LOCUS       NM_001356487            2686 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus optineurin (Optn), transcript variant 1, mRNA.
ACCESSION   NM_001356487 XM_006497546
VERSION     NM_001356487.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2686)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2686)
  AUTHORS   Hu,X., Foster,B.L., Zhao,B., Tseng,H.C., Wu,Y.C. and Ko,C.C.
  TITLE     Optineurin regulates osteoblast function in an age-dependent
            fashion in a mouse model of Paget's disease of bone
  JOURNAL   Bone 177, 116929 (2023)
   PUBMED   37802379
  REMARK    GeneRIF: Optineurin regulates osteoblast function in an
            age-dependent fashion in a mouse model of Paget's disease of bone.
REFERENCE   3  (bases 1 to 2686)
  AUTHORS   Meyer,L.M., Koschade,S.E., Vischedyk,J.B., Thoelken,M., Gubas,A.,
            Wegner,M., Basoglu,M., Knapp,S., Kaulich,M., Eimer,S., Shaid,S. and
            Brandts,C.H.
  TITLE     Deciphering the mitophagy receptor network identifies a crucial
            role for OPTN (optineurin) in acute myeloid leukemia
  JOURNAL   Autophagy 19 (11), 2982-2996 (2023)
   PUBMED   37439113
  REMARK    GeneRIF: Deciphering the mitophagy receptor network identifies a
            crucial role for OPTN (optineurin) in acute myeloid leukemia.
REFERENCE   4  (bases 1 to 2686)
  AUTHORS   Hu,Z., Xie,Y., Lu,J., Yang,J., Zhang,J., Jiang,H., Li,H., Zhang,Y.,
            Wu,D., Zeng,K., Bai,X. and Yu,X.
  TITLE     VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for
            autophagic degradation
  JOURNAL   Sci Adv 9 (25), eadg2339 (2023)
   PUBMED   37352355
REFERENCE   5  (bases 1 to 2686)
  AUTHORS   Fukushi,M., Ohsawa,R., Okinaka,Y., Oikawa,D., Kiyono,T.,
            Moriwaki,M., Irie,T., Oda,K., Kamei,Y., Tokunaga,F., Sotomaru,Y.,
            Maruyama,H., Kawakami,H. and Sakaguchi,T.
  TITLE     Optineurin deficiency impairs autophagy to cause interferon beta
            overproduction and increased survival of mice following viral
            infection
  JOURNAL   PLoS One 18 (6), e0287545 (2023)
   PUBMED   37352136
  REMARK    GeneRIF: Optineurin deficiency impairs autophagy to cause
            interferon beta overproduction and increased survival of mice
            following viral infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2686)
  AUTHORS   De Marco,N., Buono,M., Troise,F. and Diez-Roux,G.
  TITLE     Optineurin increases cell survival and translocates to the nucleus
            in a Rab8-dependent manner upon an apoptotic stimulus
  JOURNAL   J Biol Chem 281 (23), 16147-16156 (2006)
   PUBMED   16569640
  REMARK    GeneRIF: mutated form of optineurin, E50K, identified in normal
            tension loses its ability to translocate to the nucleus and when
            overexpressed compromises the mitochondrial membrane integrity
            resulting in cells that are less fit to survive under stress
            conditions
REFERENCE   7  (bases 1 to 2686)
  AUTHORS   Kroeber,M., Ohlmann,A., Russell,P. and Tamm,E.R.
  TITLE     Transgenic studies on the role of optineurin in the mouse eye
  JOURNAL   Exp Eye Res 82 (6), 1075-1085 (2006)
   PUBMED   16442524
REFERENCE   8  (bases 1 to 2686)
  AUTHORS   Miyamoto-Sato,E., Ishizaka,M., Horisawa,K., Tateyama,S.,
            Takashima,H., Fuse,S., Sue,K., Hirai,N., Masuoka,K. and Yanagawa,H.
  TITLE     Cell-free cotranslation and selection using in vitro virus for
            high-throughput analysis of protein-protein interactions and
            complexes
  JOURNAL   Genome Res 15 (5), 710-717 (2005)
   PUBMED   15867431
REFERENCE   9  (bases 1 to 2686)
  AUTHORS   Rezaie,T. and Sarfarazi,M.
