LOCUS       NM_011016                774 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus orosomucoid 2 (Orm2), mRNA.
ACCESSION   NM_011016
VERSION     NM_011016.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 774)
  AUTHORS   Nakamura,Y., Watanabe,H., Imafuku,T., Fujita,I., Ganaha,Y.,
            Takeo,T., Nakagata,N., Maeda,H. and Maruyama,T.
  TITLE     Contribution of the alpha1-Acid Glycoprotein in Drug
            Pharmacokinetics: The Usefulness of alpha1-Acid
            Glycoprotein-Knockout Mice
  JOURNAL   Mol Pharm 21 (7), 3144-3150 (2024)
   PUBMED   38862418
REFERENCE   2  (bases 1 to 774)
  AUTHORS   Li,L., Chen,J., Sun,H., Niu,Q., Zhao,Y., Yang,X. and Sun,Q.
  TITLE     Orm2 Deficiency Aggravates High-Fat Diet-Induced Obesity through
            Gut Microbial Dysbiosis and Intestinal Inflammation
  JOURNAL   Mol Nutr Food Res 68 (1), e2300236 (2024)
   PUBMED   37853937
  REMARK    GeneRIF: Orm2 Deficiency Aggravates High-Fat Diet-Induced Obesity
            through Gut Microbial Dysbiosis and Intestinal Inflammation.
REFERENCE   3  (bases 1 to 774)
  AUTHORS   Li,L., Sun,H., Chen,J., Ding,C., Yang,X., Han,H. and Sun,Q.
  TITLE     Mitigation of non-alcoholic steatohepatitis via recombinant
            Orosomucoid 2, an acute phase protein modulating the
            Erk1/2-PPARgamma-Cd36 pathway
  JOURNAL   Cell Rep 42 (7), 112697 (2023)
   PUBMED   37355990
  REMARK    GeneRIF: Mitigation of non-alcoholic steatohepatitis via
            recombinant Orosomucoid 2, an acute phase protein modulating the
            Erk1/2-PPARgamma-Cd36 pathway.
REFERENCE   4  (bases 1 to 774)
  AUTHORS   Zhou,B., Luo,Y., Ji,N., Hu,C. and Lu,Y.
  TITLE     Orosomucoid 2 maintains hepatic lipid homeostasis through
            suppression of de novo lipogenesis
  JOURNAL   Nat Metab 4 (9), 1185-1201 (2022)
   PUBMED   36050503
  REMARK    GeneRIF: Orosomucoid 2 maintains hepatic lipid homeostasis through
            suppression of de novo lipogenesis.
REFERENCE   5  (bases 1 to 774)
  AUTHORS   Watanabe,H., Fujimura,R., Hiramoto,Y., Murata,R., Nishida,K.,
            Bi,J., Imafuku,T., Komori,H., Maeda,H., Mukunoki,A., Takeo,T.,
            Nakagata,N., Tanaka,M., Matsushita,K., Fukagawa,M. and Maruyama,T.
  TITLE     An acute phase protein alpha1-acid glycoprotein mitigates AKI and
            its progression to CKD through its anti-inflammatory action
  JOURNAL   Sci Rep 11 (1), 7953 (2021)
   PUBMED   33846468
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 774)
  AUTHORS   Bahary,N., Pachter,J.E., Felman,R., Leibel,R.L., Albright,K.,
            Cram,S. and Friedman,J.M.
  TITLE     Molecular mapping of mouse chromosomes 4 and 6: use of a
            flow-sorted Robertsonian chromosome
  JOURNAL   Genomics 13 (3), 761-769 (1992)
   PUBMED   1639403
REFERENCE   7  (bases 1 to 774)
  AUTHORS   Chang,C.J., Lai,M.Y., Chen,D.S. and Lee,S.C.
