LOCUS       NM_001347213            7164 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus oxysterol binding protein-like 3 (Osbpl3), mRNA.
ACCESSION   NM_001347213 XM_006506628
VERSION     NM_001347213.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7164)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7164)
  AUTHORS   Wang,X., Liu,J., Azoitei,A., Eiseler,T., Meessen,S., Jiang,W.,
            Zheng,X., Makori,A.W., Eckstein,M., Hartmann,A., Stilgenbauer,S.,
            Elati,M., Hohwieler,M., Kleger,A., John,A., Zengerling,F.,
            Wezel,F., Bolenz,C. and Gunes,C.
  TITLE     Loss of ORP3 induces aneuploidy and promotes bladder cancer cell
            invasion through deregulated microtubule and actin dynamics
  JOURNAL   Cell Mol Life Sci 80 (10), 299 (2023)
   PUBMED   37740130
  REMARK    GeneRIF: Loss of ORP3 induces aneuploidy and promotes bladder
            cancer cell invasion through deregulated microtubule and actin
            dynamics.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7164)
  AUTHORS   Aibara,D., Sakaguchi,A. and Matsusue,K.
  TITLE     Oxysterol-binding protein-like 3 is a novel target gene of
            peroxisome proliferator-activated receptor gamma in fatty liver
            disease
  JOURNAL   Mol Cell Endocrinol 565, 111887 (2023)
   PUBMED   36781118
  REMARK    GeneRIF: Oxysterol-binding protein-like 3 is a novel target gene of
            peroxisome proliferator-activated receptor gamma in fatty liver
            disease.
REFERENCE   4  (bases 1 to 7164)
  AUTHORS   Njeru,S.N., Kraus,J., Meena,J.K., Lechel,A., Katz,S.F., Kumar,M.,
            Knippschild,U., Azoitei,A., Wezel,F., Bolenz,C., Leithauser,F.,
            Gollowitzer,A., Omrani,O., Hoischen,C., Koeberle,A., Kestler,H.A.,
            Gunes,C. and Rudolph,K.L.
  TITLE     Aneuploidy-inducing gene knockdowns overlap with cancer mutations
            and identify Orp3 as a B-cell lymphoma suppressor
  JOURNAL   Oncogene 39 (7), 1445-1465 (2020)
   PUBMED   31659255
REFERENCE   5  (bases 1 to 7164)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7164)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 7164)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 7164)
  AUTHORS   Anniss,A.M., Apostolopoulos,J., Dworkin,S., Purton,L.E. and
            Sparrow,R.L.
  TITLE     An oxysterol-binding protein family identified in the mouse
  JOURNAL   DNA Cell Biol 21 (8), 571-580 (2002)
   PUBMED   12215260
REFERENCE   9  (bases 1 to 7164)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 7164)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124689.5 and AC008160.11.
            
            On Nov 18, 2016 this sequence version replaced XM_006506628.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995048.897561.1,
                                           SRR9219380.77784.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-530               AC124689.5         132637-133166       c
            531-622             AC008160.11        17526-17617
            623-858             AC008160.11        75588-75823
            859-975             AC008160.11        92845-92961
            976-1029            AC008160.11        93109-93162
            1030-1143           AC008160.11        93989-94102
            1144-1311           AC008160.11        97808-97975
            1312-1435           AC008160.11        98457-98580
            1436-1539           AC008160.11        99515-99618
            1540-1632           AC008160.11        99843-99935
            1633-1789           AC008160.11        100916-101072
