LOCUS       NM_011015               3027 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus origin recognition complex, subunit 1 (Orc1), mRNA.
ACCESSION   NM_011015
VERSION     NM_011015.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3027)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3027)
  AUTHORS   Garcia-Juan,M., Ordonez-Gutierrez,L. and Wandosell,F.
  TITLE     Clearance of beta-amyloid mediated by autophagy is enhanced by
            MTORC1 inhibition but not AMPK activation in APP/PSEN1 astrocytes
  JOURNAL   Glia 72 (3), 588-606 (2024)
   PUBMED   38009275
  REMARK    GeneRIF: Clearance of beta-amyloid mediated by autophagy is
            enhanced by MTORC1 inhibition but not AMPK activation in APP/PSEN1
            astrocytes.
REFERENCE   3  (bases 1 to 3027)
  AUTHORS   Jaremko,M.J., On,K.F., Thomas,D.R., Stillman,B. and Joshua-Tor,L.
  TITLE     The dynamic nature of the human origin recognition complex revealed
            through five cryoEM structures
  JOURNAL   Elife 9, e58622 (2020)
   PUBMED   32808929
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3027)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3027)
  AUTHORS   Okano-Uchida,T., Kent,L.N., Ouseph,M.M., McCarty,B., Frank,J.J.,
            Kladney,R., Cuitino,M.C., Thompson,J.C., Coppola,V., Asano,M. and
            Leone,G.
  TITLE     Endoreduplication of the mouse genome in the absence of ORC1
  JOURNAL   Genes Dev 32 (13-14), 978-990 (2018)
   PUBMED   29967292
  REMARK    GeneRIF: ORC1 in mice is essential for mitotic cell divisions but
            dispensable for endoreduplication.
REFERENCE   6  (bases 1 to 3027)
  AUTHORS   Miyake,Y., Mizuno,T., Yanagi,K. and Hanaoka,F.
  TITLE     Novel splicing variant of mouse Orc1 is deficient in nuclear
            translocation and resistant for proteasome-mediated degradation
  JOURNAL   J Biol Chem 280 (13), 12643-12652 (2005)
   PUBMED   15634681
  REMARK    GeneRIF: mouse Orc1, Orc2, and Orc3 each exist in two
            alternative-splicing variants and naturally occurring Orc1B lacks a
            functional domain that is essential for nuclear translocation and
            proteasome-dependent degradation
REFERENCE   7  (bases 1 to 3027)
  AUTHORS   Kneissl,M., Putter,V., Szalay,A.A. and Grummt,F.
  TITLE     Interaction and assembly of murine pre-replicative complex proteins
            in yeast and mouse cells
  JOURNAL   J Mol Biol 327 (1), 111-128 (2003)
   PUBMED   12614612
REFERENCE   8  (bases 1 to 3027)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3027)
  AUTHORS   Natale,D.A., Li,C.J., Sun,W.H. and DePamphilis,M.L.
  TITLE     Selective instability of Orc1 protein accounts for the absence of
            functional origin recognition complexes during the M-G(1)
            transition in mammals
  JOURNAL   EMBO J 19 (11), 2728-2738 (2000)
   PUBMED   10835370
REFERENCE   10 (bases 1 to 3027)
  AUTHORS   Zisimopoulou,P., Staib,C., Nanda,I., Schmid,M. and Grummt,F.
  TITLE     Mouse homolog of the yeast origin recognition complex subunit ORC1
            and chromosomal localization of the cognate mouse gene Orc1
  JOURNAL   Mol Gen Genet 260 (2-3), 295-299 (1998)
   PUBMED   9862484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164035.1, AK141741.1 and AJ003133.1.
