LOCUS       NM_181753               1824 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus opsin 5 (Opn5), mRNA.
ACCESSION   NM_181753
VERSION     NM_181753.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1824)
  AUTHORS   D'Souza,S.P., Upton,B.A., Eldred,K.C., Glass,I., Nayak,G.,
            Grover,K., Ahmed,A., Nguyen,M.T., Hu,Y.C., Gamlin,P. and Lang,R.A.
  TITLE     Developmental control of rod number via a light-dependent
            retrograde pathway from intrinsically photosensitive retinal
            ganglion cells
  JOURNAL   Dev Cell 59 (21), 2897-2911 (2024)
   PUBMED   39142280
REFERENCE   2  (bases 1 to 1824)
  AUTHORS   Barman,B. and Thakur,M.K.
  TITLE     Neuropsin promotes hippocampal synaptogenesis by regulating the
            expression and cleavage of L1CAM
  JOURNAL   J Cell Sci 137 (3) (2024)
   PUBMED   38206094
  REMARK    GeneRIF: Neuropsin promotes hippocampal synaptogenesis by
            regulating the expression and cleavage of L1CAM.
REFERENCE   3  (bases 1 to 1824)
  AUTHORS   Jeong,H., Lee,D., Jiang,X., Negishi,K., Tsubota,K. and Kurihara,T.
  TITLE     Opsin 5 mediates violet light-induced early growth response-1
            expression in the mouse retina
  JOURNAL   Sci Rep 13 (1), 17861 (2023)
   PUBMED   37857760
  REMARK    GeneRIF: Opsin 5 mediates violet light-induced early growth
            response-1 expression in the mouse retina.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1824)
  AUTHORS   Gaitonde,K.D., Andrabi,M., Burger,C.A., D'Souza,S.P., Vemaraju,S.,
            Koritala,B.S.C., Smith,D.F. and Lang,R.A.
  TITLE     Diurnal regulation of metabolism by Gs-alpha in hypothalamic QPLOT
            neurons
  JOURNAL   PLoS One 18 (5), e0284824 (2023)
   PUBMED   37141220
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1824)
  AUTHORS   Kamalabadi-Farahani,M., Atashi,A., Jabbarpour,Z. and Aghayan,S.S.
  TITLE     Expression of osteopontin-5 splice variant in the mouse primary and
            metastatic breast cancer cells
  JOURNAL   BMC Res Notes 15 (1), 286 (2022)
   PUBMED   36064446
  REMARK    GeneRIF: Expression of osteopontin-5 splice variant in the mouse
            primary and metastatic breast cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1824)
  AUTHORS   Tamura,H., Kawata,M., Hamaguchi,S., Ishikawa,Y. and Shiosaka,S.
  TITLE     Processing of neuregulin-1 by neuropsin regulates GABAergic neuron
            to control neural plasticity of the mouse hippocampus
  JOURNAL   J Neurosci 32 (37), 12657-12672 (2012)
   PUBMED   22972991
  REMARK    GeneRIF: Thus, ErbB4 signaling induced by neuropsin-dependent
            processing of NRG-1 contributes to the modulation of synaptic
            plasticity via regulation of GABAergic transmission.
REFERENCE   7  (bases 1 to 1824)
  AUTHORS   Kojima,D., Mori,S., Torii,M., Wada,A., Morishita,R. and Fukada,Y.
  TITLE     UV-sensitive photoreceptor protein OPN5 in humans and mice
  JOURNAL   PLoS One 6 (10), e26388 (2011)
   PUBMED   22043319
  REMARK    GeneRIF: OPN5 was capable of activating heterotrimeric G protein Gi
            in a UV-dependent manner
REFERENCE   8  (bases 1 to 1824)
  AUTHORS   Tarttelin,E.E., Bellingham,J., Hankins,M.W., Foster,R.G. and
            Lucas,R.J.
  TITLE     Neuropsin (Opn5): a novel opsin identified in mammalian neural
            tissue
  JOURNAL   FEBS Lett 554 (3), 410-416 (2003)
   PUBMED   14623103
REFERENCE   9  (bases 1 to 1824)
  AUTHORS   Fredriksson,R., Hoglund,P.J., Gloriam,D.E., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
REFERENCE   10 (bases 1 to 1824)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC110552.14.
