LOCUS       NM_144500               2807 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus oxysterol binding protein-like 2 (Osbpl2), mRNA.
ACCESSION   NM_144500
VERSION     NM_144500.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2807)
  AUTHORS   Weber-Boyvat,M., Kroll,J., Trimbuch,T., Olkkonen,V.M. and
            Rosenmund,C.
  TITLE     The lipid transporter ORP2 regulates synaptic neurotransmitter
            release via two distinct mechanisms
  JOURNAL   Cell Rep 41 (13), 111882 (2022)
   PUBMED   36577376
  REMARK    GeneRIF: The lipid transporter ORP2 regulates synaptic
            neurotransmitter release via two distinct mechanisms.
REFERENCE   2  (bases 1 to 2807)
  AUTHORS   Koh,Y.I., Oh,K.S., Kim,J.A., Noh,B., Choi,H.J., Joo,S.Y., Rim,J.H.,
            Kim,H.Y., Kim,D.Y., Yu,S., Kim,D.H., Lee,S.G., Jung,J., Choi,J.Y.
            and Gee,H.Y.
  TITLE     OSBPL2 mutations impair autophagy and lead to hearing loss,
            potentially remedied by rapamycin
  JOURNAL   Autophagy 18 (11), 2593-2614 (2022)
   PUBMED   35253614
  REMARK    GeneRIF: OSBPL2 mutations impair autophagy and lead to hearing
            loss, potentially remedied by rapamycin.
REFERENCE   3  (bases 1 to 2807)
  AUTHORS   Shi,H., Wang,H., Zhang,C., Lu,Y., Yao,J., Chen,Z., Xing,G., Wei,Q.
            and Cao,X.
  TITLE     Mutations in OSBPL2 cause hearing loss associated with primary
            cilia defects via sonic hedgehog signaling
  JOURNAL   JCI Insight 7 (4), e149626 (2022)
   PUBMED   35041619
  REMARK    GeneRIF: Mutations in OSBPL2 cause hearing loss associated with
            primary cilia defects via sonic hedgehog signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2807)
  AUTHORS   Thoenes,M., Zimmermann,U., Ebermann,I., Ptok,M., Lewis,M.A.,
            Thiele,H., Morlot,S., Hess,M.M., Gal,A., Eisenberger,T.,
            Bergmann,C., Nurnberg,G., Nurnberg,P., Steel,K.P., Knipper,M. and
            Bolz,H.J.
  TITLE     OSBPL2 encodes a protein of inner and outer hair cell stereocilia
            and is mutated in autosomal dominant hearing loss (DFNA67)
  JOURNAL   Orphanet J Rare Dis 10, 15 (2015)
   PUBMED   25759012
  REMARK    GeneRIF: The regulation of OSBPL2 by Mir96 was investigated in
            Mir96 mutant mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2807)
  AUTHORS   Al-Shami,A., Jhaver,K.G., Vogel,P., Wilkins,C., Humphries,J.,
            Davis,J.J., Xu,N., Potter,D.G., Gerhardt,B., Mullinax,R.,
            Shirley,C.R., Anderson,S.J. and Oravecz,T.
  TITLE     Regulators of the proteasome pathway, Uch37 and Rpn13, play
            distinct roles in mouse development
  JOURNAL   PLoS One 5 (10), e13654 (2010)
   PUBMED   21048919
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2807)
  AUTHORS   Anniss,A.M., Apostolopoulos,J., Dworkin,S., Purton,L.E. and
            Sparrow,R.L.
  TITLE     An oxysterol-binding protein family identified in the mouse
  JOURNAL   DNA Cell Biol 21 (8), 571-580 (2002)
   PUBMED   12215260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672130.14 and AL663027.9.