            
            On Oct 20, 2007 this sequence version replaced NM_011015.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ003133.1, AK164035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2448              AK164035.1         2-2449
            2449-2841           AK141741.1         2452-2844
            2842-3008           AK164035.1         2843-3009
            3009-3027           AJ003133.1         2999-3017
FEATURES             Location/Qualifiers
     source          1..3027
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.64 cM"
     gene            1..3027
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /note="origin recognition complex, subunit 1"
                     /db_xref="GeneID:18392"
                     /db_xref="MGI:MGI:1328337"
     exon            1..122
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            123..228
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2656
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /codon_start=1
                     /product="origin recognition complex subunit 1"
                     /protein_id="NP_035145.2"
                     /db_xref="CCDS:CCDS18453.1"
                     /db_xref="GeneID:18392"
                     /db_xref="MGI:MGI:1328337"
                     /translation="MPSYLTRQKTRQTFSWVGRPLPNRKQFQQMYREICMKINDGSEI
                     HIKVGQFVLIQGEDNKKPYVAKLIELFQNGAEVPPKKCARVQWFVRFLEIPVSKRHLL
                     GRSPPAQEIFWYDCSDWDNKINVETIIGPVQVVALAPEEVIPVDQKSEETLFVKLSWN
                     KKDFAPLPPEVLAALREQEDSPEWQKPLKAKIKNVKSPARNTTEQEVKGIKSNHSTSK
                     FHQTPANIVIPNAKKSLELDGLGFTRKPNTRWSKKSSCDSLDYQKTSKRRAAFSETTS
                     PPKKPNKPREIKPSSALETRVKNGQTQPFCAKSSVVLRARNPAMTTTKLGVDNTLSPI
                     RNGLRSSVVPSGGLTPVYIRRKAKEQETHKEPIRTSRVHRKSSLLTLKRIRQQLCLLD
                     GDDRDQEEEESVDSESEEEDEFISSLPTRNSLGQSRTRQTPSKSPQKNPKPRTPHRAT
                     PQIRDRNLAVQEPASALEEARLRLHVSAVPDSLPCREQEFQDIYSFVESKLLDGTGGC
                     MYISGVPGTGKTATVHEVIRCLQQAAETDDVPPFQYVEVNGMKLTEPHQVYVQILKKL
                     TGQKATANHAAELLAKQFCGQGSQKETTVLLVDELDLLWTHKQDVMYNLFDWPTHKGA
                     HLIVLTIANTMDLPERIMMNRVSSRLGLTRMSFQPYSHSQLKQILVSRLRNLRAFEDD
                     AIQLVARKVAALSGDARRCLDICRRATEICELSHLRGDSLSLVTVAHLMEAIDEMFSS
                     SYITAIKNSSVVEQSFLRAIIAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSET
                     MAVCSRLGSCRLLLVEPSRNDLLLRVRLNVSQNDVLFALKEE"
     exon            229..353
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            354..532
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            533..848
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1197
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1299
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1453
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1551
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1653
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1825
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1933
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2083
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2203
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2373
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2461
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..3014
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2992..2997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /note="hexamer: AGTAAA"
     polyA_site      3014
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /note="major polyA site"
ORIGIN      
        1 agttcttagt cagctgagag ctgggactac gtgttgtagc cgtggtctcc cggaggagcc
       61 agacctggac gagcgagcgt cccccagcta ctccagtgcc tggactgcaa agcgtcggcg