            
            On May 2, 2007 this sequence version replaced NM_181753.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY318865.1, BC132010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC110552.14        171721-171854       c
            135-254             AC110552.14        167661-167780       c
            255-425             AC110552.14        157104-157274       c
            426-760             AC110552.14        153228-153562       c
            761-1002            AC110552.14        141088-141329       c
            1003-1060           AC110552.14        136780-136837       c
            1061-1824           AC110552.14        117324-118087       c
FEATURES             Location/Qualifiers
     source          1..1824
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.65 cM"
     gene            1..1824
                     /gene="Opn5"
                     /gene_synonym="Gpr136; Neuropsin; PGR12; TMEM13"
                     /note="opsin 5"
                     /db_xref="GeneID:353344"
                     /db_xref="MGI:MGI:2662912"
     exon            1..134
                     /gene="Opn5"
                     /gene_synonym="Gpr136; Neuropsin; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1138
                     /gene="Opn5"
                     /gene_synonym="Gpr136; Neuropsin; PGR12; TMEM13"
                     /note="G protein-coupled receptor 136; G-protein coupled
                     receptor PGR12"
                     /codon_start=1
                     /product="opsin-5"
                     /protein_id="NP_861418.2"
                     /db_xref="CCDS:CCDS37619.1"
                     /db_xref="GeneID:353344"
                     /db_xref="MGI:MGI:2662912"
                     /translation="MALNHTALPQDERLPHYLRDEDPFASKLSWEADLVAGFYLTIIG
                     ILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFG
                     WFGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAVIWAYA
                     SFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASGGGQVFILSILFFCLLLPTAVIVFS
                     YAKIIAKVKSSSKEVAHFDSRIHSSHVLEVKLTKVAMLICAGFLIAWIPYAVVSVWSA
                     FGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYRFACCQAGGLRGTKKKSLEDFRL
                     HTVTAVRKSSAVLEIHPESSSRFTSAHVMDGESHSNDGDCGKK"
     exon            135..254
                     /gene="Opn5"
                     /gene_synonym="Gpr136; Neuropsin; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     exon            255..425
                     /gene="Opn5"
                     /gene_synonym="Gpr136; Neuropsin; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     exon            426..760
                     /gene="Opn5"
                     /gene_synonym="Gpr136; Neuropsin; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     exon            761..1002
                     /gene="Opn5"
                     /gene_synonym="Gpr136; Neuropsin; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1060
                     /gene="Opn5"
                     /gene_synonym="Gpr136; Neuropsin; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1824
                     /gene="Opn5"
                     /gene_synonym="Gpr136; Neuropsin; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcatggcc ttgaaccaca ctgccctacc tcaggatgag cgcctgcccc actatcttcg
       61 agacgaggac ccttttgctt ccaaactttc ctgggaagcg gatttagtgg ctggctttta
      121 cctaacaata atcgggattc tctctacatt tggaaatggg tatgtccttt atatgtcttc
      181 tagacgcaag aagaagctga gacctgcgga aataatgact atcaatttag cagtctgtga
      241 tctggggata tcagttgtag gcaagccgtt caccatcatc tcttgcttct gccaccgctg
      301 ggtgtttggc tggtttggct gccgctggta tggctgggct ggatttttct ttggctgtgg
      361 aagcctgatt accatgactg ctgtcagcct ggaccgctat ctgaagatct gttatctgtc
      421 ttatggggtc tggctgaaga gaaagcatgc ctacatctgc ctggcagtca tctgggctta
      481 tgcttccttc tggaccacca tgcccttggt gggcctgggg gactatgcac ctgagccctt
      541 cggaacctca tgcaccctgg actggtggct ggcccaggct tcaggtgggg gtcaggtgtt
      601 catcctgagc atcctcttct tctgcctcct gctgccaacg gctgtgattg ttttctcata
      661 tgctaagatc atcgccaagg tgaagtcttc ttctaaagag gtagcccatt tcgacagtcg
      721 aatccatagc agccatgtac ttgaggtgaa gctgaccaag gtggcaatgc tgatttgtgc
      781 tggtttcctg attgcctgga ttccttatgc ggtcgtctct gtgtggtcag cttttggaag
      841 gccagactcc atccccatac agctctccgt ggtgcccaca ctccttgcaa aatcagcagc
      901 gatgtacaat ccaatcatct accaggtcat tgattacaga tttgcctgtt gccaggctgg
      961 tggtttgaga ggaacgaaga agaaatcttt ggaagacttt aggctgcata ctgtaaccgc
     1021 agtcaggaag tcttctgctg tgctggagat ccatccagag agcagttcca gatttactag
     1081 tgcccatgtt atggatggag agagtcacag taatgatggt gactgtggca agaaataagc
     1141 acctgtgttc tgaggccgag aaaccccgca cctgtccatc agggcttcag aaataagtgg
     1201 ccagcttcaa tatactcttt gaaatgctga aaaaaaaaag ctgtagtgta ttctttgcat
     1261 ttgtttttaa gtttgagaaa acatatggtc agcgttgact gcagtgttga tattgaagtt
     1321 taatcatgaa tacatagcat gtgaagtgtc cactctttag gctttataag acgattaaag
     1381 tgttctaagg agaaagcaca tcctaagctt gggaagtgca tcacccctta agcttcctat
     1441 tcatcgtgat agtaatggag cttatcgatg cattcatgac tgtgaacatg cctttgaaac
     1501 tgtcaaccac ttcttgtaca cggttagaat tttgaacatt tatctgggaa gcttctaaca
     1561 gcatactctg tcaagtcaac ttgtacatag tatttgtaag tactctctat gagaacattc
     1621 agaagatgtt ttagtgtttg actcattcac tttgtcccag ttgtgtgtcg aactgaagaa
     1681 cagtttgttg actgtactag gaaagaatgc attagtactt ttcatctctg tccatctctc
     1741 tttgcacact gaaatagttt tcttttgaag ccatagctgc tgttcaagtc cttttttttt
     1801 taaataaaga aaatatattg cacc
//
