LOCUS       NM_207530               3958 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus oxysterol binding protein-like 1A (Osbpl1a),
            transcript variant 1, mRNA.
ACCESSION   NM_207530 XM_283516
VERSION     NM_207530.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3958)
  AUTHORS   Courtney,S.C., Di,H., Stockman,B.M., Liu,H., Scherbik,S.V. and
            Brinton,M.A.
  TITLE     Identification of novel host cell binding partners of Oas1b, the
            protein conferring resistance to flavivirus-induced disease in mice
  JOURNAL   J Virol 86 (15), 7953-7963 (2012)
   PUBMED   22623793
REFERENCE   2  (bases 1 to 3958)
  AUTHORS   Vihervaara,T., Uronen,R.L., Wohlfahrt,G., Bjorkhem,I., Ikonen,E.
            and Olkkonen,V.M.
  TITLE     Sterol binding by OSBP-related protein 1L regulates late endosome
            motility and function
  JOURNAL   Cell Mol Life Sci 68 (3), 537-551 (2011)
   PUBMED   20690035
  REMARK    GeneRIF: Osbpl1a silencing in macrophage foam cells enhances
            endosome motility and results in inhibition of [(3)H]cholesterol
            efflux to apolipoprotein A-I.
REFERENCE   3  (bases 1 to 3958)
  AUTHORS   Yan,D., Lehto,M., Rasilainen,L., Metso,J., Ehnholm,C.,
            Yla-Herttuala,S., Jauhiainen,M. and Olkkonen,V.M.
  TITLE     Oxysterol binding protein induces upregulation of SREBP-1c and
            enhances hepatic lipogenesis
  JOURNAL   Arterioscler Thromb Vasc Biol 27 (5), 1108-1114 (2007)
   PUBMED   17303778
  REMARK    GeneRIF: OSBP regulates hepatic TG metabolism and suggest the
            involvement of OSBP in the insulin signaling pathways that control
            hepatic lipogenesis.
REFERENCE   4  (bases 1 to 3958)
  AUTHORS   Okamura,K., Yamada,Y., Sakaki,Y. and Ito,T.
  TITLE     An evolutionary scenario for genomic imprinting of Impact lying
            between nonimprinted neighbors
  JOURNAL   DNA Res 11 (6), 381-390 (2004)
   PUBMED   15871461
REFERENCE   5  (bases 1 to 3958)
  AUTHORS   Funatsu,N., Inoue,T. and Nakamura,S.
  TITLE     Gene expression analysis of the late embryonic mouse cerebral
            cortex using DNA microarray: identification of several region- and
            layer-specific genes
  JOURNAL   Cereb Cortex 14 (9), 1031-1044 (2004)
   PUBMED   15142957
REFERENCE   6  (bases 1 to 3958)
  AUTHORS   Anniss,A.M., Apostolopoulos,J., Dworkin,S., Purton,L.E. and
            Sparrow,R.L.
  TITLE     An oxysterol-binding protein family identified in the mouse
  JOURNAL   DNA Cell Biol 21 (8), 571-580 (2002)
   PUBMED   12215260
REFERENCE   7  (bases 1 to 3958)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131672.3, AY536214.1, BC076637.1 and BG092905.1.
            
            On Nov 16, 2011 this sequence version replaced NM_207530.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY536214.1, SRR1660819.141775.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC131672.3         173132-173252
            122-3242            AY536214.1         1-3121
            3243-3666           BC076637.1         1988-2411
            3667-3958           BG092905.1         1-292               c
FEATURES             Location/Qualifiers
     source          1..3958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 6.78 cM"
     gene            1..3958
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /note="oxysterol binding protein-like 1A"
                     /db_xref="GeneID:64291"
                     /db_xref="MGI:MGI:1927551"
     exon            1..210
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            211..333
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..3065
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     oxysterol-binding protein-related protein 1; OSBP-related
                     protein 1"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 1
                     isoform 1"
                     /protein_id="NP_997413.2"
                     /db_xref="CCDS:CCDS29067.1"
                     /db_xref="GeneID:64291"
                     /db_xref="MGI:MGI:1927551"
                     /translation="MNTEAEQQLLHHARNGNAEEVRKLLAAMARMEVVADIDCKGRSK
