LOCUS       NM_013622               4021 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus opioid receptor, delta 1 (Oprd1), mRNA.
ACCESSION   NM_013622 XM_973497
VERSION     NM_013622.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4021)
  AUTHORS   Miao,H., Zhao,Q., Dai,Y. and Qiu,J.
  TITLE     Neuroprotective effects of miRNA-326 knockout in neonatal
            hypoxic-ischemic brain damage mice via the delta-opioid receptor
  JOURNAL   Biochem Biophys Res Commun 726, 150259 (2024)
   PUBMED   38909535
  REMARK    GeneRIF: Neuroprotective effects of miRNA-326 knockout in neonatal
            hypoxic-ischemic brain damage mice via the delta-opioid receptor.
REFERENCE   2  (bases 1 to 4021)
  AUTHORS   Singleton,S., Sneddon,C., Bakina,A., Lambert,J.J. and Hales,T.G.
  TITLE     Early-life adversity increases morphine tolerance and persistent
            inflammatory hypersensitivity through upregulation of delta opioid
            receptors in mice
  JOURNAL   Pain 164 (10), 2253-2264 (2023)
   PUBMED   37171192
  REMARK    GeneRIF: Early-life adversity increases morphine tolerance and
            persistent inflammatory hypersensitivity through upregulation of
            delta opioid receptors in mice.
REFERENCE   3  (bases 1 to 4021)
  AUTHORS   Zhang,J., Junigan,J.M., Trinh,R., Kavelaars,A., Heijnen,C.J. and
            Grace,P.M.
  TITLE     HDAC6 Inhibition Reverses Cisplatin-Induced Mechanical
            Hypersensitivity via Tonic Delta Opioid Receptor Signaling
  JOURNAL   J Neurosci 42 (42), 7862-7874 (2022)
   PUBMED   36096670
REFERENCE   4  (bases 1 to 4021)
  AUTHORS   Jin,D., Chen,H., Huang,Y., Chen,S.R. and Pan,H.L.
  TITLE     delta-Opioid receptors in primary sensory neurons tonically
            restrain nociceptive input in chronic pain but do not enhance
            morphine analgesic tolerance
  JOURNAL   Neuropharmacology 217, 109202 (2022)
   PUBMED   35917874
REFERENCE   5  (bases 1 to 4021)
  AUTHORS   Quirion,B., Beaulieu,C., Cote,L., Parent,J.L. and Gendron,L.
  TITLE     Distribution of delta and mu opioid receptor mRNA in rodent dorsal
            root ganglia neurons
  JOURNAL   Eur J Neurosci 56 (3), 4031-4044 (2022)
   PUBMED   35674691
  REMARK    GeneRIF: Distribution of delta and mu opioid receptor mRNA in
            rodent dorsal root ganglia neurons.
REFERENCE   6  (bases 1 to 4021)
  AUTHORS   Standifer,K.M., Jenab,S., Su,W., Chien,C.C., Pan,Y.X.,
            Inturrisi,C.E. and Pasternak,G.W.
  TITLE     Antisense oligodeoxynucleotides to the cloned delta receptor DOR-1:
            uptake, stability, and regulation of gene expression
  JOURNAL   J Neurochem 65 (5), 1981-1987 (1995)
   PUBMED   7595481
REFERENCE   7  (bases 1 to 4021)
  AUTHORS   Gaveriaux,C., Peluso,J., Simonin,F., Laforet,J. and Kieffer,B.
  TITLE     Identification of kappa- and delta-opioid receptor transcripts in
            immune cells
  JOURNAL   FEBS Lett 369 (2-3), 272-276 (1995)
   PUBMED   7649271
REFERENCE   8  (bases 1 to 4021)
  AUTHORS   Danciger,M., Brady,J., Adamson,M.C., Farber,D.B., Piatigorsky,J.
            and Kozak,C.A.
  TITLE     Chromosomal localization of the genes for five zinc finger proteins
            expressed in mouse lens
  JOURNAL   Genomics 28 (1), 39-43 (1995)
   PUBMED   7590745
REFERENCE   9  (bases 1 to 4021)
  AUTHORS   Evans,C.J., Keith,D.E. Jr., Morrison,H., Magendzo,K. and
            Edwards,R.H.
  TITLE     Cloning of a delta opioid receptor by functional expression
  JOURNAL   Science 258 (5090), 1952-1955 (1992)
   PUBMED   1335167
REFERENCE   10 (bases 1 to 4021)
  AUTHORS   Kieffer,B.L., Befort,K., Gaveriaux-Ruff,C. and Hirth,C.G.
  TITLE     The delta-opioid receptor: isolation of a cDNA by expression
            cloning and pharmacological characterization
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 12048-12052 (1992)
   PUBMED   1334555
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1193. doi:
            10.1073/pnas.91.3.1193-c.. PMID: 8302853]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043873.1 and L06322.1.
