LOCUS       NM_001199227            3794 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus oxysterol binding protein-like 5 (Osbpl5), transcript
            variant 2, mRNA.
ACCESSION   NM_001199227
VERSION     NM_001199227.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3794)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3794)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3794)
  AUTHORS   Imaizumi,Y., Furutachi,S., Watanabe,T., Miya,H., Kawaguchi,D. and
            Gotoh,Y.
  TITLE     Role of the imprinted allele of the Cdkn1c gene in mouse
            neocortical development
  JOURNAL   Sci Rep 10 (1), 1884 (2020)
   PUBMED   32024956
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3794)
  AUTHORS   Tremblay,M.G. and Moss,T.
  TITLE     Loss of all 3 Extended Synaptotagmins does not affect normal mouse
            development, viability or fertility
  JOURNAL   Cell Cycle 15 (17), 2360-2366 (2016)
   PUBMED   27399837
REFERENCE   5  (bases 1 to 3794)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   6  (bases 1 to 3794)
  AUTHORS   Higashimoto,K., Soejima,H., Yatsuki,H., Joh,K., Uchiyama,M.,
            Obata,Y., Ono,R., Wang,Y., Xin,Z., Zhu,X., Masuko,S., Ishino,F.,
            Hatada,I., Jinno,Y., Iwasaka,T., Katsuki,T. and Mukai,T.
  TITLE     Characterization and imprinting status of OBPH1/Obph1 gene:
            implications for an extended imprinting domain in human and mouse
  JOURNAL   Genomics 80 (6), 575-584 (2002)
   PUBMED   12504849
  REMARK    GeneRIF: OBPH1/Obph1 gene is imprinted, with preferential
            expression from the maternal allele in human and mouse.
REFERENCE   7  (bases 1 to 3794)
  AUTHORS   Choi,J.D., Underkoffler,L.A., Collins,J.N., Marchegiani,S.M.,
            Terry,N.A., Beechey,C.V. and Oakey,R.J.
  TITLE     Microarray expression profiling of tissues from mice with
            uniparental duplications of chromosomes 7 and 11 to identify
            imprinted genes
  JOURNAL   Mamm Genome 12 (10), 758-764 (2001)
   PUBMED   11668390
REFERENCE   8  (bases 1 to 3794)
  AUTHORS   Engemann,S., Strodicke,M., Paulsen,M., Franck,O., Reinhardt,R.,
            Lane,N., Reik,W. and Walter,J.
  TITLE     Sequence and functional comparison in the Beckwith-Wiedemann
            region: implications for a novel imprinting centre and extended
            imprinting
  JOURNAL   Hum Mol Genet 9 (18), 2691-2706 (2000)
   PUBMED   11063728
REFERENCE   9  (bases 1 to 3794)
  AUTHORS   Laitinen,S., Olkkonen,V.M., Ehnholm,C. and Ikonen,E.
  TITLE     Family of human oxysterol binding protein (OSBP) homologues. A
            novel member implicated in brain sterol metabolism
  JOURNAL   J Lipid Res 40 (12), 2204-2211 (1999)
   PUBMED   10588946
REFERENCE   10 (bases 1 to 3794)
  AUTHORS   Bastian,H. and Gruss,P.
  TITLE     A murine even-skipped homologue, Evx 1, is expressed during early
            embryogenesis and neurogenesis in a biphasic manner
  JOURNAL   EMBO J 9 (6), 1839-1852 (1990)
   PUBMED   1971786
  REMARK    Erratum:[EMBO J 1991 Dec;10(12):3978]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY234441.1, BC079872.1 and EH108768.1.
