LOCUS       NM_001033174            4590 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus oxysterol binding protein (Osbp), mRNA.
ACCESSION   NM_001033174 XM_148904 XM_982920 XM_985687
VERSION     NM_001033174.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4590)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4590)
  AUTHORS   Sobajima,T., Yoshimura,S.I., Maeda,T., Miyata,H., Miyoshi,E. and
            Harada,A.
  TITLE     The Rab11-binding protein RELCH/KIAA1468 controls intracellular
            cholesterol distribution
  JOURNAL   J Cell Biol 217 (5), 1777-1796 (2018)
   PUBMED   29514919
REFERENCE   3  (bases 1 to 4590)
  AUTHORS   Gu,X., Li,A., Liu,S., Lin,L., Xu,S., Zhang,P., Li,S., Li,X.,
            Tian,B., Zhu,X. and Wang,X.
  TITLE     MicroRNA124 Regulated Neurite Elongation by Targeting OSBP
  JOURNAL   Mol Neurobiol 53 (9), 6388-6396 (2016)
   PUBMED   26576957
  REMARK    GeneRIF: OSBP may be a target and downstream effector of miR-124
            for regulating neurite outgrowth and elongation.
REFERENCE   4  (bases 1 to 4590)
  AUTHORS   Vihervaara,T., Kakela,R., Liebisch,G., Tarasov,K., Schmitz,G. and
            Olkkonen,V.M.
  TITLE     Modification of the lipidome in RAW264.7 macrophage subjected to
            stable silencing of oxysterol-binding proteins
  JOURNAL   Biochimie 95 (3), 538-547 (2013)
   PUBMED   22609461
  REMARK    GeneRIF: roles of different ORP proteins as regulators of
            macrophage lipid composition, with implications for inflammatory
            signaling
REFERENCE   5  (bases 1 to 4590)
  AUTHORS   Bowden,K. and Ridgway,N.D.
  TITLE     OSBP negatively regulates ABCA1 protein stability
  JOURNAL   J Biol Chem 283 (26), 18210-18217 (2008)
   PUBMED   18450749
  REMARK    GeneRIF: OSBP opposes the activity of LXR by negatively regulating
            ABCA1 activity in the cytoplasm by sterol-binding domain-dependent
            protein destabilization
REFERENCE   6  (bases 1 to 4590)
  AUTHORS   Li,X., Yin,W., Perez-Jurado,L., Bonadio,J. and Francke,U.
  TITLE     Mapping of human and murine genes for latent TGF-beta binding
            protein-2 (LTBP2)
  JOURNAL   Mamm Genome 6 (1), 42-45 (1995)
   PUBMED   7719025
REFERENCE   7  (bases 1 to 4590)
  AUTHORS   Watson,M.L., Rao,J.K., Gilkeson,G.S., Ruiz,P., Eicher,E.M.,
            Pisetsky,D.S., Matsuzawa,A., Rochelle,J.M. and Seldin,M.F.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   8  (bases 1 to 4590)
  AUTHORS   Rochelle,J.M., Watson,M.L., Oakey,R.J. and Seldin,M.F.
  TITLE     A linkage map of mouse chromosome 19: definition of comparative
            mapping relationships with human chromosomes 10 and 11 including
            the MEN1 locus
  JOURNAL   Genomics 14 (1), 26-31 (1992)
   PUBMED   1358795
REFERENCE   9  (bases 1 to 4590)
  AUTHORS   Szepetowski,P., Simon,M.P., Grosgeorge,J., Huebner,K., Bastard,C.,
            Evans,G.A., Tsujimoto,Y., Birnbaum,D., Theillet,C. and Gaudray,P.
  TITLE     Localization of 11q13 loci with respect to regional chromosomal
            breakpoints
  JOURNAL   Genomics 12 (4), 738-744 (1992)
   PUBMED   1572647
REFERENCE   10 (bases 1 to 4590)
  AUTHORS   Levanon,D., Hsieh,C.L., Francke,U., Dawson,P.A., Ridgway,N.D.,
            Brown,M.S. and Goldstein,J.L.
  TITLE     cDNA cloning of human oxysterol-binding protein and localization of
            the gene to human chromosome 11 and mouse chromosome 19
  JOURNAL   Genomics 7 (1), 65-74 (1990)
   PUBMED   1970801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ163670.1, BC107327.1, AK220301.1 and AI450082.1.
