LOCUS       NM_175423               1871 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus ORAI calcium release-activated calcium modulator 1
            (Orai1), mRNA.
ACCESSION   NM_175423
VERSION     NM_175423.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Mei,W., Zhang,X., Niu,M., Li,L., Guo,X., Wang,G., Pandol,S., Wen,L.
            and Cao,F.
  TITLE     Deletion of myeloid-specific Orai1 calcium channel does not affect
            pancreatic tissue damage in experimental acute pancreatitis
  JOURNAL   Pancreatology 24 (4), 528-537 (2024)
   PUBMED   38637233
  REMARK    GeneRIF: Deletion of myeloid-specific Orai1 calcium channel does
            not affect pancreatic tissue damage in experimental acute
            pancreatitis.
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Silva-Rojas,R., Perez-Guardia,L., Simon,A., Djeddi,S., Treves,S.,
            Ribes,A., Silva-Hernandez,L., Tard,C., Laporte,J. and Bohm,J.
  TITLE     ORAI1 inhibition as an efficient preclinical therapy for tubular
            aggregate myopathy and Stormorken syndrome
  JOURNAL   JCI Insight 9 (6), e174866 (2024)
   PUBMED   38516893
  REMARK    GeneRIF: ORAI1 inhibition as an efficient preclinical therapy for
            tubular aggregate myopathy and Stormorken syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Wei,D., Birla,H., Dou,Y., Mei,Y., Huo,X., Whitehead,V.,
            Osei-Owusu,P., Feske,S., Patafio,G., Tao,Y. and Hu,H.
  TITLE     PGE2 Potentiates Orai1-Mediated Calcium Entry Contributing to
            Peripheral Sensitization
  JOURNAL   J Neurosci 44 (1), e0329232023 (2024)
   PUBMED   37952941
  REMARK    GeneRIF: PGE2 Potentiates Orai1-Mediated Calcium Entry Contributing
            to Peripheral Sensitization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Niu,M., Zhang,X., Wu,Z., Li,B., Bao,J., Dai,J., Yang,Z., Zeng,Y.,
            Li,L., Pandol,S., Sutton,R. and Wen,L.
  TITLE     Neutrophil-specific ORAI1 Calcium Channel Inhibition Reduces
            Pancreatitis-associated Acute Lung Injury
  JOURNAL   Function (Oxf) 5 (1), zqad061 (2023)
   PUBMED   38020066
  REMARK    GeneRIF: Neutrophil-specific ORAI1 Calcium Channel Inhibition
            Reduces Pancreatitis-associated Acute Lung Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Takahashi,Y., Murakami,M., Watanabe,H., Hasegawa,H., Ohba,T.,
            Munehisa,Y., Nobori,K., Ono,K., Iijima,T. and Ito,H.
  TITLE     Essential role of the N-terminus of murine Orai1 in store-operated
            Ca2+ entry
  JOURNAL   Biochem Biophys Res Commun 356 (1), 45-52 (2007)
   PUBMED   17343823
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Ong,H.L., Cheng,K.T., Liu,X., Bandyopadhyay,B.C., Paria,B.C.,
            Soboloff,J., Pani,B., Gwack,Y., Srikanth,S., Singh,B.B., Gill,D.L.
            and Ambudkar,I.S.
  TITLE     Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved
            in store-operated calcium influx. Evidence for similarities in
            store-operated and calcium release-activated calcium channel
            components
  JOURNAL   J Biol Chem 282 (12), 9105-9116 (2007)
   PUBMED   17224452
  REMARK    GeneRIF: dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is
            involved in activation of SOC channel in response to internal Ca2+
            store depletion
            Erratum:[J Biol Chem. 2007 Sep 14;282(37):27556. Gill, Donald
            [corrected to Gill, Donald L]]
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052573.1, AK085755.1 and BQ553253.1.
