LOCUS       NM_024180               1608 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus ORM1-like 2 (S. cerevisiae) (Ormdl2), transcript
            variant 1, mRNA.
ACCESSION   NM_024180
VERSION     NM_024180.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1608)
  AUTHORS   Demkova,L., Bugajev,V., Utekal,P., Kuchar,L., Schuster,B.,
            Draber,P. and Halova,I.
  TITLE     Simultaneous reduction of all ORMDL proteins decreases the
            threshold of mast cell activation
  JOURNAL   Sci Rep 13 (1), 9615 (2023)
   PUBMED   37316542
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1608)
  AUTHORS   Bugajev,V., Halova,I., Demkova,L., Cernohouzova,S., Vavrova,P.,
            Mrkacek,M., Utekal,P., Draberova,L., Kuchar,L., Schuster,B. and
            Draber,P.
  TITLE     ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast
            Cell Signaling
  JOURNAL   Front Immunol 11, 591975 (2021)
   PUBMED   33643282
  REMARK    GeneRIF: ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes
            in Mast Cell Signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1608)
  AUTHORS   Clarke,B.A., Majumder,S., Zhu,H., Lee,Y.T., Kono,M., Li,C.,
            Khanna,C., Blain,H., Schwartz,R., Huso,V.L., Byrnes,C.,
            Tuymetova,G., Dunn,T.M., Allende,M.L. and Proia,R.L.
  TITLE     The Ormdl genes regulate the sphingolipid synthesis pathway to
            ensure proper myelination and neurologic function in mice
  JOURNAL   Elife 8, e51067 (2019)
   PUBMED   31880535
  REMARK    GeneRIF: we attempted to generate Ormdl triple knockouts mice by
            crossing Ormdl 1-/- 2 +/- 3 +/- mice, no viable Ormdl1/2/3 triple
            knockouts mice were identified at weaning.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1608)
  AUTHORS   Siow,D., Sunkara,M., Dunn,T.M., Morris,A.J. and Wattenberg,B.
  TITLE     ORMDL/serine palmitoyltransferase stoichiometry determines effects
            of ORMDL3 expression on sphingolipid biosynthesis
  JOURNAL   J Lipid Res 56 (4), 898-908 (2015)
   PUBMED   25691431
REFERENCE   5  (bases 1 to 1608)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   6  (bases 1 to 1608)
  AUTHORS   Hjelmqvist,L., Tuson,M., Marfany,G., Herrero,E., Balcells,S. and
            Gonzalez-Duarte,R.
  TITLE     ORMDL proteins are a conserved new family of endoplasmic reticulum
            membrane proteins
  JOURNAL   Genome Biol 3 (6), RESEARCH0027 (2002)
   PUBMED   12093374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV065903.1, AK002583.1 and AK002824.1.
            
            On Dec 22, 2017 this sequence version replaced NM_024180.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002583.1, SRR1660815.102681.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                DV065903.1         46-80
            36-894              AK002583.1         1-859
            895-1015            AK002824.1         604-724
            1016-1608           AK002583.1         981-1573
FEATURES             Location/Qualifiers
     source          1..1608
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.16 cM"
     gene            1..1608
                     /gene="Ormdl2"
                     /gene_synonym="0610012C09Rik"
                     /note="ORM1-like 2 (S. cerevisiae)"
                     /db_xref="GeneID:66844"
                     /db_xref="MGI:MGI:1914094"
     exon            1..88
                     /gene="Ormdl2"
                     /gene_synonym="0610012C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            89..342
                     /gene="Ormdl2"
                     /gene_synonym="0610012C09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..630