            
            Transcript Variant: This variant (2) has a different exon at its 5'
            terminus which results in the use of a downstream in-frame
            translation initiation site, compared to variant 1. It encodes an
            isoform (2) with a shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079872.1, AB074008.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 12504849
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY234441.1         29-47
            20-3043             BC079872.1         1-3024
            3044-3044           EH108768.1         603-603             c
            3045-3794           BC079872.1         3026-3775
FEATURES             Location/Qualifiers
     source          1..3794
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.29 cM"
     gene            1..3794
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /note="oxysterol binding protein-like 5"
                     /db_xref="GeneID:79196"
                     /db_xref="MGI:MGI:1930265"
     exon            1..91
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            92..248
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2737
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     oxysterol binding protein 2; oxysterol binding protein
                     homolog 1; oxysterol-binding protein-like protein 5;
                     oxysterol-binding protein-related protein 5; OSBP-related
                     protein 5; ORP-5"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 5
                     isoform 2"
                     /protein_id="NP_001186156.1"
                     /db_xref="CCDS:CCDS57598.1"
                     /db_xref="GeneID:79196"
                     /db_xref="MGI:MGI:1930265"
                     /translation="MKEEAFLRRRFSLCPPASTPQKTDPRKVPRNLLLGCENELGPIT
                     PGRDMESNGPSQPRDEEPQTPGSATKVPLAEYRLCNGSDKECTSPTTRVSKKDALKAQ
                     KENYRQEKKRATKQLFSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTP
                     KVGQWVGTVLLHCCELIERPSKKDGFCFKLFHPLDQSVWAVKGPKGESVGSITQPLPS
                     SYLIFRAASESDGRCWLDALELALRCSSLLRLSTCKQGRDGEQGSSPDASPSSLYGLP
                     TSATIPDQDLFPLNGSALENDAFSDKSERENAEDSDAETQDHSRKTNESGSDLLDSPG
                     GPWRGTTYVEQVQEELGELDETSQVETVSEENKSLMWVLLRQLRPGMDLSRVVLPTFV
                     LEPRSFLGKLSDYYYHGDLLSRAAAEDDPYCRMKLVLRWYLSGFYKKPKGIKKPYNPI
                     LGETFRCRWLHPQTNSHTFYIAEQVSHHPPVSAFYVSNRKDGFCMSGSITAKSKFYGN
                     SLSALLDGKAKLTFLNRKEEYTLTMPYAHCRGILYGTMTMELGGKVNIECEKNNLQAE
                     LDFKLKPFFGSSANINQISGKIMSGEEVLARLTGHWDRDVFIKEESSGGTELFWTPSE
                     EVRRQRLKRHTVLLEEQSELESERLWQHVTRAIREGDQHKATQEKSVLEEAQRQRARE
                     HQQSLTPWKPQLFLLDPLTQEWRYRYEDLSPWDPLKDIAQYEQDGILHTLQRETMSGQ
                     TTFLGSPDSRHKRPSSDRRLRKASDQPSGHSQVTESSGSTPESCPDLSDEDFVPGGES
                     PCPRCRREVHRLKMLQEAVLSIQEAQQELHRHLSTMLSSTVRAGQAPAPSLLQNPRSW
                     FLLCIFLTCQLFINYILK"
     exon            249..331
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            332..412
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..514
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            515..718
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..803
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..975
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1168
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1353
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1435
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1534
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1631
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1730
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1828
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1918
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2055
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2241
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2368
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2495
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2598
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..3794
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3775..3780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /note="hexamer: AATAAA"
     polyA_site      3794
                     /gene="Osbpl5"
                     /gene_synonym="1110006M06Rik; Obph1; ORP5; Osbp2"
                     /note="major polyA site"
ORIGIN      
        1 cctctggtat ttcctgctgc tcagcgacag ctgagcccct cgcgggccca ggcggcccgg
       61 cccggcccca gcactgagta caaccagcac gaagcccccc agcacccaca ccatgaagga
