LOCUS       NM_020289               1181 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus olfactory receptor family 55 subfamily B member 4
            (Or55b4), mRNA.
ACCESSION   NM_020289
VERSION     NM_020289.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1181)
  AUTHORS   Wu,C., Jeong,M.Y., Kim,J.Y., Lee,G., Kim,J.S., Cheong,Y.E.,
            Kang,H., Cho,C.H., Kim,J., Park,M.K., Shin,Y.K., Kim,K.H.,
            Seol,G.H., Koo,S.H., Ko,G. and Lee,S.J.
  TITLE     Activation of ectopic olfactory receptor 544 induces GLP-1
            secretion and regulates gut inflammation
  JOURNAL   Gut Microbes 13 (1), 1987782 (2021)
   PUBMED   34674602
  REMARK    GeneRIF: Activation of ectopic olfactory receptor 544 induces GLP-1
            secretion and regulates gut inflammation.
REFERENCE   2  (bases 1 to 1181)
  AUTHORS   Thach,T.T., Wu,C., Hwang,K.Y. and Lee,S.J.
  TITLE     Azelaic Acid Induces Mitochondrial Biogenesis in Skeletal Muscle by
            Activation of Olfactory Receptor 544
  JOURNAL   Front Physiol 11, 329 (2020)
   PUBMED   32411005
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1181)
  AUTHORS   Olender,T., Jones,T.E.M., Bruford,E. and Lancet,D.
  TITLE     A unified nomenclature for vertebrate olfactory receptors
  JOURNAL   BMC Evol Biol 20 (1), 42 (2020)
   PUBMED   32295537
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1181)
  AUTHORS   Wu,C., Hwang,S.H., Jia,Y., Choi,J., Kim,Y.J., Choi,D.,
            Pathiraja,D., Choi,I.G., Koo,S.H. and Lee,S.J.
  TITLE     Olfactory receptor 544 reduces adiposity by steering fuel
            preference toward fats
  JOURNAL   J Clin Invest 127 (11), 4118-4123 (2017)
   PUBMED   28990936
  REMARK    GeneRIF: Olfr544 orchestrates the metabolic interplay between the
            liver and adipose tissue, mobilizing stored fats from adipose
            tissue and shifting the fuel preference to fats in the liver and
            brown adipose tissue.
REFERENCE   5  (bases 1 to 1181)
  AUTHORS   Thach,T.T., Hong,Y.J., Lee,S. and Lee,S.J.
  TITLE     Molecular determinants of the olfactory receptor Olfr544 activation
            by azelaic acid
  JOURNAL   Biochem Biophys Res Commun 485 (2), 241-248 (2017)
   PUBMED   28235481
  REMARK    GeneRIF: These data indicated that a hydrogen bond between Y109
            residue and azelaic acid is a major determinant of the
            Olfr544-azelaic acid interaction and activation.
REFERENCE   6  (bases 1 to 1181)
  AUTHORS   Abaffy,T., Malhotra,A. and Luetje,C.W.
  TITLE     The molecular basis for ligand specificity in a mouse olfactory
            receptor: a network of functionally important residues
  JOURNAL   J Biol Chem 282 (2), 1216-1224 (2007)
   PUBMED   17114180
  REMARK    GeneRIF: A network of 8 residues in transmembrane domains III, V,
            and VI was identified forming part of the ligand binding pocket of
            MOR42-3
REFERENCE   7  (bases 1 to 1181)
  AUTHORS   Young,J.M., Shykind,B.M., Lane,R.P., Tonnes-Priddy,L., Ross,J.A.,
            Walker,M., Williams,E.M. and Trask,B.J.
  TITLE     Odorant receptor expressed sequence tags demonstrate olfactory
            expression of over 400 genes, extensive alternate splicing and
            unequal expression levels
  JOURNAL   Genome Biol 4 (11), R71 (2003)
   PUBMED   14611657
REFERENCE   8  (bases 1 to 1181)
  AUTHORS   Young,J.M., Friedman,C., Williams,E.M., Ross,J.A., Tonnes-Priddy,L.
            and Trask,B.J.
