LOCUS       NM_198424               1996 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ORAI calcium release-activated calcium modulator 3
            (Orai3), mRNA.
ACCESSION   NM_198424
VERSION     NM_198424.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1996)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1996)
  AUTHORS   Emrich,S.M., Yoast,R.E., Zhang,X., Fike,A.J., Wang,Y.H.,
            Bricker,K.N., Tao,A.Y., Xin,P., Walter,V., Johnson,M.T., Pathak,T.,
            Straub,A.C., Feske,S., Rahman,Z.S.M. and Trebak,M.
  TITLE     Orai3 and Orai1 mediate CRAC channel function and metabolic
            reprogramming in B cells
  JOURNAL   Elife 12, e84708 (2023)
   PUBMED   36803766
  REMARK    GeneRIF: Orai3 and Orai1 mediate CRAC channel function and
            metabolic reprogramming in B cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1996)
  AUTHORS   Wang,L., Noyer,L., Wang,Y.H., Tao,A.Y., Li,W., Zhu,J., Saavedra,P.,
            Hoda,S.T., Yang,J. and Feske,S.
  TITLE     ORAI3 is dispensable for store-operated Ca2+ entry and immune
            responses by lymphocytes and macrophages
  JOURNAL   J Gen Physiol 154 (10) (2022)
   PUBMED   35861698
  REMARK    GeneRIF: ORAI3 is dispensable for store-operated Ca2+ entry and
            immune responses by lymphocytes and macrophages.
REFERENCE   4  (bases 1 to 1996)
  AUTHORS   Gammons,J., Trebak,M. and Mancarella,S.
  TITLE     Cardiac-Specific Deletion of Orai3 Leads to Severe Dilated
            Cardiomyopathy and Heart Failure in Mice
  JOURNAL   J Am Heart Assoc 10 (8), e019486 (2021)
   PUBMED   33849280
  REMARK    GeneRIF: Cardiac-Specific Deletion of Orai3 Leads to Severe Dilated
            Cardiomyopathy and Heart Failure in Mice.
REFERENCE   5  (bases 1 to 1996)
  AUTHORS   Vaeth,M., Yang,J., Yamashita,M., Zee,I., Eckstein,M., Knosp,C.,
            Kaufmann,U., Karoly Jani,P., Lacruz,R.S., Flockerzi,V.,
            Kacskovics,I., Prakriya,M. and Feske,S.
  TITLE     ORAI2 modulates store-operated calcium entry and T cell-mediated
            immunity
  JOURNAL   Nat Commun 8, 14714 (2017)
   PUBMED   28294127
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1996)
  AUTHORS   Demaurex,N. and Nunes,P.
  TITLE     The role of STIM and ORAI proteins in phagocytic immune cells
  JOURNAL   Am J Physiol Cell Physiol 310 (7), C496-C508 (2016)
   PUBMED   26764049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1996)
  AUTHORS   Li,J., Bruns,A.F., Hou,B., Rode,B., Webster,P.J., Bailey,M.A.,
            Appleby,H.L., Moss,N.K., Ritchie,J.E., Yuldasheva,N.Y., Tumova,S.,
            Quinney,M., McKeown,L., Taylor,H., Prasad,K.R., Burke,D.,
            O'Regan,D., Porter,K.E., Foster,R., Kearney,M.T. and Beech,D.J.
  TITLE     Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular
            Endothelial Growth Factor
  JOURNAL   Arterioscler Thromb Vasc Biol 35 (9), 1987-1994 (2015)
   PUBMED   26160956
  REMARK    GeneRIF: VEGF signaling via arachidonic acid and arachidonic acid
            metabolism causes Orai3 to accumulate at the cell surface to
            mediate Ca(2+) entry and downstream endothelial cell remodeling.
REFERENCE   8  (bases 1 to 1996)
  AUTHORS   Vig,M., DeHaven,W.I., Bird,G.S., Billingsley,J.M., Wang,H.,
            Rao,P.E., Hutchings,A.B., Jouvin,M.H., Putney,J.W. and Kinet,J.P.
  TITLE     Defective mast cell effector functions in mice lacking the CRACM1
            pore subunit of store-operated calcium release-activated calcium
            channels
  JOURNAL   Nat Immunol 9 (1), 89-96 (2008)
   PUBMED   18059270
REFERENCE   9  (bases 1 to 1996)
  AUTHORS   Gross,S.A., Wissenbach,U., Philipp,S.E., Freichel,M., Cavalie,A.
            and Flockerzi,V.
  TITLE     Murine ORAI2 splice variants form functional Ca2+ release-activated
            Ca2+ (CRAC) channels
  JOURNAL   J Biol Chem 282 (27), 19375-19384 (2007)
   PUBMED   17463004
REFERENCE   10 (bases 1 to 1996)
  AUTHORS   Takahashi,Y., Murakami,M., Watanabe,H., Hasegawa,H., Ohba,T.,
            Munehisa,Y., Nobori,K., Ono,K., Iijima,T. and Ito,H.
  TITLE     Essential role of the N-terminus of murine Orai1 in store-operated
            Ca2+ entry
  JOURNAL   Biochem Biophys Res Commun 356 (1), 45-52 (2007)
   PUBMED   17343823
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK136955.1.
