LOCUS       NM_008762                939 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus olfactory receptor family 2 subfamily C member 1
            (Or2c1), mRNA.
ACCESSION   NM_008762
VERSION     NM_008762.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Wang,Y.Z., Fan,H., Ji,Y., Reynolds,K., Gu,R., Gan,Q., Yamagami,T.,
            Zhao,T., Hamad,S., Bizen,N., Takebayashi,H., Chen,Y., Wu,S.,
            Pleasure,D., Lam,K. and Zhou,C.J.
  TITLE     Olig2 regulates terminal differentiation and maturation of
            peripheral olfactory sensory neurons
  JOURNAL   Cell Mol Life Sci 77 (18), 3597-3609 (2020)
   PUBMED   31758234
  REMARK    Erratum:[Cell Mol Life Sci. 2021 Jul;78(14):5665-5666. doi:
            10.1007/s00018-021-03870-2.. PMID: 34156491]
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Olender,T., Jones,T.E.M., Bruford,E. and Lancet,D.
  TITLE     A unified nomenclature for vertebrate olfactory receptors
  JOURNAL   BMC Evol Biol 20 (1), 42 (2020)
   PUBMED   32295537
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Leem,J., Shim,H.M., Cho,H. and Park,J.H.
  TITLE     Octanoic acid potentiates glucose-stimulated insulin secretion and
            expression of glucokinase through the olfactory receptor in
            pancreatic beta-cells
  JOURNAL   Biochem Biophys Res Commun 503 (1), 278-284 (2018)
   PUBMED   29885841
  REMARK    GeneRIF: In islets from type 2 diabetic mice, the expression level
            of Olfr15 and the octanoic acid-induced enhancement of
            glucose-stimulated insulin secretion were strongly reduced.
REFERENCE   4  (bases 1 to 939)
  AUTHORS   Zhang,R., Pan,Y., Ahmed,L., Block,E., Zhang,Y., Batista,V.S. and
            Zhuang,H.
  TITLE     A Multispecific Investigation of the Metal Effect in Mammalian
            Odorant Receptors for Sulfur-Containing Compounds
  JOURNAL   Chem Senses 43 (5), 357-366 (2018)
   PUBMED   29659735
REFERENCE   5  (bases 1 to 939)
  AUTHORS   Munakata,Y., Yamada,T., Imai,J., Takahashi,K., Tsukita,S.,
            Shirai,Y., Kodama,S., Asai,Y., Sugisawa,T., Chiba,Y., Kaneko,K.,
            Uno,K., Sawada,S., Hatakeyama,H., Kanzaki,M., Miyazaki,J.I., Oka,Y.
            and Katagiri,H.
  TITLE     Olfactory receptors are expressed in pancreatic beta-cells and
            promote glucose-stimulated insulin secretion
  JOURNAL   Sci Rep 8 (1), 1499 (2018)
   PUBMED   29367680
  REMARK    GeneRIF: These findings suggest that Olfr15 and Olfr821 in
            pancreatic beta-cells has a chemo-sensor function allowing
            recognition of environmental substances obtained from food, and
            potentiates insulin secretion in a cell-autonomous manner, thereby
            modulating systemic glucose metabolism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 939)
  AUTHORS   Phan,L.K., Lin,F., LeDuc,C.A., Chung,W.K. and Leibel,R.L.
  TITLE     The mouse mahoganoid coat color mutation disrupts a novel C3HC4
            RING domain protein
  JOURNAL   J Clin Invest 110 (10), 1449-1459 (2002)
   PUBMED   12438443
REFERENCE   7  (bases 1 to 939)
  AUTHORS   Young,J.M., Friedman,C., Williams,E.M., Ross,J.A., Tonnes-Priddy,L.
            and Trask,B.J.
  TITLE     Different evolutionary processes shaped the mouse and human
            olfactory receptor gene families
  JOURNAL   Hum Mol Genet 11 (5), 535-546 (2002)
   PUBMED   11875048
  REMARK    Erratum:[Hum Mol Genet. 2002 Jul 1;11(14):1683.]
REFERENCE   8  (bases 1 to 939)
  AUTHORS   Zhang,X. and Firestein,S.
  TITLE     The olfactory receptor gene superfamily of the mouse
  JOURNAL   Nat Neurosci 5 (2), 124-133 (2002)
   PUBMED   11802173
REFERENCE   9  (bases 1 to 939)
  AUTHORS   Ressler,K.J., Sullivan,S.L. and Buck,L.B.