  TITLE     Different evolutionary processes shaped the mouse and human
            olfactory receptor gene families
  JOURNAL   Hum Mol Genet 11 (5), 535-546 (2002)
   PUBMED   11875048
  REMARK    Erratum:[Hum Mol Genet. 2002 Jul 1;11(14):1683.]
REFERENCE   9  (bases 1 to 1181)
  AUTHORS   Zhang,X. and Firestein,S.
  TITLE     The olfactory receptor gene superfamily of the mouse
  JOURNAL   Nat Neurosci 5 (2), 124-133 (2002)
   PUBMED   11802173
REFERENCE   10 (bases 1 to 1181)
  AUTHORS   Malnic,B., Hirono,J., Sato,T. and Buck,L.B.
  TITLE     Combinatorial receptor codes for odors
  JOURNAL   Cell 96 (5), 713-723 (1999)
   PUBMED   10089886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102535.17.
            
            On Nov 18, 2009 this sequence version replaced NM_020289.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DR065630.1, DR065632.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC102535.17        142073-142113
            42-1181             AC102535.17        145127-146266
FEATURES             Location/Qualifiers
     source          1..1181
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.73 cM"
     gene            1..1181
                     /gene="Or55b4"
                     /gene_synonym="MOR42-3; Olfr544; Ors6"
                     /note="olfactory receptor family 55 subfamily B member 4"
                     /db_xref="GeneID:257926"
                     /db_xref="MGI:MGI:3030378"
     exon            1..41
                     /gene="Or55b4"
                     /gene_synonym="MOR42-3; Olfr544; Ors6"
                     /inference="alignment:Splign:2.1.0"
     exon            42..1181
                     /gene="Or55b4"
                     /gene_synonym="MOR42-3; Olfr544; Ors6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacttgacca gtctttactt cccctgcctg tgtgagtcct gaaatgctgt agttaatgtc
       61 tacacccagt ccagcctggt gaggctgggg caggtcctag cagggccttt cagggactga
      121 accccggcat cctgcccctc ccctctccct ggagcctccc caagccctca ggcgtcatgt
      181 cagggtggag caatggcacc tacaatgagt cctacaccag cttcctcctc atgggcttcc
      241 cagggatgca ggaagccaga gccctcctgg tgctgccctt cctcagcctc tacctggtga
      301 tcctcttcac caatgccctg gtcatccaca cggtggcatc ccagcgcagc ctgcaccagc
      361 ccatgtacct gctcattgcc ctgctcctgg ctgtcaatat ctgcgctgcc accaccgtgg
      421 tgccccccat gctcttcagc ttctccacac gcttcaaccg catctccctc cctcgatgct
      481 tgggacagat gttctgcatc tacttcctta ttgtctttga ctgcaacatc ctcctggtca
      541 tggctctaga tcgctatgtg gctatctgct accctctccg ctacccagaa atagtgacag
      601 gacagttact ggctggtctg gtggtgctgg cagtcaccag gagcacatgc attgttgctc
      661 cagtggtggt gctggcctcg cgggttcgct tctgtcgctc agatgtgatc cgccactttg
      721 cctgtgagca catggccctg atgaagcttt cctgtgggga catctcgctg aataagacgg
      781 tgggactcac tgttcgcatc ttcaaccgag tcctggatat gctcctgtta ggtgcctcct
      841 actcccgcat catccatgct gccttcagga tctcatcagg tggagcacgg tccaaagccc
      901 tgaacacctg tggctcccac ctgctggtca tcttcactgt ctactcctcc accatgtcct
      961 catccattgt ctaccgtgtg gcgcgcactg cctcccaaga tgtgcacaac ttgctcagtg
     1021 ctttctatct gttgctcccg tgtctggtca accccatcat ctacggggcc agaaccaagg
     1081 aaatcaggca gcacctggta gctctgttcc aaaggactca gcaacaggtc ttcactgaga
     1141 agccccagtc cctgccctcg aatagagagc ttcctggatg a
//
