LOCUS       NM_025661               2023 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus ORM1-like 3 (S. cerevisiae) (Ormdl3), mRNA.
ACCESSION   NM_025661
VERSION     NM_025661.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2023)
  AUTHORS   Demkova,L., Bugajev,V., Adamcova,M.K., Kuchar,L., Grusanovic,S.,
            Alberich-Jorda,M., Draber,P. and Halova,I.
  TITLE     Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune
            cell homeostasis
  JOURNAL   Front Immunol 15, 1376629 (2024)
   PUBMED   38715613
  REMARK    GeneRIF: Simultaneous deletion of ORMDL1 and ORMDL3 proteins
            disrupts immune cell homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2023)
  AUTHORS   Brown,R.D.R., Green,C.D., Weigel,C., Ni,B., Celi,F.S., Proia,R.L.
            and Spiegel,S.
  TITLE     Overexpression of ORMDL3 confers sexual dimorphism in diet-induced
            non-alcoholic steatohepatitis
  JOURNAL   Mol Metab 79, 101851 (2024)
   PUBMED   38081412
  REMARK    GeneRIF: Overexpression of ORMDL3 confers sexual dimorphism in
            diet-induced non-alcoholic steatohepatitis.
REFERENCE   3  (bases 1 to 2023)
  AUTHORS   Cheng,Q., He,F., Zhao,W., Xu,X., Shang,Y. and Huang,W.
  TITLE     Histone acetylation regulates ORMDL3 expression-mediated NLRP3
            inflammasome overexpression during RSV-allergic exacerbation mice
  JOURNAL   J Cell Physiol 238 (12), 2904-2923 (2023)
   PUBMED   37877592
  REMARK    GeneRIF: Histone acetylation regulates ORMDL3 expression-mediated
            NLRP3 inflammasome overexpression during RSV-allergic exacerbation
            mice.
REFERENCE   4  (bases 1 to 2023)
  AUTHORS   Liu,F., Sun,Y., Zhou,Y., Gao,Y., Song,Q., Yang,J., Xu,C. and Li,G.
  TITLE     ORMDL3-mediated bronchial epithelial pyroptosis leads to lung
            inflammation in obese mice with asthma
  JOURNAL   Mol Med Rep 28 (4) (2023)
   PUBMED   37594074
  REMARK    GeneRIF: ORMDL3-mediated bronchial epithelial pyroptosis leads to
            lung inflammation in obese mice with asthma.
REFERENCE   5  (bases 1 to 2023)
  AUTHORS   Demkova,L., Bugajev,V., Utekal,P., Kuchar,L., Schuster,B.,
            Draber,P. and Halova,I.
  TITLE     Simultaneous reduction of all ORMDL proteins decreases the
            threshold of mast cell activation
  JOURNAL   Sci Rep 13 (1), 9615 (2023)
   PUBMED   37316542
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2023)
  AUTHORS   Miller,M., Rosenthal,P., Beppu,A., Mueller,J.L., Hoffman,H.M.,
            Tam,A.B., Doherty,T.A., McGeough,M.D., Pena,C.A., Suzukawa,M.,
            Niwa,M. and Broide,D.H.
  TITLE     ORMDL3 transgenic mice have increased airway remodeling and airway
            responsiveness characteristic of asthma
  JOURNAL   J Immunol 192 (8), 3475-3487 (2014)
   PUBMED   24623133
  REMARK    GeneRIF: These studies provide evidence that ORMDL3 plays an
            important role in vivo in airway remodeling potentially through
            ATF6 target genes.
REFERENCE   7  (bases 1 to 2023)
  AUTHORS   Ha,S.G., Ge,X.N., Bahaie,N.S., Kang,B.N., Rao,A., Rao,S.P. and
            Sriramarao,P.
  TITLE     ORMDL3 promotes eosinophil trafficking and activation via
            regulation of integrins and CD48
  JOURNAL   Nat Commun 4, 2479 (2013)
   PUBMED   24056518
  REMARK    GeneRIF: ORMDL3 promotes eosinophil trafficking and activation via
            regulation of CD18, CD49d, and CD48.
REFERENCE   8  (bases 1 to 2023)
  AUTHORS   Zhuang,L.L., Jin,R., Zhu,L.H., Xu,H.G., Li,Y., Gao,S., Liu,J.Y. and
            Zhou,G.P.
  TITLE     Promoter characterization and role of cAMP/PKA/CREB in the basal
            transcription of the mouse ORMDL3 gene
  JOURNAL   PLoS One 8 (4), e60630 (2013)
   PUBMED   23577138
  REMARK    GeneRIF: signaling pathway cAMP/PKA/CREB plays an important role in
            regulating ORMDL3 expression
REFERENCE   9  (bases 1 to 2023)
  AUTHORS   Miller,M., Tam,A.B., Cho,J.Y., Doherty,T.A., Pham,A., Khorram,N.,
            Rosenthal,P., Mueller,J.L., Hoffman,H.M., Suzukawa,M., Niwa,M. and
            Broide,D.H.
  TITLE     ORMDL3 is an inducible lung epithelial gene regulating
            metalloproteases, chemokines, OAS, and ATF6
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16648-16653 (2012)
   PUBMED   23011799
REFERENCE   10 (bases 1 to 2023)
  AUTHORS   Hjelmqvist,L., Tuson,M., Marfany,G., Herrero,E., Balcells,S. and
            Gonzalez-Duarte,R.
  TITLE     ORMDL proteins are a conserved new family of endoplasmic reticulum
            membrane proteins
  JOURNAL   Genome Biol 3 (6), RESEARCH0027 (2002)
   PUBMED   12093374
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL591125.20.
