LOCUS       NM_145517               1849 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus ORM1-like 1 (S. cerevisiae) (Ormdl1), mRNA.
ACCESSION   NM_145517 XM_484868
VERSION     NM_145517.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1849)
  AUTHORS   Demkova,L., Bugajev,V., Adamcova,M.K., Kuchar,L., Grusanovic,S.,
            Alberich-Jorda,M., Draber,P. and Halova,I.
  TITLE     Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune
            cell homeostasis
  JOURNAL   Front Immunol 15, 1376629 (2024)
   PUBMED   38715613
  REMARK    GeneRIF: Simultaneous deletion of ORMDL1 and ORMDL3 proteins
            disrupts immune cell homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1849)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1849)
  AUTHORS   Demkova,L., Bugajev,V., Utekal,P., Kuchar,L., Schuster,B.,
            Draber,P. and Halova,I.
  TITLE     Simultaneous reduction of all ORMDL proteins decreases the
            threshold of mast cell activation
  JOURNAL   Sci Rep 13 (1), 9615 (2023)
   PUBMED   37316542
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1849)
  AUTHORS   Clarke,B.A., Majumder,S., Zhu,H., Lee,Y.T., Kono,M., Li,C.,
            Khanna,C., Blain,H., Schwartz,R., Huso,V.L., Byrnes,C.,
            Tuymetova,G., Dunn,T.M., Allende,M.L. and Proia,R.L.
  TITLE     The Ormdl genes regulate the sphingolipid synthesis pathway to
            ensure proper myelination and neurologic function in mice
  JOURNAL   Elife 8, e51067 (2019)
   PUBMED   31880535
  REMARK    GeneRIF: we found that Ormdl1 and Ormdl3 function redundantly to
            suppress the levels of bioactive sphingolipid metabolites during
            myelination of the sciatic nerve
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1849)
  AUTHORS   Siow,D., Sunkara,M., Dunn,T.M., Morris,A.J. and Wattenberg,B.
  TITLE     ORMDL/serine palmitoyltransferase stoichiometry determines effects
            of ORMDL3 expression on sphingolipid biosynthesis
  JOURNAL   J Lipid Res 56 (4), 898-908 (2015)
   PUBMED   25691431
REFERENCE   6  (bases 1 to 1849)
  AUTHORS   Wang,S., Robinet,P., Smith,J.D. and Gulshan,K.
  TITLE     ORMDL orosomucoid-like proteins are degraded by
            free-cholesterol-loading-induced autophagy
  JOURNAL   Proc Natl Acad Sci U S A 112 (12), 3728-3733 (2015)
   PUBMED   25775599
  REMARK    GeneRIF: free-cholesterol accumulation diminishes ORMDL1 expression
REFERENCE   7  (bases 1 to 1849)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (bases 1 to 1849)
  AUTHORS   Hjelmqvist,L., Tuson,M., Marfany,G., Herrero,E., Balcells,S. and
            Gonzalez-Duarte,R.
  TITLE     ORMDL proteins are a conserved new family of endoplasmic reticulum
            membrane proteins
  JOURNAL   Genome Biol 3 (6), RESEARCH0027 (2002)
   PUBMED   12093374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN705165.1, EL956043.1, AK077562.1 and BF660823.1.
