LOCUS       NM_178751               3851 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ORAI calcium release-activated calcium modulator 2
            (Orai2), mRNA.
ACCESSION   NM_178751 XM_917288
VERSION     NM_178751.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3851)
  AUTHORS   Nakajima,H., Fujita,S., Kakae,M., Nagayasu,K., Oh-Hora,M.,
            Shirakawa,H. and Kaneko,S.
  TITLE     Orai2 channel regulates prostaglandin E2 production in
            TNFalpha/IL1alpha-stimulated astrocytes
  JOURNAL   Glia 70 (9), 1666-1680 (2022)
   PUBMED   35506586
  REMARK    GeneRIF: Orai2 channel regulates prostaglandin E2 production in
            TNFalpha/IL1alpha-stimulated astrocytes.
REFERENCE   2  (bases 1 to 3851)
  AUTHORS   Bieber,M., Schuhmann,M.K., Bellut,M., Stegner,D., Heinze,K.G.,
            Pham,M., Nieswandt,B. and Stoll,G.
  TITLE     Blockade of Platelet Glycoprotein Ibalpha Augments Neuroprotection
            in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion
  JOURNAL   Int J Mol Sci 23 (16), 9496 (2022)
   PUBMED   36012752
  REMARK    GeneRIF: Blockade of Platelet Glycoprotein Ibalpha Augments
            Neuroprotection in Orai2-Deficient Mice during Middle Cerebral
            Artery Occlusion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3851)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3851)
  AUTHORS   Grimes,D., Johnson,R., Pashos,M., Cummings,C., Kang,C.,
            Sampedro,G.R., Tycksen,E., McBride,H.J., Sah,R., Lowell,C.A. and
            Clemens,R.A.
  TITLE     ORAI1 and ORAI2 modulate murine neutrophil calcium signaling,
            cellular activation, and host defense
  JOURNAL   Proc Natl Acad Sci U S A 117 (39), 24403-24414 (2020)
   PUBMED   32929002
  REMARK    GeneRIF: ORAI1 and ORAI2 modulate murine neutrophil calcium
            signaling, cellular activation, and host defense.
REFERENCE   5  (bases 1 to 3851)
  AUTHORS   Stegner,D., Hofmann,S., Schuhmann,M.K., Kraft,P., Herrmann,A.M.,
            Popp,S., Hohn,M., Popp,M., Klaus,V., Post,A., Kleinschnitz,C.,
            Braun,A., Meuth,S.G., Lesch,K.P., Stoll,G., Kraft,R. and
            Nieswandt,B.
  TITLE     Loss of Orai2-Mediated Capacitative Ca2+ Entry Is Neuroprotective
            in Acute Ischemic Stroke
  JOURNAL   Stroke 50 (11), 3238-3245 (2019)
   PUBMED   31551038
  REMARK    GeneRIF: Calcium signals induced by calcium store depletion or
            oxygen/glucose deprivation were significantly diminished in
            Orai2-deficient neurons demonstrating that Orai2 is a central
            mediator of neuronal capacitative Ca(2+) entry and is involved in
            calcium overload during ischemia.
REFERENCE   6  (bases 1 to 3851)
  AUTHORS   Fernandez,R.A., Wan,J., Song,S., Smith,K.A., Gu,Y., Tauseef,M.,
            Tang,H., Makino,A., Mehta,D. and Yuan,J.X.
  TITLE     Upregulated expression of STIM2, TRPC6, and Orai2 contributes to
            the transition of pulmonary arterial smooth muscle cells from a
            contractile to proliferative phenotype
  JOURNAL   Am J Physiol Cell Physiol 308 (8), C581-C593 (2015)
   PUBMED   25673771
  REMARK    GeneRIF: The data from this study indicate that upregulation of
            STIM2 and Orai2 is involved in the phenotypic transition of
            pulmonary arterial smooth muscle cells from a contractile state to
            a proliferative state.