      121 ggaggccttt ctccggcgcc gtttctcgct gtgtccacca gcttctactc cacagaagac
      181 tgacccccgg aaagtcccac ggaacctgct tctgggctgc gaaaatgagc ttggtcccat
      241 caccccagga agggacatgg agtccaacgg cccatcacaa cccagagatg aagagcccca
      301 gaccccaggc tccgccacga aggtgccact ggctgagtac aggctatgca atggatctga
      361 caaggaatgt acctctccaa cgaccagggt ctccaagaag gatgctctca aggcacagaa
      421 ggagaactat cggcaggaga agaagcgggc cacgaagcag ctgttcagtg ccctgactga
      481 ccccagtgtg gtcatcatgg ctgacagcct aaagatccga gggaccctga agagctggac
      541 gaagctgtgg tgtgtactga agccaggggt gctgctcatt tacaagacac ccaaggtggg
      601 ccagtgggtg ggcacggtgc tgctgcactg ctgcgagctt attgagcgcc cctccaagaa
      661 ggacggcttc tgcttcaaac tcttccaccc gctggaccag tctgtgtggg ctgtgaaggg
      721 ccccaaaggc gagagtgtgg gctccatcac tcagcccctc cctagcagct acctgatctt
      781 cagggccgct tctgaatcag acggccgctg ctggctagat gccctggagc tggcccttcg
      841 ctgctccagc ctcctgcgac tgagcacgtg caagcagggt cgagatgggg agcaggggtc
      901 ctcgcctgat gcctctccct cttctctcta cggactgccc acctcggcca ccatcccaga
      961 tcaagacctg ttcccgctga atgggtctgc cttggagaac gatgcattct cagacaagtc
     1021 agaacgagag aatgcagaag actcggatgc cgagacccag gatcacagcc gcaagaccaa
     1081 cgagagtggg agcgacctgc tagacagccc tggtgggcca tggaggggaa ctacctatgt
     1141 ggaacaggtc caggaggagc tgggagagct ggacgagact tcccaggtgg agacagtgtc
     1201 agaggaaaac aagagcctga tgtgggtgct gctgcgacag ctgcggccag gcatggacct
     1261 gtcccgtgtg gtgctgccga ccttcgtgtt ggagcctcgg tccttcctcg gcaagctctc
     1321 tgattactac taccacggag acctgctctc cagggcagca gcagaggatg acccctactg
     1381 ccgcatgaag cttgtgctcc ggtggtacct gtctggcttc tataagaagc ccaagggcat
     1441 caagaaaccc tataatccca ttctggggga gacttttcgc tgccgctggc tgcaccctca
     1501 gaccaacagt cacaccttct acatagcaga acaggtgtct caccatcctc ctgtgtctgc
     1561 cttctatgtc agcaacagga aagatggctt ctgcatgagt ggcagcatca cagcaaagtc
     1621 taagttctat gggaactcat tgtcggcgct tctggacggc aaggctaaac tcaccttcct
     1681 taatcgcaag gaggagtata ccctcaccat gccctatgcc cactgccgag ggatcctcta
     1741 cggcaccatg accatggagc tgggaggcaa agtgaacatc gagtgtgaga agaacaacct
     1801 ccaagctgaa ctggacttca agctcaagcc tttctttgga agcagcgcca acatcaacca
     1861 gatttccggg aagatcatgt caggagagga agtcctggca cgcctcactg gacactggga
     1921 cagagatgta tttatcaagg aagagagcag tggaggcacc gagctcttct ggactccgag
     1981 tgaggaggtc cgcaggcagc ggctgaagcg gcacacagtg ctgttggaag agcagagtga
     2041 actggagtct gagaggctgt ggcagcatgt caccagggcc atccgtgagg gtgaccagca
     2101 caaagccaca caggagaagt ctgtgctgga agaggcgcag cggcagcgtg cccgtgagca
     2161 ccagcagagc ctcactccat ggaagccaca gttgttctta ctggaccctc tcactcagga
     2221 atggcgctac cgatatgagg acctcagccc ctgggacccg ctgaaggaca ttgcccaata
     2281 tgagcaagat gggattcttc atactctaca gagggagact atgtctggcc agacaacctt
     2341 tctggggagt cctgactcca ggcacaagag gcctagctct gatcggcggc tccgcaaagc
     2401 cagtgaccag ccctctggcc atagccaggt cactgagagc agcggctcca cacctgagtc
     2461 ctgcccagac ctctctgatg aggactttgt tcctggtggt gagagcccat gtcctcggtg
     2521 caggcgagag gtacaccggc taaagatgct acaagaggcc gtgctgtcca ttcaggaagc
     2581 tcagcaagag ctgcataggc acctttcgac catgttaagc tccacagtgc gtgctgggca
     2641 ggcgccagcc cccagcctcc tgcagaatcc ccgctcctgg ttcctgctct gcatcttcct
     2701 gacgtgtcag ctattcatta actatatcct caaataagag cccttggaat cagcaaggtg
     2761 acgcctgcag aactccctcc taggcaccca gcactttaca ccggcctgca gaggcagtgg
     2821 ggcccacagg catggccagt gggacagaag ggtcctcgca caagaggatg acaggtgggg
     2881 cctggggcta tgagggtgct gtgactccag ctgtaggacc ctccagggag cactggcctc
     2941 ttctttggag ccctccacct agtaccggcc ttaacgctaa agccaaatgc agtttctgcc
     3001 ctgcagtgtg cccctggtaa tctcaagttg cactcccaag ccagccccca cttgccatac
     3061 ggcatcagat ctgggggtca ggagggcctg tgcaggcttt ggacagccac ttaccacagc
     3121 acaggagaga gtgaggttgc caggagcagc aggaaggaag actccaggat tccccggagc
     3181 tctttgggtg gtaatgttga cttctggaca atctgcccac cttgtgctca cacaagcatg
     3241 gacaggctgt agctactctg gtgaggacac tgggactttt atcctgttgt taagctgttt
     3301 ccacagaagc ctgttcaggt agttacttca cctacatctg ccctacagcc agaggagccc
     3361 acctgtgcca caggagtgcc ctggccaact gcagtgtgag tttgtaagca agagaagtgc
     3421 ccagaggctg accccaaagg ccagggaggc ccaagcttgc cactctccct gaccaataca
     3481 gtcttcccat tctgttgaca ttctgactac atagaattgc aatatctgag gcagctatgt
     3541 gcagtgagca gcctctgcat ccagcccctg atcctatgtg gatgacgctc ttcgtgtgcg
     3601 tgtgtgtgtg tgtgcgtgtg tatgtatgtg agcacctatg cgtactcaca tttggagcct
     3661 taatacttag ttggtgccat ctccattgta tctgatcctt tcattttcca agttttgtat
     3721 ccatttgtct ctgtccttcc ccaatcctgg gggtatgtct gctccatgcc ttgaaataaa
     3781 tggaaataca tgta
//