            
            On Apr 5, 2007 this sequence version replaced NM_198424.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136955.1, BC061259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1996              AK136955.1         2-1997
FEATURES             Location/Qualifiers
     source          1..1996
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.73 cM"
     gene            1..1996
                     /gene="Orai3"
                     /gene_synonym="9930124N15; Tmem142c"
                     /note="ORAI calcium release-activated calcium modulator 3"
                     /db_xref="GeneID:269999"
                     /db_xref="MGI:MGI:3039586"
     exon            1..402
                     /gene="Orai3"
                     /gene_synonym="9930124N15; Tmem142c"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1047
                     /gene="Orai3"
                     /gene_synonym="9930124N15; Tmem142c"
                     /note="calcium release-activated calcium channel 3;
                     transmembrane protein 142C"
                     /codon_start=1
                     /product="protein orai-3"
                     /protein_id="NP_940816.1"
                     /db_xref="CCDS:CCDS21878.1"
                     /db_xref="GeneID:269999"
                     /db_xref="MGI:MGI:3039586"
                     /translation="MKGGEGDTGEQAPLNPEVDSPAGSATYREFVHRGYLDLMGASQH
                     SLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLENDHEYPPGLLVAFSACT
                     TVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTF
                     LFLAEVVLVGWVKFVPIGAPMGKPAPVVPMSQVPPVTVSLSLASNLTPSSASITTSQQ
                     PSKACPPRQVCDSAHGPGWQAAMASTAIMVPVGLVFMAFALHFYRSLVAHKTDRHKQE
                     LEELSRLQGELQAV"
     exon            403..1996
                     /gene="Orai3"
                     /gene_synonym="9930124N15; Tmem142c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1835..1840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Orai3"
                     /gene_synonym="9930124N15; Tmem142c"
                     /note="hexamer: AATAAA"
     polyA_site      1854
                     /gene="Orai3"
                     /gene_synonym="9930124N15; Tmem142c"
                     /note="major polyA site"
     polyA_site      1888
                     /gene="Orai3"
                     /gene_synonym="9930124N15; Tmem142c"
ORIGIN      
        1 ccagttcctg tttcggcccc tgggccttct agacgcgtcc gtaactgttc ccgctgggtc
       61 tgccttgcca cccaggatgg ggtcccaccc gcgcttgggc cgtcccttct tggggataca
      121 aggcgcctcg gcccctcctt gaccatctgc gcttgtggtg taactgctct caggatgaag
      181 ggcggcgagg gggacacggg cgaacaggcc ccgctgaacc cggaggtgga cagccccgcg
      241 ggctcagcca cgtaccggga gttcgtgcac cgcggctacc tggaccttat gggggccagt
      301 cagcactctc tgcgggcgct cagctggcgc cgcctctacc tcagccgggc taagctcaaa
      361 gcctccagcc gcacatctgc tctgctgtcg ggcttcgcca tggtggccat ggtggaggta
      421 cagctggaga acgatcatga atacccacca ggcctgctgg tggcatttag tgcctgcacc
      481 actgtgttag tagctgtgca cctctttgca ctgatggtct ccacatgtct gctgccccat
      541 attgaagccg tgagcaacat ccacaatctc aactctgtcc accagtcacc acaccaacga
      601 ctgcacagat acgtggagct tgcctggggc ttctctactg ccttgggtac ctttctcttc
      661 ctggctgaag ttgttctggt gggctgggtc aagtttgtgc ccattggggc acccatgggt
      721 aaaccagctc ctgttgtacc tatgtcccag gtgccacctg tgactgtctc ccttagttta
      781 gcttctaacc tcacaccatc ctctgcttct attaccacat cacaacagcc ttccaaagcc
      841 tgtccacccc ggcaagtgtg tgatagtgct catggaccag gctggcaggc agctatggcc
      901 tccacggcaa tcatggtacc tgtgggacta gtgtttatgg cctttgccct acatttctac
      961 cgatccttgg ttgcccacaa gacagaccgc cacaagcagg agctggagga gctcagtcgc
     1021 ctgcaggggg agctgcaggc tgtgtaagcc tggctttaga ctgttgcaag cattgcctca
     1081 gaaaccccag ggatcgacag acctccttcc ttgccctagg ctggagccac ctcctgtaag
     1141 ctctgaggta gaggccaagt acctgcccag cagcatccca cactcccagg gatgatccct
     1201 gtcatcatgt tctggtgggt tttgtaaatt ctgctctgct tggggaactg tttcagccta
     1261 aggatcctgg gttaaatgag aggaaagagg cccgcctgcc ttagtgagat ccctggtggt
     1321 gctgagcagt tgtttgctcc tccaggaagg tgacatgtct gcacaactgt cctcaaggca
     1381 atcagccctt gcttatctgt ataatctgct ttgcagttgg catcctggga gagattttac
     1441 agggctcctc agatgagcca cttcaccctt ggtgacttgt ggtggtcgtt ccactgccct
     1501 aggcactgac tgtctggcca gaactgggag aggaggaagt attgacgagt gggagattgt
     1561 gcagctactt gacaagggtt ggtgagttgg taagggagaa gattcagccc ttagaatgca
     1621 gaactcttct tcagacactg attttttttc ttttgttttg tttttcaagc cagagtttca
     1681 ctatgtctgt tgctctggct gtcctggaac actctctgta gaccaggctg gccttgagct
     1741 cagagatgta cctgcctctg cctcccatgt acagggatta aaggcatgca ccaccaccac
     1801 ctgacactga gtttttgatg caccttgttt tgtaaataaa gtgtgtctca catatgttcc
     1861 tatggctatg aatgggatga aggtgaaacc ttgggtatgg ttctttgttc ctaagggcca
     1921 gatggaggta atatgcttga tagatggtat gagtccatca ggtgctgaca agatctgata
     1981 aacttctgaa tgtggt
//