            
            On Apr 25, 2006 this sequence version replaced NM_175423.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085755.1, BC023149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1230              AK052573.1         2-1231
            1231-1808           AK085755.1         982-1559
            1809-1871           BQ553253.1         1-63                c
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.72 cM"
     gene            1..1871
                     /gene="Orai1"
                     /gene_synonym="D730049H07Rik; orai-1; Tmem142a"
                     /note="ORAI calcium release-activated calcium modulator 1"
                     /db_xref="GeneID:109305"
                     /db_xref="MGI:MGI:1925542"
     exon            1..493
                     /gene="Orai1"
                     /gene_synonym="D730049H07Rik; orai-1; Tmem142a"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1099
                     /gene="Orai1"
                     /gene_synonym="D730049H07Rik; orai-1; Tmem142a"
                     /note="calcium release-activated calcium channel 1;
                     protein orai-1; transmembrane protein 142A"
                     /codon_start=1
                     /product="calcium release-activated calcium channel
                     protein 1"
                     /protein_id="NP_780632.1"
                     /db_xref="CCDS:CCDS39261.1"
                     /db_xref="GeneID:109305"
                     /db_xref="MGI:MGI:1925542"
                     /translation="MHPEPAPPPSHSNPELPVSGGSSTSGSRRSRRRSGDGEPSGAPP
                     LPPPPPAVSYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFA
                     MVAMVEVQLDTDHDYPPGLLIVFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLN
                     SVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKRQAGQPSPTKPPA
                     ESVIVANHSDSSGITPGEAAAIASTAIMVPCGLVFIVFAVHFYRSLVSHKTDRQFQEL
                     NELAEFARLQDQLDHRGDHSLTPGTHYA"
     exon            494..1871
                     /gene="Orai1"
                     /gene_synonym="D730049H07Rik; orai-1; Tmem142a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1567..1572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Orai1"
                     /gene_synonym="D730049H07Rik; orai-1; Tmem142a"
                     /note="hexamer: AATATA"
     polyA_site      1585
                     /gene="Orai1"
                     /gene_synonym="D730049H07Rik; orai-1; Tmem142a"
                     /note="major polyA site"
ORIGIN      
        1 gcggccgctt ggaacttgcg gagcggttct gcagccagtg cctcggcctt cggatccggt
       61 gcgtccggct gcgggagacc ggctcgagtg ggaggccggc ggaggtgcgg cgcggcccgg
      121 cccggccccg gggccgcagc cttctcaggc gctcgccgcc agccgcgcct tcgcagcgta
      181 ctccatgcat ccggagcctg ccccgccccc gagtcacagc aatccggagc ttcccgtgag
      241 cggcggcagc agcactagcg gcagccgccg gagccgccgc cgcagcgggg acggggagcc
      301 ctcgggggcc ccaccgctgc cgccgccgcc acccgccgtc agctacccgg actggatcgg
      361 ccagagttac tccgaggtga tgagcctcaa cgagcactcg atgcaggcgc tgtcctggcg
      421 caagctctac ttaagccgcg ccaagctcaa agcttccagc cggacctcgg ctctgctctc
      481 cggcttcgcc atggtagcga tggtggaagt ccagctggac acagaccatg actacccacc
      541 agggttgctc atcgtcttta gtgcctgcac cacagtgcta gtggccgtgc acctgtttgc
      601 cctcatgatc agcacctgca tcctgcccaa catcgaggct gtgagcaacg tccacaacct
      661 caactcggtc aaagagtcac cccacgagcg catgcatcgc cacatcgagc tggcctgggc
      721 cttctccacg gtcatcggga cgctgctttt cctagcagag gtcgtgctgc tctgctgggt
      781 caagttctta cctctcaaga ggcaagcggg acagccaagc cccaccaagc ctcccgctga
      841 atcagtcatc gtcgccaacc acagcgacag cagcggcatc accccgggtg aggcggcagc
      901 cattgcctcc accgccatca tggttccctg tggcctggtt tttatcgtct ttgctgttca
      961 cttctaccgc tccctggtca gccataagac ggaccggcag ttccaggagc tcaatgagct
     1021 ggccgagttt gcccgcttgc aggaccagct ggaccacaga ggggaccatt ctctaacacc
     1081 gggcacccac tatgcctaag tcctcacctt cccactggcc ctttgaggcc ttggccttat
     1141 gcccttctcc atgaccttgt cctggcccag tccggaggac ggcctgtgta ggcagctggc
     1201 tttgccaggg cagagtgtgg aaggaagagg ctttaaaaaa aaaaaaatca ctgtacttgg
     1261 agattttctt ctgtgagaat aagctttccc tgttcttcca gctgtctgtc ccccctcctg
     1321 gtaggatgtg gggggtgggg cggggaatgg ggacagttgc tctctttgtc ccttcttctc
     1381 ccctgcacca gtgccacccg gatgcttcct gtcctgccct caaactcctt actccttagc
     1441 caagtgtgtg tgtgcgtgtg tgtgtgtgtg agagagaata tgtatgtgcg cacatgtctc
     1501 ctctctgtgc gtgtgtgtac atgcatgtgt gtgcaagtgt gcatgcacac ttgtatgtac
     1561 acataaaata tattcacaag ggacacctct tcctcatgtc tgtgtttgtt gggtctagac
     1621 tgcctgatcg gatggcccag tcaggtgagt cactaaacac cagtcttttt aaaaattgag
     1681 aggaaatggc tcggggacaa aacactaacc tgtcatggtc aaagccctag gattagtcca
     1741 acagctgtaa aaaactgtgt tgctggggct agaacccagg aatttgacaa gcactctccc
     1801 actgaattct actccaagac ctgtaacttt ggaaaatttc tactcaaaag aaaccttcag
     1861 ggatactaat t
//
