LOCUS       NM_177906               6324 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus opioid binding protein/cell adhesion molecule-like
            (Opcml), mRNA.
ACCESSION   NM_177906
VERSION     NM_177906.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6324)
  AUTHORS   Singh,K., Jayaram,M., Hanumantharaju,A., Tonissoo,T., Jagomae,T.,
            Mikheim,K., Muthuraman,S., Gilbert,S.F., Plaas,M., Schafer,M.K.E.,
            Innos,J., Lillevali,K., Philips,M.A. and Vasar,E.
  TITLE     The IgLON family of cell adhesion molecules expressed in developing
            neural circuits ensure the proper functioning of the sensory system
            in mice
  JOURNAL   Sci Rep 14 (1), 22593 (2024)
   PUBMED   39349721
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6324)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6324)
  AUTHORS   Fearnley,S., Raja,R. and Cloutier,J.F.
  TITLE     Spatiotemporal expression of IgLON family members in the developing
            mouse nervous system
  JOURNAL   Sci Rep 11 (1), 19536 (2021)
   PUBMED   34599206
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6324)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6324)
  AUTHORS   Zhang,Z., Ye,M., Li,Q., You,Y., Yu,H., Ma,Y., Mei,L., Sun,X.,
            Wang,L., Yue,W., Li,R., Li,J. and Zhang,D.
  TITLE     The Schizophrenia Susceptibility Gene OPCML Regulates Spine
            Maturation and Cognitive Behaviors through Eph-Cofilin Signaling
  JOURNAL   Cell Rep 29 (1), 49-61 (2019)
   PUBMED   31577955
REFERENCE   6  (bases 1 to 6324)
  AUTHORS   Caterina,J., Shi,J., Krakora,S., Bartlett,J.D., Engler,J.A.,
            Kozak,C.A. and Birkedal-Hansen,H.
  TITLE     Isolation, characterization, and chromosomal location of the mouse
            enamelysin gene
  JOURNAL   Genomics 62 (2), 308-311 (1999)
   PUBMED   10610728
REFERENCE   7  (bases 1 to 6324)
  AUTHORS   Kim,M.G., Chen,C., Lyu,M.S., Cho,E.G., Park,D., Kozak,C. and
            Schwartz,R.H.
  TITLE     Cloning and chromosomal mapping of a gene isolated from thymic
            stromal cells encoding a new mouse type II membrane serine
            protease, epithin, containing four LDL receptor modules and two CUB
            domains
  JOURNAL   Immunogenetics 49 (5), 420-428 (1999)
   PUBMED   10199918
REFERENCE   8  (bases 1 to 6324)
  AUTHORS   Hong,G., Deleersnijder,W., Kozak,C.A., Van Marck,E., Tylzanowski,P.
            and Merregaert,J.
  TITLE     Molecular cloning of a highly conserved mouse and human integral
            membrane protein (Itm1) and genetic mapping to mouse chromosome 9
  JOURNAL   Genomics 31 (3), 295-300 (1996)
   PUBMED   8838310
REFERENCE   9  (bases 1 to 6324)
  AUTHORS   Miner,L.L. and Marley,R.J.
  TITLE     Chromosomal mapping of the psychomotor stimulant effects of cocaine
            in BXD recombinant inbred mice
  JOURNAL   Psychopharmacology (Berl) 122 (3), 209-214 (1995)
   PUBMED   8748389
REFERENCE   10 (bases 1 to 6324)
  AUTHORS   Chakraborti,A., Lippman,D.L., Loh,H.H., Kozak,C.A. and Lee,N.M.
  TITLE     Genetic mapping of opioid binding protein gene(s) to mouse
            chromosome 9
  JOURNAL   Mamm Genome 4 (3), 179-182 (1993)
   PUBMED   8439730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102567.8, AC154803.2, AC116523.7 and AC166352.1.