  TITLE     Molecular cloning, genomic structure, and protein characterization
            of mouse optineurin
  JOURNAL   Genomics 85 (1), 131-138 (2005)
   PUBMED   15607428
  REMARK    GeneRIF: Optn colocalizes with vesicular structures near the
            nucleus and is expressed in anterior segment, retina, and optic
            nerve blood vessels.
REFERENCE   10 (bases 1 to 2686)
  AUTHORS   Moreland,R.J., Dresser,M.E., Rodgers,J.S., Roe,B.A., Conaway,J.W.,
            Conaway,R.C. and Hanas,J.S.
  TITLE     Identification of a transcription factor IIIA-interacting protein
  JOURNAL   Nucleic Acids Res 28 (9), 1986-1993 (2000)
   PUBMED   10756201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928662.5.
            
            On Oct 5, 2017 this sequence version replaced XM_006497546.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY071834.1, SRR7652917.983933.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AL928662.5         85326-85536         c
            212-388             AL928662.5         75959-76135         c
            389-591             AL928662.5         74407-74609         c
            592-804             AL928662.5         67406-67618         c
            805-878             AL928662.5         63866-63939         c
            879-1013            AL928662.5         61558-61692         c
            1014-1113           AL928662.5         58090-58189         c
            1114-1229           AL928662.5         56387-56502         c
            1230-1379           AL928662.5         55573-55722         c
            1380-1473           AL928662.5         54550-54643         c
            1474-1632           AL928662.5         52679-52837         c
            1633-1763           AL928662.5         48533-48663         c
            1764-1846           AL928662.5         45486-45568         c
            1847-2686           AL928662.5         42061-42900         c
FEATURES             Location/Qualifiers
     source          1..2686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 3.15 cM"
     gene            1..2686
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /note="optineurin"
                     /db_xref="GeneID:71648"
                     /db_xref="MGI:MGI:1918898"
     exon            1..211
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            212..388
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1977
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /note="TFIIIA-INTP"
                     /codon_start=1
                     /product="optineurin"
                     /protein_id="NP_001343416.1"
                     /db_xref="CCDS:CCDS15663.1"
                     /db_xref="GeneID:71648"
                     /db_xref="MGI:MGI:1918898"
                     /translation="MSHQPLSCLTEKGDSPCETPGNGPSNMVHPSLDTFTPEELLQQM
                     KELLVENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERLLFEMQSKEVKERLKALTH
                     ENERLKEELGKFKEKSEKPLEDLTGGYRYPRALEEEVEKLKTQVEQEVEHLKIQVMRL
                     RAEKADLLGIVSELQLKLNSGGSSEDSFVEIRMTEGETEGAMKEMKNCPTPTRTDPIS
                     LSNCTEDARSCAEFEELTVSQLLLCLREGNQKVERLEVALREAKERISDFEKKANGHS
                     STEKQTARRADREKEDKGQESVGSEVETLSIQVTSLFKELQEAHTKLSEAELMKKRLQ
                     EKCQALERKNSATPSELNEKQELVYSNKKLELQVESMRSEIKMEQAKTEEEKSRLATL
                     QATHNKLLQEHNKALKTIEELTKQQAEKVDKMLLQELSEKLELAEQALASKQLQMDEM
                     KQTLAKQEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENND
                     IEEGGSRQSLMEMQCRHGARTSDSDQQTYLFQRGAEDRSWQHGQQPRSIPIHSCPKCG
                     EVLPDIDTLQIHVMDCII"
     exon            389..591
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            592..804
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            805..878
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1013
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1113
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1229
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1379
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1473
