LOCUS       NP_038650                372 aa            linear   ROD 09-FEB-2025
DEFINITION  delta-type opioid receptor [Mus musculus].
ACCESSION   NP_038650 XP_978591
VERSION     NP_038650.3
DBSOURCE    REFSEQ: accession NM_013622.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 372)
  AUTHORS   Miao,H., Zhao,Q., Dai,Y. and Qiu,J.
  TITLE     Neuroprotective effects of miRNA-326 knockout in neonatal
            hypoxic-ischemic brain damage mice via the delta-opioid receptor
  JOURNAL   Biochem Biophys Res Commun 726, 150259 (2024)
   PUBMED   38909535
  REMARK    GeneRIF: Neuroprotective effects of miRNA-326 knockout in neonatal
            hypoxic-ischemic brain damage mice via the delta-opioid receptor.
REFERENCE   2  (residues 1 to 372)
  AUTHORS   Singleton,S., Sneddon,C., Bakina,A., Lambert,J.J. and Hales,T.G.
  TITLE     Early-life adversity increases morphine tolerance and persistent
            inflammatory hypersensitivity through upregulation of delta opioid
            receptors in mice
  JOURNAL   Pain 164 (10), 2253-2264 (2023)
   PUBMED   37171192
  REMARK    GeneRIF: Early-life adversity increases morphine tolerance and
            persistent inflammatory hypersensitivity through upregulation of
            delta opioid receptors in mice.
REFERENCE   3  (residues 1 to 372)
  AUTHORS   Zhang,J., Junigan,J.M., Trinh,R., Kavelaars,A., Heijnen,C.J. and
            Grace,P.M.
  TITLE     HDAC6 Inhibition Reverses Cisplatin-Induced Mechanical
            Hypersensitivity via Tonic Delta Opioid Receptor Signaling
  JOURNAL   J Neurosci 42 (42), 7862-7874 (2022)
   PUBMED   36096670
REFERENCE   4  (residues 1 to 372)
  AUTHORS   Jin,D., Chen,H., Huang,Y., Chen,S.R. and Pan,H.L.
  TITLE     delta-Opioid receptors in primary sensory neurons tonically
            restrain nociceptive input in chronic pain but do not enhance
            morphine analgesic tolerance
  JOURNAL   Neuropharmacology 217, 109202 (2022)
   PUBMED   35917874
REFERENCE   5  (residues 1 to 372)
  AUTHORS   Quirion,B., Beaulieu,C., Cote,L., Parent,J.L. and Gendron,L.
  TITLE     Distribution of delta and mu opioid receptor mRNA in rodent dorsal
            root ganglia neurons
  JOURNAL   Eur J Neurosci 56 (3), 4031-4044 (2022)
   PUBMED   35674691
  REMARK    GeneRIF: Distribution of delta and mu opioid receptor mRNA in
            rodent dorsal root ganglia neurons.
REFERENCE   6  (residues 1 to 372)
  AUTHORS   Standifer,K.M., Jenab,S., Su,W., Chien,C.C., Pan,Y.X.,
            Inturrisi,C.E. and Pasternak,G.W.
  TITLE     Antisense oligodeoxynucleotides to the cloned delta receptor DOR-1:
            uptake, stability, and regulation of gene expression
  JOURNAL   J Neurochem 65 (5), 1981-1987 (1995)
   PUBMED   7595481
REFERENCE   7  (residues 1 to 372)
  AUTHORS   Gaveriaux,C., Peluso,J., Simonin,F., Laforet,J. and Kieffer,B.
  TITLE     Identification of kappa- and delta-opioid receptor transcripts in
            immune cells
  JOURNAL   FEBS Lett 369 (2-3), 272-276 (1995)
   PUBMED   7649271
REFERENCE   8  (residues 1 to 372)
  AUTHORS   Danciger,M., Brady,J., Adamson,M.C., Farber,D.B., Piatigorsky,J.
            and Kozak,C.A.
  TITLE     Chromosomal localization of the genes for five zinc finger proteins
            expressed in mouse lens
  JOURNAL   Genomics 28 (1), 39-43 (1995)
   PUBMED   7590745
REFERENCE   9  (residues 1 to 372)
  AUTHORS   Evans,C.J., Keith,D.E. Jr., Morrison,H., Magendzo,K. and
            Edwards,R.H.
  TITLE     Cloning of a delta opioid receptor by functional expression
  JOURNAL   Science 258 (5090), 1952-1955 (1992)
   PUBMED   1335167
REFERENCE   10 (residues 1 to 372)
  AUTHORS   Kieffer,B.L., Befort,K., Gaveriaux-Ruff,C. and Hirth,C.G.
  TITLE     The delta-opioid receptor: isolation of a cDNA by expression
            cloning and pharmacological characterization
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 12048-12052 (1992)
   PUBMED   1334555
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1193. doi:
            10.1073/pnas.91.3.1193-c.. PMID: 8302853]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043873.1 and L06322.1.
            
            On Jan 26, 2007 this sequence version replaced NP_038650.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043873.1, BC137969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 64.78 cM"
     Protein         1..372
                     /product="delta-type opioid receptor"
                     /note="delta 1 opioid receptor; K56; MSL-2; D-OR-1"
                     /calculated_mol_wt=40430
     Site            18
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P32300.1)"
     Site            33
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P32300.1)"
     Site            48..75
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32300.1)"
     Region          50..329
                     /region_name="7tmA_Delta_opioid_R"
                     /note="opioid receptor subtype delta, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15089"
                     /db_xref="CDD:320217"
     Region          51..77
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320217"
     Region          84..110
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320217"
     Site            86..110
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32300.1)"
     Site            order(105,108..109,121..126,128..129,132,177,179..183,
                     199..200,210,213..215,217..219,221..222,274,277..278,
                     280..281,284,296..297,299..301,304,307..308)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320217"
     Region          121..151
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320217"
     Site            123..144
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32300.1)"
     Region          163..185
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320217"
     Site            164..186
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32300.1)"
     Site            207..238
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32300.1)"
     Region          209..239
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320217"
     Region          258..284
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320217"
     Site            262..284
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32300.1)"
     Region          297..322
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320217"
     Site            300..321
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32300.1)"
     Region          340..372
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P32300.1)"
     CDS             1..372
                     /gene="Oprd1"
                     /gene_synonym="DOR; DOR-1; mDOR; Nbor"
                     /coded_by="NM_013622.3:102..1220"
                     /db_xref="CCDS:CCDS18718.1"
                     /db_xref="GeneID:18386"
                     /db_xref="MGI:MGI:97438"
ORIGIN      
        1 melvpsarae lqssplvnls dafpsafpsa ganasgspga rsasslalai aitalysavc
       61 avgllgnvlv mfgivrytkl ktatniyifn laladalats tlpfqsakyl metwpfgell
      121 ckavlsidyy nmftsiftlt mmsvdryiav chpvkaldfr tpakaklini ciwvlasgvg
      181 vpimvmavtq prdgavvcml qfpspswywd tvtkicvflf afvvpiliit vcyglmllrl
      241 rsvrllsgsk ekdrslrrit rmvlvvvgaf vvcwapihif vivwtlvdin rrdplvvaal
      301 hlcialgyan sslnpvlyaf ldenfkrcfr qlcrtpcgrq epgslrrprq attrervtac
      361 tpsdgpggga aa
//