            
            On Jun 21, 2018 this sequence version replaced NM_177906.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076581.1, SRR9219381.208574.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC102567.8         81838-81985         c
            149-233             AC154803.2         54204-54288
            234-466             AC116523.7         34793-35025
            467-592             AC116523.7         172946-173071
            593-727             AC166352.1         88162-88296         c
            728-848             AC166352.1         87640-87760         c
            849-1000            AC166352.1         86449-86600         c
            1001-6324           AC166352.1         64405-69728         c
FEATURES             Location/Qualifiers
     source          1..6324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 13.73 cM"
     gene            1..6324
                     /gene="Opcml"
                     /gene_synonym="2900075O15Rik; 3732419F12; B930023M13Rik;
                     C230027C17; Gm181; Obcam"
                     /note="opioid binding protein/cell adhesion molecule-like"
                     /db_xref="GeneID:330908"
                     /db_xref="MGI:MGI:97397"
     exon            1..148
                     /gene="Opcml"
                     /gene_synonym="2900075O15Rik; 3732419F12; B930023M13Rik;
                     C230027C17; Gm181; Obcam"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1101
                     /gene="Opcml"
                     /gene_synonym="2900075O15Rik; 3732419F12; B930023M13Rik;
                     C230027C17; Gm181; Obcam"
                     /codon_start=1
                     /product="opioid-binding protein/cell adhesion molecule
                     precursor"
                     /protein_id="NP_808574.2"
                     /db_xref="CCDS:CCDS22942.1"
                     /db_xref="GeneID:330908"
                     /db_xref="MGI:MGI:97397"
                     /translation="MYHPAYWIVFSATTALLFIPGVPVRSGDATFPKAMDNVTVRQGE
                     SATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYD
                     EGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTV
                     TWRHLSVKGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYI
                     SKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEDTRLATGLDGVRIENKGRISTLTFF
                     NVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTFFAHFF
                     IKF"
     exon            149..233
                     /gene="Opcml"
                     /gene_synonym="2900075O15Rik; 3732419F12; B930023M13Rik;
                     C230027C17; Gm181; Obcam"
                     /inference="alignment:Splign:2.1.0"
     exon            234..466
                     /gene="Opcml"
                     /gene_synonym="2900075O15Rik; 3732419F12; B930023M13Rik;
                     C230027C17; Gm181; Obcam"
                     /inference="alignment:Splign:2.1.0"
     exon            467..592
                     /gene="Opcml"
                     /gene_synonym="2900075O15Rik; 3732419F12; B930023M13Rik;