            1790-1920           AC008160.11        109601-109731
            1921-2028           AC008160.11        112653-112760
            2029-2163           AC008160.11        117142-117276
            2164-2257           AC008160.11        118478-118571
            2258-2508           AC008160.11        122723-122973
            2509-2646           AC008160.11        125772-125909
            2647-2710           AC008160.11        133251-133314
            2711-2789           AC008160.11        136555-136633
            2790-2934           AC008160.11        137511-137655
            2935-3079           AC008160.11        142785-142929
            3080-3206           AC008160.11        144896-145022
            3207-3329           AC008160.11        146508-146630
            3330-7164           AC008160.11        148785-152619
FEATURES             Location/Qualifiers
     source          1..7164
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 24.13 cM"
     gene            1..7164
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /note="oxysterol binding protein-like 3"
                     /db_xref="GeneID:71720"
                     /db_xref="MGI:MGI:1918970"
     exon            1..530
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            531..622
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            623..858
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             766..3426
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /note="oxysterol-binding protein-related protein 3;
                     OSBP-related protein 3"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 3
                     isoform 3"
                     /protein_id="NP_001334142.1"
                     /db_xref="CCDS:CCDS85046.1"
                     /db_xref="GeneID:71720"
                     /db_xref="MGI:MGI:1918970"
                     /translation="MSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEM
                     TYTQEPPVQKGFLLKKRKWPLKGWHKRFFCLEKGILKYAKSQADIEREKLHGCIDVGL
                     SVMSVKKSSKCIDLDTEEHIYHLKVKSEELFDEWVSKLRHHRMYRQNEIAMFPRDVNH
                     FFSGSSVTDSAPGVFESVSSRKRSSLSKQNSFPPGSNLSFSCGGDTRVPFWLQSSEDM
                     EKCSKDMAHCHAYLLEMSQLLESMDVLHRTYSAPAINAIQGGAFESPKKEKRPHRRWR
                     SRAIGKDAKGTLQVPKPFSGPVRLHSSNPNLSTLDFGEEKSYSDGSEASSEFSKMQED
                     LCHVAHKVYFALRSAFNSISVEREKLKQLMELDTSPSPSAQVVGLKHALSSALAQNTD
                     LKERLRRIHAESLLLDPPAVPKPGDNLAEENSRDEGRALVHQLSNESRLSITDSLSEF
                     FDAQEVLLSPSSSENEISDDDSYVSDISDNLSLDNLSNDLDNERQTLGPVLESSGEAR
                     SKRRTSLPAPGPNTSSVSLWSILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSE
                     LLDKASRIPSPLERMVYVAAFAISAYASSYFRAGSKPFNPVLGETYECIRQDKGFQFF
                     AEQVSHHPPISACHAESGNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPAFGDHFEW
                     NKVTSCIHNILSGQRWIEHYGEIDIKNLNDDSCHCKVNFIKAKYWSTNAHEIEGTVFD
                     RSGKAVHRLFGKWHESIYCGGASSSTCVWRANPMPKGYEQYYGFTQFALELNEMDPLS
                     RSLLPPTDTRFRPDQRLLEEGNIEEAEVQKQRIEKLQRERRRVLEENGVEHQPRFFRK
                     SSDDAWVSNGTYLELRKDLGFSKLDHPVLW"
     exon            859..975
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1029
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1143
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1311
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1435
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1539
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1632
