LOCUS       NM_011011               4677 bp    mRNA    linear   ROD 20-FEB-2024
DEFINITION  Mus musculus opioid receptor, kappa 1 (Oprk1), transcript variant
            2, mRNA.
ACCESSION   NM_011011
VERSION     NM_011011.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4677)
  AUTHORS   Wang,Y.J., Zan,G.Y., Xu,C., Li,X.P., Shu,X., Yao,S.Y., Xu,X.S.,
            Qiu,X., Chen,Y., Jin,K., Zhou,Q.X., Ye,J.Y., Wang,Y., Xu,L.,
            Chen,Z. and Liu,J.G.
  TITLE     The claustrum-prelimbic cortex circuit through
            dynorphin/kappa-opioid receptor signaling underlies depression-like
            behaviors associated with social stress etiology
  JOURNAL   Nat Commun 14 (1), 7903 (2023)
   PUBMED   38036497
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4677)
  AUTHORS   Shi,Y., Tao,H., Li,X., Zhang,L., Li,C., Sun,W., Chu,M., Chen,K.,
            Zhu,P., Wang,Q., Gu,C., Wang,L., Yang,X. and Hao,Y.
  TITLE     kappa-Opioid receptor activation attenuates osteoarthritis
            synovitis by regulating macrophage polarization through the
            NF-kappaB pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (1), 82-95 (2023)
   PUBMED   38013468
  REMARK    GeneRIF: kappa-Opioid receptor activation attenuates osteoarthritis
            synovitis by regulating macrophage polarization through the
            NF-kappaB pathway.
REFERENCE   3  (bases 1 to 4677)
  AUTHORS   Zhang,J., Lu,Y., Jia,M., Bai,Y., Sun,L., Dong,Z., Tian,W., Yin,F.,
            Wei,S. and Wang,Y.
  TITLE     Kappa opioid receptor in nucleus accumbens regulates
            depressive-like behaviors following prolonged morphine withdrawal
            in mice
  JOURNAL   iScience 26 (9), 107536 (2023)
   PUBMED   37636073
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4677)
  AUTHORS   Cone,A.L., Wu,K.K., Kravitz,A.V. and Norris,A.J.
  TITLE     Kappa opioid receptor activation increases thermogenic energy
            expenditure which drives increased feeding
  JOURNAL   iScience 26 (7), 107241 (2023)
   PUBMED   37485355
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4677)
  AUTHORS   Loughran,G., Chou,M.Y., Ivanov,I.P., Jungreis,I., Kellis,M.,
            Kiran,A.M., Baranov,P.V. and Atkins,J.F.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (bases 1 to 4677)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (bases 1 to 4677)
  AUTHORS   Belkowski,S.M., Zhu,J., Liu-Chen,L.Y., Eisenstein,T.K., Adler,M.W.
            and Rogers,T.J.
  TITLE     Sequence of kappa-opioid receptor cDNA in the R1.1 thymoma cell
            line
  JOURNAL   J Neuroimmunol 62 (1), 113-117 (1995)
   PUBMED   7499487
REFERENCE   8  (bases 1 to 4677)
  AUTHORS   Gaveriaux,C., Peluso,J., Simonin,F., Laforet,J. and Kieffer,B.
  TITLE     Identification of kappa- and delta-opioid receptor transcripts in
            immune cells
  JOURNAL   FEBS Lett 369 (2-3), 272-276 (1995)
   PUBMED   7649271
REFERENCE   9  (bases 1 to 4677)
  AUTHORS   Liu,H.C., Lu,S., Augustin,L.B., Felsheim,R.F., Chen,H.C., Loh,H.H.
            and Wei,L.N.
  TITLE     Cloning and promoter mapping of mouse kappa opioid receptor gene
  JOURNAL   Biochem Biophys Res Commun 209 (2), 639-647 (1995)
   PUBMED   7733933
REFERENCE   10 (bases 1 to 4677)
  AUTHORS   Giros,B., Pohl,M., Rochelle,J.M. and Seldin,M.F.
