LOCUS       NM_008768                779 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus orosomucoid 1 (Orm1), mRNA.
ACCESSION   NM_008768
VERSION     NM_008768.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 779)
  AUTHORS   Barriola,S., Delgado-Garcia,L.M., Cartas-Cejudo,P., Inigo-Marco,I.,
            Fernandez-Irigoyen,J., Santamaria,E. and Lopez-Mascaraque,L.
  TITLE     Orosomucoid-1 Arises as a Shared Altered Protein in Two Models of
            Multiple Sclerosis
  JOURNAL   Neuroscience 535, 203-217 (2023)
   PUBMED   37949310
  REMARK    GeneRIF: Orosomucoid-1 Arises as a Shared Altered Protein in Two
            Models of Multiple Sclerosis.
REFERENCE   2  (bases 1 to 779)
  AUTHORS   Yue,L., Xu,X., Dai,S., Xu,F., Zhao,W., Gu,J., Dai,X. and Qian,X.
  TITLE     Orosomucoid 1 promotes colorectal cancer progression and liver
            metastasis by affecting PI3K/AKT pathway and inducing macrophage M2
            polarization
  JOURNAL   Sci Rep 13 (1), 14092 (2023)
   PUBMED   37640741
  REMARK    GeneRIF: Orosomucoid 1 promotes colorectal cancer progression and
            liver metastasis by affecting PI3K/AKT pathway and inducing
            macrophage M2 polarization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 779)
  AUTHORS   Matsusaka,K., Fujiwara,Y., Pan,C., Esumi,S., Saito,Y., Bi,J.,
            Nakamura,Y., Mukunoki,A., Takeo,T., Nakagata,N., Yoshii,D.,
            Fukuda,R., Nagasaki,T., Tanaka,R., Komori,H., Maeda,H.,
            Watanabe,H., Tamada,K., Komohara,Y. and Maruyama,T.
  TITLE     alpha1-Acid Glycoprotein Enhances the Immunosuppressive and
            Protumor Functions of Tumor-Associated Macrophages
  JOURNAL   Cancer Res 81 (17), 4545-4559 (2021)
   PUBMED   34210751
  REMARK    GeneRIF: alpha1-Acid Glycoprotein Enhances the Immunosuppressive
            and Protumor Functions of Tumor-Associated Macrophages.
REFERENCE   4  (bases 1 to 779)
  AUTHORS   Lee,S.H., Choi,J.M., Jung,S.Y., Cox,A.R., Hartig,S.M., Moore,D.D.
            and Kim,K.H.
  TITLE     The bile acid induced hepatokine orosomucoid suppresses adipocyte
            differentiation
  JOURNAL   Biochem Biophys Res Commun 534, 864-870 (2021)
   PUBMED   33168190
  REMARK    GeneRIF: The bile acid induced hepatokine orosomucoid suppresses
            adipocyte differentiation.
REFERENCE   5  (bases 1 to 779)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 779)
  AUTHORS   Chang,C.J., Lai,M.Y., Chen,D.S. and Lee,S.C.
  TITLE     Structure and expression of mouse alpha 1-acid glycoprotein gene-3
            (AGP-3)
  JOURNAL   DNA Cell Biol 11 (4), 315-320 (1992)
   PUBMED   1605854
REFERENCE   7  (bases 1 to 779)
  AUTHORS   Alam,T. and Papaconstantinou,J.
  TITLE     Interaction of acute-phase-inducible and liver-enriched nuclear
            factors with the promoter region of the mouse alpha 1-acid
            glycoprotein gene-1
  JOURNAL   Biochemistry 31 (7), 1928-1936 (1992)
   PUBMED   1371400
REFERENCE   8  (bases 1 to 779)
  AUTHORS   Pilz,A., Moseley,H., Peters,J. and Abbott,C.
  TITLE     Comparative mapping of mouse chromosome 4 and human chromosome 9:
            Lv, Orm, and Hxb are closely linked on mouse chromosome 4
  JOURNAL   Mamm Genome 3 (5), 247-249 (1992)
   PUBMED   1379092
REFERENCE   9  (bases 1 to 779)
  AUTHORS   Prowse,K.R. and Baumann,H.
  TITLE     Molecular characterization and acute phase expression of the
            multiple Mus caroli alpha 1-acid glycoprotein (AGP) genes.
            Differences in glucocorticoid stimulation and regulatory elements
            between the rat and mouse AGP genes
  JOURNAL   J Biol Chem 265 (18), 10201-10209 (1990)
   PUBMED   2354997
REFERENCE   10 (bases 1 to 779)
  AUTHORS   Lee,S.C., Chang,C.J., Lee,Y.M., Lei,H.Y., Lai,M.Y. and Chen,D.S.