                     SNLGWTPLHLACYFGHKQVVEDLLKAGAKVNMLNDMGDTPLHRAAFTGRKELVLLLLE
                     YDADSTVVNGSGQTAKEATHDKEIRNMLEAVERTQQRKLEELLLGAAREGRTAEVSAL
                     LSRPNPPDVNCSDQLGNTPLHCAAYRAHKQCVLKLLRSGADPSLKNKNDQKPLDLAQG
                     AEMKHILVGNKVVHKALKRYEGPLWKSSRFFGWKLFWVVLEHGVLSWYRKQPDAVHNS
                     YRQGCKHLTQAVCTVKPTDSCLFSIRCFDDTVHCFRVPKNSVQQSREKWLEAIEEHSA
                     YSTHYCSQDQVTDDEEEDVVSAMDLKESLARAQTCQQRLDREIYNFLKMIKECDVAKD
                     MLPSFLQKADIVSEASRETCVALNDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETL
                     ATEHHELERSLVEGSPPVSILSEEEFYDALSGSESEGSLTCLEAVTAHSFEENEVPGS
                     SGKHRMSEGKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITM
                     PVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKP
                     FNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGK
                     SVEAEPKGTITLELLDHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCV
                     LNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNT
                     EEKKNSKQTSSSEESDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVL
                     NEVDKEMESVIPKTDCRLRPDIRAMENGEIDLASEEKKRLEEKQRAARKNRSKSEEDW
                     KTRWFHQGPNPYSGAQDWIYSGSYWDRNYFNLPDIY"
     exon            334..419
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            420..494
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            495..606
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            607..692
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            693..837
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            838..899
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            900..944
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1018
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1082
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1181
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1304
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1386
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1493
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1656
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1813
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1889
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2024
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2122
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2305
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2413
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2503
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2630
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2747
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2871
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..2962
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3958
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3061..3066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /note="hexamer: ATTAAA"
     polyA_site      3081
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /note="major polyA site"
     regulatory      3098..3103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
                     /note="hexamer: AATAAG"
     polyA_site      3115
                     /gene="Osbpl1a"
                     /gene_synonym="G430090F17Rik; Gm753; ORP-1; Osbpl1b"
ORIGIN      
        1 cgtgctgagc tcggcgccaa catttctggc gcgcgcgttc ccggggccct ccttgctcct
       61 gacccgcgga tccttgggtt ccgcctggtt ccctttcggg atacccgggg cgtcctcgtg
      121 agagcggccc gcgtgggtga cggccgctca gtgggcgcgg ccgggcctgt ggtggaggcc
      181 gcctcaggag ccgggcccgc gagcacgcag aaatgaacac agaagcagaa cagcagcttc
      241 tccatcatgc cagaaatggc aatgctgaag aggtgcgaaa gctgctggca gccatggcac
      301 ggatggaagt ggtcgctgac atcgactgta aaggaagaag taagtctaac ttgggctgga
      361 cacctcttca cctggcatgc tattttggac acaaacaagt ggtcgaggat ctgttgaagg
      421 ctggtgcaaa agtgaacatg ttaaacgaca tgggggacac gccactgcat cgagccgcct
      481 tcacaggacg aaaggagctg gtcttgcttc ttttagaata cgatgctgac agtacagttg
      541 taaatggaag tggacagaca gcaaaagaag ccacccatga caaagaaatc agaaacatgc
      601 ttgaagctgt ggagaggact caacaaagaa agcttgaaga attgctttta ggagcagcta
