LOCUS       NM_176840               4521 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus oxysterol binding protein-like 11 (Osbpl11), mRNA.
ACCESSION   NM_176840
VERSION     NM_176840.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4521)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4521)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4521)
  AUTHORS   Arnal-Levron,M., Chen,Y., Greimel,P., Calevro,F., Gaget,K.,
            Riols,F., Batut,A., Bertrand-Michel,J., Hullin-Matsuda,F.,
            Olkkonen,V.M., Delton,I. and Luquain-Costaz,C.
  TITLE     Bis(monoacylglycero)phosphate regulates oxysterol binding
            protein-related protein 11 dependent sterol trafficking
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1864 (9), 1247-1257
            (2019)
   PUBMED   31136841
  REMARK    GeneRIF: ORP-11 knockdown abrogated the protective action of
            Bis(Monoacylglycero) Phosphate against oxidized low density
            lipoprotein induced apoptosis.
REFERENCE   4  (bases 1 to 4521)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   5  (bases 1 to 4521)
  AUTHORS   Anniss,A.M., Apostolopoulos,J., Dworkin,S., Purton,L.E. and
            Sparrow,R.L.
  TITLE     An oxysterol-binding protein family identified in the mouse
  JOURNAL   DNA Cell Biol 21 (8), 571-580 (2002)
   PUBMED   12215260
REFERENCE   6  (bases 1 to 4521)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 4521)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124195.4 and AC145198.3.
            
            On Sep 3, 2009 this sequence version replaced NM_176840.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035278.1, ERR3363658.5183092.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-930               AC124195.4         26719-27648         c
            931-999             AC124195.4         16577-16645         c
            1000-1175           AC124195.4         7872-8047           c
            1176-1255           AC124195.4         6717-6796           c
            1256-1432           AC124195.4         2617-2793           c
            1433-1634           AC145198.3         133101-133302       c
            1635-1780           AC145198.3         130785-130930       c
            1781-1921           AC145198.3         122964-123104       c
            1922-2420           AC145198.3         120289-120787       c
            2421-2607           AC145198.3         118496-118682       c
            2608-2790           AC145198.3         113039-113221       c
            2791-2944           AC145198.3         111236-111389       c
            2945-4521           AC145198.3         104332-105908       c
FEATURES             Location/Qualifiers
     source          1..4521
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 23.71 cM"
     gene            1..4521
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /note="oxysterol binding protein-like 11"
                     /db_xref="GeneID:106326"
                     /db_xref="MGI:MGI:2146553"
     exon            1..930
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             734..3007
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /note="OSBP-related protein 11"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 11"
                     /protein_id="NP_789810.2"
                     /db_xref="CCDS:CCDS28128.1"
                     /db_xref="GeneID:106326"
                     /db_xref="MGI:MGI:2146553"
                     /translation="MNFGVKMQGGEPASVMKVSESEGKLEGLATAVTPNKNSGNSSCG
                     GAISSSSSNSSRGGSAKGWQYSDHMESVNGYLMKYTNLVTGWQYRFFVLNNEAGLLEY
                     FVNEQSRNQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSR
                     LQICTQHHTEAIGKNNPPLKSRSFSLASSGNSPISQRRPSQNAMSFFNVGHSKLQSVN