                     /gene="Ormdl2"
                     /gene_synonym="0610012C09Rik"
                     /codon_start=1
                     /product="ORM1-like protein 2"
                     /protein_id="NP_077142.1"
                     /db_xref="CCDS:CCDS24295.1"
                     /db_xref="GeneID:66844"
                     /db_xref="MGI:MGI:1914094"
                     /translation="MNVGVAHSEVNPNTRVMNSRGIWLAYIILVGLLHVVLLSIPFFS
                     IPVVWTLTNVIHNLAMYIFLHTVKGTPFETPDQGKARLLTHWEQMDYGLQFTSSRKFL
                     SISPIVLYLLASFYTKYDAAHFLINTASLLSVLLPKLPQFHGVRLFGINKY"
     exon            343..494
                     /gene="Ormdl2"
                     /gene_synonym="0610012C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            495..1608
                     /gene="Ormdl2"
                     /gene_synonym="0610012C09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      979..984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ormdl2"
                     /gene_synonym="0610012C09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1017
                     /gene="Ormdl2"
                     /gene_synonym="0610012C09Rik"
                     /note="major polyA site"
     regulatory      1072..1077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ormdl2"
                     /gene_synonym="0610012C09Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1095
                     /gene="Ormdl2"
                     /gene_synonym="0610012C09Rik"
                     /note="major polyA site"
ORIGIN      
        1 acagggcgaa agtcggccac ttcctggaga ccacaggtgt aagagccagc gctgtgcccc
       61 aagccggacg ggctcctgaa gctggcagga gacagctggg gaacaagctc aatcagggct
      121 aatgaggaga ctgagttgga ctcctgcctg atccctcact gtggtaggat gaatgtgggg
      181 gtggcacaca gcgaagtaaa ccccaacact cgagtgatga acagtcgggg catctggctg
      241 gcctacatca tcttggtagg actgctgcat gtggttctcc tcagcatccc tttcttcagc
      301 attcctgttg tctggaccct gaccaacgtc atccataact tggcaatgta tatcttccta
      361 catacagtca aagggacgcc ctttgagacc cctgaccaag gaaaggctcg gcttttgaca
      421 cattgggagc agatggacta tggactacag tttacctcct cgcgaaagtt cctcagcatc
      481 tctcctattg tactttacct cctggccagc ttctacacca agtacgatgc tgctcacttc
      541 ctcatcaaca ctgcctcgct gctcagcgtg ctgctgccta agctacccca gttccatggg
      601 gttcgtctct ttggaatcaa caaatactaa aagatggttt gctagttctg caggcattga
      661 gggaaggcac tggaactaat atataatgtt ttcccttctc cacactatct tctgtatctt
      721 ggaagcctga gagataagat aaacctatct aaactccaag aaggaagaaa ctggaaaatg
      781 gggttcctgg gtccagtctt catagggtca agattctctg aatcaggaaa ggtggatgag
      841 gttaagggca ctaccactca ctctcctcta tctagcaaga agccatcatt gtttgggcag
      901 cttttctggt gattatgttt ttccatatct tctaaaccta ccaacttcaa gttctgtttt
      961 gctgtatatt tttcttaaaa taaagtcttt cagttatggc tgaaatttga taagcaagga
     1021 cagagagatt ttctcataat gctggggaga aaatgcaaaa tgctgactta ctataaaaaa
     1081 aacttttaag caaaattttg tctctactcc tttggtccaa tacctttcac tcacagctaa
     1141 cagcaaggaa agaattctca aataagaaaa aagagctcac aagtgagtag tggaggcaca
     1201 tgcctataat actagctagc cctcaggaag tggaggcaga ggcaggagaa tcactgcaat
     1261 ctggagtcca gcctggtcta cacagtaaga ctcttatctc caaaagaaaa tagaaaagga
     1321 ctcccagcta catgggtaaa gaagagaagg aagatgtaag ttgccagtta tatatttata
     1381 gaaagataat ctcctggctt taaatagata tgtacataca aatatgaaca aacttaaaaa
     1441 aatacaaacc cttggctaac aagggggcct ctgggaaccc ctctatcctt ccccctcacc
     1501 caagggcaca gggcataaat ctgcttttta aaaattaatt aattttggcc atccttgcaa
     1561 caacaagcct gaagttaggt gtcttaccaa taaagtgaaa gtcagagg
//
