LOCUS       NP_035145                840 aa            linear   ROD 30-APR-2024
DEFINITION  origin recognition complex subunit 1 [Mus musculus].
ACCESSION   NP_035145
VERSION     NP_035145.2
DBSOURCE    REFSEQ: accession NM_011015.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 840)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 840)
  AUTHORS   Garcia-Juan,M., Ordonez-Gutierrez,L. and Wandosell,F.
  TITLE     Clearance of beta-amyloid mediated by autophagy is enhanced by
            MTORC1 inhibition but not AMPK activation in APP/PSEN1 astrocytes
  JOURNAL   Glia 72 (3), 588-606 (2024)
   PUBMED   38009275
  REMARK    GeneRIF: Clearance of beta-amyloid mediated by autophagy is
            enhanced by MTORC1 inhibition but not AMPK activation in APP/PSEN1
            astrocytes.
REFERENCE   3  (residues 1 to 840)
  AUTHORS   Jaremko,M.J., On,K.F., Thomas,D.R., Stillman,B. and Joshua-Tor,L.
  TITLE     The dynamic nature of the human origin recognition complex revealed
            through five cryoEM structures
  JOURNAL   Elife 9, e58622 (2020)
   PUBMED   32808929
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 840)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 840)
  AUTHORS   Okano-Uchida,T., Kent,L.N., Ouseph,M.M., McCarty,B., Frank,J.J.,
            Kladney,R., Cuitino,M.C., Thompson,J.C., Coppola,V., Asano,M. and
            Leone,G.
  TITLE     Endoreduplication of the mouse genome in the absence of ORC1
  JOURNAL   Genes Dev 32 (13-14), 978-990 (2018)
   PUBMED   29967292
  REMARK    GeneRIF: ORC1 in mice is essential for mitotic cell divisions but
            dispensable for endoreduplication.
REFERENCE   6  (residues 1 to 840)
  AUTHORS   Miyake,Y., Mizuno,T., Yanagi,K. and Hanaoka,F.
  TITLE     Novel splicing variant of mouse Orc1 is deficient in nuclear
            translocation and resistant for proteasome-mediated degradation
  JOURNAL   J Biol Chem 280 (13), 12643-12652 (2005)
   PUBMED   15634681
  REMARK    GeneRIF: mouse Orc1, Orc2, and Orc3 each exist in two
            alternative-splicing variants and naturally occurring Orc1B lacks a
            functional domain that is essential for nuclear translocation and
            proteasome-dependent degradation
REFERENCE   7  (residues 1 to 840)
  AUTHORS   Kneissl,M., Putter,V., Szalay,A.A. and Grummt,F.
  TITLE     Interaction and assembly of murine pre-replicative complex proteins
            in yeast and mouse cells
  JOURNAL   J Mol Biol 327 (1), 111-128 (2003)
   PUBMED   12614612
REFERENCE   8  (residues 1 to 840)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 840)
  AUTHORS   Natale,D.A., Li,C.J., Sun,W.H. and DePamphilis,M.L.
  TITLE     Selective instability of Orc1 protein accounts for the absence of
            functional origin recognition complexes during the M-G(1)
            transition in mammals
  JOURNAL   EMBO J 19 (11), 2728-2738 (2000)
   PUBMED   10835370
REFERENCE   10 (residues 1 to 840)
  AUTHORS   Zisimopoulou,P., Staib,C., Nanda,I., Schmid,M. and Grummt,F.
  TITLE     Mouse homolog of the yeast origin recognition complex subunit ORC1
            and chromosomal localization of the cognate mouse gene Orc1
  JOURNAL   Mol Gen Genet 260 (2-3), 295-299 (1998)
   PUBMED   9862484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164035.1, AK141741.1 and AJ003133.1.
            
            On Oct 20, 2007 this sequence version replaced NP_035145.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ003133.1, AK164035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..840
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.64 cM"
     Protein         1..840
                     /product="origin recognition complex subunit 1"
                     /calculated_mol_wt=94972
     Region          43..169
                     /region_name="BAH"
                     /note="or Bromo Adjacent Homology domain (also called ELM1
                     and BAM for Bromo Adjacent Motif). BAH domains have first
                     been described as domains found in the polybromo protein
                     and Yeast Rsc1/Rsc2 (Remodeling of the Structure of
                     Chromatin). They also occur in...; cl02608"
                     /db_xref="CDD:470629"
     Site            93
                     /site_type="other"
                     /note="Histone H4K20me2 binding.
                     /evidence=ECO:0000269|PubMed:22398447; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1N2.2)"
     Region          195..218
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1N2.2)"
     Site            197
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13415; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1N2.2)"
     Region          242..301
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1N2.2)"
     Site            255
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1N2.2)"
     Site            258
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1N2.2)"
     Site            276
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13415; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1N2.2)"
     Site            291
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13415; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1N2.2)"
     Site            332
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1N2.2)"
     Region          392..456
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1N2.2)"
     Region          <419..765
                     /region_name="PTZ00112"
                     /note="origin recognition complex 1 protein; Provisional"
                     /db_xref="CDD:240274"
     Region          480..840
                     /region_name="Necessary and sufficient for ORC complex
                     assembly. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1N2.2)"
     Region          753..833
                     /region_name="Cdc6_C"
                     /note="Winged-helix domain of essential DNA replication
                     protein Cell division control protein (Cdc6), which
                     mediates DNA binding; cd08768"
                     /db_xref="CDD:176573"
     Site            order(775,796..797,815,817,821..823)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176573"
     CDS             1..840
                     /gene="Orc1"
                     /gene_synonym="MmORC1; Orc1l"
                     /coded_by="NM_011015.2:134..2656"
                     /db_xref="CCDS:CCDS18453.1"
                     /db_xref="GeneID:18392"
                     /db_xref="MGI:MGI:1328337"
ORIGIN      
        1 mpsyltrqkt rqtfswvgrp lpnrkqfqqm yreicmkind gseihikvgq fvliqgednk
       61 kpyvakliel fqngaevppk kcarvqwfvr fleipvskrh llgrsppaqe ifwydcsdwd
      121 nkinvetiig pvqvvalape evipvdqkse etlfvklswn kkdfaplppe vlaalreqed
      181 spewqkplka kiknvkspar ntteqevkgi ksnhstskfh qtpanivipn akksleldgl
      241 gftrkpntrw skksscdsld yqktskrraa fsettsppkk pnkpreikps saletrvkng
      301 qtqpfcakss vvlrarnpam tttklgvdnt lspirnglrs svvpsggltp vyirrkakeq
      361 ethkepirts rvhrkssllt lkrirqqlcl ldgddrdqee eesvdsesee edefisslpt
      421 rnslgqsrtr qtpskspqkn pkprtphrat pqirdrnlav qepasaleea rlrlhvsavp
      481 dslpcreqef qdiysfvesk lldgtggcmy isgvpgtgkt atvhevircl qqaaetddvp
      541 pfqyvevngm kltephqvyv qilkkltgqk atanhaaell akqfcgqgsq kettvllvde
      601 ldllwthkqd vmynlfdwpt hkgahlivlt iantmdlper immnrvssrl gltrmsfqpy
      661 shsqlkqilv srlrnlrafe ddaiqlvark vaalsgdarr cldicrrate icelshlrgd
      721 slslvtvahl meaidemfss syitaiknss vveqsflrai iaefrrsgle eatfqqiysq
      781 hvalcrmegl pyptmsetma vcsrlgscrl llvepsrndl llrvrlnvsq ndvlfalkee
//
