LOCUS       NP_653083                484 aa            linear   ROD 05-JUN-2024
DEFINITION  oxysterol-binding protein-related protein 2 [Mus musculus].
ACCESSION   NP_653083
VERSION     NP_653083.2
DBSOURCE    REFSEQ: accession NM_144500.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 484)
  AUTHORS   Weber-Boyvat,M., Kroll,J., Trimbuch,T., Olkkonen,V.M. and
            Rosenmund,C.
  TITLE     The lipid transporter ORP2 regulates synaptic neurotransmitter
            release via two distinct mechanisms
  JOURNAL   Cell Rep 41 (13), 111882 (2022)
   PUBMED   36577376
  REMARK    GeneRIF: The lipid transporter ORP2 regulates synaptic
            neurotransmitter release via two distinct mechanisms.
REFERENCE   2  (residues 1 to 484)
  AUTHORS   Koh,Y.I., Oh,K.S., Kim,J.A., Noh,B., Choi,H.J., Joo,S.Y., Rim,J.H.,
            Kim,H.Y., Kim,D.Y., Yu,S., Kim,D.H., Lee,S.G., Jung,J., Choi,J.Y.
            and Gee,H.Y.
  TITLE     OSBPL2 mutations impair autophagy and lead to hearing loss,
            potentially remedied by rapamycin
  JOURNAL   Autophagy 18 (11), 2593-2614 (2022)
   PUBMED   35253614
  REMARK    GeneRIF: OSBPL2 mutations impair autophagy and lead to hearing
            loss, potentially remedied by rapamycin.
REFERENCE   3  (residues 1 to 484)
  AUTHORS   Shi,H., Wang,H., Zhang,C., Lu,Y., Yao,J., Chen,Z., Xing,G., Wei,Q.
            and Cao,X.
  TITLE     Mutations in OSBPL2 cause hearing loss associated with primary
            cilia defects via sonic hedgehog signaling
  JOURNAL   JCI Insight 7 (4), e149626 (2022)
   PUBMED   35041619
  REMARK    GeneRIF: Mutations in OSBPL2 cause hearing loss associated with
            primary cilia defects via sonic hedgehog signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 484)
  AUTHORS   Thoenes,M., Zimmermann,U., Ebermann,I., Ptok,M., Lewis,M.A.,
            Thiele,H., Morlot,S., Hess,M.M., Gal,A., Eisenberger,T.,
            Bergmann,C., Nurnberg,G., Nurnberg,P., Steel,K.P., Knipper,M. and
            Bolz,H.J.
  TITLE     OSBPL2 encodes a protein of inner and outer hair cell stereocilia
            and is mutated in autosomal dominant hearing loss (DFNA67)
  JOURNAL   Orphanet J Rare Dis 10, 15 (2015)
   PUBMED   25759012
  REMARK    GeneRIF: The regulation of OSBPL2 by Mir96 was investigated in
            Mir96 mutant mice.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 484)
  AUTHORS   Al-Shami,A., Jhaver,K.G., Vogel,P., Wilkins,C., Humphries,J.,
            Davis,J.J., Xu,N., Potter,D.G., Gerhardt,B., Mullinax,R.,
            Shirley,C.R., Anderson,S.J. and Oravecz,T.
  TITLE     Regulators of the proteasome pathway, Uch37 and Rpn13, play
            distinct roles in mouse development
  JOURNAL   PLoS One 5 (10), e13654 (2010)
   PUBMED   21048919
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 484)
  AUTHORS   Anniss,A.M., Apostolopoulos,J., Dworkin,S., Purton,L.E. and
            Sparrow,R.L.
  TITLE     An oxysterol-binding protein family identified in the mouse
  JOURNAL   DNA Cell Biol 21 (8), 571-580 (2002)
   PUBMED   12215260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672130.14 and AL663027.9.
            
            On Jul 23, 2006 this sequence version replaced NP_653083.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170669.1, AK145292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 102.64 cM"
     Protein         1..484
                     /product="oxysterol-binding protein-related protein 2"
                     /note="OSBP-related protein 2"
                     /calculated_mol_wt=55254
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1P3; propagated from
                     UniProtKB/Swiss-Prot (Q8BX94.1)"
     Site            20
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1P3; propagated from
                     UniProtKB/Swiss-Prot (Q8BX94.1)"
     Region          35..61
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX94.1)"
     Region          75..475
                     /region_name="Oxysterol_BP"
                     /note="Oxysterol-binding protein; pfam01237"
                     /db_xref="CDD:460126"
     Region          319..348
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX94.1)"
     Region          423..454
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX94.1)"
     CDS             1..484
                     /gene="Osbpl2"
                     /gene_synonym="C130070J12Rik; ORP-2; Orp2"
                     /coded_by="NM_144500.4:262..1716"
                     /db_xref="CCDS:CCDS17170.1"
                     /db_xref="GeneID:228983"
                     /db_xref="MGI:MGI:2442832"
ORIGIN      
        1 mngeeeffda vtgfdsdnss igefseanki sgmidldtsk strsgkngek pqqengiqkh
       61 rtalpapmft rsdfsvwsil kkciglelsk itmpiafnep lsflqritey mehvylihka
      121 ssqsqplerm qsvaafavsa vasqwertgk pfnpllgety eliredlgfr fiseqvshhp
      181 pisafysegl nqdfrfhgsi ypklkfwgks veaeprgtit lellkhneay twtnptccvh
      241 nvilgqlwie qygiveivnh rtgdkcilhf kpcglfgkel hrvegyiqdk nrkklfimyg
      301 kwteclwgid pasyesfkkq ekrgdqarka kmddgpekan sdvpgdvadd vpvaqetvqv
      361 ipgskllwri nsrppnsaqm ynftsftvsl nelesgmekt lpptdcrlrp dirgmengnm
      421 dlasqekerl eekqrearke rakedaewrt rwfspgnnpy tgapdwlyag hyfernfsdc
      481 pdiy
//