  TITLE     Structure and expression of mouse alpha 1-acid glycoprotein gene-3
            (AGP-3)
  JOURNAL   DNA Cell Biol 11 (4), 315-320 (1992)
   PUBMED   1605854
REFERENCE   8  (bases 1 to 774)
  AUTHORS   Alam,T. and Papaconstantinou,J.
  TITLE     Interaction of acute-phase-inducible and liver-enriched nuclear
            factors with the promoter region of the mouse alpha 1-acid
            glycoprotein gene-1
  JOURNAL   Biochemistry 31 (7), 1928-1936 (1992)
   PUBMED   1371400
REFERENCE   9  (bases 1 to 774)
  AUTHORS   Bahary,N., Zorich,G., Pachter,J.E., Leibel,R.L. and Friedman,J.M.
  TITLE     Molecular genetic linkage maps of mouse chromosomes 4 and 6
  JOURNAL   Genomics 11 (1), 33-47 (1991)
   PUBMED   1684952
REFERENCE   10 (bases 1 to 774)
  AUTHORS   Prowse,K.R. and Baumann,H.
  TITLE     Molecular characterization and acute phase expression of the
            multiple Mus caroli alpha 1-acid glycoprotein (AGP) genes.
            Differences in glucocorticoid stimulation and regulatory elements
            between the rat and mouse AGP genes
  JOURNAL   J Biol Chem 265 (18), 10201-10209 (1990)
   PUBMED   2354997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB949119.1 and M27009.1.
            
            On Aug 12, 2006 this sequence version replaced NM_011016.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M27009.1, CB949119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-643               CB949119.1         4-646
            644-774             M27009.1           609-739
FEATURES             Location/Qualifiers
     source          1..774
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.96 cM"
     gene            1..774
                     /gene="Orm2"
                     /gene_synonym="Agp1; Orm-2"
                     /note="orosomucoid 2"
                     /db_xref="GeneID:18406"
                     /db_xref="MGI:MGI:97444"
     exon            1..155
                     /gene="Orm2"
                     /gene_synonym="Agp1; Orm-2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..298
                     /gene="Orm2"
                     /gene_synonym="Agp1; Orm-2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..369
                     /gene="Orm2"
                     /gene_synonym="Agp1; Orm-2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..477
                     /gene="Orm2"
                     /gene_synonym="Agp1; Orm-2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..581
                     /gene="Orm2"
                     /gene_synonym="Agp1; Orm-2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..774
                     /gene="Orm2"
                     /gene_synonym="Agp1; Orm-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctcttcca agccctggtg cctctgagtg tcctaagcat ggcactgcac atgattcttg
       61 tcatggtgag cctcctgccg ctgttggaag ctcagaaccc agaacatgtc aacatcacca
      121 taggcgaccc tatcaccaat gagaccctga gctggctctc tgacaaatgg tttttcattg
      181 gtgcggctgt cctaaaccct gattaccggc aggaaattca aaagacgcag atggtatttt
      241 ttaaccttac ccccaacttg ataaatgaca cgatggagct tcgagagtat cacaccatag
      301 atgaccactg tgtctataac tccactcatc taggaatcca gagagagaat gggaccctct
      361 ccaagtatgt aggaggagta aaaatctttg cagacctgat agtcttgaag atgcatgggg
      421 ccttcatgct tgcctttgac ttgaaggatg agaagaaacg gggactgtcc ctcaatgcaa
      481 aaaggccaga tatcaccccg gagctgcggg aagtattcca gaaggctgtc acacacgtgg
      541 gcatggatga atcagaaatc atatttgtcg actggaaaaa ggacaggtgc agtcagcagg
      601 agaagcagca gcttgagctg gagaaggaga ccaagaaaga tcctgaggaa ggccaggcat
      661 gaactcagct ctctgaactc cgagggctgt ccacaggctc accaaacccc acccctcctg
      721 tgcactttga ttctgtctct gccacaataa aggtttgctg acacagtcaa tatc
//
