LOCUS       NM_130866               3496 bp    mRNA    linear   ROD 26-OCT-2024
DEFINITION  Mus musculus olfactory receptor family 51 subfamily E member 2
            (Or51e2), transcript variant 1, mRNA.
ACCESSION   NM_130866
VERSION     NM_130866.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3496)
  AUTHORS   Colinas,O., Mombaerts,P., Lopez-Barneo,J. and Ortega-Saenz,P.
  TITLE     Carotid Body Function in Tyrosine Hydroxylase Conditional Olfr78
            Knockout Mice
  JOURNAL   Function (Oxf) 5 (3), zqae010 (2024)
   PUBMED   38706960
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3496)
  AUTHORS   Dinsart,G., Leprovots,M., Lefort,A., Libert,F., Quesnel,Y.,
            Veithen,A., Vassart,G., Huysseune,S., Parmentier,M. and Garcia,M.I.
  TITLE     The olfactory receptor Olfr78 promotes differentiation of
            enterochromaffin cells in the mouse colon
  JOURNAL   EMBO Rep 25 (1), 304-333 (2024)
   PUBMED   38177905
  REMARK    GeneRIF: The olfactory receptor Olfr78 promotes differentiation of
            enterochromaffin cells in the mouse colon.
REFERENCE   3  (bases 1 to 3496)
  AUTHORS   Nakashima,A., Nakashima,N., Nakashima,K. and Takano,M.
  TITLE     Olfactory receptor 78 is expressed in hypothalamic
            vasopressin/oxytocin neurons, parenchymal microglia and choroidal
            macrophages in mice
  JOURNAL   Mol Brain 15 (1), 29 (2022)
   PUBMED   35379313
  REMARK    GeneRIF: Olfactory receptor 78 is expressed in hypothalamic
            vasopressin/oxytocin neurons, parenchymal microglia and choroidal
            macrophages in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3496)
  AUTHORS   Cook,T.M., Gavini,C.K., Jesse,J., Aubert,G., Gornick,E., Bonomo,R.,
            Gautron,L., Layden,B.T. and Mansuy-Aubert,V.
  TITLE     Vagal neuron expression of the microbiota-derived metabolite
            receptor, free fatty acid receptor (FFAR3), is necessary for normal
            feeding behavior
  JOURNAL   Mol Metab 54, 101350 (2021)
   PUBMED   34626852
  REMARK    GeneRIF: Vagal neuron expression of the microbiota-derived
            metabolite receptor, free fatty acid receptor (FFAR3), is necessary
            for normal feeding behavior.
REFERENCE   5  (bases 1 to 3496)
  AUTHORS   Poll,B.G., Xu,J., Gupta,K., Shubitowski,T.B. and Pluznick,J.L.
  TITLE     Olfactory receptor 78 modulates renin but not baseline blood
            pressure
  JOURNAL   Physiol Rep 9 (18), e15017 (2021)
   PUBMED   34549531
  REMARK    GeneRIF: Olfactory receptor 78 modulates renin but not baseline
            blood pressure.
REFERENCE   6  (bases 1 to 3496)
  AUTHORS   Young,J.M., Shykind,B.M., Lane,R.P., Tonnes-Priddy,L., Ross,J.A.,
            Walker,M., Williams,E.M. and Trask,B.J.
  TITLE     Odorant receptor expressed sequence tags demonstrate olfactory
            expression of over 400 genes, extensive alternate splicing and
            unequal expression levels
  JOURNAL   Genome Biol 4 (11), R71 (2003)
   PUBMED   14611657
REFERENCE   7  (bases 1 to 3496)
  AUTHORS   Young,J.M., Friedman,C., Williams,E.M., Ross,J.A., Tonnes-Priddy,L.
            and Trask,B.J.
  TITLE     Different evolutionary processes shaped the mouse and human
            olfactory receptor gene families
  JOURNAL   Hum Mol Genet 11 (5), 535-546 (2002)
   PUBMED   11875048
  REMARK    Erratum:[Hum Mol Genet. 2002 Jul 1;11(14):1683.]
REFERENCE   8  (bases 1 to 3496)
  AUTHORS   Zhang,X. and Firestein,S.
  TITLE     The olfactory receptor gene superfamily of the mouse
  JOURNAL   Nat Neurosci 5 (2), 124-133 (2002)
   PUBMED   11802173
REFERENCE   9  (bases 1 to 3496)
  AUTHORS   Yuan,T.T., Toy,P., McClary,J.A., Lin,R.J., Miyamoto,N.G. and
            Kretschmer,P.J.
  TITLE     Cloning and genetic characterization of an evolutionarily conserved
            human olfactory receptor that is differentially expressed across
            species
  JOURNAL   Gene 278 (1-2), 41-51 (2001)
   PUBMED   11707321
REFERENCE   10 (bases 1 to 3496)
  AUTHORS   Conzelmann,S., Levai,O., Bode,B., Eisel,U., Raming,K., Breer,H. and
            Strotmann,J.