            
            On Apr 26, 2018 this sequence version replaced NM_144500.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170669.1, AK145292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AL672130.14        49123-49286
            165-298             AL663027.9         7897-8030
            299-443             AL663027.9         9131-9275
            444-519             AL663027.9         12023-12098
            520-654             AL663027.9         15750-15884
            655-752             AL663027.9         16007-16104
            753-935             AL663027.9         19344-19526
            936-1043            AL663027.9         21097-21204
            1044-1133           AL663027.9         21934-22023
            1134-1257           AL663027.9         24117-24240
            1258-1398           AL663027.9         26185-26325
            1399-1522           AL663027.9         28747-28870
            1523-1613           AL663027.9         29947-30037
            1614-2807           AL663027.9         32407-33600
FEATURES             Location/Qualifiers
     source          1..2807
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 102.64 cM"
     gene            1..2807
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /note="oxysterol binding protein-like 2"
                     /db_xref="GeneID:228983"
                     /db_xref="MGI:MGI:2442832"
     exon            1..164
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            165..298
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..443
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            444..519
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..654
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..752
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..935
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1043
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1133
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1257
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1398
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1522
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1613
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..2807
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2785..2790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /note="hexamer: ATTAAA"
     polyA_site      2807
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /note="major polyA site"
ORIGIN      
        1 ggcggctgac ggacggcgcg gggcgcggcg agcggcgagc agcacggcgg gctgtaggtc
       61 ggagaggcgc gggccgcact tccgcttggg tgtcagaggg ttgccggctg cggtcggggg
      121 cggggcggcc gtggggtcgg cgactccgcg gggaccgcgt tcggatttcc aggatccaca
      181 caacttcaac ataaatatag atcagatatg atccagtagg aggaccaaac cccagaacag
      241 tgacagtctt gtcactgaag gatgaacggg gaggaagaat tctttgatgc cgtcacaggc
      301 tttgattctg ataattcttc tataggggaa ttttcagagg caaataaaat tagtgggatg
      361 attgacttgg ataccagcaa aagtactagg agtgggaaaa atggggagaa accacaacaa
      421 gagaatggaa ttcaaaagca caggacagcc cttcctgctc ccatgttcac cagaagcgac
      481 ttcagtgtgt ggagtatcct gaagaaatgc attggcttgg aactctccaa gatcacaatg
      541 ccaattgcct tcaatgagcc actgagcttc ctgcagcgga tcacagagta catggagcat
      601 gtgtacctca ttcacaaagc ctcaagtcag tcccagccgc tggagagaat gcagtctgtc
      661 gctgcctttg cggtctcagc tgtggcttcc cagtgggaga gaactggcaa accctttaac
      721 ccactcttgg gagagacata tgagttgatc agggaagact tagggttcag atttatatct
      781 gagcaggtca gtcaccaccc tcctattagc gcattttatt cagaaggtct caatcaagac
      841 ttcaggttcc acggttccat ctacccaaag ctgaagttct ggggcaagag tgtggaggcg
      901 gagccccggg ggaccatcac actggagctg ctcaaacata atgaagccta tacctggacc
      961 aaccctacct gctgtgtaca caatgtcatc cttgggcagc tatggataga gcagtatggg
     1021 atagtggaga ttgtaaatca cagaactgga gataagtgta tacttcactt caagccttgt
     1081 ggattgtttg ggaaggaact tcacagagta gaagggtaca ttcaagacaa aaacaggaag
     1141 aagctcttta tcatgtatgg caagtggaca gagtgcttgt ggggaataga tcctgcttca
     1201 tacgagtcct ttaagaagca agagaagaga ggtgaccagg ccaggaaggc caagatggat
     1261 gatggccccg agaaagctaa cagtgatgtg cctggtgatg tggcagacga cgttcctgtg
     1321 gctcaggaga cggtgcaagt catccccggc agcaagctgc tctggaggat caacagccgg
     1381 ccccccaact ctgctcagat gtacaacttt accagcttca ctgtgagtct caatgagttg
     1441 gagtcaggca tggagaagac tctgccaccc acagactgcc gcctccgtcc tgacatacga
     1501 ggcatggaga acggaaacat ggatctggcc agccaggaga aggagcggct agaggaaaag
     1561 cagagagagg ccagaaaaga gcgtgccaaa gaggacgcag agtggcggac caggtggttc
     1621 tctccaggca ataaccccta cacaggagct cctgactggc tgtacgccgg ccattacttt
     1681 gagcgtaact tctcagactg cccagacata tactaaggcc tgtgagccca ggagcagcct
     1741 tggaatcctc aaatagcatc tgagctttat ggtggcagac accacaaatc atggagatag
     1801 cctcggacgt gacagaggcc ctcagagagc ctcagattgc ccagtgcgtc actatgttgc
     1861 agccccttca tgaagctcca gttgggtctt tctagtcact gaggcctcag aactccacag
     1921 tcctttccta gatgacagag tgtaaaaggc cagcagagct ggcagcacac tctgttataa
     1981 aatgtataat gaaggaagac ccagcagggc ctgtgtgttc cactcaaggc tgtggcgtgg
     2041 gttctggaag actttcaaac tcagacccaa ggaggagggg agcatggatc ctggaagtgt
     2101 cctgtggcca gggtcccctt ctttgtggaa tgaagtgaca agcctccaga ttctgtattt
     2161 tctaccaatc ttgaataagg taaagatgac tttagaaaat atttaaattg aaactacttg
     2221 aattatctgc taaagtgcag caaacacata atcaccactg tgtaccgtcc aaacaaagtg
     2281 tccccgtgcc aagccagagt ggcaggaaca ctgtgactta gatgaggaac ccccagggcc
     2341 gctccagcct cgaaggccct gcctcatcca cagcgctcca tagcttcact gtcactgtgg
     2401 accacacctg tctctaaggt catttcttca ctcacctcgc ctgtgtgccc tccctgctcc
     2461 cccaaagtct tgtgttcggt tccccagtgt gcatgtttca gtccaggcaa gttacattcg
     2521 gttgtgtgca atagaaggtc agaagcaaga tcttacctgg tgtcattaaa attgttttaa
     2581 cacaagtagg tgtgtccacc tctgcattcc tgtcacatga tggactttat gtaaaaatgg
     2641 tgacaccaag gctcacagtg gagctctttg catcaaagat aatctactgt gtacacacct
     2701 gtgcattcat agtgtgagtc acaccaggca tttgtaaatg agaaggtatg atcactatgt
     2761 ccaggcttcc aaactgcctc tgtcattaaa acactttgaa aatccaa
//