            
            On or before Mar 20, 2007 this sequence version replaced
            XM_148904.9, XM_982920.1, XM_985687.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.9110.1,
                                           SRR11927937.5434625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               CJ163670.1         2-285
            285-2516            BC107327.1         19-2250
            2517-4555           AK220301.1         1555-3593
            4556-4590           AI450082.1         1-35                c
FEATURES             Location/Qualifiers
     source          1..4590
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.58 cM"
     gene            1..4590
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /note="oxysterol binding protein"
                     /db_xref="GeneID:76303"
                     /db_xref="MGI:MGI:97447"
     exon            1..453
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2515
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /codon_start=1
                     /product="oxysterol-binding protein 1"
                     /protein_id="NP_001028346.1"
                     /db_xref="CCDS:CCDS37925.1"
                     /db_xref="GeneID:76303"
                     /db_xref="MGI:MGI:97447"
                     /translation="MAATELRGVVGPGPAAIAAPGGGGAGPPAVGGGGGRGDAGPGPG
                     VAAATAATAGGPGPGAGGVAAGGPGSAPPAAGSGGSGAGGSGSAREGWLFKWTNYIKG
                     YQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLK
                     ASSEVERQRWVTALELAKAKAVKMLAESDDSGDEESVSQTDKTELQSTLRTLSSKVED
                     LSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRD
                     FLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANPPGSA
                     GSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDVSLDEQY
                     KHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTE
                     DLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEE
                     NGYRSICEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHS
                     TGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARK
                     VTGEVTDPSGKVHFALLGTWDEKMDCFKVQAASGENGGDARQRGHEAEDSRVMLWKRN
                     PLPKNAENMYYFSELALTLNAWEGGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEK
                     QRLSRKKREAEAAKATEDGTPHDPYKALWFERKKDPVTRELTHIYSGEYWECKEKQDW
                     GSCPDIF"
     exon            454..662
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     exon            663..913
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1112
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1215
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1270
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1402
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1648
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1769
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1873
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1969
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2151
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2372
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..4587
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4565..4570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /note="hexamer: ATTAAA"
     polyA_site      4587
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggct gaagcgctag ccgtgttggg cgctccgggc ggcggcggcg gagctcgtag
       61 gcggttccgg tcgtgtctct ccgggcggcg gcggctcatg gcggcgaccg agctgagagg
      121 agtggtgggg ccgggcccgg cagccatcgc ggctccgggc ggcggcggcg cgggtccacc
      181 cgcggtggga ggcggcggcg gacgcgggga cgcggggccc ggccccgggg tggcggccgc
      241 gacggcggcg acggcgggcg gcccgggccc cggggccgga ggagtggcgg caggcggccc
      301 gggctctgca ccgccagccg cgggctcggg cggttcgggc gccgggggct cgggctcggc
      361 tagagagggc tggctcttca aatggaccaa ttacatcaaa ggctaccagc ggcgatggtt
      421 cgtgctgagc aacgggctcc taagctacta caggtccaag gcagagatga gacacacctg
      481 ccgaggtacc atcaacctcg ccacagccaa catcactgtg gaggactctt gcaacttcat
      541 catctccaat ggcggtgctc agacctacca cttgaaggcc agctccgaag tagagcgtca
      601 gcgctgggtg acagccttag aactggccaa ggccaaggct gtgaagatgc tggccgaatc
      661 agatgactca ggagatgaag agtctgtctc acagactgac aagaccgagc tccagagcac
      721 cctgcgaaca ctctccagca aagtggagga cctcagcacg tgcaacgact tgatagctaa
      781 gcatggcacc gccctgcagc gttccctcag tgagctggag tccctgaagc tgcctgctga
      841 gagcaatgag aaaatcaagc aggtcaatga acgagccacg ctttttagga taacatccaa
      901 tgccatgatc aatgcttgca gagatttcct catgttagcc cagacacaca gtaagaagtg