  TITLE     A novel brain receptor is expressed in a distinct population of
            olfactory sensory neurons
  JOURNAL   Eur J Neurosci 12 (11), 3926-3934 (2000)
   PUBMED   11069588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036356.1, AK028467.1 and AC162175.10.
            
            On Dec 9, 2009 this sequence version replaced NM_130866.3.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028467.1, ERR3363658.736363.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AK036356.1         2-77
            77-2746             AK028467.1         2-2671
            2747-3496           AC162175.10        183547-184296
FEATURES             Location/Qualifiers
     source          1..3496
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.83 cM"
     gene            1..3496
                     /gene="Or51e2"
                     /gene_synonym="4633402A21Rik; MOL2.3; MOR18-2; Olfr78;
                     PSGR; RA1c"
                     /note="olfactory receptor family 51 subfamily E member 2"
                     /db_xref="GeneID:170639"
                     /db_xref="MGI:MGI:2157548"
     exon            1..162
                     /gene="Or51e2"
                     /gene_synonym="4633402A21Rik; MOL2.3; MOR18-2; Olfr78;
                     PSGR; RA1c"
                     /inference="alignment:Splign:2.1.0"
     exon            163..1031
                     /gene="Or51e2"
                     /gene_synonym="4633402A21Rik; MOL2.3; MOR18-2; Olfr78;
                     PSGR; RA1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1164
                     /gene="Or51e2"
                     /gene_synonym="4633402A21Rik; MOL2.3; MOR18-2; Olfr78;
                     PSGR; RA1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..3496
                     /gene="Or51e2"
                     /gene_synonym="4633402A21Rik; MOL2.3; MOR18-2; Olfr78;
                     PSGR; RA1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             1216..2178
                     /gene="Or51e2"
                     /gene_synonym="4633402A21Rik; MOL2.3; MOR18-2; Olfr78;
                     PSGR; RA1c"
                     /note="GA_x6K02T2PBJ9-5459657-5458695; olfactory receptor
                     MOR18-2; olfactory receptor 78"
                     /codon_start=1
                     /product="olfactory receptor 51E2"
                     /protein_id="NP_570936.1"
                     /db_xref="CCDS:CCDS21546.1"
                     /db_xref="GeneID:170639"
                     /db_xref="MGI:MGI:2157548"
                     /translation="MSSCNFTHATFLLIGIPGLEEAHFWFGFPLLSMYAVALFGNCIV
                     VFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREITFDACLAQMFF
                     IHTLSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTVQIGMVALVRGSLFFFPLPL
                     LIKRLAFCHSNVLSHSYCVHQDVMKLAYTDTLPNVVYGLTAILLVMGVDVMFISLSYF
                     LIIRTVLQLPSKSERAKAFGTCVSHISVVLAFYVPLIGLSVVHRFGNSLDPIVHVLMG
                     DVYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDIEAGGNT"
     regulatory      2810..2815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Or51e2"
                     /gene_synonym="4633402A21Rik; MOL2.3; MOR18-2; Olfr78;
                     PSGR; RA1c"
                     /note="hexamer: ATTAAA"
     polyA_site      2832
                     /gene="Or51e2"
                     /gene_synonym="4633402A21Rik; MOL2.3; MOR18-2; Olfr78;
                     PSGR; RA1c"
                     /note="major polyA site"
     regulatory      3469..3474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Or51e2"
                     /gene_synonym="4633402A21Rik; MOL2.3; MOR18-2; Olfr78;
                     PSGR; RA1c"
                     /note="hexamer: AATAAA"
     polyA_site      3490
                     /gene="Or51e2"
                     /gene_synonym="4633402A21Rik; MOL2.3; MOR18-2; Olfr78;
                     PSGR; RA1c"
                     /note="major polyA site"
ORIGIN      
        1 acagtgaatt agcactgccg ctgggaaccg gtccctcgac tctgctgatc tccaaacaag
       61 ctgaataaat ctcaacataa gctggaccct cctctggaat ctgaagcttc ctccaacctt
      121 ctgagttaga ttgaggggac tcattgctgc tggatgggct ctatttggga aacgagctcc
