LOCUS       NP_001028346             805 aa            linear   ROD 27-APR-2025
DEFINITION  oxysterol-binding protein 1 [Mus musculus].
ACCESSION   NP_001028346 XP_148904 XP_988014 XP_990781
VERSION     NP_001028346.1
DBSOURCE    REFSEQ: accession NM_001033174.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 805)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 805)
  AUTHORS   Sobajima,T., Yoshimura,S.I., Maeda,T., Miyata,H., Miyoshi,E. and
            Harada,A.
  TITLE     The Rab11-binding protein RELCH/KIAA1468 controls intracellular
            cholesterol distribution
  JOURNAL   J Cell Biol 217 (5), 1777-1796 (2018)
   PUBMED   29514919
REFERENCE   3  (residues 1 to 805)
  AUTHORS   Gu,X., Li,A., Liu,S., Lin,L., Xu,S., Zhang,P., Li,S., Li,X.,
            Tian,B., Zhu,X. and Wang,X.
  TITLE     MicroRNA124 Regulated Neurite Elongation by Targeting OSBP
  JOURNAL   Mol Neurobiol 53 (9), 6388-6396 (2016)
   PUBMED   26576957
  REMARK    GeneRIF: OSBP may be a target and downstream effector of miR-124
            for regulating neurite outgrowth and elongation.
REFERENCE   4  (residues 1 to 805)
  AUTHORS   Vihervaara,T., Kakela,R., Liebisch,G., Tarasov,K., Schmitz,G. and
            Olkkonen,V.M.
  TITLE     Modification of the lipidome in RAW264.7 macrophage subjected to
            stable silencing of oxysterol-binding proteins
  JOURNAL   Biochimie 95 (3), 538-547 (2013)
   PUBMED   22609461
  REMARK    GeneRIF: roles of different ORP proteins as regulators of
            macrophage lipid composition, with implications for inflammatory
            signaling
REFERENCE   5  (residues 1 to 805)
  AUTHORS   Bowden,K. and Ridgway,N.D.
  TITLE     OSBP negatively regulates ABCA1 protein stability
  JOURNAL   J Biol Chem 283 (26), 18210-18217 (2008)
   PUBMED   18450749
  REMARK    GeneRIF: OSBP opposes the activity of LXR by negatively regulating
            ABCA1 activity in the cytoplasm by sterol-binding domain-dependent
            protein destabilization
REFERENCE   6  (residues 1 to 805)
  AUTHORS   Li,X., Yin,W., Perez-Jurado,L., Bonadio,J. and Francke,U.
  TITLE     Mapping of human and murine genes for latent TGF-beta binding
            protein-2 (LTBP2)
  JOURNAL   Mamm Genome 6 (1), 42-45 (1995)
   PUBMED   7719025
REFERENCE   7  (residues 1 to 805)
  AUTHORS   Watson,M.L., Rao,J.K., Gilkeson,G.S., Ruiz,P., Eicher,E.M.,
            Pisetsky,D.S., Matsuzawa,A., Rochelle,J.M. and Seldin,M.F.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   8  (residues 1 to 805)
  AUTHORS   Rochelle,J.M., Watson,M.L., Oakey,R.J. and Seldin,M.F.
  TITLE     A linkage map of mouse chromosome 19: definition of comparative
            mapping relationships with human chromosomes 10 and 11 including
            the MEN1 locus
  JOURNAL   Genomics 14 (1), 26-31 (1992)
   PUBMED   1358795
REFERENCE   9  (residues 1 to 805)
  AUTHORS   Szepetowski,P., Simon,M.P., Grosgeorge,J., Huebner,K., Bastard,C.,
            Evans,G.A., Tsujimoto,Y., Birnbaum,D., Theillet,C. and Gaudray,P.
  TITLE     Localization of 11q13 loci with respect to regional chromosomal
            breakpoints
  JOURNAL   Genomics 12 (4), 738-744 (1992)
   PUBMED   1572647
REFERENCE   10 (residues 1 to 805)
  AUTHORS   Levanon,D., Hsieh,C.L., Francke,U., Dawson,P.A., Ridgway,N.D.,
            Brown,M.S. and Goldstein,J.L.
  TITLE     cDNA cloning of human oxysterol-binding protein and localization of
            the gene to human chromosome 11 and mouse chromosome 19
  JOURNAL   Genomics 7 (1), 65-74 (1990)
   PUBMED   1970801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ163670.1, BC107327.1, AK220301.1 and AI450082.1.
            
            On or before Mar 20, 2007 this sequence version replaced
            XP_148904.8, XP_988014.1, XP_990781.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.9110.1,
                                           SRR11927937.5434625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..805
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.58 cM"
     Protein         1..805
                     /product="oxysterol-binding protein 1"
                     /calculated_mol_wt=88666
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P22059; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Region          18..83
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Region          89..187
                     /region_name="PH_OSBP_ORP4"
                     /note="Human Oxysterol binding protein and OSBP-related
                     protein 4 Pleckstrin homology (PH) domain; cd13284"
                     /db_xref="CDD:270101"
     Site            188
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            191
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            196
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            236
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P22059; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            238
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Region          331..351
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            336
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P22059; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            343
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            349
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Region          356..362
                     /region_name="FFAT.
                     /evidence=ECO:0000250|UniProtKB:P22059"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Region          369..388
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            375
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            377
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P22059; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            380
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            383
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            384
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P22059; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Site            387
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P22059; propagated from
                     UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     Region          416..794
                     /region_name="Oxysterol_BP"
                     /note="Oxysterol-binding protein; pfam01237"
                     /db_xref="CDD:460126"
     Region          708..764
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3B7Z2.3)"
     CDS             1..805
                     /gene="Osbp"
                     /gene_synonym="1110018F06Rik; mKIAA4220"
                     /coded_by="NM_001033174.1:98..2515"
                     /db_xref="CCDS:CCDS37925.1"
                     /db_xref="GeneID:76303"
                     /db_xref="MGI:MGI:97447"
ORIGIN      
        1 maatelrgvv gpgpaaiaap ggggagppav gggggrgdag pgpgvaaata ataggpgpga
       61 ggvaaggpgs appaagsggs gaggsgsare gwlfkwtnyi kgyqrrwfvl sngllsyyrs
      121 kaemrhtcrg tinlatanit vedscnfiis nggaqtyhlk asseverqrw vtalelakak
      181 avkmlaesdd sgdeesvsqt dktelqstlr tlsskvedls tcndliakhg talqrslsel
      241 eslklpaesn ekikqvnera tlfritsnam inacrdflml aqthskkwqk slqyerdqri
      301 rleetleqla kqhnhleraf rgatvlpanp pgsagsgkdq ccsgkgdmsd eddeneffda
      361 peiitmpenl ghkrtgsnis gassdvslde qykhqleetk kekrtripyk pnyslnlwsi
      421 mkncigkels kipmpvnfne plsmlqrlte dleyhelldr aakcensleq lcyvaaftvs
      481 systtvfrts kpfnpllget feldrleeng yrsiceqvsh hppaaahhae skngwtlrqe
      541 ikitskfrgk ylsimplgti hcifhstghh ytwkkvtttv hniivgklwi dqsgeidivn
      601 hktgdkcnlk fvpysyfsrd varkvtgevt dpsgkvhfal lgtwdekmdc fkvqaasgen
      661 ggdarqrghe aedsrvmlwk rnplpknaen myyfselalt lnaweggtap tdsrlrpdqr
      721 lmengrwdea naekqrleek qrlsrkkrea eaakatedgt phdpykalwf erkkdpvtre
      781 lthiysgeyw eckekqdwgs cpdif
//