  TITLE     Information coding in the olfactory system: evidence for a
            stereotyped and highly organized epitope map in the olfactory bulb
  JOURNAL   Cell 79 (7), 1245-1255 (1994)
   PUBMED   7528109
REFERENCE   10 (bases 1 to 939)
  AUTHORS   Nef,P., Hermans-Borgmeyer,I., Artieres-Pin,H., Beasley,L.,
            Dionne,V.E. and Heinemann,S.F.
  TITLE     Spatial pattern of receptor expression in the olfactory epithelium
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8948-8952 (1992)
   PUBMED   1384038
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129021.4.
            
            On Oct 14, 2006 this sequence version replaced NM_008762.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC100680.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-939               AC129021.4         107704-108642       c
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.26 cM"
     gene            1..939
                     /gene="Or2c1"
                     /gene_synonym="MOR256-17; Olfr15; OR3"
                     /note="olfactory receptor family 2 subfamily C member 1"
                     /db_xref="GeneID:18312"
                     /db_xref="MGI:MGI:106182"
     CDS             1..939
                     /gene="Or2c1"
                     /gene_synonym="MOR256-17; Olfr15; OR3"
                     /note="olfactory receptor MOR256-17; odorant receptor OR3;
                     olfactory receptor 256-17; GA_x54KRFPKG5P-348087-349025;
                     olfactory receptor 15"
                     /codon_start=1
                     /product="olfactory receptor 2C1"
                     /protein_id="NP_032788.2"
                     /db_xref="CCDS:CCDS27910.1"
                     /db_xref="GeneID:18312"
                     /db_xref="MGI:MGI:106182"
                     /translation="MEVDSNSSSGSFILMGVSDHPHLEIIFFAVILASYLLTLVGNLT
                     IILLSRLDARLHTPMYFFLSNLSSLDLAFTTSSVPQMLKNLWGPDKTISYGGCVTQLY
                     VFLWLGATECILLVVMAFDRYVAVCRPLHYMTVMNPRLCWGLAAISWLGGLGNSVIQS
                     TFTLQLPFCGHRKVDNFLCEVPAMIKLACGDTSLNEAVLNGVCTFFTVVPVSVILVSY
                     CFIAQAVMKIRSVEGRRKAFNTCVSHLVVVFLFYGSAIYGYLLPAKSSNQSQGKFISL
                     FYSVVTPMVNPLIYTLRNKEVKGALGRLLGKGRGAS"
     exon            1..939
                     /gene="Or2c1"
                     /gene_synonym="MOR256-17; Olfr15; OR3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaggtgg acagcaacag ctcctctggg agcttcattc tgatgggtgt ctctgaccat
       61 ccccatctgg agatcatctt ttttgctgtc atcctggcct cttacttgtt gacgctggtt
      121 gggaacttga ccatcatcct gctttcgcgc cttgatgctc ggctccacac acccatgtac
      181 ttcttcctca gcaacctctc ctctctagac cttgccttta ctaccagttc agtccctcag
      241 atgctgaaaa atttatgggg gccagacaag acaatcagct atggtgggtg tgtaactcaa
      301 ctctatgttt tcctttggct gggggctact gagtgcatac tgctcgtggt gatggcattt
      361 gatcggtatg tggcagtttg tcggcccctg cactacatga ccgtcatgaa tcctcgcctc
      421 tgctgggggc tggctgctat tagctggttg ggtggcttag gcaactccgt gattcagtca
      481 acattcactc tccagctccc attttgcgga caccgaaaag tggacaactt cctgtgtgag
      541 gtacccgcca tgattaaatt ggcctgtgga gacacaagtc tcaatgaggc ggtgctcaat
      601 ggtgtttgta ccttcttcac tgtggtccca gtaagcgtca tcctggtctc ttactgcttc
      661 attgctcagg cagtgatgaa gatccgctct gtggagggac gtcgaaaggc tttcaatacg
      721 tgtgtctccc acttggtggt agtgtttctc ttctatggct ctgcgatcta tgggtatctg
      781 cttccagcta agagcagtaa tcaaagccaa ggaaaattca tttctctctt ctactctgtg
      841 gtcacaccca tggtgaatcc gctcatctat actctaagaa acaaagaagt gaagggggcc
      901 ctgggaagat tgctggggaa aggaagagga gccagctga
//
