LOCUS       NP_056639                715 aa            linear   ROD 30-APR-2024
DEFINITION  origin recognition complex subunit 3 isoform 1 [Mus musculus].
ACCESSION   NP_056639
VERSION     NP_056639.3
DBSOURCE    REFSEQ: accession NM_015824.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 715)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 715)
  AUTHORS   Jaremko,M.J., On,K.F., Thomas,D.R., Stillman,B. and Joshua-Tor,L.
  TITLE     The dynamic nature of the human origin recognition complex revealed
            through five cryoEM structures
  JOURNAL   Elife 9, e58622 (2020)
   PUBMED   32808929
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 715)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 715)
  AUTHORS   Ma,S., Kwon,H.J., Johng,H., Zang,K. and Huang,Z.
  TITLE     Radial glial neural progenitors regulate nascent brain vascular
            network stabilization via inhibition of Wnt signaling
  JOURNAL   PLoS Biol 11 (1), e1001469 (2013)
   PUBMED   23349620
REFERENCE   5  (residues 1 to 715)
  AUTHORS   Xie,L., Hoffmann,A.D., Burnicka-Turek,O., Friedland-Little,J.M.,
            Zhang,K. and Moskowitz,I.P.
  TITLE     Tbx5-hedgehog molecular networks are essential in the second heart
            field for atrial septation
  JOURNAL   Dev Cell 23 (2), 280-291 (2012)
   PUBMED   22898775
REFERENCE   6  (residues 1 to 715)
  AUTHORS   Ma,S., Kwon,H.J. and Huang,Z.
  TITLE     A functional requirement for astroglia in promoting blood vessel
            development in the early postnatal brain
  JOURNAL   PLoS One 7 (10), e48001 (2012)
   PUBMED   23110156
  REMARK    GeneRIF: Data indicate that conditional deletion from glial
            progenitors of orc3, a gene required for DNA replication,
            dramatically reduces glial progenitor cell number in the
            subventricular zone and astrocytes in the early postnatal cerebral
            cortex.
REFERENCE   7  (residues 1 to 715)
  AUTHORS   Kwon,H.J., Ma,S. and Huang,Z.
  TITLE     Radial glia regulate Cajal-Retzius cell positioning in the early
            embryonic cerebral cortex
  JOURNAL   Dev Biol 351 (1), 25-34 (2011)
   PUBMED   21185282
REFERENCE   8  (residues 1 to 715)
  AUTHORS   Miyake,Y., Mizuno,T., Yanagi,K. and Hanaoka,F.
  TITLE     Novel splicing variant of mouse Orc1 is deficient in nuclear
            translocation and resistant for proteasome-mediated degradation
  JOURNAL   J Biol Chem 280 (13), 12643-12652 (2005)
   PUBMED   15634681
  REMARK    GeneRIF: mouse Orc1, Orc2, and Orc3 each exist in two
            alternative-splicing variants and naturally occurring Orc1B lacks a
            functional domain that is essential for nuclear translocation and
            proteasome-dependent degradation
REFERENCE   9  (residues 1 to 715)
  AUTHORS   Springer,J., Nanda,I., Hoehn,K., Schmid,M. and Grummt,F.
  TITLE     Identification and chromosomal localization of murine ORC3, a new
            member of the mouse origin recognition complex
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 245-251 (1999)
   PUBMED   10702681
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB663298.1, AK045388.1, AK086579.1 and AK041216.1.
            
            On Apr 21, 2009 this sequence version replaced NP_056639.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK086579.1, AK045388.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 16.81 cM"
     Protein         1..715
                     /product="origin recognition complex subunit 3 isoform 1"
                     /note="origin of replication 3 homolog; origin recognition
                     complex subunit Latheo"
                     /calculated_mol_wt=82211
     Region          25..350
                     /region_name="ORC3_N"
                     /note="Origin recognition complex (ORC) subunit 3
                     N-terminus; pfam07034"
                     /db_xref="CDD:462070"
     Site            order(150,267,270..271,275)
                     /site_type="other"
                     /note="Orc4 interface [polypeptide binding]"
                     /db_xref="CDD:412052"
     Site            order(156,160,163)
                     /site_type="other"
                     /note="Orc1 interface [polypeptide binding]"
                     /db_xref="CDD:412052"
     Region          361..592
                     /region_name="ORC3_ins"
                     /note="Origin recognition complex subunit 3 insertion
                     domain; pfam19675"
                     /db_xref="CDD:466140"
     Site            522
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17525332; propagated from
                     UniProtKB/Swiss-Prot (Q9JK30.1)"
     Site            523
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBD5; propagated from
                     UniProtKB/Swiss-Prot (Q9JK30.1)"
     Region          603..712
                     /region_name="ORC_WH_C"
                     /note="Origin recognition complex winged helix C-terminal;
                     pfam18137"
                     /db_xref="CDD:436299"
     CDS             1..715
                     /gene="Orc3"
                     /gene_synonym="Orc3l"
                     /coded_by="NM_015824.4:34..2181"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS18028.1"
                     /db_xref="GeneID:50793"
                     /db_xref="MGI:MGI:1354944"
ORIGIN      
        1 mhtgprtmat ssvskgcfvf kpdfkkrkvf vpiedyfnne eldsedsklr fetysllwqr
       61 mkseteqlqe elnenlfdnl vdflqkshpe fqknsrdwgs qmkfreipta alilgvnvtd
      121 hdvilrslte tlqnnvtpyv vslqakdcpd vkhflqkfts qlmdccvdrh skevtsgkal
      181 kktnysmdsl cswysavtqk adhkvtikkr tasghwrspp vvlilksmes ftskvlqdfi
      241 tissqhlhef plilifgiat spviihrllp hsvssllcve lfqslsceqh ltvvldklll
      301 tpqfpfklsk kalqvltnif lyhdfsiqsf ikgiklslle hfysqplsvl ccdlseakkr
      361 vnvfsvsqce nirrlpsfrr yvenqplgkq valltnetfl kektqslled lhvyhinyfl
      421 vlrclhnfts slpkyplgrq irelyctcle kkiwdseeyk salqllrmla kdelvsilqr
      481 cievldsste kqlgnttqki kdfltqfqnl dadskeeeda cgsqpkglqk tdlyhlqksl
      541 lemkelrrtk kptkfemlre nvmnfidnlv rdyllppesq plhevvyfsa antlrehlna
      601 aprialhtal nnpyyylkne elegcipnta pdiciayklh lecsllinlv dwaeafatvv
      661 taaekmdans tvseemsevi harfiravse lellgfikpt kqktdhvarl twggc
//
