LOCUS       NM_001302793            2230 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1, mRNA.
ACCESSION   NM_001302793 XM_006512438
VERSION     NM_001302793.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2230)
  AUTHORS   Yin,G., Duan,K., Dong,D., Du,F., Guo,C., Zhang,C., Liu,X., Sun,Y.,
            Huang,T., Cui,G. and Cheng,L.
  TITLE     Central control of opioid-induced mechanical hypersensitivity and
            tolerance in mice
  JOURNAL   Neuron 112 (23), 3897-3923 (2024)
   PUBMED   39406237
REFERENCE   2  (bases 1 to 2230)
  AUTHORS   Lazaridis,I., Crittenden,J.R., Ahn,G., Hirokane,K.,
            Wickersham,I.R., Yoshida,T., Mahar,A., Skara,V., Loftus,J.H.,
            Parvataneni,K., Meletis,K., Ting,J.T., Hueske,E., Matsushima,A. and
            Graybiel,A.M.
  TITLE     Striosomes control dopamine via dual pathways paralleling canonical
            basal ganglia circuits
  JOURNAL   Curr Biol 34 (22), 5263-5283 (2024)
   PUBMED   39447573
REFERENCE   3  (bases 1 to 2230)
  AUTHORS   Gora,C., Dudas,A., Vaugrente,O., Drobecq,L., Pecnard,E., Lefort,G.
            and Pellissier,L.P.
  TITLE     Deciphering autism heterogeneity: a molecular stratification
            approach in four mouse models
  JOURNAL   Transl Psychiatry 14 (1), 416 (2024)
   PUBMED   39366951
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2230)
  AUTHORS   Beane,C.R., Lewis,D.G., Bruns Vi,N., Pikus,K.L., Durfee,M.H.,
            Zegarelli,R.A., Perry,T.W., Sandoval,O. and Radke,A.K.
  TITLE     Cholinergic mu-opioid receptor deletion alters reward preference
            and aversion-resistance
  JOURNAL   Neuropharmacology 255, 110019 (2024)
   PUBMED   38810926
  REMARK    GeneRIF: Cholinergic mu-opioid receptor deletion alters reward
            preference and aversion-resistance.
REFERENCE   5  (bases 1 to 2230)
  AUTHORS   Furdui,A., da Silveira Scarpellini,C. and Montandon,G.
  TITLE     Anatomical distribution of micro-opioid receptors, neurokinin-1
            receptors, and vesicular glutamate transporter 2 in the mouse
            brainstem respiratory network
  JOURNAL   J Neurophysiol 132 (1), 108-129 (2024)
   PUBMED   38748514
  REMARK    GeneRIF: Anatomical distribution of micro-opioid receptors,
            neurokinin-1 receptors, and vesicular glutamate transporter 2 in
            the mouse brainstem respiratory network.
REFERENCE   6  (bases 1 to 2230)
  AUTHORS   Song,K.Y., Hwang,C.K., Kim,C.S., Choi,H.S., Law,P.Y., Wei,L.N. and
            Loh,H.H.
  TITLE     Translational repression of mouse mu opioid receptor expression via
            leaky scanning
  JOURNAL   Nucleic Acids Res 35 (5), 1501-1513 (2007)
   PUBMED   17284463
  REMARK    GeneRIF: Upstream open reading frames in mouse MOR mRNA act as
            negative regulators of translation through a ribosome leaky
            scanning mechanism.
REFERENCE   7  (bases 1 to 2230)
  AUTHORS   Rossi,G.C., Pan,Y.X., Brown,G.P. and Pasternak,G.W.
  TITLE     Antisense mapping the MOR-1 opioid receptor: evidence for
            alternative splicing and a novel morphine-6 beta-glucuronide
            receptor
  JOURNAL   FEBS Lett 369 (2-3), 192-196 (1995)
   PUBMED   7649256
REFERENCE   8  (bases 1 to 2230)
  AUTHORS   Liang,Y., Mestek,A., Yu,L. and Carr,L.G.
  TITLE     Cloning and characterization of the promoter region of the mouse mu
            opioid receptor gene
  JOURNAL   Brain Res 679 (1), 82-88 (1995)
   PUBMED   7648268
REFERENCE   9  (bases 1 to 2230)
  AUTHORS   Belknap,J.K., Mogil,J.S., Helms,M.L., Richards,S.P., O'Toole,L.A.,
            Bergeson,S.E. and Buck,K.J.
  TITLE     Localization to chromosome 10 of a locus influencing morphine
            analgesia in crosses derived from C57BL/6 and DBA/2 strains
  JOURNAL   Life Sci 57 (10), PL117-PL124 (1995)
   PUBMED   7643715
REFERENCE   10 (bases 1 to 2230)
  AUTHORS   Inturrisi,C.E., Umans,J.G., Wolff,D., Stern,A.S., Lewis,R.V.,
            Stein,S. and Udenfriend,S.
  TITLE     Analgesic activity of the naturally occurring heptapeptide
            [Met]enkephalin-Arg6-Phe7
  JOURNAL   Proc Natl Acad Sci U S A 77 (9), 5512-5514 (1980)
   PUBMED   6933569
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153981.5, AF062753.1 and
            AC164171.5.
            
            On Nov 14, 2014 this sequence version replaced XM_006512438.1.
            
            Summary: This gene encodes the mu opioid receptor which is where
            drugs such as morphine and other opioids have pharmacological
            effects. Several alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2014].
            