      961 gcagaagtca ctacagtatg aaagagacca gcgaatccga ctggaagaaa ctcttgagca
     1021 gctggcaaag cagcacaatc acctggagag agccttccgg ggagccacag tgctgccagc
     1081 aaaccctccg ggcagcgctg ggtctggtaa agatcagtgc tgttctggca aaggggacat
     1141 gagcgatgaa gatgacgaga atgagttttt tgatgcacca gagattatca ccatgcctga
     1201 aaatttgggc cacaaacgta ctggcagcaa tatcagtggg gccagcagtg atgtcagcct
     1261 tgatgaacag tacaagcatc agctggagga gaccaagaag gaaaagagaa ccagaatacc
     1321 atataagcca aactacagcc tcaacttgtg gagcatcatg aagaactgca ttggaaagga
     1381 gctctctaag atcccaatgc cggtaaactt taatgagccc ttgtccatgc ttcagcgcct
     1441 tactgaagat ctggagtacc atgagctgtt agacagagct gcaaagtgtg agaactctct
     1501 agaacagctc tgctatgttg cagccttcac tgtttcctcc tattccacta ccgtcttccg
     1561 aaccagcaag ccattcaacc ctctccttgg ggagacattt gaactggacc gactggagga
     1621 gaatgggtat cggtccatct gtgagcaggt gagtcatcat ccccctgctg ctgcgcacca
     1681 tgctgaatcc aaaaatggct ggacattgcg tcaggaaatt aaaatcacca gcaagtttcg
     1741 aggcaaatac ctctccatta tgccccttgg tactatccac tgcattttcc actcaactgg
     1801 gcaccattac acttggaaaa aagttaccac aacagtacac aacattattg tgggcaagtt
     1861 gtggatagat cagtctggtg agattgacat tgtaaatcac aagacaggag acaagtgtaa
     1921 tcttaaattt gttccttata gctacttctc tcgggatgta gcaagaaagg tgacaggtga
     1981 agtgacagac ccatcaggaa aagttcactt tgccctcctg gggacatggg atgagaaaat
     2041 ggattgtttc aaagtacagg cagcctccgg ggagaatggg ggtgatgctc ggcagagagg
     2101 ccatgaagca gaagacagca gggtcatgct gtggaagagg aacccattac cgaagaatgc
     2161 agagaacatg tactacttct cagagcttgc cctcactctc aatgcctggg aaggtggcac
     2221 tgctcccacg gacagccggc tgcggcccga ccagagactc atggaaaacg ggcgttggga
     2281 tgaagcaaat gctgagaagc agcgcctgga ggagaaacag cggctttcca ggaagaagag
     2341 agaagcagaa gctgcgaaag ccacggaaga tggcacacca catgacccct ataaagcact
     2401 gtggtttgag cggaagaagg accctgtcac cagggagcta acccatattt atagtggcga
     2461 gtactgggaa tgtaaggaaa agcaggactg gggttcttgc ccagatattt tctgaagcag
     2521 ctgtaactca aaggaagagg gctgatcgga gaagacggca gaggatgtgc gggaaggctg
     2581 gcagttggga ctcttaccga gtgctttcct caaatttgtc tgtcttaacc aatcactttt
     2641 tccaaatcaa tcaccagaag cagacacccg tggtggtgat tggctggttg ccttagctga
     2701 ttgacgctga aatcgacgta gtagatgccc atgtttgtaa gggagtggtt tagtggctgg
     2761 aagttagtgt tcctctacat ctcaaaggca agtaagtgtg cttccctctc ggcctcattg
     2821 agatgatgtc attgaccctc acctgtgtcc tgctcagcca agatctgcat aagattggga
     2881 ttcaggagca ttttggtgct gttcagagca agaactgatt ttaaagttcc tttaaaaaga
     2941 aacacataag atttacccag cagaggcatc acgcctaggt ctcagtgtat gaagtgtact
     3001 cacacgtggg attgctgtaa caggtcgtcg cgtgtagata actaaggctt tggagcatct
     3061 gcaggagaga gtgttctcta gggcttgaat attgaattat gttcttggag attttatctt
     3121 cacttgcata caattcccct ctgcggtttt gtctactttg acagcaacca ggggcctcct
     3181 tggtcgttga taagagggtc acacgctcct cataaagggg ttttatggac tccctcaggt
     3241 ggagaacctc tgcaaacaca ggcagggtgg gagaagactg ctagccactt gtaccttccc
     3301 agtccctcct catccgtctt tcgttgcctt tctggcttct gtttcctggc acagtaccat
     3361 tttgagtttg tgccacagtc tggagcaaaa cattgcctga cccattctgt atacttcaga
     3421 atcttagaga agttcctctg caacaaatgt tttcatcttg aaagtcccag tagaatggag
     3481 ccacttctga aataatgtgt taaatcatct gtatattata tatatatata tatatatgta
     3541 gagaaaatct aattttttcc ccctttccca tgaagaatct tggttttttt atatcacctg
     3601 tctccctggg actctctcaa gtgcgcgtta atatgggttg gtgcctctgc tttccatgtt
     3661 tgagggacat tgcaacccca agcagggtca tgtgtggcag ttgctgagca gggacaagga
     3721 ggaaggtttt tgtgcctacc ctgcggctgc ctcagctcgg ctttgccgat cacacgtggc
     3781 tcttggaaag gaagtcctgg tctttttcct gcctcagttt ccttccctag gaggcgtacg
     3841 ggtagaaagt caagagggtg atttctagct tccttatgtc ccagctcagg ctaaatccca
     3901 aaaacgtttc cttccaagga tgagagctaa gagcgctcgt gctctgtggg agctgctcct
     3961 gctggcactg gcaccctccc tttttcttta ttagttctag tttcctgttc agaaatgtag
     4021 cccttgtgca acccaccctt ggttgagggt cataaattga ggtgccttcc ttgtgtactt
     4081 tttgttagtg tttttgtttt tgttccttaa ctgttgagcc tcagccagtg tgggtccttg
     4141 gggaaaataa ccattccaga ggaagctatc cctccaggga aattggattt tactgggtaa
     4201 attagtattt tcagtccgtt cccactgact ctccttcctt agataaaatg atcaaagatt
     4261 gagcactagg gaatttcctc ctaagaaggc ttccccagca caaggggtta ctccagggag
     4321 gcccataaaa tgggcgccgt ctcggaggct ttggatagaa tggaaatttc ccaaggaacc
     4381 tctgtgcttt cccctttccc tctatctgca ctacatttct agcttgattc ccagatccct
     4441 gctaatggaa gaagcttaga agtcctgaag atggaataaa gtcacatgaa agcaaaataa
     4501 gactatatat atattttcag tttttttgcc ttattgcttt ttttcaaaaa aaaaaaacta
     4561 ctaaattaaa taatttttaa aaagctaaaa
//
