117
                     /gene="Oscar"
                     /gene_synonym="mOSCAR; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3"
                     /inference="alignment:Splign:2.1.0"
     exon            118..150
                     /gene="Oscar"
                     /gene_synonym="mOSCAR; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3"
                     /inference="alignment:Splign:2.1.0"
     exon            151..450
                     /gene="Oscar"
                     /gene_synonym="mOSCAR; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3"
                     /inference="alignment:Splign:2.1.0"
     exon            451..732
                     /gene="Oscar"
                     /gene_synonym="mOSCAR; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1829
                     /gene="Oscar"
                     /gene_synonym="mOSCAR; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1793..1798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oscar"
                     /gene_synonym="mOSCAR; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3"
                     /note="hexamer: AATAAA"
     polyA_site      1829
                     /gene="Oscar"
                     /gene_synonym="mOSCAR; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3"
                     /note="major polyA site"
ORIGIN      
        1 gctttctggt gttgcttcat ttcctcagag tgaaaaaggc agggtcaacc ttttcctcag
       61 ctccacggag agtgcccacc atggtcctgt cgctgatact ccagctgtcg actctctggc
      121 ctgcatgccg tgctgacttc acaccaacag cgcccctagc ctcatacccc cagccatggc
      181 tgggagctca tcctgctgca gttgtgactc ctgggatcaa cgtgaccttg acttgccgcg
      241 cacctcaatc tgcctggcgg tttgcactct tcaaaagtgg ccttgtcacc cctctgctcc
      301 tccgggatgt gtccgttgag ctggctgagt tcttcctgga agaagtgact ccggcccaag
      361 ggggcagtta tcactgccgc taccgcaaga cagactgggg gccaggtgtc tggtctcagc
      421 ccagtaatgt tctggaactg ctggtaacgg atcagctccc cagaccatca ctggtggcac
      481 tgcctgggcc tgtggtggcc ccgggagcca acgtaagcct gcgctgtgca ggccgcatac
      541 cgggcatgag ttttgcactg taccgcgtag gcgtggcaac ccctctgcag tatattgact
      601 ctgtgcagcc ctgggctgac ttccttttga tcggcacaca cacacctggc acctactgtt
      661 gctattacca cacgccttct gccccctatg tgctatcaca gcgcagccag ccactggtca
      721 tcagtttcga aggttctggc tccttggact atacccaggg aaacctcatc cgtttggggc
      781 tggcaggaat ggtcctcatc tgcttgggca tcatagttac ttgtgattgg cacagcagga
      841 gctctgcctt tgatggtctc ctgccccagc aaaactgaag agactgcctg gagatggaca
      901 gagaagctgg gatccttggt gaccagcccc tctgaaacac tctaggcctc cagactccac
      961 cagatactca ttcttcacca cactgtcagg cttgttgaag gattaaagga agtgactggc
     1021 ctgtggtaaa tgatgttcag ctaatgttag tgactttatc ctcccttgaa aacctctatt
     1081 tccttcctgt gccttatttc cggctcccca cctctccttt ctttttcttt ctggccgcgt
     1141 tgggatcata ggttcattct accacaccca gcaaaaattt ctaattccat attttaaggg
     1201 taatacccag gcctcagccg tgtgtagagg caaaaaagac aacttccagg agttgatttt
     1261 ctctgtccat cctgtaggtc ctagggtttg aactcaggct gccaggctta gccacaacaa
     1321 ctttacccac tgagccatct ggctggctcc taagtaattt atgtttttat atatatgaat
     1381 gctttgcctg tatgcatgta ggcctcgctc cccaaggaag ccagaagaag gcatctgatc
     1441 tcttggaatt agagttacag atgggtgtga gccaccatgt agtgctagaa gccccaacca
     1501 aggtcctcta gaagagtagc cagtactctt aactgctaag ccatctctcc aaggccccca
     1561 aatctataag attaaagtac tcattctctc ttctcttcca atgttttggg ggtttgttcg
     1621 tttgtttttt agtgcaattt tttagtattg aacccaggtc cttctacgtg ctaggcaagt
     1681 actttaccct gtgctacaat cccatctccc aggtaatttt taaaaaatta atcataaatt
     1741 tttgatgttt tggaaacagt cttattctgt aatgtaaaat gacttgaact tgaataaatg
     1801 ttcctgcctc agcctcttga ataccaaaaa
//
