LOCUS       NP_690031                908 aa            linear   ROD 27-APR-2025
DEFINITION  oxysterol-binding protein 2 isoform 1 [Mus musculus].
ACCESSION   NP_690031 XP_483975
VERSION     NP_690031.2
DBSOURCE    REFSEQ: accession NM_152818.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 908)
  AUTHORS   Ge,T., Yuan,L., Xu,L., Yang,F., Xu,W., Niu,C., Li,G., Zhou,H. and
            Zheng,Y.
  TITLE     Coiled-coil domain containing 159 is required for spermatid head
            and tail assembly in micedagger
  JOURNAL   Biol Reprod 110 (5), 877-894 (2024)
   PUBMED   38236177
REFERENCE   2  (residues 1 to 908)
  AUTHORS   Udagawa,O., Ito,C., Ogonuki,N., Sato,H., Lee,S., Tripvanuntakul,P.,
            Ichi,I., Uchida,Y., Nishimura,T., Murakami,M., Ogura,A., Inoue,T.,
            Toshimori,K. and Arai,H.
  TITLE     Oligo-astheno-teratozoospermia in mice lacking ORP4, a
            sterol-binding protein in the OSBP-related protein family
  JOURNAL   Genes Cells 19 (1), 13-27 (2014)
   PUBMED   24245814
  REMARK    GeneRIF: ORP4 is essential for the postmeiotic differentiation of
            germ cells
REFERENCE   3  (residues 1 to 908)
  AUTHORS   Anniss,A.M., Apostolopoulos,J., Dworkin,S., Purton,L.E. and
            Sparrow,R.L.
  TITLE     An oxysterol-binding protein family identified in the mouse
  JOURNAL   DNA Cell Biol 21 (8), 571-580 (2002)
   PUBMED   12215260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049816.1 and BC058356.1.
            
            On or before Mar 25, 2005 this sequence version replaced
            XP_483975.1, NP_690031.1.
            
            Summary: The protein encoded by this gene belongs to the
            oxysterol-binding protein-related family of proteins, which are
            defined by a C-terminal sterol domain with a highly conserved
            EQVSHHPP motif. Oxysterols are oxygenated derivatives of
            cholesterol that are involved in mechanisms that include apoptosis,
            cholesterol homeostasis, lipid trafficking and cell
            differentiation. This protein is selectively expressed at high
            levels in the brain and testis. Within the testis, the mRNA is
            localized to postmeiotic germ cells, including spermatids and
            spermatozoa, but is not detectable in somatic cells. Mice
            homozygous mutant for a targeted deletion in this gene do not
            exhibit overt developmental phenotypes but are male sterile.
            Females display normal fertility. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            partial transcripts because no single transcript was available for
            the full length of the gene. The full-length structure is inferred
            from partial transcripts, RNA-seq data and orthologous alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.131757.1,
                                           SRR1660817.3301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..908
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.6 cM"
     Protein         1..908
                     /product="oxysterol-binding protein 2 isoform 1"
                     /calculated_mol_wt=101223
     Region          42..112
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QNQ6.1)"
     Region          182..278
                     /region_name="PH_OSBP_ORP4"
                     /note="Human Oxysterol binding protein and OSBP-related
                     protein 4 Pleckstrin homology (PH) domain; cd13284"
                     /db_xref="CDD:270101"
     Region          279..299
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QNQ6.1)"
     Site            284
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5QNQ6.1)"
     Region          413..445
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QNQ6.1)"
     Region          519..897
                     /region_name="Oxysterol_BP"
                     /note="Oxysterol-binding protein; pfam01237"
                     /db_xref="CDD:460126"
     Region          822..843
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QNQ6.1)"
     CDS             1..908
                     /gene="Osbp2"
                     /gene_synonym="1700095P05Rik; C630001G20Rik; Gm244; ORP-4;
                     OSBPL1"
                     /coded_by="NM_152818.3:37..2763"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS24367.1"
                     /db_xref="GeneID:74309"
                     /db_xref="MGI:MGI:1921559"
ORIGIN      
        1 mgkaaalsrg ggcagrsrgl sslftvvpcl schtaapgmn ssafgsgpas kpqlqpvqap
       61 erellskqvc qpisepasrs epgsqttsvp rpsgvgqese lqglwpgsen gtrsvsiika
      121 spelampspl qstvgslpvt kpesklvpkt qsflrqgqak isvgtpvsgi gvqmvsppld
      181 sykgwllkwt nylkgyqrrw fvlgngllsy yrnqgemaht cratinlast hfetedscgi
      241 llcngartyh lkassevdrq hwitalelak akairvmktq sddsgdddee paapadnsel
      301 hhtlktlslk lndlstcndl iakhgaalqr slneldslki psecgeklkv vneratlfri
      361 tsnaminacr dflelaeths rkwqralnye qeqrvhleet ieqlakqhns lerafcntpg
      421 gpasssksfs egsfltskge nseededtey fdamedstsf itvvteaked rkpesgpgtt
      481 tvdwtsadnv ldgasfmpkn sckvkrrvri pdkpnyslnl wsimkncigr elsripmpvn
      541 fneplsmlqr ltedleyhhl ldkavnctss veqmclvaaf svssysttvh riakpfnpml
      601 getfeldrme dmglrslceq vshhppsaah hvfskhgwsl wqeitiaskf rgkyisimpl
      661 gaihlefqas gnhyvwrkst stvhniivgk lwidqsgdie ivnhktkdrc qlkfvpysyf
      721 skeaarkvtg vvsdsqgkah yvlsgswddq mecskivhss pssdgrqktv yqtlpakllw
      781 rkyplpenae nmyyfselal tlneqedgva ptdsrlrpdq rlmergrwde antekqrlee
      841 kqrlsrrrrl esctagcgge eekesdgyvp lwfekrldpl tgemacmykg gyweakekkd
      901 whmcpnif
//