  TITLE     Chromosomal localization of opioid peptide and receptor genes in
            the mouse
  JOURNAL   Life Sci 56 (18), PL369-PL375 (1995)
   PUBMED   7752808
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L11065.1, AK136866.1,
            AC124029.15 and BB079154.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_011011.3.
            
            On Feb 26, 2011 this sequence version replaced NM_011011.1.
            
            Summary: This gene encodes an opioid receptor, which is a member of
            the 7 transmembrane-spanning G protein-coupled receptor family. It
            functions as a receptor for endogenous ligands, as well as a
            receptor for various synthetic opioids. Ligand binding results in
            inhibition of adenylate cyclase activity and neurotransmitter
            release. This opioid receptor plays a role in the perception of
            pain and mediating the hypolocomotor, analgesic and aversive
            actions of synthetic opioids. Variations in this gene have also
            been associated with alcohol dependence and opiate addiction.
            Alternatively spliced transcript variants have been found for this
            gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Transcript Variant: This variant (2) uses an alternate acceptor
            splice site in the 5' non-coding region and has a shorter 5' UTR
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L11065.1, SRR9219379.28377.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1410              L11065.1           1-1410
            1411-2572           AK136866.1         335-1496
            2573-2573           AC124029.15        191002-191002
            2574-4675           AK136866.1         1498-3599
            4676-4677           BB079154.1         299-300
FEATURES             Location/Qualifiers
     source          1..4677
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 1.89 cM"
     gene            1..4677
                     /gene="Oprk1"
                     /gene_synonym="K-OR-1; KOR; KOR-1; MSL-1; Oprk2; R21"
                     /note="opioid receptor, kappa 1"
                     /db_xref="GeneID:18387"
                     /db_xref="MGI:MGI:97439"
     exon            1..171
                     /gene="Oprk1"
                     /gene_synonym="K-OR-1; KOR; KOR-1; MSL-1; Oprk2; R21"
                     /inference="alignment:Splign:2.1.0"
     exon            172..442
                     /gene="Oprk1"
                     /gene_synonym="K-OR-1; KOR; KOR-1; MSL-1; Oprk2; R21"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1328
                     /gene="Oprk1"
                     /gene_synonym="K-OR-1; KOR; KOR-1; MSL-1; Oprk2; R21"
                     /note="isoform 1 is encoded by transcript variant 2;
                     kappa-type opioid receptor; opioid receptor, kappa 2"
                     /codon_start=1
                     /product="kappa-type opioid receptor isoform 1"
                     /protein_id="NP_035141.1"
                     /db_xref="CCDS:CCDS14809.1"
                     /db_xref="GeneID:18387"
                     /db_xref="MGI:MGI:97439"
                     /translation="MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGS
                     EDQQLESAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLA
                     LADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAV
                     CHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDE
                     YSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLV
                     LVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVLYAFLD
                     ENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV"
     exon            443..795
                     /gene="Oprk1"
                     /gene_synonym="K-OR-1; KOR; KOR-1; MSL-1; Oprk2; R21"
                     /inference="alignment:Splign:2.1.0"
     exon            796..4677
                     /gene="Oprk1"
                     /gene_synonym="K-OR-1; KOR; KOR-1; MSL-1; Oprk2; R21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcaccttg ctgatcccaa acaggcagag cttcttccag tcttggaagg cacaaattga
       61 gcatcaggaa cgtggaccca tcagggctga acagctactc aggatctaaa gtggtgactt
      121 ggaaagctga cggtgacttg ggaagggagg tcgccaatca gcgatctgga gctgcagcgc
      181 tcaccatgga gtcccccatt cagatcttcc gaggagatcc aggccctacc tgctctccca
      241 gtgcttgcct tctccccaac agcagctctt ggttccccaa ctgggcagaa tccgacagta
      301 atggcagtgt gggctcagag gatcagcagc tggagtccgc gcacatctct ccggccatcc
      361 ctgttatcat caccgctgtc tactctgtgg tatttgtggt gggcttagtg ggcaattctc
      421 tggtcatgtt tgtcatcatc cgatacacga agatgaagac cgcaaccaac atctacatat
      481 ttaacctggc tttggcagat gctttggtta ctaccactat gccctttcag agtgctgtct
      541 acttgatgaa ttcttggcct tttggagatg tgctatgcaa gattgtcatt tccattgact
      601 actacaacat gtttaccagc atattcacct tgaccatgat gagtgtggac cgctacattg
      661 ctgtgtgcca ccctgtgaaa gctttggact tccgaacacc tttgaaagca aagatcatca
      721 acatctgcat ttggctcctg gcatcatctg ttggtatatc agcgatagtc cttggaggca
      781 ccaaagtcag ggaagatgtg gatgtcattg aatgctcctt gcagtttcct gatgatgaat
      841 attcctggtg ggatctcttc atgaagatct gtgtcttcgt ctttgccttt gtgatcccag
      901 tcctcatcat cattgtctgc tacaccctga tgatcctgcg cctgaagagt gtccggctcc
      961 tgtctggctc ccgagagaag gaccgaaatc tccgccgcat caccaagctg gtgctggtag
     1021 tagttgcagt cttcatcatc tgttggaccc ccattcacat ctttatcctg gtggaggctc
     1081 tgggaagcac ctcccacagc acagctgccc tctccagcta ttatttctgt attgccttgg
     1141 gttataccaa cagcagcctg aatcctgttc tctatgcctt tctggatgaa aacttcaagc
     1201 ggtgttttag ggacttctgc ttccctatta agatgcgaat ggagcgccag agcaccaata
     1261 gagttagaaa cacagttcag gatcctgctt ccatgagaga tgtgggaggg atgaataagc
     1321 cagtatgact agtcgtggaa atgtcttctt attgttctcc aggtagagaa gagttcaatg
     1381 atcttggttt aacccagatt acaactgcag tctgaagtgg aaaggtgagg tattcagtaa
     1441 cttagacatg tcatactctg aaatattaag gtgcagggca cattagtgat ctagctgagt
     1501 aggagcagca agtctgaaga acagagcaca gcagatcctg gcaacaatac acctctttcc
     1561 taggacagaa aagaagccaa gccgatttca atcccttgag aaacaaagac aacactcttt
     1621 cttttggttt ccttgatttt gtggatgtcc atctgtgtgg cctttctatg caacataatt
     1681 ccaaagctct agagaagaaa ataaaagaaa aaaaatccat tggatgcaaa acttactgga
     1741 cacccaacct gcctgttgat actggcaaaa ccaacttcag ttacaatgag gccatatcaa
     1801 gggtcatatc cagctcactg tcttctggtg atcatgtctc atgtgtgatg ataatagaat
     1861 atcttaggaa gaacttggat tcagaccctg acactggtgg agagcaccat attgacattt
     1921 gtgaacctat ttagagttgt tgatgttgtc ttctcacagt gtctaatgcc ttgaaaacta
     1981 cagttgctcc ttaagatctc tggtttttaa catgctattc aggtagatag tcttctgagg