  TITLE     Molecular cloning of cDNAs corresponding to two genes of alpha
            1-acid glycoprotein and characterization of two alleles of AGP-1 in
            the mouse
  JOURNAL   DNA 8 (4), 245-251 (1989)
   PUBMED   2475311
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL683828.8, AK138985.1,
            AA611123.1 and AW113734.1.
            
            On Aug 21, 2015 this sequence version replaced NM_008768.1.
            
            Summary: This gene encodes a member of the lipocalin family of
            proteins. The encoded protein is an abundant acute-phase protein
            that is synthesized by hepatocytes in response to cytokines during
            the acute phase response. The encoded protein may regulate
            inflammation and metabolism. This gene is present in a gene cluster
            on chromosome 4. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA458313.1, CA457519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL683828.8         58174-58174
            2-21                AK138985.1         2-21
            22-645              AA611123.1         1-624
            646-777             AW113734.1         1-132               c
            778-779             AL683828.8         61780-61781
FEATURES             Location/Qualifiers
     source          1..779
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.96 cM"
     gene            1..779
                     /gene="Orm1"
                     /gene_synonym="Agp-1; Agp-2; Orm-1"
                     /note="orosomucoid 1"
                     /db_xref="GeneID:18405"
                     /db_xref="MGI:MGI:97443"
     exon            1..159
                     /gene="Orm1"
                     /gene_synonym="Agp-1; Agp-2; Orm-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..666
                     /gene="Orm1"
                     /gene_synonym="Agp-1; Agp-2; Orm-1"
                     /note="alpha-1-acid glycoprotein 1; AGP 1; OMD 1"
                     /codon_start=1
                     /product="alpha-1-acid glycoprotein 1 precursor"
                     /protein_id="NP_032794.1"
                     /db_xref="CCDS:CCDS18251.1"
                     /db_xref="GeneID:18405"
                     /db_xref="MGI:MGI:97443"
                     /translation="MALHTVLIILSLLPMLEAQNPEHANFTIGEPITNETLSWLSDKW
                     FFMGAAFRKLEYRQAIQTMQSEFFYLTTNLINDTIELRESQTIGDQCVYNSTHLGFQR
                     ENGTFSKYEGGVETFAHLIVLRKHGAFMLAFDLKDEKKRGLSLYAKRPDITPELREVF
                     QKAVTHVGMDESEIIFVDWKKDRCGQQEKKQLELGKETKKDPEEGQA"
     exon            160..302
                     /gene="Orm1"
                     /gene_synonym="Agp-1; Agp-2; Orm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..373
                     /gene="Orm1"
                     /gene_synonym="Agp-1; Agp-2; Orm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..481
                     /gene="Orm1"
                     /gene_synonym="Agp-1; Agp-2; Orm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..585
                     /gene="Orm1"
                     /gene_synonym="Agp-1; Agp-2; Orm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..779
                     /gene="Orm1"
                     /gene_synonym="Agp-1; Agp-2; Orm-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      750..755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Orm1"
                     /gene_synonym="Agp-1; Agp-2; Orm-1"
                     /note="hexamer: AATAAA"
     polyA_site      774
                     /gene="Orm1"
                     /gene_synonym="Agp-1; Agp-2; Orm-1"
                     /note="major polyA site"
ORIGIN      
        1 aatgatcttt tcccaggcct ggtggctctg agtgccctca gcatggcgct gcacacggtt
       61 cttatcatat tgagccttct gccgatgttg gaagctcaga acccagaaca tgccaacttc
      121 accataggcg aacctatcac caatgagacc ctgagctggc tctctgacaa atggtttttc
      181 atgggtgcag ctttcagaaa actcgagtac aggcaggcaa ttcaaacaat gcagagtgaa
      241 tttttttacc ttaccaccaa cttgataaac gacacaatag agcttcggga gtctcaaaca
      301 ataggtgacc agtgtgtcta taactccacc catctaggat tccagagaga aaatgggacc
      361 ttctccaagt atgaaggagg agtagaaacc tttgcccacc ttatagtgct gaggaaacat
      421 ggggccttca tgcttgcctt tgacctcaag gatgagaaga aacggggact gtccctctat
      481 gccaaaaggc cagatatcac cccggagctg cgggaagtat tccagaaggc tgtcacacac
      541 gtgggcatgg atgaatcaga aatcatattt gtcgactgga aaaaggatag gtgcggtcag
      601 caggagaaga agcagcttga gttggggaag gagaccaaga aagatcctga ggaaggccag
      661 gcatgaactc agctctctga actccgaggg ctgtccacag gctcaccaaa ccccacccct
      721 cctgtgcact ttgattctgt ctctgccaca ataaaggttt gctgacatag tcaatatca
//