                     KRAHLHPDHLVEVREMMSHAEGQQRDLIRRIECLPASGLLSSLDQDLLMLKATSMATM
                     NCLNDCFHILQLQHASHQKGALPSGTTIEWLEPKIPLSNHYKNGAEQPFATEPNKPMG
                     APEAQCVAESGVLAREPEDINADDEVEDTCDNKEDDLGAVEEQRSVILHLLSQLKLGM
                     DLTRVVLPTFILEKRSLLEMYADFMSHPDLFIGITNGATPEDRMIRFVEYYLTSFHEG
                     RKGAIAKKPYNPIIGETFHCSWRMPKSEVASGVSSSSSTPAITDHAPLPEEAPTQSVS
                     DCYTVRFVAEQVSHHPPVSGFYAECAERKMCVNAHVWTKSKFLGMSIGVTMVGEGVLC
                     LLEHGEEYTFSLPCAYARSILTVPWVELGGKVSVNCAKTGYSASITFHTKPFYGGKLH
                     RVTAEVKYNLTNTVVCRVQGEWNSVLEFTYSNGETKFVDLAKLAVTKKRVRPLEKQDP
                     FESRRLWKNVTDSLRESEIDKATEHKRSLEERQRTEERLRTETGTPWKTKYFIKEGDG
                     WVYHKPLWKGIPSQPAE"
     exon            931..999
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1175
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1255
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1432
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1634
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1780
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1921
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2420
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2607
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2790
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2944
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..4521
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4380..4385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /note="hexamer: ATTAAA"
     polyA_site      4404
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /note="major polyA site"
     regulatory      4502..4507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /note="hexamer: AATAAA"
     polyA_site      4521
                     /gene="Osbpl11"
                     /gene_synonym="9430097N02Rik; ORP-11"
                     /note="major polyA site"
ORIGIN      
        1 gctagcaggc gggtgggtga ccggctgtgg gtggggcggc ggcccgggcc ctggctctgg
       61 cttttacgtt tagggctaag gaagctccag ggagcggtcg gctcctgtga actccgtggg
      121 gctccagggc tagcgctctc ggaggaggcc acggtgaacc cctcgcctcc ggcccaagct
      181 cagcggcctc ggagcccgcg tcctgcccgg cggcgtctgc ccgaccctcc gcgggcttcg
      241 cgcgaccgct ccggctcagt tcggggctgc ggtgggaacc gcggagctgg ctggacaggg
      301 ccctttctcc cgaggacccg gctgaggaga agaagcggcg cggctggccc gacccccgag
      361 tcctgaggtc aggccgtggg ctccggggct cccgggccgt ggaccccgtc cttgccccgc
      421 gttcccaggc agaggatccg cgacctcgcc cgcgccgccc ggctgctcct cggagtgtgg
      481 caccgagccc tctggcgggg tgatttgtcc tccttgttct tgctcgggag aggcatctat
      541 ctgaagggta cccgtgctct ttaaaacttt taaccaaagt ggaaatgcgt gtcctctttt
      601 tctggaccac tgtcgatttc cactctagcc gaggtctgag atcccgttga gagtaaaaaa
      661 acgagagaga gaaaggggga aaagtactta caaaataact ctgcacttgg tgtccctcgc
      721 ccgagaaggg cagatgaact ttggagttaa gatgcaggga ggtgagccgg catcggtgat
      781 gaaagtctcc gagagtgaag ggaagctgga gggcttggcc acagcagtga ccccgaacaa
      841 gaacagcggc aacagcagct gtgggggtgc catcagcagt agcagcagca acagcagccg
      901 cggtggcagt gcgaaaggct ggcagtacag tgaccacatg gagagtgtta atggctattt
      961 aatgaagtac accaaccttg tcaccgggtg gcagtacagg ttttttgttt taaacaatga
     1021 agctgggctg ttggagtact ttgtaaatga acagtctaga aatcagaaac ccagagggac
     1081 tttgcagctt gcgggggccg tgatctctcc cagcgatgag gactcgcaca ccttcacagt
     1141 gaatgccgcc agcggggagc agtataaact cagagccaca gatgctaaag agcggcagca
     1201 ttgggtgagc agacttcaga tatgtacaca gcaccacacg gaagctattg gaaagaataa
     1261 ccctcccctg aagtcccgga gcttctcgct ggcatctagt ggtaattctc ccatatccca
     1321 gcggagacca agtcagaatg ccatgtcttt ttttaatgtt ggacattcca aactgcagtc
     1381 agtcaacaaa agagcccatt tgcatccaga ccatctggtg gaggtcagag aaatgatgtc
     1441 tcatgcggaa ggacaacaac gagacctaat tagacggatc gaatgccttc ctgcttctgg