      181 accctatgta cataccatga ttgctaatac ctacctgctg attcctcctg tcatgaaccc
      241 catcatctac agtgtgaaga ccaaacagat acgtaaagct gtgataaaag ttttccaatc
      301 taaagaaata tagaatcata aaagcctaga gctaaacggc ctgcttcagg ccatgttgtc
      361 aattaaggct agactacatc ttgaatgtca gttactttag cccctttact tcacagatga
      421 ggagacgctg atatataagt gagaagcaat atatagcctt atgcctagag ttcctcttcc
      481 tccacaccat ttcttctaag ctggtgcttt tctaactttg tcaatagccc ttttattctt
      541 atctcatcat agcagttaca ttttcatatt aatttcatat tacatcattc ctttgtagaa
      601 aagtaggtag cattttctaa cgctctgcca tctactgttc aaagaaactt ctctgatgag
      661 gattgatagc ttcttataga gaaagatgtg tatttagaag gtagtttgat actatgtcca
      721 tttggcaaaa taatagcagt agtttaatcc tggggcctgt gatcttcaca accatgagtt
      781 cttggtcaga tttacaacat tagacataaa taagtactgt gaagttagct ttaaagcaca
      841 tcataaaaca ggtgttttac cctcaaaaca ttttaccatg atttcaccca tgaatatatt
      901 ttgccagttc tatcattatt gcagcttgtg gtactcacag ctgggtaagg tgatcagtga
      961 cttttgttcc ctagcagcct ggatggcacc ttctggtcct atgaaaacca cccagcaggg
     1021 ggagcttcca gatccctgga gcatcagctg gtataccaac agcttgttcc ccgagcctac
     1081 tgagtagcgt tataaagaga cctggtccgg aaagggaaag ccagaccctg ctgctctcct
     1141 tgagtagaac tgcgccattc ccaggctgtc agtgtggcct ctccctcttc cagtccgccc
     1201 cacttggtgt caacgatgag ttcctgcaac ttcacccatg ccaccttcct gcttattggt
     1261 attccaggac tggaggaagc tcacttttgg tttggcttcc ccctgctttc catgtatgct
     1321 gtagcattgt ttggaaactg cattgtggtc ttcatagtga gaacagagcg gagcctgcat
     1381 gcacccatgt acctttttct ctgcatgctg gcagctattg atctggcttt gtccacatcc
     1441 acaatgccca agattctcgc cctcttttgg tttgactccc gggagattac ttttgatgcc
     1501 tgtcttgccc agatgttttt cattcatact ctctcagcaa ttgaatctac tatcctgctg
     1561 gccatggcct ttgaccggta cgtggctatc tgccacccac tgcgtcacgc tgctgtcctc
     1621 aacaatacag taacagtcca aataggcatg gtggctctgg tccggggatc cctattcttt
     1681 ttcccactcc cactactgat caagcgactg gctttctgtc actccaatgt gctctcccac
     1741 tcctattgtg tccaccagga tgtgatgaag ttggcctata cagacacatt acccaatgta
     1801 gtctatggtc taactgccat tctgctagtc atgggtgtag atgtcatgtt catctccttg
     1861 tcctacttcc tgatcatacg aacggttctg caactgcctt ccaagtctga gcgagctaag
     1921 gcatttggga cttgtgtgtc acacattagt gtggtcctgg ctttctatgt accactcatt
     1981 ggtctgtcag tggtgcaccg ttttggaaac agcctggatc ccattgtgca tgttctaatg
     2041 ggggatgtct acctgctgct gcctcctgtg atcaatccca tcatctacgg tgctaagacc
     2101 aaacagatca gaacacgggt tctggctatg ttcaagatca gctgtgacaa ggacattgaa
     2161 gctgggggaa acacgtgacc cttaccatcc tatcaccctt gtcctacatg gcttaatata
     2221 ataacttcaa cacatctgct taattccaat caccaaaaag catattagtg cttttccctg
     2281 aatgggatag tgaactgaag tatggtttta tcttcatcat ggatataatg tgaatgtgtc
     2341 tatttcgatg aatattatgt gttttaaaga ttctgctgta aaatgagacc cactgataat
     2401 accaaatgaa acaacttgga tttgtgattt aaactaatta ttgggtttgt gacttgaatg
     2461 aaatattttc aaattactaa catttttatt cctacttcct ttgttataaa gctattgttt
     2521 agctataatg tttaacttct gaaatgtgga gcatgaagct gacagtatgt ttcctcgctc
     2581 atttcaattt tattattcag tacccaggaa catatatgag ctctgaacag gaaggcttat
     2641 gtgtatcatg tatgcttaac atgttccaga tcctgtgata agtgcttttc cacctttctg
     2701 tgttcttgtt cttttcccag ggaagatacc acttttgccc accacaacat gtgatagagg
     2761 ctttaatgag caaagaaact ttcttgtatg tgctgtgcca agattttaaa ttaaatttga
     2821 taattgaatg catttgcttt actaccatgt tatattgctt cctgcttaac atctgccatc
     2881 tatttcctct gcctattaca aatcctgttt tctctttgtc gtgtgctaac atggatgtct
     2941 tgtgtttgtg gtaagtgatt aaccatgttc tggtggcggg taccaaactg ttcttcatga
     3001 tagagtagct gcttcctctc agatgaacag aggaggttta aattttttag tctctttcat
     3061 atctttgatt atgtcttctt tgtattgtgt tcttcggctg tcaaatctct tgaatatata
     3121 acgtatgaca ttgtctgagt cttgacttag gtatcaaaca acatagtaat ttatcttaaa
     3181 atgttcagta ttattttcac tgtttttatg ttcataaagt aacattggga gatatgagtg
     3241 atcctccagt cctctttacc aacactgcaa agggcctgct ggatatgggt tgtacaacta
     3301 tagagatgtt gaatgaactt atgtgatgta gaatattccc ttcatactga gtggatgatg
     3361 aaaaggttct aagattaggt tttagtgata cctacaaaat aatgttaata tactcaatgt
     3421 acacataatg cttaaaatgt tgaaatttat gtggtgtgta tctgccacaa taaaaaaaaa
     3481 tcatttaaaa tactgt
//