      121 agcccatcag accatgccat cctacctcac aaggcagaag accagacaaa ctttctcatg
      181 ggttggcagg ccattgccga atcgaaaaca gttccaacaa atgtacagag aaatttgtat
      241 gaaaatcaat gatggttctg agattcacat caaggttgga cagtttgtat tgattcaggg
      301 ggaagataat aaaaagccct atgtggctaa actgattgaa ttatttcaaa atggagctga
      361 agttcctccc aagaaatgtg cacgagtaca gtggtttgtc agattccttg agattcctgt
      421 ctctaaaagg cacttgttag gccgcagtcc tcctgcacag gagatattct ggtatgactg
      481 ttctgactgg gataacaaga ttaatgtgga gaccatcatt ggccctgttc aggtagtggc
      541 attagcccca gaagaagtga ttcctgtgga tcagaaaagt gaggagacac tgtttgtgaa
      601 gctatcctgg aataaaaagg actttgcacc actgccacca gaagtgcttg cagcattaag
      661 ggaacaagaa gatagtcctg agtggcaaaa acctttaaaa gccaagatta agaatgtaaa
      721 aagccctgcc cggaacacaa cagaacaaga ggtcaaaggg atcaaatcaa atcattccac
      781 ttccaaattt caccagactc ctgctaatat tgtcatcccc aatgcaaaga agtcgctgga
      841 actcgatggc ttaggtttta ccaggaagcc taacacgagg tggtcaaaga agagctcgtg
      901 tgactccttg gattatcaaa aaacatctaa aagaagagca gccttctctg agaccacctc
      961 gcctcctaaa aagcctaata aacctcgtga aatcaagccc tcttcagctt tggaaactcg
     1021 agttaaaaat ggacaaactc aacctttttg tgccaaaagt agtgtggttc tgagagcccg
     1081 gaacccagct atgacgacca caaagcttgg tgtggacaac acacttagcc ctatcaggaa
     1141 tgggttgaga tcttcagtgg tgccctctgg gggtctgaca ccagtataca ttaggaggaa
     1201 ggcaaaagaa caagaaactc acaaagaacc catccgtact tctcgtgtcc atagaaagag
     1261 ttctctcttg actttgaagc ggattaggca acagctttgt cttctagatg gtgatgacag
     1321 ggaccaagaa gaggaagagt ccgtagactc tgagagtgag gaggaagatg agtttatttc
     1381 ctccctccca acaagaaatt ccctggggca gtccaggacc cggcagaccc cctccaagtc
     1441 accacagaaa aatcctaaac ctagaacacc tcatcgtgcc actcctcaga tccgagacag
     1501 aaacctggct gtccaggagc cagctagtgc gctggaagag gcacggctga ggttgcatgt
     1561 ttctgctgtg cctgactctc tcccctgtcg agagcaggaa ttccaagaca tctacagctt
     1621 tgtggaaagt aaacttcttg atgggactgg agggtgtatg tacatttctg gggtccctgg
     1681 gacagggaag acagccactg tgcatgaggt catacgctgt ctgcagcagg cagcagaaac
     1741 agatgatgtt cctccctttc aatatgttga ggttaatggg atgaagctga cagaacccca
     1801 ccaagtctat gtgcagattt taaagaaact gacaggccag aaggcaacag ccaatcatgc
     1861 agcagaactg ctggcgaagc aattctgtgg ccaagggtcc cagaaggaaa ccactgtact
     1921 gctcgtggat gagcttgacc ttctttggac tcacaaacaa gatgtaatgt acaacctctt
     1981 tgattggcct actcacaaag gggcccactt gatagtgctg accattgcca acaccatgga
     2041 ccttcccgag aggatcatga tgaaccgtgt gtctagccga ctgggcctca ccaggatgtc
     2101 tttccagccc tattctcaca gccagctgaa acagatctta gtgtctcgac tgaggaattt
     2161 aagggccttt gaggacgatg ccatccagct ggtggccagg aaggtagcag ccctctctgg
     2221 agatgcccgg cgctgcctgg acatctgcag gcgtgccacg gagatctgcg agctttccca
     2281 tctacgcggt gactctctga gcctggtgac tgtggcccac ttaatggaag ctatagatga
     2341 aatgttctcc tcgtcatata ttactgccat caaaaactct tctgtcgtgg aacagagctt
     2401 cctgagagcc attattgcgg aattccgtcg gtcaggacta gaggaagcaa cctttcaaca
     2461 gatatacagt cagcacgtgg ctctgtgccg aatggaggga ctgccatacc caaccatgtc
     2521 agagaccatg gctgtgtgct cacgtctggg ttcttgccgc ctccttctgg tggagcccag
     2581 tagaaatgac ctcctccttc gagtgagact caatgttagc cagaatgacg tgctgtttgc
     2641 tctcaaagaa gagtgaagga cttcacaaat ttctgctttg tctcagagct ttattttatt
     2701 tcttcagaac atggaattac agcagaatat acaggatgga aattgttgtt ataaatttgt
     2761 tattttccat tatttatttt gctttttcca aagtgttgga gaagttacgg taacatacta
     2821 tgtatataaa gatatgtata caatatactt gtatctatat aaaatagttc tgggagaatt
     2881 tgtatgaagt taggtatact ggttgcctct gagaaatccc tggtgggttg gtcagaggtt
     2941 agaggaagac ttgactatat gctatgatgt attggatttt aaatgataca aagtaaaatt
     3001 gattttatag aaaaaaaaaa aaaaaaa
//