            
            On Oct 19, 2007 this sequence version replaced NM_025661.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009621.1, BC046594.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN02415130
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AL591125.20        76608-76725
            119-317             AL591125.20        79713-79911
            318-469             AL591125.20        80566-80717
            470-2023            AL591125.20        81006-82559
FEATURES             Location/Qualifiers
     source          1..2023
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.07 cM"
     gene            1..2023
                     /gene="Ormdl3"
                     /gene_synonym="2810011N17Rik"
                     /note="ORM1-like 3 (S. cerevisiae)"
                     /db_xref="GeneID:66612"
                     /db_xref="MGI:MGI:1913862"
     exon            1..118
                     /gene="Ormdl3"
                     /gene_synonym="2810011N17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            119..317
                     /gene="Ormdl3"
                     /gene_synonym="2810011N17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..605
                     /gene="Ormdl3"
                     /gene_synonym="2810011N17Rik"
                     /codon_start=1
                     /product="ORM1-like protein 3"
                     /protein_id="NP_079937.1"
                     /db_xref="CCDS:CCDS25355.1"
                     /db_xref="GeneID:66612"
                     /db_xref="MGI:MGI:1913862"
                     /translation="MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHVVLLSIPFVS
                     VPVVWTLTNLIHNLGMYIFLHTVKGTPFETPDQGKARLLTHWEQMDYGVQFTASRKFL
                     TITPIVLYFLTSFYTKYDQVHFILNTVSLMTVLIPKLPQLHGVRIFGINKY"
     exon            318..469
                     /gene="Ormdl3"
                     /gene_synonym="2810011N17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            470..2023
                     /gene="Ormdl3"
                     /gene_synonym="2810011N17Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gattcggcca gagctgccag cggggtagcc accgccgctg gtttgttaca gctgctggag
       61 cggccgcggc ccgggttctc gggctctctc ccgggccctc gacctccaac cccgcgcgag
      121 cggcagtcaa gaggggtggc aggatgaatg tgggcacagc acacagtgag gtgaacccca
      181 acacacgggt gatgaacagt cgcggcatct ggctctccta cgtgctggcc atcggactcc
      241 tgcatgtcgt gctgctgagc attccctttg tgagcgtccc tgtcgtctgg accctcacca
      301 accttatcca caacctgggc atgtacatct ttctgcacac cgtgaaaggg acgcccttcg
      361 agactccaga ccaaggcaaa gcaaggttgc tgacccactg ggagcagatg gactacgggg
      421 tccagttcac agcctctagg aagttcttaa ccatcacgcc tatagtgctg tacttcctca
      481 ccagcttcta caccaagtat gaccaagtcc atttcatact caacactgtg tccttgatga
      541 ctgtgctcat tcccaagctc ccccagctcc acggagtccg gatctttgga atcaataagt
      601 actgaggttg tagccccttc cccagccggg ttggcagggg aagggtggaa ggcctttgct
      661 gtgatgctga agacaggagc ctctggacac tgccagagat gggggtgtgc cctgggcctg
      721 gcttccccct cgcttcccca gtagccgact tggagtagct tgtagtgggg ttagggtggg
      781 gcccttgggc tctaacccat tctgaagttt ttgatctttt tccttttgcc ttttgaatag
      841 agatgccatg ggggtggtca ggaaagaggc tgggctctct ggctgactgt gggcctgaga
      901 aattgggaca ggaagccagg aaaaggccct gttggcttgt ttaccctcag gcagccatag
      961 cactttagcc cccaaaaagg ggggcagagg gacggtacag cttctgcatt ggttgccctc
     1021 attccttcag tgtgtgaagc gagactcgct gttctgtatg tattagaacc ctgcgccgtg
     1081 ctgcctctgc cgccaggcag ggagcaggcg ggctttgtgg gcttcctggc aacccacgat
     1141 gggtaggctg tggggcaggg gagattagga aaggaagatg ggttgatggg acacctagag
     1201 gtggggacag gatgctgcca ccttggtcct ggggagaggg gagttctgag caagggttgg
     1261 gtggggatag taagttgggt cttacttaga atggacaaga taactgcagc cgatatggat
     1321 cagtgtaaaa aaaaaagagg tctgggaagg agaagccaga ctccgcctcc tctgagatgt
     1381 gggctaggag gagagctggc gtggagggtt aatttaccca cagaacgatg ctgataggaa
     1441 gggaggcccc tgtgggtttg aactcctggg ttggaatgag gatatgcaca ggctggaagg
     1501 gcctgtgagt cctcagaagc gggttcactt cgacacttcc cttagtggtg tgtgtgggcg
     1561 cgcgcggaag ctttctgaga ggctcttcct taagcgttca attcgtattc ttgtgtagat
     1621 tgtgctgggg cagtgcctct tgtgtggctt gcatgtgaat ggtcaggagg ccacctccac
     1681 atgtggtcag tggcctccac agtgctacag gatctctgcc caaaccaggc agtagtaggg
     1741 gcagctgcag gcactgtcct cagcccaaag agaggcaggt catggagcct gaggctaggc
     1801 cgagaggagc tgtctctcca ctcgctgggt cgactggggc atgttccttt ggaaacgcgt
     1861 ggctacccaa gccctctccc agggaggggc tggagggagg tcactcacct gtttgtcccc
     1921 ctccccctca ttctgaaccc agtgtatcat agggaacttt caccttctgg tctttctaag
     1981 caaagtgtga ataggatttt tactcccttt gtacagtatt ctg
//