            
            On Jan 26, 2007 this sequence version replaced NM_013622.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043873.1, BC137969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               AK043873.1         2-462
            462-2163            L06322.1           419-2120
            2164-4021           AK043873.1         2165-4022
FEATURES             Location/Qualifiers
     source          1..4021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 64.78 cM"
     gene            1..4021
                     /gene="Oprd1"
                     /gene_synonym="DOR; DOR-1; mDOR; Nbor"
                     /note="opioid receptor, delta 1"
                     /db_xref="GeneID:18386"
                     /db_xref="MGI:MGI:97438"
     exon            1..328
                     /gene="Oprd1"
                     /gene_synonym="DOR; DOR-1; mDOR; Nbor"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1220
                     /gene="Oprd1"
                     /gene_synonym="DOR; DOR-1; mDOR; Nbor"
                     /note="delta 1 opioid receptor; K56; MSL-2; D-OR-1"
                     /codon_start=1
                     /product="delta-type opioid receptor"
                     /protein_id="NP_038650.3"
                     /db_xref="CCDS:CCDS18718.1"
                     /db_xref="GeneID:18386"
                     /db_xref="MGI:MGI:97438"
                     /translation="MELVPSARAELQSSPLVNLSDAFPSAFPSAGANASGSPGARSAS
                     SLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTL
                     PFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR
                     TPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCMLQFPSPSWYWDTVTKICVF
                     LFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAP
                     IHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCR
                     TPCGRQEPGSLRRPRQATTRERVTACTPSDGPGGGAAA"
     exon            329..678
                     /gene="Oprd1"
                     /gene_synonym="DOR; DOR-1; mDOR; Nbor"
                     /inference="alignment:Splign:2.1.0"
     exon            679..4021
                     /gene="Oprd1"
                     /gene_synonym="DOR; DOR-1; mDOR; Nbor"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1926..1931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oprd1"
                     /gene_synonym="DOR; DOR-1; mDOR; Nbor"
                     /note="hexamer: AATAAA"
     polyA_site      1954
                     /gene="Oprd1"
                     /gene_synonym="DOR; DOR-1; mDOR; Nbor"
                     /note="major polyA site"
     regulatory      2445..2450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oprd1"
                     /gene_synonym="DOR; DOR-1; mDOR; Nbor"
                     /note="hexamer: AATAAA"
     polyA_site      2466
                     /gene="Oprd1"
                     /gene_synonym="DOR; DOR-1; mDOR; Nbor"
                     /note="major polyA site"
ORIGIN      
        1 gctgcagcct gcggcgtcgg ggccgtggcc tccgttttcc gcgcgccact cgctgggtcc
       61 ctgcgcccag ggcgcacggt ggagacggac acggcggcgc catggagctg gtgccctctg
      121 cccgtgcgga gctgcagtcc tcgcccctcg tcaacctctc ggacgccttt cccagcgcct
      181 tccccagcgc gggcgccaat gcgtcggggt cgccgggagc ccgtagtgcc tcgtccctcg
      241 ccctagccat cgccatcacc gcgctctact cggctgtgtg cgcagtgggg cttctgggca
      301 acgtgctcgt catgtttggc atcgtccggt acaccaaatt gaagaccgcc accaacatct
      361 acatcttcaa tctggctttg gctgatgcgc tggccaccag cacgctgccc ttccagagcg
      421 ccaagtactt gatggaaacg tggccgtttg gcgagctgct gtgcaaggct gtgctctcca
      481 ttgactacta caacatgttc actagcatct tcaccctcac catgatgagc gtggaccgct
      541 acattgctgt ctgccatcct gtcaaagccc tggacttccg gacaccagcc aaggccaagc
      601 tgatcaatat atgcatctgg gtcttggctt caggtgtcgg ggtccccatc atggtcatgg
      661 cagtgaccca accccgggat ggtgcagtgg tatgcatgct ccagttcccc agtcccagct
      721 ggtactggga cactgtgacc aagatctgcg tgttcctctt tgccttcgtg gtgccgatcc
      781 tcatcatcac ggtgtgctat ggcctcatgc tactgcgcct gcgcagcgtg cgtctgctgt