REFERENCE   7  (bases 1 to 3851)
  AUTHORS   Gerasimenko,J.V., Gryshchenko,O., Ferdek,P.E., Stapleton,E.,
            Hebert,T.O., Bychkova,S., Peng,S., Begg,M., Gerasimenko,O.V. and
            Petersen,O.H.
  TITLE     Ca2+ release-activated Ca2+ channel blockade as a potential tool in
            antipancreatitis therapy
  JOURNAL   Proc Natl Acad Sci U S A 110 (32), 13186-13191 (2013)
   PUBMED   23878235
  REMARK    GeneRIF: Data indicate that the Ca(2+) release-activated Ca(2+)
            channels (CRAC) blocker GSK-7975A inhibited store-operated Ca(2+)
            entry in a concentration-dependent manner.
REFERENCE   8  (bases 1 to 3851)
  AUTHORS   Vig,M., DeHaven,W.I., Bird,G.S., Billingsley,J.M., Wang,H.,
            Rao,P.E., Hutchings,A.B., Jouvin,M.H., Putney,J.W. and Kinet,J.P.
  TITLE     Defective mast cell effector functions in mice lacking the CRACM1
            pore subunit of store-operated calcium release-activated calcium
            channels
  JOURNAL   Nat Immunol 9 (1), 89-96 (2008)
   PUBMED   18059270
REFERENCE   9  (bases 1 to 3851)
  AUTHORS   Gross,S.A., Wissenbach,U., Philipp,S.E., Freichel,M., Cavalie,A.
            and Flockerzi,V.
  TITLE     Murine ORAI2 splice variants form functional Ca2+ release-activated
            Ca2+ (CRAC) channels
  JOURNAL   J Biol Chem 282 (27), 19375-19384 (2007)
   PUBMED   17463004
REFERENCE   10 (bases 1 to 3851)
  AUTHORS   Takahashi,Y., Murakami,M., Watanabe,H., Hasegawa,H., Ohba,T.,
            Munehisa,Y., Nobori,K., Ono,K., Iijima,T. and Ito,H.
  TITLE     Essential role of the N-terminus of murine Orai1 in store-operated
            Ca2+ entry
  JOURNAL   Biochem Biophys Res Commun 356 (1), 45-52 (2007)
   PUBMED   17343823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB640180.1, BC115648.1 and AC087420.4.
            
            On Jul 28, 2006 this sequence version replaced NM_178751.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042940.1, AK079619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BB640180.1         1-74
            75-1238             BC115648.1         1-1164
            1239-3851           AC087420.4         193637-196249       c
FEATURES             Location/Qualifiers
     source          1..3851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.84 cM"
     gene            1..3851
                     /gene="Orai2"
                     /gene_synonym="A730041O15Rik; Tmem142b"
                     /note="ORAI calcium release-activated calcium modulator 2"
                     /db_xref="GeneID:269717"
                     /db_xref="MGI:MGI:2443195"
     exon            1..119
                     /gene="Orai2"
                     /gene_synonym="A730041O15Rik; Tmem142b"
                     /inference="alignment:Splign:2.1.0"
     exon            120..357
                     /gene="Orai2"
                     /gene_synonym="A730041O15Rik; Tmem142b"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..885
                     /gene="Orai2"
                     /gene_synonym="A730041O15Rik; Tmem142b"
