LOCUS       NM_054076               1906 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus opticin (Optc), transcript variant 1, mRNA.
ACCESSION   NM_054076
VERSION     NM_054076.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1906)
  AUTHORS   Hansen U, Holmes DF, Bruckner P and Bishop PN.
  TITLE     Analysis of opticin binding to collagen fibrils identifies a single
            binding site in the gap region and a high specificity towards thin
            heterotypic fibrils containing collagens II, and XI or V/XI
  JOURNAL   PLoS One 15 (8), e0234672 (2020)
   PUBMED   32764753
  REMARK    GeneRIF: Analysis of opticin binding to collagen fibrils identifies
            a single binding site in the gap region and a high specificity
            towards thin heterotypic fibrils containing collagens II, and XI or
            V/XI.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1906)
  AUTHORS   Farran A, Valverde-Franco G, Tio L, Lussier B, Fahmi H, Pelletier
            JP, Bishop PN, Monfort J and Martel-Pelletier J.
  TITLE     In vivo effect of opticin deficiency in cartilage in a surgically
            induced mouse model of osteoarthritis
  JOURNAL   Sci Rep 8 (1), 457 (2018)
   PUBMED   29323130
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1906)
  AUTHORS   Le Goff MM, Sutton MJ, Slevin M, Latif A, Humphries MJ and Bishop
            PN.
  TITLE     Opticin exerts its anti-angiogenic activity by regulating
            extracellular matrix adhesiveness
  JOURNAL   J Biol Chem 287 (33), 28027-28036 (2012)
   PUBMED   22669977
  REMARK    GeneRIF: opticin binds to collagen and thereby competitively
            inhibits endothelial cell interactions with collagen via
            alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing
            the strong adhesion that is required for proangiogenic signaling
            via these integrins.
REFERENCE   4  (bases 1 to 1906)
  AUTHORS   Le Goff MM, Lu H, Ugarte M, Henry S, Takanosu M, Mayne R and Bishop
            PN.
  TITLE     The vitreous glycoprotein opticin inhibits preretinal
            neovascularization
  JOURNAL   Invest Ophthalmol Vis Sci 53 (1), 228-234 (2012)
   PUBMED   22159013
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1906)
  AUTHORS   Liu P and Johnson RL.
  TITLE     Lmx1b is required for murine trabecular meshwork formation and for
            maintenance of corneal transparency
  JOURNAL   Dev Dyn 239 (8), 2161-2171 (2010)
   PUBMED   20568247
REFERENCE   6  (bases 1 to 1906)
  AUTHORS   Zhang Y, Burgess D, Overbeek PA and Govindarajan V.
  TITLE     Dominant inhibition of lens placode formation in mice
  JOURNAL   Dev Biol 323 (1), 53-63 (2008)
   PUBMED   18778700
REFERENCE   7  (bases 1 to 1906)
  AUTHORS   Friedman JS, Faucher M, Hiscott P, Biron VL, Malenfant M, Turcotte
            P, Raymond V and Walter MA.
  TITLE     Protein localization in the human eye and genetic screen of opticin
  JOURNAL   Hum Mol Genet 11 (11), 1333-1342 (2002)
   PUBMED   12019215
REFERENCE   8  (bases 1 to 1906)
  AUTHORS   Takanosu M, Boyd TC, Le Goff M, Henry SP, Zhang Y, Bishop PN and
            Mayne R.
  TITLE     Structure, chromosomal location, and tissue-specific expression of
            the mouse opticin gene
  JOURNAL   Invest Ophthalmol Vis Sci 42 (10), 2202-2210 (2001)
   PUBMED   11527931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA223016.1, AY077682.1, AK153750.1, AC157924.6, FQ976559.1 and
            AW124672.1.
            
            [WARNING] On Jul 24, 2023 this sequence was replaced by
            NM_054076.4.
