LOCUS       NM_010098               1783 bp    mRNA    linear   ROD 11-APR-2023
DEFINITION  Mus musculus opsin 3 (Opn3), mRNA.
ACCESSION   NM_010098
VERSION     NM_010098.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Upton BA, Nayak G, Schweinzger I, D'Souza SP, Vorhees CV, Williams
            MT, Earl BR and Lang RA.
  TITLE     Comprehensive Behavioral Analysis of Opsin 3
            (Encephalopsin)-Deficient Mice Identifies Role in Modulation of
            Acoustic Startle Reflex
  JOURNAL   eNeuro 9 (5) (2022)
   PUBMED   36041828
  REMARK    GeneRIF: Comprehensive Behavioral Analysis of Opsin 3
            (Encephalopsin)-Deficient Mice Identifies Role in Modulation of
            Acoustic Startle Reflex.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Wu AD, Dan W, Zhang Y, Vemaraju S, Upton BA, Lang RA, Buhr ED,
            Berkowitz DE, Gallos G, Emala CW and Yim PD.
  TITLE     Opsin 3-Galphas Promotes Airway Smooth Muscle Relaxation Modulated
            by G Protein Receptor Kinase 2
  JOURNAL   Am J Respir Cell Mol Biol 64 (1), 59-68 (2021)
   PUBMED   33058732
  REMARK    GeneRIF: Opsin 3-Galphas Promotes Airway Smooth Muscle Relaxation
            Modulated by G Protein Receptor Kinase 2.
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Olinski LE, Tsuda AC, Kauer JA and Oancea E.
  TITLE     Endogenous Opsin 3 (OPN3) Protein Expression in the Adult Brain
            Using a Novel OPN3-mCherry Knock-In Mouse Model
  JOURNAL   eNeuro 7 (5) (2020)
   PUBMED   32737180
  REMARK    GeneRIF: Endogenous Opsin 3 (OPN3) Protein Expression in the Adult
            Brain Using a Novel OPN3-mCherry Knock-In Mouse Model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Sato M, Tsuji T, Yang K, Ren X, Dreyfuss JM, Huang TL, Wang CH,
            Shamsi F, Leiria LO, Lynes MD, Yau KW and Tseng YH.
  TITLE     Cell-autonomous light sensitivity via Opsin3 regulates fuel
            utilization in brown adipocytes
  JOURNAL   PLoS Biol 18 (2), e3000630 (2020)
   PUBMED   32040503
  REMARK    GeneRIF: Opsin3-knockout (Opn3-KO) mice are prone to diet-induced
            obesity and insulin resistance. Opn3-KO brown adipocytes cultured
            in darkness have decreased glucose uptake and lower
            nutrient-induced mitochondrial respiration than wild-type (WT)
            cells. Direct exposure of brown adipose tissue (BAT) to light in
            living mice significantly enhances thermogenic capacity of BAT, and
            this effect is diminished in Opn3-KO animals.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   Nayak G, Zhang KX, Vemaraju S, Odaka Y, Buhr ED, Holt-Jones A,
            Kernodle S, Smith AN, Upton BA, D'Souza S, Zhan JJ, Diaz N, Nguyen
            MT, Mukherjee R, Gordon SA, Wu G, Schmidt R, Mei X, Petts NT, Batie
            M, Rao S, Hogenesch JB, Nakamura T, Sweeney A, Seeley RJ, Van
            Gelder RN, Sanchez-Gurmaches J and Lang RA.
  TITLE     Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent
            Adipocyte Light Sensing
  JOURNAL   Cell Rep 30 (3), 672-686 (2020)
   PUBMED   31968245
  REMARK    GeneRIF: Adaptive Thermogenesis in Mice Is Enhanced by Opsin
            3-Dependent Adipocyte Light Sensing.
REFERENCE   6  (bases 1 to 1783)
  AUTHORS   Arlotta P, Molyneaux BJ, Chen J, Inoue J, Kominami R and Macklis
            JD.