                     C230027C17; Gm181; Obcam"
                     /inference="alignment:Splign:2.1.0"
     exon            593..727
                     /gene="Opcml"
                     /gene_synonym="2900075O15Rik; 3732419F12; B930023M13Rik;
                     C230027C17; Gm181; Obcam"
                     /inference="alignment:Splign:2.1.0"
     exon            728..848
                     /gene="Opcml"
                     /gene_synonym="2900075O15Rik; 3732419F12; B930023M13Rik;
                     C230027C17; Gm181; Obcam"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1000
                     /gene="Opcml"
                     /gene_synonym="2900075O15Rik; 3732419F12; B930023M13Rik;
                     C230027C17; Gm181; Obcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..6324
                     /gene="Opcml"
                     /gene_synonym="2900075O15Rik; 3732419F12; B930023M13Rik;
                     C230027C17; Gm181; Obcam"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6297..6302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Opcml"
                     /gene_synonym="2900075O15Rik; 3732419F12; B930023M13Rik;
                     C230027C17; Gm181; Obcam"
                     /note="hexamer: AATAAA"
     polyA_site      6324
                     /gene="Opcml"
                     /gene_synonym="2900075O15Rik; 3732419F12; B930023M13Rik;
                     C230027C17; Gm181; Obcam"
                     /note="major polyA site"
ORIGIN      
        1 agcacagagg aagcagcctc ggtagcagca gcagtagcag cagcaccagc aggagctagc
       61 cgggccgccg cgcaccacag cctcgagatg taccatcccg cctactggat cgtcttctcg
      121 gccaccactg ccctgctctt catcccagga gtgccggtgc gcagcggaga tgccaccttt
      181 cccaaagcta tggacaacgt gacggtccgg cagggggaga gcgccaccct caggtgtacc
      241 atagatgatc gggtcacccg ggtagcctgg ctaaaccgca gcacaatcct ctatgctggg
      301 aatgacaagt ggtccataga ccctcgagtg atcattttgg tcaacacgcc tacccaatac
      361 agtatcatga tccagaatgt ggatgtatac gatgaaggtc catacacctg ctctgtgcag
      421 acagacaatc accccaaaac ctcccgggtc catctcatag tgcaagttcc tccccagata
      481 atgaacatct cgtcagacat taccgtgaat gaaggaagca gtgtgaccct gttatgtctt
      541 gcaattggca gaccagaacc aacggtgaca tggaggcacc tgtcagtcaa gggccaggga
      601 tttgtgagtg aagatgaata cctggaaatc tcagacatca aacgtgacca gtctggggag
      661 tacgagtgca gcgccttgaa tgacgtcgct gcacctgatg ttcggaaagt aaaaatcact
      721 gtaaactacc ctccctatat atctaaagcc aagaacactg gtgtttcagt gggtcagaag
      781 ggcatcttga gctgcgaagc ctctgctgtc ccgatggctg aattccagtg gttcaaagaa
      841 gataccaggt tagccactgg cctggatggg gtgagaattg agaacaaagg ccgcatatcc
      901 actttgactt tcttcaatgt ctcagagaag gattatggga actatacctg tgtggccaca
      961 aacaagcttg ggaacaccaa tgccagcatc accctgtatg ggcctggagc agtgattgat
     1021 ggtgtaaact cggcctccag agcactggct tgtctctggc tctcagggac cttctttgcc
     1081 cacttcttca tcaagttttg ataagaaacc ataggtcctc tgagcatcgc ctgcttctcc
     1141 atatcacaga ctttaatcta cactgcggag ggcaaaccag tttgggcttc tttttgttta
     1201 tttttcgttc ttcttgacta ttttggtttt tggtttgatt tcttggattt tcaattttat
     1261 ttgatttttc tttttttttc ttctttttct tcttcttctt tttttttttt ttttttttga