            
            On Mar 23, 2012 this sequence version replaced NM_054076.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF333980.1, AY077682.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AA223016.1         1-8
            9-1375              AY077682.1         1-1367
            1376-1465           AK153750.1         1107-1196
            1466-1611           AC157924.6         1008-1153
            1612-1720           FQ976559.1         1-109
            1721-1906           AW124672.1         1-186               c
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.02 cM"
     gene            1..1906
                     /gene="Optc"
                     /note="opticin"
                     /db_xref="GeneID:269120"
                     /db_xref="MGI:MGI:2151113"
     exon            1..243
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
     exon            244..523
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
     exon            524..656
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
     exon            657..815
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1018
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1114
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1892
                     /gene="Optc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgttcatt aagtgaagaa atgagattag ggacccctga ggaaaaagga agggaaacag
       61 cagggcactt gaaagaatgg ggaatctaat tagacacatg catccctggc caaccactcg
      121 tcctctccct ggccaataga tgagggggtg tctagctgtc ccctgctctg acaggcagtc
      181 atcatctcca ccagaagctc cctggaagct gctgagccag acggaaccaa aagcatctaa
      241 aaggatgtac ctcagaggga ttcagccatt cccactccta cccctccctc agaacctcat
      301 gaagttcctg gctttcctga gtctgttgag cttggtgctg cagaaggcag agacagcttc
      361 tctcctaggg gagagagaaa gagaagagca gagccctgag gaaggtgaca cttacgcgtc
      421 cctgtatgtg gggaaccata ccctgagcat agaggactac aacgaggtca ttgatctcag
      481 caactatgaa gaactggcag actatggaga ccagatccct gaggctaaaa taagcaatct
      541 gactcttcca acaagaacta gtcccactag cactgtggct cagaagacat tgtcaccaaa
      601 cctcacgatg gccgtaccta ccaccactgg cctactaaac tcccagagca gtcatggcct
      661 gcctacctgc ctggtctgtg tgtgccttgg ctcttctgtc tactgtgatg atgcagacct
      721 ggagaacatc cctcctcttc cccagatgac cacctaccta tatgctcgct tcaaccacat
      781 cagccacatc caggctggag acttcaaagg gctgacaaaa ctgagaagga tcgacctctc
      841 tggcaactcc atctcctcca tccacaacga tgccctccgc ctgctgcctg ccctgcagga
      901 tctgatcctt ccagagaacc agctggcagc cctgcctgtg ctgcccagtg gcattgagtt
      961 cctggacgtc cgcctgaatc ggctgcagag ctctgggata cagcctgagg cattcgtggc
     1021 gctgaagaag ctgcagtttc tctacctggc caacaacatg ctggattcca tccctgggcc
     1081 tttgcccctc agcctgcgct ctctgcacct gcagaataac atgatcgaga ccatggaaag
     1141 cgacaccttc tgtgacaccg gggaacacag acatgagcgc cggcagctgg aagacatccg
     1201 cctggacggg aaccccatca acctgagcct tttcccagag gcctattttt gcctgccacg
     1261 gctccctgtg ggccacttca cctagggcca ctgctcttct cttcccagat ggtgctaaga
     1321 ggctcactga gggagcacta tttacctgca cccagaaagt catctgtagc ccaagttcca
     1381 ggcagcctgt gagccacagc tgcaaaattg cacaacacgc acgcacacac acacagagac
     1441 agagagagag agagacagac agacagacag acacagacag accgacagac agacagacag
     1501 ggccttcagc cacttaattt gcatttcgcc ctcctctttc cctacacctt atggttcctg
     1561 actcagagaa cagcagcatc cacagcagag atcttttcca cactctccac acccatcttc
     1621 ccacacagaa ttccaggaga accatgaaag aaagggatgg aagaggaggc agcggaggga
     1681 cagaagctag gagggagggg gacgagggag aggaggaggg aggggaggag ggagggaagg
     1741 agggaggggg aggagaatca tcagtgtgct gaagcctggt ctttctgact ggtaggctga
     1801 caggactgat aattacattt tccagaattt tgcagttcag ttgttaaaca cagccattat
     1861 gaaaaattaa attatataac cttgcagtta aaaaaaaaaa aaaaaa
//