     2041 aaacatgaac tgatataaaa aagtgtgagg cttaaatacc agcaaagtgt gtgtaatttc
     2101 atctgtaaat agtagtctgt atgtaaataa gtaccaggtt ttcttgtcca gcctgatcat
     2161 ttctcaagga tgcagtagac atagccccca aggcatggag aattgaggat tagatatgtt
     2221 gttgcaatat aatctactct ctggaatttg gtcttggtat gatttccact ggattcctca
     2281 aacaccattt actctacctt ggtgttaact tatccctaaa ctttgaattc actctaaaat
     2341 gttagctttg atcaaatata ctttgtggta gcatctgttt gtaaacacac acctattgcc
     2401 agattctcta ctcttgtaga ggaagttgat ttgatcatgt acatctttta atattatgtt
     2461 ctggctttcc acagaaagta gaattgttaa aaaatgtgtg ctgaaaaagc aaatggggct
     2521 tgagatggct gagcacaatt tgcatggtat tgattaaggg ggtacctgtg gagggtacta
     2581 tctgagaagc ccatttagga taattttgct aagtcttcca aatgacacat aaattcccca
     2641 ttctttactt taaaacttat agttcagaga taagaaagtt tttttttcaa ttttccttga
     2701 aagaaaaaga aaaggataat ttaaaaataa cacccctttc taagcttgta cctggttaga
     2761 gcagcaccct tcagagtcta aaagagcatc agatgtgtga acctcgatac tgtaggcaca
     2821 gttccatctg taagctctca tcaccagctg tctcacaggt gtcgctcctt cactttctgg
     2881 agacagaggg cctgcataaa gatatgacac actctacaaa gtcactgccc ttatgtttaa
     2941 ctccctatga cacctttatg cttatgaatt tgatggtgag taatgacatt gtagagatac
     3001 ttcttagtga aaattaagtg ctcttttgag tatatcttga atttcactga ataccttgat
     3061 gctctggaat tcttttgtaa tgatatagct agaatttatt aagagaaagg tattaatata
     3121 gattttagcg tgaagtctaa cacaggaaca gagaaatgta aaagagggac aggcacatgc
     3181 cctagagtag acacaatctt cttttaaaac ttattattgt tattaactat ttttcacgtg
     3241 aaggcatgca ttatgagatg catattgatg tcagaggata gctttcacag ttacttttct
     3301 tctttacatg ggttctgggg atggtactca cattgccagt cttgcactct catgtggcat
     3361 gtgcctttac tcactgagca atcttaccag ctcagaatac agctctctta taagagaaag
     3421 tcaccaccct tacattctta aaactagata tatagataag aatgacttaa acattgagaa
     3481 acattaaccc aatagtttaa aactttagct attatgctga agagatattt atgtggacca
     3541 aacaattcca gaataaatcc ttcggaaaag cttctataag acagtaagat gcaggagatg
     3601 ctcataaatc cacccccccc aagcccacaa ggtagttatc acgtaacctc aggatggagt
     3661 tataatagtg acttctttaa cattccatat gccctcctaa tctctctgtt tcctgcattt
     3721 cttgataact aagttggaat cccatggaaa gagagtgagt gtctcccagg gagggagagt
     3781 gacatggagg ggggagtgag tatctttact gctcttgaga tctattttga gtttccctgt
     3841 gatcctgaga ttgaaactga agaatagata acagctattt tgggacacta atttaaagaa
     3901 taacaaacag acttatatac tgtaaggata gtatcattta catatatgtg ctttattgtt
     3961 gaactatata catttgcatg tatatgtaaa agagaacagg tgcatacatg tgtgcacgtg
     4021 tacatgatac taggaagcag tggttatact actatgtttg cgcaatgcaa ccagtgcttt
     4081 tgtctaattc tgcaaccctc aagtggctcc ccatgcttga ggttcccaga agcttgtccc
     4141 atcaaacaaa gaagttatgg cttgctatgt ctgagacttg agatgaactc tacctagagt
     4201 ctatgttccc attctactgg cgacttttgg ggaaaaagta acttgtttgg agataaaaca
     4261 agaatttttg agaaaagtgt ttaattttgt gattgatatg ttagatcgtt gttaaactta
     4321 tatctatcaa tttatatata tatattccat ctaatactgg gtcataagat gaaagcaatc
     4381 aaagaataaa ggctttaagt gaaagaattt taaggaaaac ctatgacaaa gttgtgcctc
     4441 tattgtgcaa attttatttt tcaagaaata attgttgaat aattaatgct gggttggcat
     4501 taatatgaaa gtcccataag gctaaaaatt agctcagacc atgacagttt tcaatctgaa
     4561 agaaagttgt atttcttacc atgtcaatat tggttatatc ttagactatt agagaatgac
     4621 tatacattgt atatatgatt gtgtgccttg aaataaagcc aaaattgtac ctgctaa
//
