LOCUS       NM_013623                772 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus orosomucoid 3 (Orm3), transcript variant 2, mRNA.
ACCESSION   NM_013623
VERSION     NM_013623.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 772)
  AUTHORS   Lee,S.H., Choi,J.M., Jung,S.Y., Cox,A.R., Hartig,S.M., Moore,D.D.
            and Kim,K.H.
  TITLE     The bile acid induced hepatokine orosomucoid suppresses adipocyte
            differentiation
  JOURNAL   Biochem Biophys Res Commun 534, 864-870 (2021)
   PUBMED   33168190
  REMARK    GeneRIF: The bile acid induced hepatokine orosomucoid suppresses
            adipocyte differentiation.
REFERENCE   2  (bases 1 to 772)
  AUTHORS   Mburu,P., Mustapha,M., Varela,A., Weil,D., El-Amraoui,A.,
            Holme,R.H., Rump,A., Hardisty,R.E., Blanchard,S., Coimbra,R.S.,
            Perfettini,I., Parkinson,N., Mallon,A.M., Glenister,P.,
            Rogers,M.J., Paige,A.J., Moir,L., Clay,J., Rosenthal,A., Liu,X.Z.,
            Blanco,G., Steel,K.P., Petit,C. and Brown,S.D.
  TITLE     Defects in whirlin, a PDZ domain molecule involved in stereocilia
            elongation, cause deafness in the whirler mouse and families with
            DFNB31
  JOURNAL   Nat Genet 34 (4), 421-428 (2003)
   PUBMED   12833159
REFERENCE   3  (bases 1 to 772)
  AUTHORS   Chang,C.J., Lai,M.Y., Chen,D.S. and Lee,S.C.
  TITLE     Structure and expression of mouse alpha 1-acid glycoprotein gene-3
            (AGP-3)
  JOURNAL   DNA Cell Biol 11 (4), 315-320 (1992)
   PUBMED   1605854
REFERENCE   4  (bases 1 to 772)
  AUTHORS   Carter,K.C., Post,D.J. and Papaconstantinou,J.
  TITLE     Differential expression of the mouse alpha 1-acid glycoprotein
            genes (AGP-1 and AGP-2) during inflammation and aging
  JOURNAL   Biochim Biophys Acta 1089 (2), 197-205 (1991)
   PUBMED   2054382
REFERENCE   5  (bases 1 to 772)
  AUTHORS   Cooper,R. and Papaconstantinou,J.
  TITLE     Evidence for the existence of multiple alpha 1-acid glycoprotein
            genes in the mouse
  JOURNAL   J Biol Chem 261 (4), 1849-1853 (1986)
   PUBMED   3003086
REFERENCE   6  (bases 1 to 772)
  AUTHORS   Craig,A.G., Mullins,J.J., McTurk,P. and Brammar,W.J.
  TITLE     A mouse gene family associated with a major submaxillary-gland
            glycoprotein
  JOURNAL   Biochem J 225 (3), 657-663 (1985)
   PUBMED   3977853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL683828.8.
            
            On Apr 7, 2020 this sequence version replaced NM_013623.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849375, SAMN00849379
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AL683828.8         69776-69931
            157-299             AL683828.8         70189-70331
            300-370             AL683828.8         70529-70599
            371-478             AL683828.8         71162-71269
            479-582             AL683828.8         71407-71510
            583-772             AL683828.8         72935-73124
FEATURES             Location/Qualifiers
     source          1..772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.96 cM"
     gene            1..772
                     /gene="Orm3"
                     /gene_synonym="Agp-3; Orm-3"
                     /note="orosomucoid 3"
                     /db_xref="GeneID:18407"
                     /db_xref="MGI:MGI:97445"
     exon            1..156
                     /gene="Orm3"
                     /gene_synonym="Agp-3; Orm-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..663
                     /gene="Orm3"
                     /gene_synonym="Agp-3; Orm-3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; alpha-1-acid glycoprotein 3; AGP 3; OMD 3"
                     /codon_start=1
                     /product="alpha-1-acid glycoprotein 3 isoform 2 precursor"
                     /protein_id="NP_038651.2"
                     /db_xref="CCDS:CCDS18252.1"
                     /db_xref="GeneID:18407"
                     /db_xref="MGI:MGI:97445"
                     /translation="MELHTVLIMLSLLPLLEAQNPEHAINIGDPITNETLSWLSGKWF
                     LIAVADSDPDYRQEIQKVQTIFFYLTLNLINDTMELREYHTKDDHCVYNSNLLGFQRE
                     NGTLFKYEGEVETLLHLRVLEKHGAIMLFFDLKDEKKRGLSLSARRPDIPPELREVFQ
                     KAVTHVGMDESEIIFVDWKKDRCSEQEKKHLELEKETKKDPEESQA"
     exon            157..299
                     /gene="Orm3"
                     /gene_synonym="Agp-3; Orm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            300..370
                     /gene="Orm3"
                     /gene_synonym="Agp-3; Orm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            371..478
                     /gene="Orm3"
                     /gene_synonym="Agp-3; Orm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            479..582
                     /gene="Orm3"
                     /gene_synonym="Agp-3; Orm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            583..772
                     /gene="Orm3"
                     /gene_synonym="Agp-3; Orm-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      748..753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Orm3"
                     /gene_synonym="Agp-3; Orm-3"
                     /note="hexamer: AATAAA"
     polyA_site      772
                     /gene="Orm3"
                     /gene_synonym="Agp-3; Orm-3"
                     /note="major polyA site"
ORIGIN      
        1 agttatctct tcccagctct ggtgcctctg agtatcctca gcatggaact acacacggtt
       61 ctcatcatgt tgagcctcct gccactgttg gaagctcaga acccagagca tgccatcaac
      121 ataggcgacc ctatcaccaa tgagaccctg agctggctat ctggcaaatg gtttctcatt
      181 gctgtggctg actcagaccc tgattatagg caggaaattc aaaaggtaca gactatattt
      241 ttttacctta ccctaaactt gataaatgac acgatggagc ttcgagagta tcacaccaaa
      301 gatgaccact gtgtctataa ctccaacctt ctgggattcc agagagagaa tgggaccctc
      361 ttcaagtatg aaggagaagt agaaaccctt ctccacctga gagtgctaga gaaacatggg
      421 gccatcatgc ttttctttga cctgaaggat gagaagaaac ggggactgtc cctgagcgct
      481 agaaggccag atatcccccc ggagctgcgg gaagtatttc agaaggctgt cacacacgtg
      541 ggcatggatg aatcagaaat catatttgtc gactggaaaa aggacaggtg cagtgaacag
      601 gaaaagaagc atcttgagtt ggagaaggag accaagaaag atcctgagga aagccaggca
      661 tgaactcagc tctctggtct ccttgggctg tccccatgtg caccacaccc taccccatcc
      721 tgtgcacttt gattctgtct ctgtaacaat aaaggtttgc tgacactgtc aa
//