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1789
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1920
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2028
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2163
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2257
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2508
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2646
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2710
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2789
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2934
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3079
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3206
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3329
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..7164
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3667..3672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /note="hexamer: AATAAA"
     polyA_site      3686
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /note="major polyA site"
     regulatory      4694..4699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /note="hexamer: ATTAAA"
     polyA_site      4718
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /note="major polyA site"
     regulatory      7144..7149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /note="hexamer: AATAAA"
     polyA_site      7164
                     /gene="Osbpl3"
                     /gene_synonym="1200014M06Rik; 6720421I08Rik; A530055M08;
                     ORP-3; ORP3; OSBP3"
                     /note="major polyA site"
ORIGIN      
        1 taccatcact ctccaccgct ccacacgccc tgaaccctgg ctggcgtcac ggaatccgcc
       61 tgcagcttcc aagtccaacg cctcaccgcc ttcccccgat gactcctgat tggtgggagt
      121 gggagccact ctgctgcccc ccctccaccg cccttttcac gttattccgc ccagtggaga
      181 actcaggctc ctcctcttag ctccctcccc tcgctccagc tcttcagcta attgcccggc
      241 agcgcgcgcc ctaaagttct aggcgaagta ttgagaactg gtcgcgggga tcgcacaccg
      301 gccagtagca ggggaccagg gaccccggca ccaggagagc tggtgcactg cgcgggctct
      361 cgcccaccat ctgtctgcga gcagcgctcg gcgccccagt ctcctgcggc tggtgctgga
      421 actgccgtcg gctgagactt gcagggaccc gagaagcccg gtttgcgtcc ttctcggtct
      481 gaagcacgca ctggggaatc gagaagcgtc cccagcagcg gaacacttag gtctgtcctg
      541 tgtcagcgaa gaccacgaga agagagtcat gcaacattga tcatactgcc tgccttcttt
      601 cggaagtatt gaacttattc agagatttcc tctgagactt ccagaatggc ttctaaacac
      661 attgggtaag agctggcacc tgcctgcgag gacttcatac tctcagctcc accatcttcc
      721 catggcattt tgactgcgct gagcccaaag gaccagctct tcacaatgag tgacgagaag
      781 aatctcggtg tgtctcaaaa gttggtttca ccttcaagaa gcacaagtag ttgctcctcc
      841 aagcaaggaa gccggcagga cagctgggaa gtcgtggaag gattgagagg ggaaatgact
      901 tacacccagg agccgccagt gcagaaagga tttttgctga aaaagaggaa gtggccctta
      961 aaaggctggc acaagagatt cttctgcctg gaaaagggaa tcttgaaata tgccaagagc
     1021 caagctgata ttgagcggga gaagttgcat ggctgcattg acgtggggct ctctgtgatg
     1081 tctgtgaaga agtcgtctaa gtgtatcgac ctagacacgg aggagcacat ctaccacctg
     1141 aaggtgaagt cagaagaact ctttgacgag tgggtgtcca agctccgtca ccacagaatg
     1201 taccggcaga atgagatcgc catgtttccc cgggatgtca atcacttttt ctcagggtcc
     1261 tctgtcacag attctgcccc aggagtgttc gagtcagttt ccagtaggaa gcgtagcagt
     1321 ctatcaaagc agaattcatt tccacccgga agcaatttgt cattttcttg tggtggcgac
     1381 actcgagttc ctttctggct acagtcttca gaggacatgg aaaaatgttc aaaagacatg
     1441 gcacactgcc atgcctacct gctggaaatg agccagctct tagaaagcat ggacgtcctg