     1501 ccttctcagt tccttggacc aggacctctt gatgcttaaa gctacttcca tggcaactat
     1561 gaactgctta aatgactgct ttcacattct gcagctgcag catgcctcac accagaaggg
     1621 tgcactgccc tcagggacaa caattgaatg gttggaacca aagattcctt tatcaaacca
     1681 ctataaaaat ggagctgagc agccctttgc aacggagccg aacaagccca tgggagcccc
     1741 ggaagcgcag tgcgttgcag agtctggagt attagccagg gaacctgaag acatcaatgc
     1801 agatgatgag gtagaggaca cctgtgacaa caaggaggat gacctggggg ccgtggagga
     1861 gcagcgcagt gtcatcctgc accttctgtc acagctcaag ctgggcatgg acttaaccag
     1921 agtggtgctt cctacgttta tcctggagaa gcgttcctta ctggagatgt acgcagattt
     1981 catgtcgcat ccagacctgt tcataggcat caccaatgga gccacgccag aggaccgaat
     2041 gattcgattt gttgagtact accttacctc atttcatgaa ggcagaaagg gagccattgc
     2101 taagaagccg tacaacccta tcattggaga aactttccac tgctcctgga ggatgcctaa
     2161 gagcgaagtg gcatctggtg tgagcagcag ctcttctacc ccagccatca ctgatcatgc
     2221 tcctctgccg gaggaggctc cgacccagag tgtctcagac tgctacactg tcagattcgt
     2281 tgctgagcag gtttcccatc atcctccagt ctcaggattt tatgcagaat gtgcagaaag
     2341 gaagatgtgt gtaaatgcac atgtctggac taaaagcaag ttcttgggca tgtcaatagg
     2401 tgtgacaatg gttggagaag gtgtcctttg tctgttggag cacggagagg agtacacatt
     2461 ttctctgcct tgtgcatatg cccgttccat tctcactgtc ccgtgggtag aactaggggg
     2521 caaagtcagc gtcaactgtg caaagacggg atactcagcc agcatcacct ttcatactaa
     2581 gccgttctat ggtggcaaac tgcaccgagt cacagctgaa gtgaaataca accttaccaa
     2641 cactgtggtg tgcagagtcc agggggaatg gaacagcgtt ctggagttca cctacagcaa
     2701 cggagagacc aagtttgtgg acctggctaa actggccgtg acaaagaaaa gagtgaggcc
     2761 tctggagaag caggatccct tcgaatccag gcgattatgg aaaaatgtaa cagattctct
     2821 gagggaatct gaaattgaca aggccacaga gcacaaacgt tccctggaag aacgccagag
     2881 aacagaagaa aggctgcgga ctgaaacagg cacaccctgg aaaaccaaat attttattaa
     2941 agagggagat ggctgggtgt atcacaaacc cctgtggaaa ggaattccat cacaaccagc
     3001 tgagtgacac acgctttcta agactggaca aacgaggttc tcctctgtgt accccaagcc
     3061 ctctcagatg gagtctttgc actgagtgac ctgtttgcta actgtacagc ctgaacacga
     3121 atgtccctac tgagcccatc cccctgcagc aagaccaaag tgttaaggac agccgatggg
     3181 cctccagcct gctccccaac acgagcagtg ccatctcaga gccttccacc taccggttcc
     3241 tgcgtcatct gatctgctct gaacgctgct caagcctctg gtgttttcgg gggcaacaga
     3301 tgacagcaga gagaactcaa tgacttgggt tcctgtggag tcagaagtaa cgtctcttgc
     3361 agcatctgtg ttgctttctg tccatagctg aagtgttcac tgctcttgta agccagccaa
     3421 gaggaagagg aacgtgacct ccaagtggat tcagccgctg tgcctgaagt cagtgttcac
     3481 acatcactgg gctgttgtac caaggcctct ctcctctgga ggccatgcct gtgtctgagg
     3541 aaggccgtca gtgctctgtt ggaactctct tttaaaagtg tatttataat tagaattgta
     3601 accatggagg aatttttttc ttctgaacat tttaatatac ttgaaaacaa cattgacttg
     3661 aaaaatttca gaacattttt caatacctag ttttattaaa tattatactt aagagacaat
     3721 tttttaaaat gtgttcatgt caatatgaga ttttgggctt tctcaagaac taaggcattt
     3781 aaaaaaatag aaaatattaa gaagaaaact gttacttttc cttacctatt ttcacttgta
     3841 ggttcatatt cagtattatg tgctatcctg agcaagtttg ctttatctga cctctgttca
     3901 ctcaaaagtt aaaacttcaa cctgttcatg tctgtcagta attcaattat gtctgtggct
     3961 gagtacacgt aacatatggt tttattttat ttttcaagga aatgtaaaca ctgaagaaag
     4021 agtatgaact aaaaagcagc aatctgcatt caggtaaaaa ttggtttttt ataggtattt
     4081 tattggggtt gaagaattgc tggcgatgaa cagaatcgtg ctaattatgg ttttcattta
     4141 ttcaagtatt tgctgagcac ccactcgtgg tgctgactct tgttactgca agctacctta
     4201 ctgtccagag tggtgcctta ccctgctcct gcccacgtgg tcttccagtc agtgtgcaaa
     4261 tgcacctggc gctcgctcgt aggccgtgcc aggcggctgc ggctgcgctc tgagaaaccg
     4321 ttctcttagt agggttcata gggtgaaaac agcgacaatg atttttcagc aaattgtaaa
     4381 ttaaaagaat tggtctgtgt tcaaccattt taatgattcc gttttcattt ttgctgtgaa
     4441 gtgcactgaa aaataaattt caaaatgagc tgtcattcat gtgttgggaa aattgaaaaa
     4501 caataaaaat agagaccagc a
//