                     /note="calcium release-activated calcium channel 2;
                     transmembrane protein 142B"
                     /codon_start=1
                     /product="protein orai-2"
                     /protein_id="NP_848866.2"
                     /db_xref="CCDS:CCDS39326.1"
                     /db_xref="GeneID:269717"
                     /db_xref="MGI:MGI:2443195"
                     /translation="MSAELNVPMDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHS
                     VQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETKYQYPQPLLIAFSACTT
                     VLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILL
                     FLAEVVLLCWIKFLPVDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSL
                     VRHKTERHNREIEELHKLKVQLDGHERSLQVV"
     exon            358..3851
                     /gene="Orai2"
                     /gene_synonym="A730041O15Rik; Tmem142b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3827..3832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Orai2"
                     /gene_synonym="A730041O15Rik; Tmem142b"
                     /note="hexamer: AATAAA"
     polyA_site      3851
                     /gene="Orai2"
                     /gene_synonym="A730041O15Rik; Tmem142b"
                     /note="major polyA site"
ORIGIN      
        1 ggagggggcc ggtcctccgc cctggcccgg ccgccgggcc acccggccgc gacacagacg
       61 ctagccacga gccggagccg tgagctggag ccaagcgcgc tgagggctgg acagtcaggc
      121 ctggtcccca ccatgagtgc agagctcaat gtgcccatgg acccctctgc ccctgcctgc
      181 cctgaacccg gccacaaggg catggattac cgagactggg tccggcgcag ctacctggaa
      241 ctcgtcacgt ctaaccacca ttcggtgcag gcactgtcct ggaggaagct ctacctgagc
      301 agggccaagc tgaaagcctc cagccggacc tcagccctcc tgtctggctt cgccatggtg
      361 gccatggtgg aggtgcagct ggagaccaag taccagtacc ctcagcccct gctcattgcc
      421 ttcagcgcct gcaccacggt gctggtagcc gtgcatctgt ttgctctgct catcagcact
      481 tgcatcctgc ccaacgtgga agcggtgagc aacatccaca acctcaactc catcagcgag
      541 tcgccgcacg agcgcatgca cccgtacatc gagctggcct ggggcttctc caccgttctg
      601 ggcatcctgc ttttcctggc tgaggtggtc ctgctctgct ggatcaagtt cctcccagtg
      661 gatgccaagg atcagccagg ctcccacagc cacacgggct ggcaggccgc tctggtgtcc
      721 accatcatca tggtacctgt gggtctcatc ttcgtggtct tcaccatcca cttctaccgt
      781 tccctggtgc ggcacaagac ggagcgccac aaccgtgaga tcgaagagct gcacaagctc
      841 aaggtgcagc tggatgggca cgagcggagc ctgcaggtgg tgtgagggag gccgttgcga
      901 tttgctacca acctgcacgg gagggcaacc ctcaggccac cacgcagctg gtcagagtag
      961 ccaagggggc cgccagacaa acccgggctg catgagatcc accacacatc ccaagagcca
     1021 cagtgtgggg atggctaaac agactgcctg gatgctgctc caataatccc atactcctgt
     1081 ccccgcatga ataagggtct aaaaggagtg agaaagcgtc cgtttcatca tggaggccgg
     1141 aggaagaaac acgaccacgt ggccctgggg acttcctggt ccaatcatat cagagagcac
     1201 tgtagatctc agacgtctgg accttgtgat tggcagggca gggtggtgaa ttcccaaagc
     1261 cagctggggg ctggggctca ggtgggagag tgtttgccta gtgtgcagga agcactgcct
     1321 aagccaagtc atcccagggt catcgaggtg ctagggaggt ggaggaaggc agatcagggc
