LOCUS       NM_019716               1663 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus origin recognition complex, subunit 6 (Orc6),
            transcript variant 1, mRNA.
ACCESSION   NM_019716
VERSION     NM_019716.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1663)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1663)
  AUTHORS   Jaremko,M.J., On,K.F., Thomas,D.R., Stillman,B. and Joshua-Tor,L.
  TITLE     The dynamic nature of the human origin recognition complex revealed
            through five cryoEM structures
  JOURNAL   Elife 9, e58622 (2020)
   PUBMED   32808929
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1663)
  AUTHORS   Murai,S., Stein,P., Buffone,M.G., Yamashita,S. and Schultz,R.M.
  TITLE     Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is
            essential for DNA replication in 1-cell embryos
  JOURNAL   Dev Biol 341 (1), 205-212 (2010)
   PUBMED   20219456
  REMARK    GeneRIF: Study reports that ORC6L is another component required for
            acquisition of DNA replication competence that is absent in mouse
            oocytes.
REFERENCE   4  (bases 1 to 1663)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   5  (bases 1 to 1663)
  AUTHORS   Kneissl,M., Putter,V., Szalay,A.A. and Grummt,F.
  TITLE     Interaction and assembly of murine pre-replicative complex proteins
            in yeast and mouse cells
  JOURNAL   J Mol Biol 327 (1), 111-128 (2003)
   PUBMED   12614612
REFERENCE   6  (bases 1 to 1663)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134854.3, AK163256.1, BC080739.1, AK078405.1, BF661105.1 and
            BP771997.1.
            
            On Aug 4, 2009 this sequence version replaced NM_019716.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF139659.1, BC080739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC134854.3         102493-102549       c
            58-361              AK163256.1         2-305
            362-491             BC080739.1         81-210
            492-1342            AK163256.1         306-1156
            1343-1497           AK078405.1         947-1101
            1498-1498           BF661105.1         354-354             c
            1499-1621           AK078405.1         1103-1225
            1622-1663           BP771997.1         52-93               c
FEATURES             Location/Qualifiers
     source          1..1663
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.61 cM"
     gene            1..1663
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
                     /note="origin recognition complex, subunit 6"
                     /db_xref="GeneID:56452"
                     /db_xref="MGI:MGI:1929285"
     exon            1..361
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1085
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="origin recognition complex subunit 6 isoform a"
                     /protein_id="NP_062690.2"
                     /db_xref="CCDS:CCDS22497.1"
                     /db_xref="GeneID:56452"
                     /db_xref="MGI:MGI:1929285"
                     /translation="MESELVRRLAPRLGLAEPSVLRKAEEFLRLSKVKCVSLSARSSE
                     TSNAVICLDLAASCRKCPLDRAYLIRLSGLNKMVYQSCLKSFECLLGLNSNVGIRDLA
                     VQFSCTEAVNLAAEILQSYESGLPETQRADLDLSRPLFTTAALLSACKILKIKVDKTK
                     MITASGVKKAILDRLCKQLEKIGQQINRDSADLARPALKRKKPEFSPTLKKKEPGLEP
                     PAKEIEVIETLHKLPKDEDLTQDYEEWKRKILENAAKAQTATAE"
     exon            362..491
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
                     /inference="alignment:Splign:2.1.0"
     exon            492..655
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
                     /inference="alignment:Splign:2.1.0"
     exon            656..745
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
                     /inference="alignment:Splign:2.1.0"
     exon            746..858
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
                     /inference="alignment:Splign:2.1.0"
     exon            859..960
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1654
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1425..1430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
                     /note="hexamer: AATAAA"
     polyA_site      1446
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
                     /note="major polyA site"
     regulatory      1632..1637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
                     /note="hexamer: AATAAA"
     polyA_site      1654
                     /gene="Orc6"
                     /gene_synonym="6720420I10Rik; Orc6l"
ORIGIN      
        1 atagtggacg gggcggggcg agaatagtac aacgctgcgg cgaactaggg acagcaggaa
       61 gggaagcctt agttaaggag atccgcggcc gaggaagggc agcgagagaa ccttctgcgc
      121 gtccacttcg cctgggcccg cgcctcatcg tgtgcacatg cgtagaagga tgaccaggat
      181 tggtgtgtgg aacggtctca acctctggtc gcaaccaatc tggacgcgcc gggggtgggt
      241 cttaaccctc tgacaatctg cgcgcgcatt gctcttggcg cgcatttctt ccagcgatgg
      301 agtcggagct ggtacgccgc ctcgccccgc gtctcggcct tgcggagccg agtgtactga
      361 ggaaagcaga ggagttcctg cggctgtcta aggtgaagtg tgtcagtctg tctgcacgta
      421 gctcagaaac cagcaatgct gtcatatgcc tggaccttgc agcttcctgt aggaagtgcc
      481 ccttggatag agcatattta attaggctct ctggtttgaa caagatggtg tatcagagct
      541 gtcttaaatc ttttgagtgt ttactaggat taaattcaaa tgttggaatc agagacctag
      601 ctgtacagtt cagctgtaca gaagcagtga acttggctgc agagatactg cagagctacg
      661 agtctggtct tcctgaaaca cagcgagcag atcttgactt gtccaggcca cttttcacca
      721 ctgccgcact actctcagca tgcaaaattc taaagataaa ggtggataaa accaaaatga
      781 taactgcatc cggtgtgaaa aaggcaatac ttgatcgact gtgtaagcag ttagaaaaga
      841 ttgggcagca gattaacaga gactctgcag atttagctag accagcactg aagagaaaga
      901 agccagagtt tagtccaaca ctgaagaaaa aggagccagg acttgaacca ccagcaaaag
      961 aaatagaagt aatagaaacc cttcataaac tacctaaaga tgaagatctg acacaggatt
     1021 atgaagaatg gaaaaggaag attttggaaa atgctgccaa agctcagaca gccacagcag
     1081 agtgatttcc atctcactgc aggcatgtgc agtctgtctg ggagatgaag ggtgtggaag
     1141 tcttctctaa gcctgaattc caggtgtgct gaggagtgtc tcagtacaga ggatgctagc
     1201 actgggcacc tcacatggac attagatcaa ccatattgcc tctgaagact cagatctgtc
     1261 ctctcacgtg gggtgaaatt gggaccattt tgcttctatg tgtttaagaa aatttcctga
     1321 ctaaacctag aatgcaaatt tcaagctgaa agacatctca gacattttat ttggttttgt
     1381 ggttttttaa attttatttc actaaatgtt atatagccta agttaataaa tattttttaa
     1441 acattttttt aaatgtgtat gagtattttg cctgcatgta tgtctggtgc agtggaagcc
     1501 agaagagaat gccagatccc taagccttga gttacagaca gtgagcgttg ccatatgagt
     1561 gctgggactt aaaccccagt cctctagaag agcagctagt gctttttacc actgaaccat
     1621 ctctcaagcc caataaatgt tatttttata tgcaaaaaaa aaa
//