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1632
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1763
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1846
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2686
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2029
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /note="major polyA site"
     regulatory      2665..2670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
                     /note="hexamer: AGTAAA"
     polyA_site      2686
                     /gene="Optn"
                     /gene_synonym="4930441O07Rik; FIP2; HYPL; NRP"
ORIGIN      
        1 gagtgggcgt ggtctgggaa atttcttggc tagggcggga gcgggcgctg cggtcagctg
       61 agcggcgcct ggcgggtcgc gaggccgcgc gtcaccgtcc agctgcccgg tcgccgcccc
      121 ccggctggtc cctggcgggc gtcggcatcc agagctttgg gacaaaatac caacgaagca
      181 gtgacctaag aggagaggat ccctgtggcc ggacctgtta ccatgtccca tcaacctctg
      241 agctgcctga ctgagaaggg ggacagccct tgtgagaccc caggaaatgg accctccaat
      301 atggttcacc ccagcctgga cacattcacc cctgaggagc tgctgcagca aatgaaggaa
      361 ctcctggttg agaaccacca gctgaaagaa gccatgaagc taaataatca agctatgaaa
      421 gggcgatttg aggagctgtc cgcctggaca gagaagcaga aggaagagcg cctgttgttt
      481 gagatgcaaa gcaaagaggt taaggagcgc cttaaggccc tgactcatga aaatgagagg
      541 ctgaaggaag agcttggaaa attcaaagag aaatcagaaa agccattgga agacctcaca
      601 ggtggctaca ggtatcccag agccttggag gaggaagtgg agaagctgaa gacccaggtg
      661 gagcaggaag tggagcatct gaagatccag gtgatgcgcc ttcgggctga aaaggcagac
      721 ctgctgggca tcgtctcaga actgcagctc aaactcaact ccggcggctc ctcggaagac
      781 tccttcgttg agatcaggat gaccgaagga gagactgaag gggcaatgaa ggagatgaag
      841 aactgcccta cacccacaag aacagacccc atcagcttga gcaactgtac agaggatgcc
      901 aggagttgtg cggagtttga agaactgact gtgagccagc ttctgctttg cctaagggaa
      961 ggaaaccaaa aggtggagag acttgaagtc gccctcagag aagccaaaga aagaatttca
     1021 gattttgaaa agaaagcaaa tggccattct tctactgaga agcagacagc gaggagagca
     1081 gacagagaga aggaggacaa aggccaagag agtgttggaa gcgaagtgga aacactgagc
     1141 attcaagtga cctctctgtt taaggagctt caagaggcac acacaaaact cagtgaggct
     1201 gagctgatga agaagagact tcaagaaaag tgtcaggctc tggagaggaa gaactctgca
     1261 acaccatcag agctgaatga aaagcaagag ctcgtttaca gtaacaagaa gttagagctg
     1321 caggtggaga gcatgcgctc cgaaatcaag atggagcagg ccaagacaga ggaggagaag
     1381 tccaggttag ccactctgca ggcaactcac aacaagctcc ttcaagaaca taataaggca
     1441 ctgaaaacaa ttgaagaact aaccaagcaa caggcagaaa aggtggacaa gatgttgctg
     1501 caggagctca gcgagaagct ggagctggca gagcaggctc tggcatccaa acagctccag
     1561 atggatgaga tgaagcagac gctcgctaag caggaggaag acctggagac catggccgtc
     1621 ctcagggctc agatggaggt gtactgctca gattttcacg ctgagagagc agcaagagag
     1681 aagattcatg aagaaaagga gcagctggcc ttgcagctcg cgattttgct gaaagagaac
     1741 aatgacattg aagagggagg cagtagacag tccctgatgg aaatgcagtg ccgacacggg
     1801 gcaagaacca gtgactctga ccagcagact tacctgtttc aaagaggagc cgaggacagg
     1861 agctggcagc acgggcagca gcctcgcagt attccgattc actcctgccc caagtgcggg
     1921 gaggtcctgc cggacatcga cacgcttcag atccatgtga tggactgcat catttgagtg
     1981 ttctctccag tccccaaagc tcttggtaaa tgccagattt ctcctccaac acttgtactt
     2041 ctgtcttctt tattgtcaca tatatcacaa atatttttga cacactgtac ccctcctagg
     2101 gagagcatct tctggaccga caggaagtca caaagaggaa tctaattagc acccttccac
     2161 ataagccagc cagtgttttt atgttctgct catgagagtc actgtgagca gtcagccaga
     2221 atggctgcag tgtttttcta ggtaaatctt cccttagtgg gcatcttgtt gtgtgtgtaa
     2281 ttctgtggaa gttccatgtg gctctttctg actgaacact gtggtatctg ttgacaccag
     2341 gacaggtgag agatagggac aagctcagga ttggagtcct tccctcagct gttcggtgtg
     2401 acattaccct caggctccgt actggagctg tacaggatag tacagtacat agtttaattt
     2461 ttaaaagaac agctattttc tttgcagatg aagtagcagc ttacagatgt ctgagacact
     2521 gagagcctaa cagtgggtag caggacagga gggaaggtgt gggaagagtg agagtgctgg
     2581 ccgatggcac agcgtctcag gagggataat ctgtacagaa tagtgactgt aatcatttgt
     2641 atattaaggc catatcacca gtttagtaaa caccttgcaa accctc
//