      661 gagaaggaag aacagccgaa gtatcagctc tgctcagcag gcccaatcct cctgatgtga
      721 actgctcaga tcagctagga aataccccct tacactgtgc cgcctaccgg gcccacaagc
      781 agtgtgtcct aaagctcctg agaagcggag ctgaccccag cctgaagaac aagaacgatc
      841 agaaacctct tgaccttgcc cagggtgctg aaatgaagca tattcttgtt ggtaataagg
      901 ttgtccacaa agcactgaaa cgctacgaag gccctctctg gaagagttca agattttttg
      961 gctggaagtt attttgggta gtgttagaac atggagtcct ttcctggtat aggaagcagc
     1021 ctgatgcagt ccataattct tatcgccaag gatgcaaaca cctgactcaa gccgtgtgca
     1081 cggtgaaacc tacagatagc tgcctcttct ccattcgatg ctttgatgac actgttcact
     1141 gcttcagggt tcctaagaac agcgtacagc aatcaagaga gaagtggctg gaagcaattg
     1201 aagaacactc cgcatacagc actcactact gttcccagga tcaggtgact gatgatgaag
     1261 aagaagatgt agtttcggcc atggacttga aggagtcgtt agcgagagca caaacatgtc
     1321 aacagagact agatagggaa atttacaact ttctcaaaat gattaaggag tgtgatgtgg
     1381 ccaaagatat gcttccatcg tttcttcaga aagctgatat tgtctccgaa gcttctagag
     1441 agacttgtgt ggcgttgaat gactgtctta atctcttcac taaacaggaa ggggtgagga
     1501 attttaaatt ggaacaggag caagaaaaaa acaaaatttt gtcagaagca ctggagactt
     1561 tagccactga gcatcatgaa ctagaacgat ccctggttga aggatccccg cctgtcagca
     1621 tccttagtga ggaggagttc tatgatgcac tgtcaggttc cgagtccgag gggtcgctga
     1681 cttgcctgga agctgtgaca gcacactcct ttgaagagaa cgaagtgcct gggagcagcg
     1741 gaaagcacag aatgtctgaa ggaaaagact gtggtggggg agatgcgctc tccaatggca
     1801 tcaaaaagca cagaacaagc ctgccatcac ctatgttctc cagaaacgat ttcagcatct
     1861 ggagcatcct cagaaaatgc attgggatgg aactgtccaa gatcacaatg ccagtgatat
     1921 ttaatgagcc tctgagcttc ctgcagcggc taactgaata catggagcac acgtacctca
     1981 tccacaaagc cagttcactt tctgatcctg tggaaaggat gcagtgtgtg gctgcatttg
     2041 ctgtgtctgc tgtcgcctct cagtgggagc gcaccggaaa gcccttcaac ccgcttctgg
     2101 gagagactta tgaattagtt cgagatgacc ttgggtttag gctcatctca gaacaggtca
     2161 gccatcatcc cccaatcagt gcattccatg cagaagggct caacaatgac ttcatcttcc
     2221 atggctcaat ttaccccaaa ctgaagttct ggggcaagag tgtagaagca gagcctaaag
     2281 gaaccatcac cttggagctt ttagaccaca acgaagcata cacatggaca aaccccacct
     2341 gttgtgtgca taacatcatc gtgggcaagc tctggattga acagtatggc aacgtggaaa
     2401 tcataaacca caagactggg gacaaatgtg tgctgaattt taagccatgt ggtctttttg
     2461 gcaaggaatt acacaaagtt gaaggctaca tacaagataa aagcaaaaag aagctctgtg
     2521 ctctctatgg gaagtggact gagtgcttgt acagcgtaga ccctgccact tttgatgctt
     2581 acaaaaaaaa tgataagaaa aacacagaag agaagaagaa cagcaaacag acaagctcat
     2641 ctgaggagtc tgatgaaatg ccagtgccag attccgagag cgtattcatt atccctggaa
     2701 gtgtgctcct gtggcggata gccccgcggc ctcccaactc tgctcagatg tataacttta
     2761 ccagctttgc catggttttg aatgaagtcg acaaggagat ggagagtgtg attcccaaga
     2821 ctgactgcag gctacggcct gacatcagag ccatggagaa cggagagata gatctagcta
     2881 gtgaagaaaa gaaacggctt gaggaaaagc aaagagcagc ccgcaagaac aggtccaagt
     2941 cggaagagga ctggaagaca aggtggttcc atcaaggtcc taacccctac agtggagcac
     3001 aggactggat ttattctggc agctactggg acagaaacta cttcaatttg cctgatattt
     3061 attaaagtac agagaagtca aggtgtttgc taatctaaat aagtcttaag cttaagattt
     3121 ttaaatgttt ttccttggtt tctactcctc tataatttgc gtttcaccca atagggcaag
     3181 gcatctggta cagtggggat gacctgaaag agaagaggca gtgctgtgcc acagctgccc
     3241 ccttggagcc ctgctcatgg ccagtgagaa gctgttggct gcagctccta tccccacact
     3301 gtaatactca gctctatgga attctatagt gatccaaaaa tcaagttatt ttgaatattt
     3361 ttatgctata atgcttaaat attttaggtg tagctttgaa atgtttagaa ttcttctgta
     3421 caatgttacg tgttcaaatg tagagattat cattttacaa aaactaaatt ggtaagatgg
     3481 ccttttaggg aaattaatcc tctcaacctc actttccttc ctcctagaga gggggcagaa
     3541 ttcctgatct gaaaattcta aactggaaca ggtatttatt atcttagtgc tcggaattta
     3601 cgttcacatc ttgttattag actttacagg gttaacttgt aacaaaaatg ccctaaaaat
     3661 agattttaat caatattatc taatgacaca ccttttagcc tcaacttcca gtggcaaatg
     3721 ccacagagaa attaagctgc actcatgtat tgcaaggtac tggagaccta ctgtacagta
     3781 gctttcccca ttcattgggg caatctcata gtatttatcc aaccaaacca gactgagata
     3841 cttgccctaa agagccttag gtagcttcca gtaagttatg ttgtcttgaa gttaacaagt
     3901 gttatgatgc taaataaagg ctttagaata tcaaataaaa aagtgtgaat gctttcag
//