      841 ccggttccaa ggagaaggac cgcagcctgc ggcgcatcac gcgcatggtg ctggtggtgg
      901 tgggcgcctt cgtggtgtgc tgggcgccca tccacatctt cgtcatcgtc tggacgctgg
      961 tggacatcaa tcggcgcgac ccacttgtgg tggccgcact gcacctgtgc attgcgctgg
     1021 gctacgccaa cagcagcctc aacccggttc tctacgcctt cctggacgag aacttcaagc
     1081 gctgcttccg ccagctctgt cgcacgccct gcggccgcca agaacccggc agtctccgtc
     1141 gtccccgcca ggccaccacg cgtgagcgtg tcactgcctg caccccctcc gacggcccgg
     1201 gcggtggcgc tgccgcctga cctacccgac cttcccctta aacgcccctc ccaagtgaag
     1261 tgatccagag gccacaccga gctccctggg aggctgtggc caccaccagg acagctagaa
     1321 ttgggcctgc acagagggga ggcctcctgt ggggacgggg cctgagggat caaaggctcc
     1381 aggttggaac ggtgggggtg aggaagcaga gctggtgatt cctaaactgt atccattagt
     1441 aaggcctctc caatgggaca gagcctccgc cttgagataa catcgggttc tggccttttt
     1501 gaacacccag ctccagtcca agacccaagg attccagctc caggaaccag gaggggcagt
     1561 gatggggtcg atgatttggt ttggctgaga gtcccagcat ttgtgttatg gggaggatct
     1621 ctcatcttag agaagataag gggacagggc attcaggcaa ggcagcttgg ggtttggtca
     1681 ggagataagc gcccccttcc cttgggggga ggataagtgg gggatggtca acgttggaga
     1741 agagtcaaag ttctcaccac ctttctaact actcagctaa actcgttgag gctagggcca
     1801 acgtgacttc tctgtagaga ggatacaagc cgggcctgat ggggcaggcc tgtgtaatcc
     1861 cagtcatagt ggaggctgag gctggaaaat taaggaccaa cagcctgggc aatttagtgt
     1921 ctcaaaataa aatgtaaaga gggctgggaa tgtagctcag tggtagggtg tttgtgtgag
     1981 gctctgggat caataagaca aaacaaccaa ccaaccaaaa accttccaaa caacaaaacc
     2041 aaccctcaaa ccaaaaaact atgtgggtgt ctctgagtct ggtttgaaga gaacccgcag
     2101 ccctgtatcc ctgtggggct gtggacagtg ggcagaagca gaggctccct ggatcctgaa
     2161 caagggcccc aaaagcaagt tctaaaggga cccctgaaac cgagtaagcc tttgtgtcaa
     2221 gaagtgggag tagaaccaga aaggtggctg agtgattaag ggcacgtgac tctcttgcag
     2281 aggacatagg ttcgattccc agcacccaca tagtggctca cagccatctg taaccccagt
     2341 cgcagtcaat ctaatgcttt ccaacaactg tgggcaccag acatgaacat ggtacacata
     2401 catacatata tacatacata caggtgaaac actcagacac ataaaataaa tcttctttta
     2461 aaagtggtgg cacatgcctt taatcccagc acctgggagg cagaggccag cctggtctac
     2521 atagtgagtt ccaggatgct cagggctaca tggtgagacc ctgtctcaat aaaagtgtgt
     2581 gttgtaggga gagtaaatcg tgaggcaggg ggctgaggcc tctgcttaca ggttaaatcc
     2641 tgaagcctga acatggatgc ttttggggtt cctggggtac tagtgtatgt ggctcagtac
     2701 cagagcaccg agaccctttg tttgagcccc cccgtatgtg gtaacatgaa taaggattct
     2761 caccaaatac ttggaccctt gataagaacc cggaagaaga ctcttgcccc ttctcccagc
     2821 gtctggctgt ccatcagatg cctggtgtcc atgactccca gggactggaa ctgccccagt
     2881 cggactctgc tttgaaggga ttgagggaag aagggctttt atagcagtga tgtcggtgtg
     2941 gccctttgct ctctcccatt tctcctgagt ccctcatttg ctctcgctgc agagggtggc
     3001 ccagaaactg atccaggctc tcctggatct cagctcccct ggatgtcatt gtttgccctg
     3061 tccccgttcc tcctccactg cctgagggag caacctgccc ctgactccct attgaagcag
     3121 tctgctgaca tccttgtaaa aacaaattta attctcttcc ttttttggga cagatgggaa
     3181 gaaattgacg cctttgtctc aaaccaaaaa agaaagaagc agagagacaa tatacttctt
     3241 ttctttttga cagccatttc tttggaacaa aagctgcagg ctgtcactcc agcagggacc
     3301 taactgcctt ccgggaggcg ggagctagac tagtgagtag aaaaggttcc tttgatggac
     3361 aaagcatagt ccttttctcc ctgtggggtc cctaaaagct taggtccttg ggaatctctg
     3421 tagcctggga tacagagtga ttgtcaccgc tgacatcaga cctgcccagc cactgtagcc
     3481 tggaacttaa cctcttagct gacctttacc acctaaatgg tcactatgac catggagatt
     3541 tctgtagagt gtggtggtgg tggtgaggtg gtcaccaggc caaagacacc cctagacact
     3601 cactggaaag tcctgctact ctgctaggga ggtagcagac agcagactcc tgaagcaggt
     3661 gtcacgggac ttagtgctgt gtgtccttgc aaggactgtg gccttgtgcc ccacccaggg
     3721 cagagttgtg ttagagctga cccagccggt cctttcctgt agggatgaga actgacttgg
     3781 cctcatgagt ataggtattg caggtgtgat ttcaaaattg tttaaacgtt gattgatttt
     3841 gtgttggatg gggcatgctc ccgccactgt gcacatgagg aggtcagggg agagttttaa
     3901 tagaggtgct tctcttcctc tgcctcctga gttcataggg gttgaactcc agtcagcagg
     3961 tttgacagaa aggaccttta tccaccaacc ccaattaaaa gaaattattt atttgtttgc
     4021 t
//
