LOCUS       NM_010983               1250 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus olfactory receptor family 6 subfamily A member 2
            (Or6a2), mRNA.
ACCESSION   NM_010983
VERSION     NM_010983.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1250)
  AUTHORS   Raja,R., Dumontier,E., Phen,A. and Cloutier,J.F.
  TITLE     Insertion of a neomycin selection cassette in the Amigo1 locus
            alters gene expression in the olfactory epithelium leading to
            region-specific defects in olfactory receptor neuron development
  JOURNAL   Genesis 62 (2), e23594 (2024)
   PUBMED   38590146
REFERENCE   2  (bases 1 to 1250)
  AUTHORS   Orecchioni,M., Kobiyama,K., Winkels,H., Ghosheh,Y., McArdle,S.,
            Mikulski,Z., Kiosses,W.B., Fan,Z., Wen,L., Jung,Y., Roy,P.,
            Ali,A.J., Miyamoto,Y., Mangan,M., Makings,J., Wang,Z., Denn,A.,
            Vallejo,J., Owens,M., Durant,C.P., Braumann,S., Mader,N., Li,L.,
            Matsunami,H., Eckmann,L., Latz,E., Wang,Z., Hazen,S.L. and Ley,K.
  TITLE     Olfactory receptor 2 in vascular macrophages drives atherosclerosis
            by NLRP3-dependent IL-1 production
  JOURNAL   Science 375 (6577), 214-221 (2022)
   PUBMED   35025664
  REMARK    GeneRIF: Olfactory receptor 2 in vascular macrophages drives
            atherosclerosis by NLRP3-dependent IL-1 production.
REFERENCE   3  (bases 1 to 1250)
  AUTHORS   Kuboki,A., Kikuta,S., Otori,N., Kojima,H., Matsumoto,I., Reisert,J.
            and Yamasoba,T.
  TITLE     Insulin-Dependent Maturation of Newly Generated Olfactory Sensory
            Neurons after Injury
  JOURNAL   eNeuro 8 (3) (2021)
   PUBMED   33906971
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1250)
  AUTHORS   Olender,T., Jones,T.E.M., Bruford,E. and Lancet,D.
  TITLE     A unified nomenclature for vertebrate olfactory receptors
  JOURNAL   BMC Evol Biol 20 (1), 42 (2020)
   PUBMED   32295537
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1250)
  AUTHORS   Zapiec,B. and Mombaerts,P.
  TITLE     The Zonal Organization of Odorant Receptor Gene Choice in the Main
            Olfactory Epithelium of the Mouse
  JOURNAL   Cell Rep 30 (12), 4220-4234 (2020)
   PUBMED   32209480
REFERENCE   6  (bases 1 to 1250)
  AUTHORS   Zhang,X. and Firestein,S.
  TITLE     The olfactory receptor gene superfamily of the mouse
  JOURNAL   Nat Neurosci 5 (2), 124-133 (2002)
   PUBMED   11802173
REFERENCE   7  (bases 1 to 1250)
  AUTHORS   Lane,R.P., Cutforth,T., Young,J., Athanasiou,M., Friedman,C.,
            Rowen,L., Evans,G., Axel,R., Hood,L. and Trask,B.J.
  TITLE     Genomic analysis of orthologous mouse and human olfactory receptor
            loci
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7390-7395 (2001)
   PUBMED   11416212
REFERENCE   8  (bases 1 to 1250)
  AUTHORS   Krautwurst,D., Yau,K.W. and Reed,R.R.
  TITLE     Identification of ligands for olfactory receptors by functional
            expression of a receptor library
  JOURNAL   Cell 95 (7), 917-926 (1998)
   PUBMED   9875846
REFERENCE   9  (bases 1 to 1250)
  AUTHORS   Ressler,K.J., Sullivan,S.L. and Buck,L.B.
  TITLE     Information coding in the olfactory system: evidence for a
            stereotyped and highly organized epitope map in the olfactory bulb
  JOURNAL   Cell 79 (7), 1245-1255 (1994)
   PUBMED   7528109
REFERENCE   10 (bases 1 to 1250)
  AUTHORS   Chess,A., Simon,I., Cedar,H. and Axel,R.
  TITLE     Allelic inactivation regulates olfactory receptor gene expression
  JOURNAL   Cell 78 (5), 823-834 (1994)
   PUBMED   8087849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            S73844.1 and AC137524.4.