            
            On Mar 12, 2008 this sequence version replaced NM_145517.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025572.1, AK050385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-645               CN705165.1         1-645
            646-1088            EL956043.1         144-586
            1089-1839           AK077562.1         1152-1902
            1840-1849           BF660823.1         1-10                c
FEATURES             Location/Qualifiers
     source          1..1849
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.99 cM"
     gene            1..1849
                     /gene="Ormdl1"
                     /gene_synonym="C730042F17Rik"
                     /note="ORM1-like 1 (S. cerevisiae)"
                     /db_xref="GeneID:227102"
                     /db_xref="MGI:MGI:2181669"
     exon            1..94
                     /gene="Ormdl1"
                     /gene_synonym="C730042F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            95..275
                     /gene="Ormdl1"
                     /gene_synonym="C730042F17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..563
                     /gene="Ormdl1"
                     /gene_synonym="C730042F17Rik"
                     /codon_start=1
                     /product="ORM1-like protein 1"
                     /protein_id="NP_663492.3"
                     /db_xref="CCDS:CCDS14952.1"
                     /db_xref="GeneID:227102"
                     /db_xref="MGI:MGI:2181669"
                     /translation="MNVGVAHSEVNPNTRVMNSRGMWLTYALGVGLLHIVLLSIPFCS
                     VPVAWTLTNIIHNLGMYVFLHAVKGTPFETPDQGRARLLTHWEQLDYGVQFTSSRKFF
                     TISPIILYFLASFYTKYDPTHFILNTASLLSVLIPKMPQLHGVRIFGINKY"
     exon            276..427
                     /gene="Ormdl1"
                     /gene_synonym="C730042F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            428..1846
                     /gene="Ormdl1"
                     /gene_synonym="C730042F17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1819..1824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ormdl1"
                     /gene_synonym="C730042F17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1841
                     /gene="Ormdl1"
                     /gene_synonym="C730042F17Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccggaagcgg tggggcgcac cagtagctct agccagagga cctactgtgg ctgccgcggg
       61 aattgtcctg tgaccagcca ggagctggcg gccgagcaaa catgaatgtt ggagttgccc
      121 acagtgaggt aaaccccaat actcgtgtaa tgaacagccg tggtatgtgg ctgacatatg
      181 cgttgggagt tggcctgctt catattgtat tactcagcat ccccttctgc agtgttcctg
      241 ttgcctggac cttaaccaac ataatacata atctggggat gtatgtgttt ttgcatgcag
      301 taaaaggaac gccttttgag actccggatc agggtagagc aaggctccta actcactggg
      361 aacagctgga ctacggagta cagtttacat cttctcggaa gtttttcaca atttctccaa
      421 taattctata ctttctggca agtttctata caaagtatga cccgactcac ttcatcctaa
      481 acacagcttc tctgctgagt gtacttattc ccaaaatgcc acagctgcat ggtgttcgca
      541 tctttggaat taataagtat tgaaatgtct gtgcaactga agagaactgt taagagcttc
      601 ctgtaatgaa agagtagtta atgaactgca ctgtttctgt gataatgtga aataagaggt
      661 atttacattg gagggccaag tactgctcct tcacaagctg tcttgaagtg ctctacttaa
      721 ggatgcctct gtctagtttg cttggtatat ttctgagaga ggctttgcag gcaggctggg
      781 caggcccagc ttataacttg atggtagtag gataagagta cagtaactaa atccaaggaa
      841 atgtgggatt tgtaagaaac taggtccagc ttatagtgag cgagcattat gttagggaaa
      901 gagcattcca atcattcgtt catagccggt tgaagcagac ttctagaaag cagaacctcc
      961 tgtgtacatg tttttattac tgtgcacagt ctgctttgta tgacatacac ctgatatatg
     1021 tcctcaggtt cctggcttag tatcatgcat tgataaatga ggtactgttt gcatttatta
     1081 cattacaggg tttgtgaggg ttttgtcttc atttcttgct ctaagagaag aagataggca
     1141 tcttacagtc aaggctctga gtcaacgtgc tcattttgga acaaagtagg ttttactgct
     1201 tttccagaag caaagctgcc aaaccaatta agagaataac ttacttcaag cacttcaggt
     1261 cttgagtagc tgaaaattat tgtttagttg gttaagtctt ttctttcttc taaaaaggaa
     1321 atgcaagatg gggccggctg gtgtggggag acctaagtaa agagtcctct gtcagcaatg
     1381 ttatctgaag taacagataa tattgtctgc tcttagtctc ttactctcca tccgcacagt
     1441 ttggtttgcc cattaatatt tcctgtaaat gtgtcagtct tagtgtagat gacccaaaat
     1501 ggtacctata ttcacagcaa caactatatt gaattcttgt gacttgggga agcttcctat
     1561 agttgctagc attcattaat tgtataaaga gaagtaaata cctttctaaa atgatataaa
     1621 gctgaaaaac tcagtaactt aagagtgaag acagttgtca accaacttac aaatcgattg
     1681 tggcaataca cagagttaag ggtagtgatc attgtttcat atctcaaaag tactgaattt
     1741 agaaatcact tgtttgatac cccctttgta tgtttgcctt ttcttgtgta tctttaaata
     1801 actggtaatt gatgctttaa taaaagtttt ctttggtgta agattaaaa
//