     1321 atgagtgggg ttgggatggg cagggttcta ccaagggtag ggtaatcatt cattggtatg
     1381 cccccaaacg gaatctattc ctgctacctt ggtcttcctt ttctctactt ctcttcttac
     1441 caccattaac acacacacac acacacacac acacacacac accctaaaaa taaaaatggg
     1501 ctaaaaaatg tcccatgata agtaccctga tggtacacct tggctcacaa tgcagtacac
     1561 aataagagtt gcatctacat gtcctatttt ctttgtcctt taagctttca ataagacagt
     1621 tttaaaagtg catatcctta tccccatgct aatagcacct atcccattag gcttcacatc
     1681 ttgtctttct aagaagctgc ctaactgcat ccttaaatgt gtacacacat acaaatatat
     1741 gtaaaaaatt tccatcttca ctggccattc tcctctatat gctttttgcc actagctgta
     1801 agacttacag aattgagact atatatgtac ccaacgctac aaatttagga gtcaagtaaa
     1861 caaatgaggg aagtctattt aggatagtac ttcccttaaa acgctgttgc aactcataaa
     1921 aaactgatca atagctggct aattatatta agctttcaaa gcaatcatac tattatccat
     1981 ttactcaatt gatttgtggc tccatctagt tctacataac ctgtcttttt ctcttataat
     2041 ctatttgatc tatttaacta atcattcttt ttctcttccc actacacact atcaattcat
     2101 cccatattaa tctctaatca tattgtgtct atgccactat ctccatatct ctactaccat
     2161 caatagacat ttccaccttc aaaattgcct agcaacttct tatgtgaaag ccagtggtct
     2221 tgcaggctaa ctacccagaa gaacaatttc ctatgccatg gatccttgag aatgcagtaa
     2281 cccatccacc caaattagac cttgtgaaca gatggaccaa agtagcaatc taaagatcag
     2341 tcactcatga ttttcagaga ggctgttccc taagccacct tctcaggagg caggtcagcc
     2401 ctgggaaagc cttgattatg ctgcatttct cctttaacag ctggaaaatt aaggtaccaa
     2461 ccccgtgctt ctctcagcct ttcaagaaaa gtacatgtca ggaacttggg gaaacttctt
     2521 cgtggctggc tttcattagc agaaagaacc tgacctccct ccaccacacc cccccccccc
     2581 cagaaaagca tatatctttc ccttcaatgt aaagacagtg gtccatcagc caaagcgtga
     2641 taaccagagc tcagcatctc cctactgctc cagttttgat ttgaattgtt tgaaaattat
     2701 ccagccaagg gctgatggag gccaattacg tggcgtgtgt gttgacaact ctggtatttg
     2761 tttcagaaag ctcttctgag ctgagggcac ttgagctact gacttaattt ccaagcactt
     2821 gattaacaca acatggcaaa cagaggggaa gtgtaagtaa tactgttttc ctgggctgtt
     2881 tctctcgaag ctttggggat aaatgtcccc aaattcctat gttcaaagca ggcctcctgt
     2941 acaaagaaga tctgattcca cctctcagca ttgactcttg ggaaaagaag agcccagcca
     3001 acaagagagc ctacagttca aacatcatta aaggtcacaa ggggctctgg aggaactggc
     3061 ttactgagaa gttgagaagg agcaccagca gtgattttct taaagacatg tcctgcctcc
     3121 ctcagggacc tttttcaggt ccacctctaa aaactaaatg actgtgggct ccattagagt
     3181 tcatttccct tagagcttaa ctgatcactt gttacagtat aactgcccac tctgtggcac
     3241 tatggccaca gaagtacaaa acccacagta gggacatata tacctgtgta tacatattca
     3301 catatataca aatgcaggct tctttggcat acaaaaagct cagcactgtc ataagagata
     3361 gagctggggt gagcaaaatt aatactcttc ttgccagctg taaacagaca tctgcatttc
     3421 ctagtgagct gccaagaatg agactctggg agcataaatg atgtgccaaa aacagtctat
     3481 ttattccaac ttccagaagc aatcaggagc aggcacaaag tcagaattac aggtcggata
     3541 tatgaatttc agatctgtca ccacgctcag cacctgggat tgggttggtg tcaagcattg
     3601 tatgagacat aaacatggca tttgcgtttt ctactaatac tacttttgtt gctttggaga
     3661 aaaggaaatg tggatgccat ggaaactgaa aagtgttggg tgatgtgctg cttgaaatgg
     3721 acaagcccaa attggtcttc actaccttgt gcaagcagat catcaaaacc ccagttgagt
     3781 atggactcag ggtcatcctg catctctgat gtgcctactt tcactggata ctagaaattt