  TITLE     Neuronal subtype-specific genes that control corticospinal motor
            neuron development in vivo
  JOURNAL   Neuron 45 (2), 207-221 (2005)
   PUBMED   15664173
REFERENCE   7  (bases 1 to 1783)
  AUTHORS   Woodruff ML, Wang Z, Chung HY, Redmond TM, Fain GL and Lem J.
  TITLE     Spontaneous activity of opsin apoprotein is a cause of Leber
            congenital amaurosis
  JOURNAL   Nat Genet 35 (2), 158-164 (2003)
   PUBMED   14517541
  REMARK    GeneRIF: studies clearly show that activation of sensory
            transduction by unliganded opsin, and not the accumulation of
            retinyl esters, causes light-independent retinal degeneration in
            Leber congenital amaurosis
REFERENCE   8  (bases 1 to 1783)
  AUTHORS   Tarttelin EE, Bellingham J, Bibb LC, Foster RG, Hankins MW,
            Gregory-Evans K, Gregory-Evans CY, Wells DJ and Lucas RJ.
  TITLE     Expression of opsin genes early in ocular development of humans and
            mice
  JOURNAL   Exp Eye Res 76 (3), 393-396 (2003)
   PUBMED   12573668
REFERENCE   9  (bases 1 to 1783)
  AUTHORS   Kasper G, Taudien S, Staub E, Mennerich D, Rieder M, Hinzmann B,
            Dahl E, Schwidetzky U, Rosenthal A and Rump A.
  TITLE     Different structural organization of the encephalopsin gene in man
            and mouse
  JOURNAL   Gene 295 (1), 27-32 (2002)
   PUBMED   12242008
REFERENCE   10 (bases 1 to 1783)
  AUTHORS   Blackshaw S and Snyder SH.
  TITLE     Encephalopsin: a novel mammalian extraretinal opsin discretely
            localized in the brain
  JOURNAL   J Neurosci 19 (10), 3681-3690 (1999)
   PUBMED   10234000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043135.1, AC124366.4 and AW492784.1.
            
            [WARNING] On Apr 26, 2023 this sequence was replaced by
            NM_010098.4.
            
            On Oct 18, 2013 this sequence version replaced NM_010098.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043135.1, AF140241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AK043135.1         2-73
            73-78               AC124366.4         134575-134580       c
            79-1605             AK043135.1         80-1606
            1606-1783           AW492784.1         1-178               c
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..1783
                     /gene="Opn3"
                     /gene_synonym="Ecpn; ERO"
                     /note="opsin 3"
                     /db_xref="GeneID:13603"
                     /db_xref="MGI:MGI:1338022"
     exon            1..463
                     /gene="Opn3"
                     /gene_synonym="Ecpn; ERO"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1299
                     /gene="Opn3"
                     /gene_synonym="Ecpn; ERO"
                     /note="opsin (encephalopsin); panopsin"
                     /codon_start=1
                     /product="opsin-3"
                     /protein_id="NP_034228.1"
                     /db_xref="CCDS:CCDS15549.1"
                     /db_xref="GeneID:13603"
                     /db_xref="MGI:MGI:1338022"
                     /translation="MYSGNRSGDQGYWEDGAGAEGAAPAGTRSPAPLFSPTAYERLAL