     1381 ttcaaagttg ttctttgcta catggtcagt ttgaggctac acgaaaaagt cagacacatg
     1441 cacatgcatg cagaagagcg cgcacgtgca cacacgtgcg tacacacgca cacacatgca
     1501 cacagacaca cacaaagaag gggctgcttg agtgtgcaga ggtgggcccg gggctggcac
     1561 agggtaacat ggcttatgat gaaagacagg gatgttttac cagatctgta gctcagcttg
     1621 gctctttcct cccgattgga aagggtcaca gagtgttcag gaccctgggg cacacagcag
     1681 ctcaacaagg gtaacagata ctgttattgg agtgagagtt tcctggttct agagagacag
     1741 ccataggcct gagggcagcc atgccacccc caccccccat ggactgtgtc aacgcaggca
     1801 ggggcaccat ctcagagacc aggcagctca gatcccttct gcctgtggcc cccagatgtt
     1861 gagaggataa actggggcga cttcctgttt ttgcaaagtg gttagccctg tggttaggcc
     1921 tgtgggtggg gcagggacct ggcccagcct aatataggca gctattccct gtaatgaggc
     1981 tatgggcaga gaaggggaga cttcaacacc ccatttctgg gcctaccaga cactccatgc
     2041 aggtccctgc cccgtgttta cacagctgtg tatgggtttg gcattgccac tacgggcatc
     2101 tggctatcca gctggtattg tcatgcatac tgtgctatac cacaccagct tgcgtggggg
     2161 ccagtactta cccattctgt cacattacct agagggctga ggtctcttac tctgtatata
     2221 aatggtcgct gggctcctgc gagtaccact tccatctctt acaacagctt ttctttggag
     2281 tctggatttg gtgcccgtgg gatcctggag ggccccaccc ccatcctgaa gtctctggaa
     2341 atgggtcata ctgccaagca taaacttcaa caggcagagg gccctgggga gcctggtgga
     2401 ggtcttcctt gtaaagtgtg acatcagtgg acagccagga catagtgtcc tgtgaaccca
     2461 ggagaaacgc cctctgtctt tcaaaggctg tatccttcaa cactctcagc ccttgcacac
     2521 atctgtctga gacctcttgc gtttcagatc tctgttttcc tggggtcttt ttgggaaggc
     2581 cagcctagtt tgatttgttt gtcttgctaa agaatgctat aatcctgggt ggacaagatg
     2641 gctcagtggg taaaggcgct tgccaccaag cctggagacc tgagtttagt cccaatcctc
     2701 tgacccacaa ccaagtaaat ataacgagaa aaacgattta ctgtgagcat cactgtaagc
     2761 tggtgtgcga gcaggggagg agaagatgac ctctggaagg aatccacaca tggccaggca
     2821 catctgtaag gtaaaccttc aaggggtgga ggcaggagga tcaggggttc aaggccagct
     2881 tgggctggac agactctatc aggaaaaggg ggtgctgcag atgacccccg tatttaggaa
     2941 tgcttgctgc tcttgcagag gaccagagtt catctcccag cacctatgta gggcagctca
     3001 caacggcctg tgactcaagt tctagaggat acaacaccct cttctggcct ctacaggcac
     3061 ccactcacat gtccatattt acacatataa aataaaaaag gggattcctg ctaaacattg
     3121 agtccactcc ttctacccat tttctgaagc catttggtgc ctctgctcat gggggcaccc
     3181 ggcactagtg cagtagggga ctcctgccat tcttcacgtt ctaccattag tcttcctagc
     3241 gctgagcatg ggacagccat ctgtgtatga acagaggtgt cagcccatgt ggtcacccat
     3301 gggcaggagt cacagggcca tcccacagct ttgtcaggag ttggtggata agccctccct
     3361 gccaccagtg gcggaagcca gcaagctcaa ggctggaagt tcagtttctg gaggcataac
     3421 ctgatttttg aatcttgttc taactgcagc cacgtggcta gaaccactgg gggctcctgg
     3481 gacaggcaca ggctcgccct aatttcatct atccaagatt cagcccttcc tggtgctcaa
     3541 gggacccgtg tcctcagaca caccaaggcc cttcccaaca cggcctcccc gcaccctcaa
     3601 ccacaaagtc tctaaattca agcgtttcta cttaagacat ttcaaaggca gaacatgatt
     3661 ggtgtctttt gggaaaggct actgaaaaca aactacagga gcctggcggg ctcaagacta
     3721 tatcattatt tctgcaggac actgtaaata actcctttcc tgggtgtgtg gttttttgtt
     3781 tgtttgtttg ttgatttttt ttttgcagtt gccccggatt gagctgaata aactggtaca
     3841 gattttaaaa a
//