            Transcript Variant: This variant (MOR-1) lacks several 3' coding
            exons and contains an alternate 3' coding exon compared to variant
            MOR-1U. The resulting isoform (MOR-1) has a shorter and distinct
            C-terminus compared to isoform MOR-1U. This variant likely
            represents the major transcript of this gene.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB047546.1, U19380.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC153981.5         85330-85568
            240-1463            AF062753.1         1-1224
            1464-2230           AC164171.5         11304-12070
FEATURES             Location/Qualifiers
     source          1..2230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 1.85 cM"
     gene            1..2230
                     /gene="Oprm1"
                     /gene_synonym="M-OR-1; MOP-R; mor; MOR-1; MOR-1O; muOR;
                     Oprm"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:18390"
                     /db_xref="MGI:MGI:97441"
     exon            1..589
                     /gene="Oprm1"
                     /gene_synonym="M-OR-1; MOP-R; mor; MOR-1; MOR-1O; muOR;
                     Oprm"
                     /inference="alignment:Splign:2.1.0"
     exon            590..942
                     /gene="Oprm1"
                     /gene_synonym="M-OR-1; MOP-R; mor; MOR-1; MOR-1O; muOR;
                     Oprm"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1463
                     /gene="Oprm1"
                     /gene_synonym="M-OR-1; MOP-R; mor; MOR-1; MOR-1O; muOR;
                     Oprm"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..2230
                     /gene="Oprm1"
                     /gene_synonym="M-OR-1; MOP-R; mor; MOR-1; MOR-1O; muOR;
                     Oprm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctctggatc cctcacagcc catgctccct cccttccact cagagagtgg cgctttgggg
       61 atgctaagga tgcgcctccg tgtacttcta aggtgggagg gggctacaag cagaggagaa
      121 tatcggacgc tcagacgttc cattctgcct gccgctcttc tctggttcca ctagggcttg
      181 tccttgtaag aaactgacgg agcctagggc agctgtgaga ggaagaggct ggggcgcctg
      241 gaacccgaac actcttgagt gctctcagtt acagcctacc gagtccgcag caagcattca
      301 gaaccatgga cagcagcgcc ggcccaggga acatcagcga ctgctctgac cccttagctc
      361 ctgcaagttg ctccccagca cctggctcct ggctcaactt gtcccacgtt gatggcaacc
      421 agtccgaccc atgcggtcct aaccgcacgg ggcttggcgg gagccacagc ctgtgccctc
      481 agaccggcag cccttccatg gtcacagcca tcaccatcat ggccctctat tctatcgtgt
      541 gtgtagtggg cctctttgga aacttcctgg tcatgtatgt gattgtaaga tataccaaaa
      601 tgaagactgc caccaacatc tacattttca accttgctct ggcagatgcc ttagccacta
      661 gcacgctgcc ctttcagagt gttaactacc tgatgggaac gtggcccttt ggaaacatcc
      721 tctgcaagat cgtgatctca atagactact acaacatgtt caccagtatc ttcaccctct
      781 gcaccatgag tgtagaccgc tacattgccg tctgccaccc ggtcaaggcc ctggatttcc
      841 gtaccccccg aaatgccaaa attgtcaatg tctgcaactg gatcctctct tctgccattg
      901 gtctgcccgt aatgttcatg gcaaccacaa aatacaggca ggggtccata gattgcaccc
      961 tcacgttctc tcatcccaca tggtactggg agaacctgct caaaatctgt gtcttcatct
     1021 tcgccttcat catgccggtc ctcatcatca ctgtgtgtta tggactgatg atcttacgac
     1081 tcaagagtgt ccgcatgctg tcgggctcca aagaaaagga caggaacctg cgcaggatca
     1141 cccggatggt gctggtggtc gtggctgtat ttattgtctg ctggaccccc atccacatct
     1201 atgtcatcat caaagcactg atcacgattc cagaaaccac tttccagact gtttcctggc
     1261 acttctgcat tgccttgggt tacacaaaca gctgcctgaa cccagttctt tatgcgttcc
     1321 tggatgaaaa cttcaaacga tgttttagag agttctgcat cccaacttcc tccacaatcg
     1381 aacagcaaaa ctctgctcga atccgtcaaa acactaggga acacccctcc acggctaata
     1441 cagtggatcg aactaaccac cagctagaaa atctggaagc agaaactgct ccattgccct
     1501 aactgggtcc cacgccatcc agaccctcgc taaacttaga ggctgccatc tacttggaat
     1561 caggttgctg tcagggtttg tgggaggcgc tggtttcctg gaaaagcatc tgatcctgca
     1621 tcattcaaag tcattcctct ctggctattc acgctacacg tcagagacac tcagactgtg
     1681 tcaagcactc agaaggaaga gactgcaggc cactactgaa tccagctcat gtacagaaac
     1741 atccaatgga ccacaatact ctgtggtatg tgaattgtga tcaacataga aggtgaccct
     1801 tccctatgtg gaatttttaa tttcaaggaa atacttatga tctcatcaag ggaaaaatag
     1861 atgtcacttg ttaaattcac tgtagtgatg cataaaggaa aagctacctc tgacctctag
     1921 cccagtcacc ttctatggaa agttccatag ggaatatgtg agggaaaatg ttgcttccaa
     1981 attaaatttt cacctttatg ttatagtcta gttaagacat caggggcatc tctgtttctt
     2041 ggttttgtat tgtttgaaag aagacatctt cctccctagc tgcgtgttga aaatgaaagg
     2101 gatttaaaac acagtgtcaa ctgcagaata gttgattctc acactgaagg gggggggggc
     2161 taatcttacc aattctttcc atgtcctcca agtgttcaca aggtcaaact cagagtcacc
     2221 cagtaagctc
//