                     LLGCLALLGVGGNLLVLLLYSKFPRLRTPTHLFLVNLSLGDLLVSLFGVTFTFASCLR
                     NGWVWDAVGCAWDGFSGSLFGFVSITTLTVLAYERYIRVVHARVINFSWAWRAITYIW
                     LYSLAWAGAPLLGWNRYILDIHGLGCTVDWRSKDANDSSFVLFLFLGCLVVPVGIIAH
                     CYGHILYSVRMLRCVEDLQTIQVIKMLRYEKKVAKMCFLMAFVFLTCWMPYIVTRFLV
                     VNGYGHLVTPTVSIVSYLFAKSSTVYNPVIYIFMNRKFRRSLLQLLCFRLLRCQRPAK
                     NLPAAESEMHIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVEDSDRSSASKV
                     DVIQVRPL"
     exon            464..783
                     /gene="Opn3"
                     /gene_synonym="Ecpn; ERO"
                     /inference="alignment:Splign:2.1.0"
     exon            784..1035
                     /gene="Opn3"
                     /gene_synonym="Ecpn; ERO"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1769
                     /gene="Opn3"
                     /gene_synonym="Ecpn; ERO"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaatggcct gagcggcccg cagagcgtga gatccaccct gttcgggccg cccggctcac
       61 cgagccctct ctctcacggc gcgccggcgt cgggccatgt actcggggaa ccgtagtggc
      121 gaccagggct actgggagga cggggcgggc gccgagggcg cagcaccggc gggcacgcgg
      181 agccccgcgc ctctcttcag ccccaccgcg tacgagcgcc tggcgctgct actcggctgc
      241 ctcgcgctgc tgggcgtcgg cggcaacctg ctggtgctgc ttctctactc caagttcccg
      301 agactgcgca cgcccaccca cctcttcctg gtcaacctga gcctgggcga cctgctggta
      361 tccctgttcg gagtcacctt caccttcgcg tcgtgcctgc ggaacggctg ggtgtgggac
      421 gccgtgggct gcgcgtggga cgggtttagc ggcagcctct ttgggttcgt ttccattacc
      481 accctcactg tgctggccta tgaacgttat atccgtgtgg tacatgccag agtgatcaac
      541 ttttcctggg cctggagggc cattacctat atctggctct actccttggc atgggcagga
      601 gcacctctcc tgggctggaa caggtacatc ctagacatac atggactggg ctgtaccgtg
      661 gactggagat ccaaggatgc caacgactct tcctttgtgc tcttcctgtt tctcggctgc
      721 ctggtggtgc ccgtgggcat catagcccat tgctacggcc acattctcta ttctgttcga
      781 atgcttcgct gtgttgaaga tcttcagacc attcaagtga tcaagatgct aagatatgaa
      841 aagaaagtag caaagatgtg ctttttgatg gcctttgtct ttctcacctg ctggatgcct
      901 tacattgtga cccgcttctt ggtggtcaat ggctatggac acctggtcac cccaactgtg
      961 tccattgttt cttatctctt tgctaaatcg agcactgtgt acaacccagt tatctacatc
     1021 ttcatgaaca gaaagtttcg gaggtccctt ctgcagctcc tatgcttccg cctgctgaga
     1081 tgccagcggc ctgctaaaaa cctcccagcg gctgagagtg aaatgcacat caggcccatc
     1141 gtgatgtcac agaaagatgg ggacaggcca aagaagaaag tgacctttaa ctcttcctct
     1201 atcatcttta tcatcaccag tgatgagtcc ctgtcagtcg aggacagtga cagaagcagc
     1261 gcatctaagg tcgatgtcat ccaagtgcgt cctctataag aatggaagac agagtcctat
     1321 atcagccacc acaatgttcc tgtcaggagt gccccagagt ccccatttgg tgtaatagtg
     1381 acagaacctc tgtggccctg tgggaaatcc gaatcaccca catgttgtct gtattcaaga
     1441 agcgactgag caagacaaat tattttaact caatgggtgc tttataactt gagaacctcc
     1501 tggtggcaca agatgagcat ctggcgtcat cgtctactat gccaggattt aatatttgaa
     1561 tgactgtatt tgccaaagca cataatacat tttgtttatc aaatgtattt cactataaaa
     1621 ataacaatct catatacacg tgtacaatga ctggaacatc tggagtacgt tgcggtgttg
     1681 agtcctgttc tgtgccatgt tgtgtgtttg accaattaaa tttattgaag agataataaa
     1741 tcaatcccta cttttatctg aaacccaaaa aaaaaaaaaa aaa
//