     3841 ctgtggtggt aacctactcc agccaaactt ccgaaggaaa cacatgctgc agtcaatcct
     3901 cctctgtctg ggagaaaaat caaaagccaa gtagaaatga ctaaaggcaa ctgagtacca
     3961 gatataaaag tgacttcctc acagcaaatg tgccccagct cttgttattt gagtgacttt
     4021 ggtaaggatg actccatgtg atgggagctg acaggacagc agctgcttcc taaaaacaac
     4081 atgtatactt acacatgcct ttccaaccat atacatgaag ggtggacaat caggcccact
     4141 agacagattt gtttagcttg ccaagggtgg gtgtgaggaa ggtataaggt taggaaaaag
     4201 gaatcacatt agtctaagta gctggtaaaa tgttgtgggt tttctaagtg aaacccaaat
     4261 acaggttatc aagagattag gtaaaagaaa gtcagcaaag gtagttattc taaaacttct
     4321 ccccttccca aaccaatgct aatttgttct tccaccaaag tatgccaatg aaagtgctag
     4381 tgttctgcct ctggcaaagc ctgttttttg aatagtttaa tgtcaagtgc ctgatacagt
     4441 catctgcaag tttaatcaag agtgtttgga ttttcttttt ttgttctcat tggttaggtt
     4501 ggagacatag tagattagtt gtcaaaacat atacagctct gacacagaga gctaggtatg
     4561 tggctcttct gctgtgggcg aagctgtgtt caacagatgg aaatggacat ctgtatgtca
     4621 ccaagatggc tcatgcctgt ccttacactg ctttgggctg ttgttcacag gttgggaagt
     4681 tagttttcaa aatatggtca taggtttggt ttggaattct aggaccttca taactgaggc
     4741 tgcattttaa tgatctcttt ctatatccat ctggtcacat tgtcctcagc aagaaggaat
     4801 agcaaacctg cctacaatag gaaaaatatc aaaagagcag agccccacct tccccaagtg
     4861 gacactggat cccagagagt ttatcacagg cactggataa agaaaagttg gaaatttaat
     4921 acaaatgatt tgattgatac ttccagggac aaagaacaca tgctcttcgt agcctatatg
     4981 gctaatacca gcctcataag acagtggggg aggaatagct tatgaatatt tgagggaata
     5041 tctgccccca atttgatcct gagtttttac caggatcaaa aaaaaaaatt gtttgacaat
     5101 acccagaata cccttttccc ctccagagct actcttgttg gaattagagg aagcaacata
     5161 attcttattt ttaatttttt ggggcaaaat gtatttttcc ccaacagcaa gaatatttgg
     5221 gttttctttg gcataaacct tatttctaga aatcctcatg tccaattgct ttccccctta
     5281 ttatccaaag cttcagtctc tctttctttc aagacaaata tgtttaagta gctgcagtca
     5341 cacctcacag gtgttcaaag agaagggcaa ctctatacag gataccatat gattagagct
     5401 tctaatgacc acacagaagg caaacaaata aaaatgccaa gctcatttcc ctcatttctt
     5461 actcaagaga agagaagtaa atgaaaggaa ggagaactag atttgcaatt acaaatgtgg
     5521 caaaaagata cagcagaacc ggtgcaattt agccttcagg tgcagaatat ggaggccaaa
     5581 agaatgtgga gtggacttaa ttagatgcaa ttgtcttcat agtgaaagta gtcagctaaa
     5641 cccaatctcc agcattttgg aagagacttc ctgcccctcc tccccggagt ggtgccctct
     5701 ttaggcacat ggttgttcca caccactagg tggagaagga aagattgaga gctactcaca
     5761 atccttgtgg agctccattc taggttattt ggcagagcat aagaatctca ataataacag
     5821 tggtaagtaa tagctgccct tgtgttagtg aagaggaaca tttttaatca ttcagaaatt
     5881 ttcgtgacat gtaaagtgca attgtgagga atgtgtgggt gtacgaaaat gtatctgtca
     5941 agttcagagt cctctagatt aaaaaaaaaa aacttataag attatcaatg gtgccgttaa
     6001 tagatgtgtt ggacaatggg tgtacccatt ttcacaatta ttctcaaaac aaatctatgt
     6061 tcagatgctt taaaatttta tcacatgata caagaatata actttgtcag cctttaaaag
     6121 ttccttttct tttactttct tatttttttt ccttcaaaaa tcaatgaaga cttgatttct
     6181 gtcaatcatt gtattgaggg tgaatatact acctgaattt tgtgcatgtt acattgtagt
     6241 tgtaaccttt tctaattcag gatgaataca agatggttgt gattgtgcag tgtatcaata
     6301 aagtttgaag acatttgtaa cttt
//