     1501 catcggacat actcggcgcc agccatcaac gccatccagg gtggagcttt tgaaagtccc
     1561 aaaaaggaaa aacgaccaca caggaggtgg cggtccagag ctattggcaa agatgctaaa
     1621 ggaacgctgc aggtccctaa gcctttttct ggccctgtga gactgcactc ctccaatcct
     1681 aacttgtcga cgctggactt tggagaagag aagtcttact cggatggttc tgaagcctcg
     1741 tcggagttct ccaagatgca ggaggatctg tgccatgtcg cccacaaagt ttacttcgct
     1801 ttaaggtcgg ctttcaatag catatcggtg gagagagaga aactgaagca gctgatggag
     1861 ctggacacct ccccctcccc ctccgctcag gtcgtcgggc tgaagcacgc tctgtcatcc
     1921 gccctagcac aaaacacaga tcttaaagaa cgcttacgca gaatccatgc ggaatctctg
     1981 ctcctcgacc cgcccgctgt tcccaagccg ggggacaacc tggcagagga aaactccagg
     2041 gatgagggcc gagccctggt gcaccagctc tccaatgaga gcaggctgtc tatcaccgac
     2101 tccctttctg agttcttcga tgcccaggaa gttctgctgt ctcctagctc ttcagaaaac
     2161 gagatttctg atgatgattc atacgtcagt gacataagtg ataatctgtc cttagacaac
     2221 ctcagtaatg atttagacaa tgaaagacag accttggggc ctgttctcga gagtagtggg
     2281 gaagccagat ccaaaaggag gaccagcttg ccggcaccgg gtcccaacac cagtagcgtt
     2341 agcttgtgga gcatcctgcg caacaacatt gggaaggacc tgtccaaggt ggccatgccg
     2401 gtggagctga acgagcccct gaacacgctg cagcggctct gcgaggagct ggaatacagc
     2461 gagcttctgg acaaggcctc gagaatcccc agtcccctgg agaggatggt gtacgtagca
     2521 gccttcgcca tctccgcata tgcatccagc tacttccgag caggcagcaa gccgtttaac
     2581 ccggtccttg gagaaacgta cgaatgcatc cgacaggaca agggtttcca gttttttgcc
     2641 gagcaggtca gccaccaccc acctatctcc gcctgccacg ctgagtccgg aaactttgtt
     2701 ttctggcaag atgtgagatg gaaaaataaa ttctggggta aatccatgga aattgtcccg
     2761 attggcacaa cccacgtgac tctgcctgct tttggagatc actttgagtg gaacaaagta
     2821 acctcctgca tccacaacat cttgagcgga cagcgatgga tcgagcacta tggcgaaatt
     2881 gacatcaaga acctgaatga cgactcctgc cactgcaaag tgaacttcat aaaggctaag
     2941 tactggagca ctaatgccca cgagatcgaa ggcacggtgt tcgaccgcag tgggaaggct
     3001 gtgcaccggc tgtttgggaa atggcacgag agcatctact gtggcggcgc ctcctcttcc
     3061 acatgcgtct ggagagcaaa tcccatgccg aaaggctatg agcagtatta tggcttcaca
     3121 cagtttgcac tagagttaaa tgaaatggat cctttgtcaa ggtctttatt accacccacc
     3181 gacactcggt ttagaccaga tcaaaggctt ctagaggaag ggaacataga ggaggctgag
     3241 gttcagaagc agaggatcga gaagctgcag agagagcggc ggagggtctt ggaggagaac
     3301 ggtgtggagc accagccccg gtttttcagg aaatccagtg acgatgcttg ggtaagcaat
     3361 gggacctacc tggaactgag gaaagacctt ggcttttcca agttggacca tcccgtctta
     3421 tggtgaaatg taaaagagaa ggagatttcc tgtaactttg cccacatttg cttccggaag
     3481 cagcgcacag ctgtctgtat gtttaaaaga tagcatctag aatgatcact tgtgcttagc
     3541 gtagcattgt aagcgctgaa gtatatattt tcttcagtaa gtctctttaa aatttcaagt
     3601 gttatcatga ttgtttatat gaatgtagaa cacctcggta tttcttttta tatatataaa
     3661 ctatttaata aaaatgaaag attgaatgtt aatgtgtggg ttacaaaaaa aaaaacattt
     3721 aacactaatt ttccagaggt aagggggaaa tttcaaattt atgccttata aaatcacact
     3781 ggaaaaaaat tgtcccagat gcgttaagaa ataataacac ccagggatac tcacccatgc
     3841 atagctaccc agggttaatt ggtagctggg atatcttttc gcctcagaca gctcttcgat
     3901 tgctcataca gaacaattct gccggtgctg aagtaccaag aatgttttca tttgcatttt
     3961 cctggttaag aaatctgtat aaagttagtg agatgcatat tctttatata aggtgggcat
     4021 caagcaacca gaagtgcaaa cttccctccc tttacttctg ttgccttgtg tataaaactg
     4081 cccccagctt gcctagagac gttgccttca tcagagaaga ctccattaat tcagtgtccc
     4141 aatggtgtcc tagggaggca gcagacgttt cgtttgtcct cagtaagagc tgaatcctta
     4201 aaaatttaag aaactacttt cagcttcctg ctccacccct ggcttgcaag ccctcttttt
     4261 ggcccctatt gaggatgaaa tgtctctcat ttagtataaa cagtaacagc ccacggcagt
     4321 gtgaccttct aaacttcagc gaagtcactg gtggctttaa ataacccagc gttgttcctc
