LOCUS       NM_146776                933 bp    mRNA    linear   ROD 26-OCT-2024
DEFINITION  Mus musculus olfactory receptor family 6 subfamily C member 74
            (Or6c74), mRNA.
ACCESSION   NM_146776
VERSION     NM_146776.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 933)
  AUTHORS   Olender,T., Jones,T.E.M., Bruford,E. and Lancet,D.
  TITLE     A unified nomenclature for vertebrate olfactory receptors
  JOURNAL   BMC Evol Biol 20 (1), 42 (2020)
   PUBMED   32295537
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 933)
  AUTHORS   Munakata,Y., Yamada,T., Imai,J., Takahashi,K., Tsukita,S.,
            Shirai,Y., Kodama,S., Asai,Y., Sugisawa,T., Chiba,Y., Kaneko,K.,
            Uno,K., Sawada,S., Hatakeyama,H., Kanzaki,M., Miyazaki,J.I., Oka,Y.
            and Katagiri,H.
  TITLE     Olfactory receptors are expressed in pancreatic beta-cells and
            promote glucose-stimulated insulin secretion
  JOURNAL   Sci Rep 8 (1), 1499 (2018)
   PUBMED   29367680
  REMARK    GeneRIF: These findings suggest that Olfr15 and Olfr821 in
            pancreatic beta-cells has a chemo-sensor function allowing
            recognition of environmental substances obtained from food, and
            potentiates insulin secretion in a cell-autonomous manner, thereby
            modulating systemic glucose metabolism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 933)
  AUTHORS   Young,J.M., Shykind,B.M., Lane,R.P., Tonnes-Priddy,L., Ross,J.A.,
            Walker,M., Williams,E.M. and Trask,B.J.
  TITLE     Odorant receptor expressed sequence tags demonstrate olfactory
            expression of over 400 genes, extensive alternate splicing and
            unequal expression levels
  JOURNAL   Genome Biol 4 (11), R71 (2003)
   PUBMED   14611657
REFERENCE   4  (bases 1 to 933)
  AUTHORS   Young,J.M., Friedman,C., Williams,E.M., Ross,J.A., Tonnes-Priddy,L.
            and Trask,B.J.
  TITLE     Different evolutionary processes shaped the mouse and human
            olfactory receptor gene families
  JOURNAL   Hum Mol Genet 11 (5), 535-546 (2002)
   PUBMED   11875048
  REMARK    Erratum:[Hum Mol Genet. 2002 Jul 1;11(14):1683.]
REFERENCE   5  (bases 1 to 933)
  AUTHORS   Zhang,X. and Firestein,S.
  TITLE     The olfactory receptor gene superfamily of the mouse
  JOURNAL   Nat Neurosci 5 (2), 124-133 (2002)
   PUBMED   11802173
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY073318.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..933
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.67 cM"
     gene            1..933
                     /gene="Or6c74"
                     /gene_synonym="MOR109-1; Olfr821"
                     /note="olfactory receptor family 6 subfamily C member 74"
                     /db_xref="GeneID:258772"
                     /db_xref="MGI:MGI:3030655"
     CDS             1..933
                     /gene="Or6c74"
                     /gene_synonym="MOR109-1; Olfr821"
                     /note="olfactory receptor MOR109-1;
                     GA_x6K02T2PULF-11704843-11705775; olfactory receptor 821"
                     /codon_start=1
                     /product="olfactory receptor family 6 subfamily C member
                     74"
                     /protein_id="NP_666987.1"
                     /db_xref="CCDS:CCDS24346.1"
                     /db_xref="GeneID:258772"
                     /db_xref="MGI:MGI:3030655"
                     /translation="MRNHTTVTVFILLGLTDDLQLQVVVFVLLFLTYMLSVTGNLTII
                     TLTLLDSHLKTPMYFFLRNFSFLEISFTTVCIPKFLVSMATGDKTISYNECAAQLFFT
                     ILLGATEFFLLAAMSYDRYVAICKPLHYMTIMSSKICNLLVFVSWLSGFLIIFPPLLM
                     GLQLDFCAANTVDHFFCDVSPILQLSCTDTHIIELMMLLSAILTLLVTLVLVSLSYTN
                     IIRTILRIPSSQQRRKAFSTCSSHMVVVSISYGSCIFMYVKPSAKERVALNKGIALLS
                     TSVAPMLNPFIYTLRNKQVKDAFKNMTKRWSFYQ"
     exon            1..933
                     /gene="Or6c74"
                     /gene_synonym="MOR109-1; Olfr821"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaggaacc acacaacggt gacagtattc attcttcttg gattaacaga tgatctacaa
       61 ctgcaagtgg ttgttttcgt ccttctcttt ctcacataca tgctgagtgt tactgggaac
      121 ctgaccatca tcacactcac tctgctggat tctcatctca agacacccat gtatttcttc
      181 ctacgaaact tctcattttt agaaatttca ttcacaactg tctgtatccc caaattcctt
      241 gttagtatgg ccacagggga taaaaccatt tcatataatg agtgtgcagc tcaactattt
      301 ttcactattc tcttgggagc aactgaattt tttcttctgg ctgccatgtc ctacgatcgc
      361 tatgtggcca tctgcaaacc cctgcactac atgaccatca tgagcagcaa aatttgcaac
      421 ttgttggtct ttgtttcctg gttgtctggt tttctgatca ttttccctcc actcctcatg
      481 ggtctccagc tagatttctg tgcagccaac actgtagacc atttcttctg tgatgtttct
      541 cctatacttc agctctcctg cacagacaca cacataatag aattaatgat gcttctctct
      601 gccattttga cactcttggt tacactggta ttagtaagcc tttcctacac aaacatcatc
      661 aggactattc tgagaatccc atcttctcaa caaagaagaa aagctttttc tacatgttct
      721 tcccacatgg ttgtggtgtc catttcttat ggcagctgca tctttatgta tgtaaagcca
      781 tctgcaaaag aaagagttgc tttaaataaa gggatagctc tgctcagcac ttcagttgca
      841 cccatgttga atcccttcat ttatacactt agaaacaaac aagtaaaaga tgcttttaag
      901 aatatgacaa aaagatggag cttttatcaa tga
//