            
            On Apr 7, 2010 this sequence version replaced NM_010983.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S73844.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               S73844.1           1-226
            227-290             S73844.1           228-291
            291-1250            AC137524.4         180067-181026       c
FEATURES             Location/Qualifiers
     source          1..1250
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 56.1 cM"
     gene            1..1250
                     /gene="Or6a2"
                     /gene_synonym="I7; MOR103-15; Olfr2; Olfr41"
                     /note="olfactory receptor family 6 subfamily A member 2"
                     /db_xref="GeneID:18317"
                     /db_xref="MGI:MGI:97432"
     exon            1..143
                     /gene="Or6a2"
                     /gene_synonym="I7; MOR103-15; Olfr2; Olfr41"
                     /inference="alignment:Splign:2.1.0"
     exon            144..1250
                     /gene="Or6a2"
                     /gene_synonym="I7; MOR103-15; Olfr2; Olfr41"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1250
                     /gene="Or6a2"
                     /gene_synonym="I7; MOR103-15; Olfr2; Olfr41"
                     /note="odorant receptor B2; I7 olfactory receptor;
                     GA_x6K02T2PBJ9-9381439-9380456; olfactory recepter I7;
                     olfactory receptor 41"
                     /codon_start=1
                     /product="olfactory receptor 2"
                     /protein_id="NP_035113.1"
                     /db_xref="CCDS:CCDS21683.1"
                     /db_xref="GeneID:18317"
                     /db_xref="MGI:MGI:97432"
                     /translation="MERRNHTGRVSEFVLLGFPAPAPLRALLFFLSLLAYVLVLTENI
                     LIITAIRNHPTLHKPMYFFLANMSFLEIWYVTVTIPKMLAGFIGSEENHGQLISFEAC
                     MTQLYFFLGLGCTECVLLAVMAYDRYVAICHPLHYPVIVSSRLCVQMAAGSWAGGFGI
                     SMVKVFLISRLSYCGPNTINHFFCDVSPLLNLSCTDMSTAELTDFILAIFILLGPLSV
                     TGASYMAITGAVMRIPSAAGRHKAFSTCASHLTVVIIFYAASIFIYARPKALSAFDTN
                     KLVSVLYAVIVPLLNPIIYCLRNQEVKKALRRTLHLAQGQDANTKKSSRDG"
ORIGIN      
        1 agttctctac tgactgctaa cttggtcttg atgctaaagg aattgtgcta gtcttactca
       61 aagagagtta gctgaacttt cagaatcaat gacctgttca gtactcacat catccaggac
      121 ctacttcatg tcctgatatc tagctcatcg aacagctgct attaatcaca cctaccacaa
      181 gcattgcaga gaatagtcac caagctagat tcttgctgct gcttttataa gataccttgg
      241 tctatctctt gaacaagact gaaaacatgg agcgaaggaa ccacactggg agagtgagtg
      301 aatttgtgtt gctgggtttc ccagctcctg ccccactgcg ggcactacta tttttccttt
      361 ctctgttggc ctacgtgttg gtgctgactg aaaacatact catcattaca gcaattagga
      421 accaccccac cctccacaaa cccatgtatt ttttcttggc taatatgtca ttcctggaga
      481 tttggtatgt cactgttacg attcctaaga tgcttgctgg cttcattggt tccgaggaga
      541 atcatggaca gctgatctcc tttgaggcat gcatgacaca gctctacttt ttcctaggct
      601 tgggttgcac agagtgtgtc cttcttgctg tcatggccta tgaccgctat gtggccatct
      661 gtcacccact ccactatcct gtcattgtca gtagccggct atgtgtgcag atggcagctg
      721 gatcctgggc tggaggtttt ggtatctcca tggttaaagt tttcctcatt tctcgcctgt
      781 cttactgtgg ccccaacacc atcaaccact ttttctgtga tgtttctcca ttgctcaact
      841 tgtcatgcac tgacatgtcc acagcagagc ttacagactt tatcctggcc atttttattc
      901 tgctggggcc actctctgtc actggggctt cctatatggc catcacaggt gcagtgatgc
      961 gcatcccctc agctgctggc cgccataagg ccttttcaac ctgtgcctcc cacctcactg
     1021 ttgtgattat cttctatgca gccagtattt tcatctatgc caggcctaag gcactctcag
     1081 cttttgacac caacaagctg gtctctgtac tctacgctgt cattgtacca ttgctcaatc
     1141 ccatcatcta ctgcttgcgc aatcaagaag tcaaaaaagc cctacgtcgc actctgcacc
     1201 tggcccaagg ccaggacgcc aataccaaga aatccagcag agatggttag
//