     4381 cacacggctt tggtactctc tacctcttac cgagcaccgc ccttttgacc ttgtatagcc
     4441 agtttgacca tctgccttat agacaaacat tgctgttctt ctatgtcgtc ctcttgagaa
     4501 agctgcaagg gtttacctct ttccttgact ctcttcttat ttgtaatact ctgagttctg
     4561 catctgtctc agacaggagc taccaaaggg aaactgttgt tcttataagt gtcttacttt
     4621 aaatcatgat aatagaatgt gcacagtagc tgaattgtgt tatcaaaaca actctgactt
     4681 ctgcccagag cacattaaaa ccaaagtctg attgttaagc ctttgactcg gatgtctgta
     4741 gcagttctat gaaacattgc gtgtaatgat agggtaaaga gatttctata gaacgaattt
     4801 gggaggccag tgagatcggc tcggcaggca caggcactta ttgtgtgaac ctggcactgg
     4861 gtccagtctc caggacctat ctaaaagata gaaggaaaga gccaactccc agagttgacc
     4921 tgtgtcacac cagataacca actgcactgc tgaagttttc acaagtggag tgttgaaggt
     4981 gaatcagtag tctttggagt ctacaagtga ctgtcatttt aagcaactca ttaaatattg
     5041 gttcattttt tttccatgtt gtggagacac caagatgaac gcagcatgaa tctcatttcc
     5101 atttctaagc agctgggtgg tgcggcgatt ctttagttcc tgttttgttt tttttccttt
     5161 tcaagcgcta tccacatctg accacaggct ggagatgtaa gcagggatct cggcagggaa
     5221 acaaacccga gaggacacgt gggatttcag caatactgac tgtgaagtag gcctgctcga
     5281 gaggccgccc caaaggagaa ggaaaatgac aaaaaaaaaa aaaaaatccc acaaaatcga
     5341 gaatgtatcc ccagaatcag tacagccagt tgtttgaaca ttcttaaagt atctcgtggt
     5401 ataatttctg ttgacttcaa gctttaattt ggatccacac ctacagctga cccaaatgtc
     5461 tcctctgtag tcatcttatt tggatcaggg agaagcatga acaaaaatat gttccagaac
     5521 catgtgcaag ctctgtaagt cactgcccgt gtctggatga agggctttcg gaatgtagat
     5581 ggtcaggagg tgcatgctgc tatgtgaatc ttaaaactcc ctgctggagg gaggaggctg
     5641 ctacattcct ctcgttctgt ctcacacact cttcctccga gtttgtgtgt ctagaacttg
     5701 gatgtttcca taaggaaaac agaactgtgg tattgtttcg agaagaatta agtaaagttt
     5761 aatctttctg aactcctgac ttactccagt acacaatgcc aatcgctgca ccatttgatg
     5821 tgcatgtttc agcccctttc attctaatta tcctatttca agtttatggt aagtcacaga
     5881 tgttctccca gtagcaggac cttgtgctaa ccacaaactg caccttctca gtactcacaa
     5941 ccccgatctg caaggtatcg ttaaggaatg agtatcttca gtgtggcaaa ggagtagtgt
     6001 agttccctcc acaggccctg tcgtaataaa agcctcagtg cagcttcttc ctgcagttca
     6061 catcttgatg ctaggatgct cctggtacta actaaacatt ggcagttcac atcccagaca
     6121 ccaggggtca ggtactaact aaagagatgg aatgcagtgt gctttttgag acactagggg
     6181 gagcctggta ttaactaaac agcttgccat tcaacagtct caggagggtt cttgtactaa
     6241 acagatgggg gttcactcta ggtcataaat acaattacct actaagtagc aagaatgcct
     6301 cagcaatccc caagccttcc agtgcctctg ggggcttcct gatggaaaac tacacaaact
     6361 gagtttttta aatgttaact ccacttaggc ttctgttttc ctcatatcct atttttaatt
     6421 acttccaata aatcatttgc tcagccttct agcactgtct tcctttgtat ttgtcagatt
     6481 tatgatgcat tgtttcagtc tacccttaaa gaagtcaagc caaaaataga ggtgagggct
     6541 actttgcttc ttaatgtagg cctactgtgc acaccacaca ctctctctga gggactgtag
     6601 ctattagata ctgtcctcac accctcgagc taccagccag ggctctaagt tgctctcgtg
     6661 atcttagtta gaaatacagg ctacagtgtt tggtcagaat ttattcgaat gtctttattt
     6721 ttaataccaa catcagcata aatctatttt tgctagtaga tcaaagctat tttcacacgc
     6781 tctgttttct atcttgtatc gatcctgcga atcagtgatt atctttgttg gaaaacctta
     6841 tcaaatgtgt ctgcaaatca agatggtcta aagtgcaagc cagttttttg tttgcttgtt
     6901 tttgaaactg ggtttagggg atacagttgt cagaagtgac tcattcgctt catttgtgat
     6961 gatttttttt taatcttcct ctgttagccc acaggacatg ttttggggaa aatgatactt
     7021 gtaaatcttc tatttaacca tttgtaaaat ctaaatcata ccccactccc cactcccatt
     7081 tcgattctcc agcggctcct tttagtttgt tgtcttgccc tactgtgtag ctcactgact
     7141 gagaataaag aatacagcaa aggc
//
